Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers:A Randomized Controlled Trial

Objective To explore the effectiveness of a nutritional intervention in rescuers who screened positive for depression.Methods A randomized controlled trial design was employed.From June to August,2022,4,460 rescuers were screened using the Self-Rating Depression Scale(SDS),and 1,615 positive cases were identified.Thirty-one volunteers were recruited and randomly divided into a nutritional intervention group and a control group.The intervention group received health education and nutritional intervention(a compound paste therapy primarily composed of red roses and Seville orange flowers),while the control group received psychological education.SDS scores were assessed before and after the intervention.Results There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention(P<0.05).Furthermore,the SDS scores of the intervention group were significantly lower than those of the control group,both before and after the intervention(P<0.05).No severe adverse reactions were observed during safety evaluation.Conclusion The nutritional intervention effectively reduced the depression scores in rescuers.Early nutritional intervention is recommended for rescuers who initially screen positive for depression.

晚期肾上腺皮质癌靶向治疗和免疫治疗的研究进展

肾上腺皮质癌(adrenocoritical carcinoma,ACC)是肾上腺最常见的恶性肿瘤,晚期ACC预后较差,手术切除肿瘤仅限于临床Ⅰ、Ⅱ期的患者,且术后复发率高。对于晚期ACC,米托坦(mitotane,M)联合依托泊苷(etoposide,E)、阿霉素(doxorubicin,D)、顺铂(cisplatin,P)(EDP-M)是目前唯一批准可行的一线治疗方案,但化疗和放疗等治疗效果有限,EDP-M方案失败后尚无标准或一致的二线全身治疗选择。近年来随着对ACC发病分子机制的深入研究与认识,针对表皮生长因子受体(epidermal growth factor receptor,EGFR)、内皮细胞上血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)等靶点的酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)、mTOR抑制剂和免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)正在研究中。此外,多项针对ACC的研究发现CTNBB1、TP53、KDM5A、CENP-H等突变,有望成为潜在的治疗靶点或生物标志物,为ACC治疗提供更多可能的选择。ICIs已经被证实对非小细胞肺癌、肝癌、肾细胞癌、尿路上皮细胞癌等多种肿瘤有效,积极探索靶向、免疫治疗、特别是联合疗法对延长患者生存期和改善患者生活质量展现出良好的发展潜力。

Finite Element Method Simulation of Wellbore Stability under Different Operating and Geomechanical Conditions

The variation of the principal stress of formations with the working and geo-mechanical conditions can trigger wellbore instabilities and adversely affect the well completion.A finite element model,based on the theory of poro-elasticity and the Mohr-Coulomb rock damage criterion,is used here to analyze such a risk.The changes in wellbore stability before and after reservoir acidification are simulated for different pressure differences.The results indicate that the risk of wellbore instability grows with an increase in the production-pressure difference regardless of whether acidification is completed or not;the same is true for the instability area.After acidizing,the changes in the main geomechanical parameters(i.e.,elastic modulus,Poisson’s ratio,and rock strength)cause the maximum wellbore instability coefficient to increase.

Review of Three-phase Soft Switching Inverters and Challenges for Motor Drives

For electric vehicles (EVs),it is necessary to improve endurance mileage by improving the efficiency.There exists a trend towards increasing the system voltage and switching frequency,contributing to improve charging speed and power density.However,this trend poses significant challenges for high-voltage and high-frequency motor controllers,which are plagued by increased switching losses and pronounced switching oscillations as consequences of hard switching.The deployment of soft switching technology presents a viable solution to mitigate these issues.This paper reviews the applications of soft switching technologies for three-phase inverters and classifies them based on distinct characteristics.For each type of inverter,the advantages and disadvantages are evaluated.Then,the paper introduces the research progress and control methods of soft switching inverters (SSIs).Moreover,it presents a comparative analysis among the conventional hard switching inverters (HSIs),an active clamping resonant DC link inverter (ACRDCLI) and an auxiliary resonant commuted pole inverter (ARCPI).Finally,the problems and prospects of soft switching technology applied to motor controllers for EVs are put forward.

