In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satelli...In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated.展开更多
Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacanc...Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacancy of the global early-morning-orbit satellite observation,working together with the FY-3C and FY-3D satellites to achieve the data coverage of early morning,morning,and afternoon orbits.The combination of these three satellites will provide global data coverage for numerical weather prediction(NWP)at 6-hour intervals,effectively improving the accuracy and time efficiency of global NWP,which is of great significance to perfect the global earth observing system.In this article,the background and meteorological requirements for the early-morning-orbit satellite are reviewed,and the specifications of the FY-3E satellite,as well as the characteristics of the onboard instrumentation for earth observations,are also introduced.In addition,the ground segment and the retrieved geophysical products are also presented.It is believed that the NWP communities will significantly benefit from an optimal temporal distribution of observations provided by the early morning,mid-morning,and afternoon satellite missions.Further benefits are expected in numerous applications such as the monitoring of severe weather/climate events,the development of improved sampling designs of the diurnal cycle for accurate climate data records,more efficient monitoring of air quality by thermal infrared remote sensing,and the quasicontinuous monitoring of the sun for space weather and climate.展开更多
This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, ...This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4.展开更多
This paper evaluates the microwave instruments onboard the latest Chinese polar-orbiting satellite, Fengyun 3D (FY- 3D). Comparing three months of observations from the Microwave Temperature Sounder 2 (MWTS-2), the Mi...This paper evaluates the microwave instruments onboard the latest Chinese polar-orbiting satellite, Fengyun 3D (FY- 3D). Comparing three months of observations from the Microwave Temperature Sounder 2 (MWTS-2), the Microwave Humidity Sounder 2 (MWHS-2), and the Microwave Radiation Imager (MWRI) to Met Office short-range forecasts, we characterize the instrumental biases, show how those biases have changed with respect to their predecessors onboard FY- 3C, and how they compare to the Advanced Technology Microwave Sounder (ATMS) onboard NOAA-20 and the Global Precipitation Measurement Microwave Imager (GMI). The MWTS-2 global bias is much reduced with respect to its predecessor and compares well to ATMS at equivalent channel frequencies, differing only by 0.36 ± 0.28 K (1σ) on average. A suboptimal averaging of raw digital counts is found to cause an increase in striping noise and an ascending- descending bias. MWHS-2 benefits from a new calibration method improving the 183-GHz humidity channels with respect to its predecessor and biases for these channels are within ± 1.9 K to ATMS. MWRI presents the largest improvements, with reduced global bias and standard deviation with respect to FY-3C;although, spurious, seemingly transient, brightness temperatures have been detected in the observations at 36.5 GHz (vertical polarization). The strong solar-dependent bias that affects the instrument on FY-3C has been reduced to less than 0.2 K on average for FY-3D MWRI. Experiments where radiances from these instruments were assimilated on top of a full global system demonstrated a neutral to positive impact on the forecasts, as well as on the fit to the background of independent instruments.展开更多
In order to evaluate the impact of assimilating FY-3C satellite Microwave Humidity Sounder(MWHS2)data on rainfall forecasts in the new-generation Rapid-refresh Multi-scale Analysis and Prediction System–Short Term(RM...In order to evaluate the impact of assimilating FY-3C satellite Microwave Humidity Sounder(MWHS2)data on rainfall forecasts in the new-generation Rapid-refresh Multi-scale Analysis and Prediction System–Short Term(RMAPS-ST)operational system,which is developed by the Institute of Urban Meteorology of the China Meteorological Administration,four experiments were carried out in this study:(i)Coldstart(no observations assimilated);(ii)CON(assimilation of conventional observations);(iii)FY3(assimilation of FY-3C MWHS2 only);and(iv)FY3+CON(simultaneous assimilation of FY-3C MWHS2 and conventional observations).A precipitation process that took place in central-eastern China during 4–6 June 2019 was selected as a case study.When the authors assimilated the FY-3C MWHS2 data in the RMAPS-ST operational system,data quality control and bias correction were performed so that the O-B(observation minus background)values of the five humidity channels of MWHS2 became closer to a normal distribution,and the data basically satisfied the unbiased assumption.The results showed that,in this case,the predictions of both precipitation location and intensity were improved in the FY3+CON experiment compared with the other three experiments.Meanwhile,the prediction of atmospheric parameters for the mesoscale field was also improved,and the RMSE of the specific humidity forecast at the 850–400 hPa height was reduced.This study implies that FY-3C MWHS2 data can be successfully assimilated in a regional numerical model and has the potential to improve the forecasting of rainfall.展开更多
Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,...Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke.展开更多