区块链技术在“三农”融资领域应用的路径研究——以江苏省为例

区块链技术作为计算机技术发展的产物已经延伸到许多领域,尤其是在金融领域更加成熟和稳定。文章对区块链技术在江苏省“三农”融资领域应用现状及存在的问题进行分析,以现有区块链网络为基础,深入调查研究区块链技术在“三农”融资领域应用的具体措施,以期为“三农”工作资金流、信息流、物流的链上流转提供有力支撑。

Fatigue Life Analysis of Coiled Tubing in Deep Well Jet Plugging Removal

The coiled tubing plugging has become the main means of plugging in gas Wells in Xinjiang. These Wells are deep and have high pressure, which can easily affect the fatigue life of the operating coiled tubing. In order to improve the life of coiled tubing in high-pressure gas Wells, this paper studies the plugging conditions of coiled tubing in high-pressure ultra-deep Wells. Firstly, the cross section deformation of coiled tubing under high internal pressure is analyzed. Secondly, the factors influencing the fatigue life of coiled tubing and the influence of surface damage on the fatigue life of coiled tubing were studied. Finally, the mechanism of furrow damage caused by coiled tubing and the main measures to reduce furrow damage are analyzed. The following suggestions are made to improve the life of coiled tubing: select the right material and the right size coiled tubing;Use appropriate measures to prevent premature coiled tubing failure and reduce operating costs.

基于Au MOFs的SERS传感器构筑及对挥发性有机化合物的检测

针对挥发性有机气体(volatile organic compounds,VOCs)检测难度大的问题,选用MIL 100(Fe)、UiO 66(Zr)2种具有拉曼吸附增强效应的金属有机框架材料(metal-organic frameworks,MOFs)作为表面增强拉曼散射(surface-enhanced Raman scatting,SERS)基底,用于检测几种常见的VOCs,并通过掺入金纳米颗粒(Au NPs)构筑“热点”得到检测性能更优异的复合基底。结果表明:MIL 100(Fe)能够检测出甲苯、丙酮及乙酸乙酯的拉曼信号,UiO 66(Zr)能够检测出异丙醇、异戊二烯的拉曼信号。加入Au NPs提高检测能力后,复合基底Au MIL 100(Fe)对甲苯的检测限为0.004 mg/m^(3),异戊二烯的检测限为13.900 mg/m^(3);Au UiO 66(Zr)对甲苯的检测限为0.400 mg/m^(3),异戊二烯的检测限为0.300 mg/m^(3)。复合基底对于VOCs的检测优势来源于不同的MOFs材料对于不同目标物的富集能力和材料自身的拉曼吸附增强效应以及金纳米颗粒构筑热点后的拉曼增强效果。

Chemical bonding of perovskite LaFeO_(3) with Li_(1.2)Mn_(0.6)Ni_(0.2)O_(2) to moderate anion redox for achieving high cycling stability

Oxygen anion redox reaction provides a high theoretical capacity for Li-rich manganese-based cathodes.However,irreversible surface oxygen release often results in further oxygen loss and exacerbates the decomposition of the electrolyte,which could reduce the capacity contribution from the anionic redox and produce more acidic substances to corrode the surface of the material.In this paper,the surface oxygen release is suppressed by moderating oxygen anion redox activity via constructing chemical bonds between M(M=Fe and La)in LaFeO_(3)and surface oxygen anions of Li_(1.2)Mn_(0.6)Ni_(0.2)O_(2).The constructed interface layer stabilizes the surface lattice oxygen and retards the electrolyte from being attacked by the nucleophilic oxygen generated in the process of oxygen release,as evidenced by Differential Electrochemical Mass Spectrometry(DEMS)and X-ray Photoelectron Spectroscopy(XPS)detections.Moreover,in the charge and discharge process,the formed FeF_(3),located at the cathode electrolyte interfacial layer,is conducive to the stability of the cathode surface.The modified Li_(1.2)Mn_(0.6)Ni_(0.2)O_(2)electrode with 3 wt%LaFeO_(13)exhibits a high specific capacity of 189.5 mA h g-at 1C(200 mA g^(-1))after 150 cycles with capacity retentions of 96.6%,and 112.6 mA h g^(-1)(84.7%)at 5C after 200 cycles higher than the pristine sample.This study provides a rational design chemical bonding method to suppress the oxygen release from the cathode surface and enhance cyclic stability.

Rucklidge-based memristive chaotic system:Dynamic analysis and image encryption

A new four-dimensional(4D)memristive chaotic system is obtained by introducing a memristor into the Rucklidge chaotic system,and a detailed dynamic analysis of the system is performed.The sensitivity of the system to parameters allows it obtains 16 different attractors by changing only one parameter.The various transient behaviors and excellent spectral entropy and C0 complexity values of the system can also reflect the high complexity of the system.A circuit is designed and verified the feasibility of the system from the physical level.Finally,the system is applied to image encryption,and the security of the encryption system is analyzed from multiple aspects,providing a reference for the application of such memristive chaotic systems.

Guideline for the diagnosis and treatment of rheumatoid arthritis with integrated traditional Chinese medicine and Western medicine to increase efficiency and reduce toxicity

Rheumatoid arthritis imposes a huge disease burden.Existing practice guidelines do not meet the needs of integrated traditional Chinese medicine and Western medicine in the treatment of rheumatoid arthritis.We established a guideline working group consists of a steering committee,a secretary group,an evidence evaluation group,a consensus group and a review group and developed a guideline following the guidance of the World Health Organization Handbook and the Chinese Medical Association.The guideline includes 35 recommendations which reached consensus by the two rounds Delphi surveys.These recommendations were formulated to address the following themes of most concern to clinician:diagnostic imaging,disease staging,traditional Chinese medicine syndromes,effectiveness and toxicity of integrated traditional Chinese medicine and Western medicine.

Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis by inhibiting mast cell degranulation

Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis was used to evaluate the effect of GSZ in preventing arthritis and joint destruction.Immunohistochemical staining revealed the accumulation of histamine H4 receptor and tryptase alpha/beta-1 in the ankle joint of the model.Then,we explored the effect of GSZ serum on fibroblast-like synoviocytes using standard transwell invasion and migration assays.Real-time quantitative polymerase chain reaction and western blot were used to detect the expression of toll-like receptor 4(TLR4)/myeloid differentiationfactor 88(MyD88)/nuclear factor-κB p65(NF-κB p65).Results:The results showed that pre-rheumatoid arthritis treatment with GSZ could reduce inflammation and maintain cartilage structure in the collagen-induced arthritis model.Moreover,GSZ significantly blocked mast cell degranulation and inhibited the TLR4/MyD88/NF-κB p65 pathway.Since the combined activation of mast cells via TLR4 and immune complexes enhances inflammation in synovial tissue,we concluded that GSZ may block mast cell degranulation by inhibiting the TLR4/MyD88/NF-κB p65 pathway and thus influence rheumatoid arthritis onset.Conclusion:Taken together,our data suggested that GSZ may be a promising therapeutic decoction for the prophylactic treatment of rheumatoid arthritis.

非结构农田环境机器视觉障碍物检测方法

非结构农田环境准确感知与理解,是农业生产自动化向自主化进程中的关键技术支撑。针对农田作业机器人障碍物感知检测技术,提出3个田间避障路径规划的基本原则。分析阐述非结构复杂农田背景下基于视觉检测田间障碍物的优劣势,概述目前基于单目视觉和双目视觉检测障碍物的主要方法及各方法检测田间障碍物的局限性。探讨基于机器视觉的田间障碍物检测技术的实现方式、优缺点对比和局限性等问题,指出基于视觉的多传感器融合是农田作业机器人环境感知、认知进而自主作业的发展方向。

Kinetics of leaching lithium from α-spodumene in enhanced acid treatment using HF/H_2SO_4 as medium

An enhanced leaching of Li fromα-spodumene was carried out using a mixture of hydrofluoric and sulfuric acid(HF/H2SO4)as the medium.Based on the optimized leaching conditions,the leaching kinetics of Li was investigated in an ore/HF/H2SO4 ratio of 1:3:2 g:mL:mL with leaching temperature ranging from 50 to 100°C.The results indicate that the leaching kinetics of Li fitted well with a model based on the shrinking core model.In addition,the leaching rate of Li was controlled by chemical reactions and diffusion through the product layers.The apparent activation energy Ea was calculated to be 32.68 kJ/mol.Solid films were formed because of the generation of insoluble products such as cryolithionite(Na3Li2Al2F12),cryolite(Na3AlF6),calcium fluoride(CaF2),potassium cryolite(K2AlF5),aluminum fluoride(AlF3),and fluorosilicates(Na2SiF6 or KNaSiF6).Furthermore,the effects of the ore/HF ratio and leaching temperature on the leaching behavior of Li,Al and Si were investigated.The results indicate that the ore/HF ratio and leaching temperature could clearly affect the distribution of HF molecules on the leaching of Li,Al and Si,which are important for the selective leaching of Li over Al and Si with this fluorine-based chemical method.