Biomimetic flexible tactile sensors endow prosthetics with the ability to manipulate objects,similar to human hands.However,it is still a great challenge to selectively respond to static and sliding friction forces,wh...Biomimetic flexible tactile sensors endow prosthetics with the ability to manipulate objects,similar to human hands.However,it is still a great challenge to selectively respond to static and sliding friction forces,which is crucial tactile information relevant to the perception of weight and slippage during grasps.Here,inspired by the structure of fingerprints and the selective response of Ruffini endings to friction forces,we developed a biomimetic flexible capacitive sensor to selectively detect static and sliding friction forces.The sensor is designed as a novel plane-parallel capacitor,in which silver nanowire-3D polydimethylsiloxane(PDMS)electrodes are placed in a spiral configuration and set perpendicular to the substrate.Silver nanowires are uniformly distributed on the surfaces of 3D polydimethylsiloxane microcolumns,and silicon rubber(Ecoflex^(■))acts as the dielectric material.The capacitance of the sensor remains nearly constant under different applied normal forces but increases with the static friction force and decreases when sliding occurs.Furthermore,aiming at the slippage perception of neuroprosthetics,a custom-designed signal encoding circuit was designed to transform the capacitance signal into a bionic pulsed signal modulated by the applied sliding friction force.Test results demonstrate the great potential of the novel biomimetic flexible sensors with directional and dynamic sensitivity of haptic force for smart neuroprosthetics.展开更多
A tactile sensor system enables natural interaction between humans and machines;this interaction is crucial for dexterous robotic hands,interactive entertainment,and other smart scenarios.However,the lack of sliding f...A tactile sensor system enables natural interaction between humans and machines;this interaction is crucial for dexterous robotic hands,interactive entertainment,and other smart scenarios.However,the lack of sliding friction detection significantly limits the accuracy and scope of interactions due to the absence of sophisticated information,such as slippage,material and roughness of held objects.Here,inspired by the stick-slip phenomena in the sliding process,we have developed a multifunctional biomimetic tactile system based on the stick-slip sensing strategy,which is a universal method to detect slippage and estimate the surface properties of objects by sliding.This system consists of a flexible fingertip-inspired tactile sensor,a read-out circuit and a machinelearning module.Based on the stick-slip sensing strategy,our system was endowed with high recognition rates for slippage detection(100.0%),material classification(93.3%)and roughness discrimination(92.8%).Moreover,robotic hand manipulation,interactive games and object classification are demonstrated with this multifunctional system for comprehensive and promising human-machine interactions.展开更多
The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by th...The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks.展开更多
The advancement in flexible electronics and neuromorphic electronics has opened up opportunities to construct artificial perception systems to emulate biological functions which are of great importance for intelligent...The advancement in flexible electronics and neuromorphic electronics has opened up opportunities to construct artificial perception systems to emulate biological functions which are of great importance for intelligent robotics and human-machine interactions.However,artificial systems that can mimic the somatosensory feedback functions have not been demonstrated yet despite the great achievement in this area.In this work,inspired by human somatosensory feedback pathways,an artificial somatosensory system with both perception and feedback functions was designed and constructed by integrating the flexible tactile sensors,synaptic transistor,artificial muscle,and the coupling circuit.Also,benefiting from the synaptic characteristics of the designed artificial synapse,the system shows spatio-temporal information-processing ability,which can further enhance the efficiency of the system.This research outcome has a potential contribution to the development of sensor technology from signal sensing to perception and cognition,which can provide a special paradigm for the next generation of bionic tactile perception systems towards e-skin,neurorobotics,and advanced bio-robots.展开更多
Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the function...Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems.展开更多
Imbuing artificial sensory system with intelligence of the biological counterpart is limited by challenges in emulating perceptual learning ability at the device level.In biological systems,stimuli from the surroundin...Imbuing artificial sensory system with intelligence of the biological counterpart is limited by challenges in emulating perceptual learning ability at the device level.In biological systems,stimuli from the surrounding environment are detected,transmitted,and processed by receptor,afferent nerve,and brain,respectively.This process allows the living creatures to identify the potential hazards and improve their adaptability in various environments.Here,inspired by the biological olfaction system,a gas sensory system with perceptual learning is developed.As a proof-of-concept,H2S gas with various concentrations is used as the stimulation and the stimuli will be converted to pulse-like physiological signals in the designed system,which consists of a gas sensor,a flexible oscillator,and a memristor-type artificial synapse.Furthermore,the learning ability is implemented using a supervised learning method based on k-nearest neighbors(KNN)algorithm.The recognition accuracy can be enhanced by repeating training,illustrating a great potential to be used as the neuromorphic sensory system with a learning ability for the applications in robotics.展开更多
Epidermal electronics play increasingly important roles in human-machine intetfaces.However,their efficient fabrication while maintaining device stability and reliability remains an unresolved challenge.Here,a facile ...Epidermal electronics play increasingly important roles in human-machine intetfaces.However,their efficient fabrication while maintaining device stability and reliability remains an unresolved challenge.Here,a facile in situ Joule heating method is proposed for fabricating stable epidermal electronics on a polyvinyl alcohol(PVA)substrate.Benefiting from the precise control of heating locations,the crystallization and enhanced rigidity of PVA are restricted to desired areas,leading to strain isolation of the active regions.As a result,the electronic device can be conformably attached to skin while showing negligible degradation in device performance during deformation.Based on this method,a flexible surface electromyography(sEMG)sensor with outstanding stability and highly comfortable wearability is demonstrated,showing high accuracy(91.83%)for human hand gesture recognition.These results imply that the fabrication method proposed in this research is a facile and reliable approach for the fabrication of epidermal electronics.展开更多
基金funded by the National Key R&D Program of China(Grant Nos.2018YFB0504900 and 2015AA123700)
文摘In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated.
基金funded by the FY3-03 project and the National Key Technology Research and Development Program of China(Grant Nos.2018YFB0504900 and 2018YFB0504905)。
文摘Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacancy of the global early-morning-orbit satellite observation,working together with the FY-3C and FY-3D satellites to achieve the data coverage of early morning,morning,and afternoon orbits.The combination of these three satellites will provide global data coverage for numerical weather prediction(NWP)at 6-hour intervals,effectively improving the accuracy and time efficiency of global NWP,which is of great significance to perfect the global earth observing system.In this article,the background and meteorological requirements for the early-morning-orbit satellite are reviewed,and the specifications of the FY-3E satellite,as well as the characteristics of the onboard instrumentation for earth observations,are also introduced.In addition,the ground segment and the retrieved geophysical products are also presented.It is believed that the NWP communities will significantly benefit from an optimal temporal distribution of observations provided by the early morning,mid-morning,and afternoon satellite missions.Further benefits are expected in numerous applications such as the monitoring of severe weather/climate events,the development of improved sampling designs of the diurnal cycle for accurate climate data records,more efficient monitoring of air quality by thermal infrared remote sensing,and the quasicontinuous monitoring of the sun for space weather and climate.
基金We acknowledge funding from the EUMETSAT Fellowship Programme for Heather LAWRENCE,Katrin LONITZ and David DUNCAN.
文摘This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4.
基金This work was supported by the UK-China Research&Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)China as part of the Newton Fund.
文摘This paper evaluates the microwave instruments onboard the latest Chinese polar-orbiting satellite, Fengyun 3D (FY- 3D). Comparing three months of observations from the Microwave Temperature Sounder 2 (MWTS-2), the Microwave Humidity Sounder 2 (MWHS-2), and the Microwave Radiation Imager (MWRI) to Met Office short-range forecasts, we characterize the instrumental biases, show how those biases have changed with respect to their predecessors onboard FY- 3C, and how they compare to the Advanced Technology Microwave Sounder (ATMS) onboard NOAA-20 and the Global Precipitation Measurement Microwave Imager (GMI). The MWTS-2 global bias is much reduced with respect to its predecessor and compares well to ATMS at equivalent channel frequencies, differing only by 0.36 ± 0.28 K (1σ) on average. A suboptimal averaging of raw digital counts is found to cause an increase in striping noise and an ascending- descending bias. MWHS-2 benefits from a new calibration method improving the 183-GHz humidity channels with respect to its predecessor and biases for these channels are within ± 1.9 K to ATMS. MWRI presents the largest improvements, with reduced global bias and standard deviation with respect to FY-3C;although, spurious, seemingly transient, brightness temperatures have been detected in the observations at 36.5 GHz (vertical polarization). The strong solar-dependent bias that affects the instrument on FY-3C has been reduced to less than 0.2 K on average for FY-3D MWRI. Experiments where radiances from these instruments were assimilated on top of a full global system demonstrated a neutral to positive impact on the forecasts, as well as on the fit to the background of independent instruments.