β-细辛醚对抑郁模型小鼠的快速抗抑郁作用

本文研究了β-细辛醚快速抗抑郁作用,并对其不同给药方式的作用效果及潜在的生物学机制进行探讨。将70只昆明种雄性小鼠随机分为模型组(n=60)、正常组(n=10),模型组给予慢性不可预见性刺激,正常组常规饲养;21d后,采用糖水偏好实验选取40只造模成功小鼠,随机分成五组:β-细辛醚鼻腔组、β-细辛醚灌胃组、越鞠丸鼻腔组、越鞠丸灌胃组、模型对照组;正常组中随机选取8只小鼠作为正常对照组。单次给药30 min后依次进行旷场实验,悬尾实验和强迫游泳实验;采用Western blot实验检测给药后45 min小鼠海马区脑源性神经营养因子(BDNF)和酪氨酸激酶B(TrkB)蛋白的表达变化。β-细辛醚用药组的旷场实验得分高于模型对照组(p<0.05);强迫游泳实验和悬尾实验中小鼠的静止时间更短(p<0.05);与模型对照组比较,β-细辛醚用药组给药45 min后小鼠海马中的BDNF及其受体TrkB的表达均明显上调(p<0.05)。β细辛醚具有快速抗抑郁作用,且这种潜在的快速抗抑郁作用可能与BDNF及其受体TrkB的激活相关。

Patients with culture negative pyogenic liver abscess have the same outcomes compared to those withKlebsiella pneumoniae pyogenic liver abscess

BACKGROUND: Etiologic organism is not frequently isolated despite multiple blood and lfuid cultures during management of pyogenic liver abscess (PLA). Such culture negative pyogen-ic liver abscess (CNPLA) is routinely managed by antibiotics targeted toKlebsiella pneumoniae. In this study, we evaluated the outcomes of such clinical practice. METHODS: All the patients with CNPLA andKlebsiella pneu-moniaePLA (KPPLA) admitted from January 2003 to Decem-ber 2011 were included in the study. A retrospective review of medical records was performed and demographic, clinical and outcome data were collected. RESULTS: A total of 528 patients were treated as CNPLA or KPPLA over the study period. CNPLA presented more com-monly with abdominal pain (P=0.024). KPPLA was more com-mon in older age (P=0.029) and was associated with thrombo-cytopenia (P=0.001), elevated creatinine (P=0.002), bilirubin (P=0.001), alanine aminotransferase (P=0.006) and C-reactive protein level (P=0.036). CNPLA patients tend to have anemia (P=0.015) and smaller abscess (P=0.008). There was no differ-ence in hospital stay (15.7 vs 16.8 days) or mortality (14.0% vs 11.0%). No patients required surgical drainage after initiation of medical therapy. CONCLUSION: Despite demographic and clinical differences between CNPLA and KPPLA, overall outcomes are not different.

The pre-Kasai procedure in living donor liver transplantation for children with biliary atresia

BACKGROUND:Biliary atresia(BA) is a major cause of chronic cholestasis,a fatal disorder in infants.This study was undertaken to evaluate the safety and effectiveness of primary living donor liver transplantation(LDLT) in comparison with the traditional first-line treatment,the Kasai procedure.METHODS:We assessed 28 children with BA at age of less than two years(3-21.3 months) who had undergone LDLT in two hospitals in Southwest China during the period of 2008-2011.Eighteen children who had had primary LDLT were included in a primary LDLT group,and ten children who had undergone the Kasai operation in a pre-Kasai group.All patients were followed up after discharge from the hospital.The records of the BA patients and donors were reviewed.RESULTS:The time of follow-up ranged 12-44.5 months with a median of 31 months.The 30-day and 1-year survival rates were 85.7% and 78.6%,respectively.There was no significant difference in the 30-day or 1-year survival between the two groups(83.3% vs 90% and 77.8% vs 80%,P】0.05).The main cause of death was hepatic artery thrombosis.There were more patients with complications who required intensive medical care or re-operation in the pre-Kasai group(8,80%) than in the primary LDLT group(9,50%)(P=0.226).But no significant differences were observed in operating time(9.3 vs 8.9 hours,P=0.77),intraoperative blood loss(208.6 vs 197.0 mL,P=0.84) and blood transfusion(105.6 vs 100.0 mL,P=0.91) between the two groups.The durations of ICU and hospital stay in the primary LDLT group and pre-Kasai group were 180.4 vs 157.7 hours(P=0.18) and 27 vs 29 days(P=0.29),respectively.CONCLUSIONS:Primary LDLT is a safe and efficient management for young pediatric patients with BA.Compared with the outcome of LDLT for patients receiving a previous Kasai operation,a similar survival rate and a low rate of re-operation and intensive medical care for patients with BA can be obtained.