基金Supported by the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(grant no.2019QZKK0105)the National Key Research and Development Program of China(2018YFC1506603).
文摘In order to evaluate the impact of assimilating FY-3C satellite Microwave Humidity Sounder(MWHS2)data on rainfall forecasts in the new-generation Rapid-refresh Multi-scale Analysis and Prediction System–Short Term(RMAPS-ST)operational system,which is developed by the Institute of Urban Meteorology of the China Meteorological Administration,four experiments were carried out in this study:(i)Coldstart(no observations assimilated);(ii)CON(assimilation of conventional observations);(iii)FY3(assimilation of FY-3C MWHS2 only);and(iv)FY3+CON(simultaneous assimilation of FY-3C MWHS2 and conventional observations).A precipitation process that took place in central-eastern China during 4–6 June 2019 was selected as a case study.When the authors assimilated the FY-3C MWHS2 data in the RMAPS-ST operational system,data quality control and bias correction were performed so that the O-B(observation minus background)values of the five humidity channels of MWHS2 became closer to a normal distribution,and the data basically satisfied the unbiased assumption.The results showed that,in this case,the predictions of both precipitation location and intensity were improved in the FY3+CON experiment compared with the other three experiments.Meanwhile,the prediction of atmospheric parameters for the mesoscale field was also improved,and the RMSE of the specific humidity forecast at the 850–400 hPa height was reduced.This study implies that FY-3C MWHS2 data can be successfully assimilated in a regional numerical model and has the potential to improve the forecasting of rainfall.
基金supported by grants from the Guangxi Zhuang Autonomous Region Health and Family Planning Commission Science and Technology Project(Z2016419)Guangxi Natural Science Foundation Project(No.:2018JJA140853)the Science and Technology Project of Hunan Province,China(2014FJ4233).
文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke.
基金The authors acknowledge the funding support from the National Key R&D Program of China(2017YFA0701101,2018YFB1304700)the National Natural Science Foundation of China(51702354,61801473)+1 种基金the Youth Promotion Association of Chinese Academy of Sciences(2020320)the Foundation Research Project of Jiangsu Province(SBK2020021442)。
文摘Biomimetic flexible tactile sensors endow prosthetics with the ability to manipulate objects,similar to human hands.However,it is still a great challenge to selectively respond to static and sliding friction forces,which is crucial tactile information relevant to the perception of weight and slippage during grasps.Here,inspired by the structure of fingerprints and the selective response of Ruffini endings to friction forces,we developed a biomimetic flexible capacitive sensor to selectively detect static and sliding friction forces.The sensor is designed as a novel plane-parallel capacitor,in which silver nanowire-3D polydimethylsiloxane(PDMS)electrodes are placed in a spiral configuration and set perpendicular to the substrate.Silver nanowires are uniformly distributed on the surfaces of 3D polydimethylsiloxane microcolumns,and silicon rubber(Ecoflex^(■))acts as the dielectric material.The capacitance of the sensor remains nearly constant under different applied normal forces but increases with the static friction force and decreases when sliding occurs.Furthermore,aiming at the slippage perception of neuroprosthetics,a custom-designed signal encoding circuit was designed to transform the capacitance signal into a bionic pulsed signal modulated by the applied sliding friction force.Test results demonstrate the great potential of the novel biomimetic flexible sensors with directional and dynamic sensitivity of haptic force for smart neuroprosthetics.
基金funding support from the National Key R&D Program of China (2017YFA0701101,2018YFB1304700,2020YFB2008501)the National Science Fund for Distinguished Young Scholars of China (62125112)+4 种基金the National Natural Science Foundation of China (62071462,62071463)the Youth Promotion Association of Chinese Academy of Sciences (2020320)the Foundation Research Project of Jiangsu Province (BK20201195,BK20200259)the Zhejiang Lab’s International Talent Fund for Young Professionals (ZJ2020GZ016)the Suzhou Key Industrial Technology Innovation Project (SYG202029).