Influence of nitrogen impurities on the characteristics of a patterned helium dielectric barrier discharge at atmospheric pressure

In this paper, a two-dimensional axisymmetric fluid model was established to investigate the influence of nitrogen impurity content on the discharge pattern and the relevant discharge characteristics in an atmosphere pressure helium dielectric barrier discharge(DBD). The results indicated that when the nitrogen content was increased from 1 to 100 ppm, the discharge pattern evolved from a concentric-ring pattern into a uniform pattern, and then returned to the concentricring pattern. In this process, the discharge mode at the current peak moment transformed from glow mode into Townsend mode, and then returned to glow mode. Further analyses revealed that with the increase of impurity level, the rate of Penning ionization at the pre-ionization stage increased at first and decreased afterwards, resulting in a similar evolution pattern of seed electron level. This evolution trend was believed to be resulted from the competition between the N2 partial pressure and the consumption rate of metastable species. Moreover, the discharge uniformity was found positively correlated with the spatial uniformity of seed electron density as well as the seed electron level. The reason for this correlation was explained by the reduction of radial electric field strength and the promotion of seed electron uniformity as pre-ionization level increases. The results obtained in this work may help better understand the pattern formation mechanism of atmospheric helium DBD under the variation of N2 impurity level, thereby providing a possible means of regulating the discharge performance in practical application scenarios.

玛咖生物碱通过调节小鼠免疫力抑制结肠癌细胞的成瘤能力

研究观察玛咖生物碱对小鼠结肠癌CT-26细胞成瘤能力的影响并初步探讨其可能机制。构建BALB/c小鼠CT-26细胞移植瘤动物模型,随机分为玛咖生物碱高剂量组、玛咖生物碱低剂量组及生理盐水模型对照组。连续灌胃用药27 d,绘制小鼠体重增长曲线及移植瘤体积增长曲线。第28 d处死小鼠,计算抑瘤率、相对肿瘤增殖率、脾脏指数;ELISA法检测血清IL-2、IFN-γ水平;HE切片观察移植瘤、脾脏、肝脏及肾脏组织学形态变化。结果表明,与对照组比较,实验组移植瘤重量明显降低(p<0.05),抑瘤率分别为43.37%和45.26%,组织学观察实验组移植瘤坏死面积较对照组明显增大。实验组小鼠脾脏指数明显高于对照组(p<0.05),且实验组脾脏白髓增生较显著。同时,血清IL-2及IFN-γ水平均明显高于对照组(p<0.05)。可见,玛咖生物碱可以通过提高小鼠免疫力抑制CT-26细胞的成瘤。

Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel

Timataxel(13-(N-Boc-3-i-butylisoserinoyl-4,10-β-diacetoxy-2-α-benzoyloxy-5-β-20-epoxy-1,13-α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene)), used to be called TM-2, is a novel semi-synthetic promising candidate for cancer treatment. However the preformulation study showed that TM-2 was insoluble and chemically instable in water, which would limit its application. This study aimed at the preparation of Timataxel lipid microspheres(TM-2 LMs)and investigated the difference between TM-2 LMs and TM-2 solution in pharmacokinetics. In this work, the final formulation was as follows: 0.10%(w/v) TM-2;10.00%(w/v) oil phase(long chain triglyceride:media chain triglyceride = 2.50%:7.50%);1.40%(w/v) phospholipid;0.02%(w/v) NaH2 PO4;2.25%(w/v) glycerin and water to a total volume of 100 ml.The particle size distribution, content and entrapment efficacy were 205.0 ± 43.3 nm, 101.00% and 99.12%, respectively. TM-2 LMs were stable during storage at 25 °C for 3 months, even under the condition of 60 °C and 4500 lx for 10 d. Phosphatidylethanolamine(PE) in phospholipid may contribute to the stability of TM-2 LMs. The pharmacokinetic parameters for TM-2 LMs were as follows: AUC(0-∞) 3663.71 μg/l h and the clearance 2.26 l/h/kg. As for solution, these parameters were 1712.52 μg/l h and 4.77 l/h/kg, respectively. The t1/2 of TM-2 LMs was similar to TM-2 solution. The pharmacokinetic results indicated that the AUC of TM-2 LMs was larger, the clearance was smaller than that of TM-2 solution. In a word, lipid microspheres were a promising drug delivery system for TM-2.

Application system and data description of the China Seismo-Electromagnetic Satellite

The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carries eight scientific payloads including high-precision magnetometers to detect electromagnetic changes in space, in particular changes associated with global earthquake disasters. In order to encourage and facilitate use by geophysical scientists of data from the satellite's payloads, this paper introduces the application systems developed for the China Seismo-Electromagnetic Satellite by the Institute of Crustal Dynamics, China Earthquake Administration;these include platform construction, data classification, data storage, data format, and data access and acquisition.