文摘A tactile sensor system enables natural interaction between humans and machines;this interaction is crucial for dexterous robotic hands,interactive entertainment,and other smart scenarios.However,the lack of sliding friction detection significantly limits the accuracy and scope of interactions due to the absence of sophisticated information,such as slippage,material and roughness of held objects.Here,inspired by the stick-slip phenomena in the sliding process,we have developed a multifunctional biomimetic tactile system based on the stick-slip sensing strategy,which is a universal method to detect slippage and estimate the surface properties of objects by sliding.This system consists of a flexible fingertip-inspired tactile sensor,a read-out circuit and a machinelearning module.Based on the stick-slip sensing strategy,our system was endowed with high recognition rates for slippage detection(100.0%),material classification(93.3%)and roughness discrimination(92.8%).Moreover,robotic hand manipulation,interactive games and object classification are demonstrated with this multifunctional system for comprehensive and promising human-machine interactions.
基金The authors acknowledge the funding support from the National Key R&D Program of China(No.2018YFB1304700)the National Natural Science Foundation of China(No.61574163,No.61801473)+2 种基金the Science Foundation for Distinguished Young Scholars of Jiangsu Province,China(Nos.BK20170008 and BK20160011)the National Natural Science Foundation of China(No.61801473)the NANO-X Workstation scientifically supported this research.
文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks.
基金support from China Postdoctoral Science Foundation (2022M712323)the National Key R&D Program of China (2018YFB1304700,2020YFB2008501)+2 种基金the National Natural Science Foundation of China (62071463,62071462,22109173)the National Science Fund for Distinguished Young Scholars (62125112)XJTLU Research Development Funding (RDF-21-01-027).
文摘The advancement in flexible electronics and neuromorphic electronics has opened up opportunities to construct artificial perception systems to emulate biological functions which are of great importance for intelligent robotics and human-machine interactions.However,artificial systems that can mimic the somatosensory feedback functions have not been demonstrated yet despite the great achievement in this area.In this work,inspired by human somatosensory feedback pathways,an artificial somatosensory system with both perception and feedback functions was designed and constructed by integrating the flexible tactile sensors,synaptic transistor,artificial muscle,and the coupling circuit.Also,benefiting from the synaptic characteristics of the designed artificial synapse,the system shows spatio-temporal information-processing ability,which can further enhance the efficiency of the system.This research outcome has a potential contribution to the development of sensor technology from signal sensing to perception and cognition,which can provide a special paradigm for the next generation of bionic tactile perception systems towards e-skin,neurorobotics,and advanced bio-robots.
基金We acknowledge the funding support from the National Key R&D Program of China(No.2018YFB1304700),the National Natural Science Foundation of China(61574163)the Science Foundation for Distinguished Young Scholars of Jiangsu Province,China(BK20170008,BK20160011)the National Natural Science Foundation of China(61801473),and the NANO-X Workstation scientifically supported this research.
文摘Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems.
基金the funding support from the National Key R&D Program of China(No.2018YFB1304700)the National Natural Science Foundation of China(Nos.61574163 and 61801473).
文摘Imbuing artificial sensory system with intelligence of the biological counterpart is limited by challenges in emulating perceptual learning ability at the device level.In biological systems,stimuli from the surrounding environment are detected,transmitted,and processed by receptor,afferent nerve,and brain,respectively.This process allows the living creatures to identify the potential hazards and improve their adaptability in various environments.Here,inspired by the biological olfaction system,a gas sensory system with perceptual learning is developed.As a proof-of-concept,H2S gas with various concentrations is used as the stimulation and the stimuli will be converted to pulse-like physiological signals in the designed system,which consists of a gas sensor,a flexible oscillator,and a memristor-type artificial synapse.Furthermore,the learning ability is implemented using a supervised learning method based on k-nearest neighbors(KNN)algorithm.The recognition accuracy can be enhanced by repeating training,illustrating a great potential to be used as the neuromorphic sensory system with a learning ability for the applications in robotics.
基金support from the National Key R&D Program of China(2018YFB1304700)the National Natural Science Foundation of China(61574163,61801473).
文摘Epidermal electronics play increasingly important roles in human-machine intetfaces.However,their efficient fabrication while maintaining device stability and reliability remains an unresolved challenge.Here,a facile in situ Joule heating method is proposed for fabricating stable epidermal electronics on a polyvinyl alcohol(PVA)substrate.Benefiting from the precise control of heating locations,the crystallization and enhanced rigidity of PVA are restricted to desired areas,leading to strain isolation of the active regions.As a result,the electronic device can be conformably attached to skin while showing negligible degradation in device performance during deformation.Based on this method,a flexible surface electromyography(sEMG)sensor with outstanding stability and highly comfortable wearability is demonstrated,showing high accuracy(91.83%)for human hand gesture recognition.These results imply that the fabrication method proposed in this research is a facile and reliable approach for the fabrication of epidermal electronics.