The impact of cold rolling deformation,which was introduced after solid solution and before aging treatment,on microstructure evolution and mechanical properties of the as-extruded spray formed Al−9.8Zn−2.3Mg−1.73Cu−0...The impact of cold rolling deformation,which was introduced after solid solution and before aging treatment,on microstructure evolution and mechanical properties of the as-extruded spray formed Al−9.8Zn−2.3Mg−1.73Cu−0.13Cr(wt.%)alloy,was investigated.SEM,TEM,and EBSD were used to analyze the microstructures,and tensile tests were conducted to assess mechanical properties.The results indicate that the D1-T6 sample,subjected to 25%cold rolling deformation,exhibits finer grains(3.35μm)compared to the D0-T6 sample(grain size of 4.23μm)without cold rolling.Cold rolling refines the grains that grow in solution treatment.Due to the combined effects of finer and more dispersed precipitates,higher dislocation density and smaller grains,the yield strength and ultimate tensile strength of the D1-T6 sample can reach 663 and 737 MPa,respectively.In comparison to the as-extruded and D0-T6 samples,the yield strength of the D1-T6 sample increases by 415 and 92 MPa,respectively.展开更多
BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and i...BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.展开更多
Fast radio burst(FRB)is a type of extragalactic radio signal characterized by millisecond duration,extremely high brightness temperature,and large dispersion measure.It remains a mystery in the universe.Advancements i...Fast radio burst(FRB)is a type of extragalactic radio signal characterized by millisecond duration,extremely high brightness temperature,and large dispersion measure.It remains a mystery in the universe.Advancements in instrumentation have led to the discovery of 816 FRB sources and 7622 bursts from 67 repeating FRBs(https://blinkverse.alkaidos.cn/).This field is undergoing rapid development,rapidly advancing our understanding of the physics of FRBs as new observational data accumulates.The accumulation of data has also promoted exploration of our universe.In this review,we summarize the statistical analysis and cosmological applications using large samples of FRBs,including the energy functions,the waiting time distributions of repeating FRBs,probe of missing baryons and circumgalactic medium in the universe,measurements of cosmological parameters,exploration of the epoch of re-ionization history,and research of the gravitational lensing of FRBs.展开更多
锂离子电池的健康状态(state of health,SOH)准确估计对于储能电站的稳定高效运行至关重要。为了进一步提高数据驱动方法对SOH估计的精度,本团队提出了一种利用交叉验证训练的线性回归加权融合模型的方法。首先,从放电电压曲线、充电和...锂离子电池的健康状态(state of health,SOH)准确估计对于储能电站的稳定高效运行至关重要。为了进一步提高数据驱动方法对SOH估计的精度,本团队提出了一种利用交叉验证训练的线性回归加权融合模型的方法。首先,从放电电压曲线、充电和放电温度曲线中提取了健康特征,并使用Pearson相关系数对所选特征进行了相关性分析,确定了网络模型输入的健康因子参数。随后,通过在LSTM与GRU中加入注意力机制,建立了LSTM-Attention与GRU-Attention模型,分别以NASA电池老化数据集B0005、B0006、B0007和B0018电池的前50%作为模型训练集,用剩余数据对模型进行验证,分别得到了模型对应的ŷ_(L-A)与ŷ_(G-A)估计值,然后使用所提融合模型方法对两个估计值进行线性回归加权,结果显示该方法的最大均方根误差和平均绝对误差分别为0.00291和0.00200。最后,为验证所提模型的抗干扰能力,在输入模型的健康因子中加入不同比例的高斯白噪声,实验结果显示融合模型的抗干扰能力较强,最大均方根误差和平均绝对误差仅为0.03562和0.02889。展开更多
Nitrogen-vacancy(NV)centers in a bulk diamond are often employed to realize measurement of multiple physical quantities,which depends on orientation information of NV axis.We report a fast and effective method to dete...Nitrogen-vacancy(NV)centers in a bulk diamond are often employed to realize measurement of multiple physical quantities,which depends on orientation information of NV axis.We report a fast and effective method to determine the orientation of NV axis with the aid of a static magnetic field.By measuring the optically detected magnetic resonance spectra,we can precisely extract the polar angle information between the NV axis and the known magnetic field.Combining with the polar angle information of different kinds of NV centers,we employ the Nelder-Mead algorithm to get the optimal solution of the orientation of NV axis.This method is simple and efficient,and is easily applied in NV-based quantum sensing.展开更多
BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes.The condition is typically marked by pruritus(itching)and el...BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes.The condition is typically marked by pruritus(itching)and elevated levels of liver enzymes and bile acids.The standard treatment for ICP has generally been ursodeoxycholic acid and ademetionine 1,4-butanedisulfonate,but the efficacy of this approach remains less than optimal.Recently,polyene phosphatidylcholine has emerged as a promising new therapeutic agent for ICP due to its potential hepatoprotective effects.AIM To evaluate the effect of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate on bile acid levels,liver enzyme indices,and pregnancy outcomes in patients with ICP.METHODS From June 2020 to June 2021,600 patients with ICP who were diagnosed and treated at our hospital were recruited and assigned at a ratio of 1:1 via randomnumber table method to receive either ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate(control group,n=300)or polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate(combined group,n=300).Outcome measures included bile acids levels,liver enzyme indices,and pregnancy outcomes.RESULTS Prior to treatment,no significant differences were observed between the two groups(P>0.05).Post-treatment,patients in both groups had significantly lower pruritus scores,but the triple-drug combination group had lower scores than the dual-drug combination group(P<0.05).The bile acid levels decreased significantly in both groups,but the decrease was more significant in the triple-drug group(P<0.05).The triple-drug group also exhibited a greater reduction in the levels of certain liver enzymes and a lower incidence of adverse pregnancy outcomes compared to the dual-drug group(P<0.05).CONCLUSION Polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate effectively relieves pruritus and reduces bile acid levels and liver enzyme indices in patients with ICP,providing a positive impact on pregnancy outcome and a high safety profile.Further clinical trials are required prior to clinical application.展开更多
基金the support from the National Natural Science Foundation of China(No.52271177)the Science and Technology Innovation Leaders Projects in Hunan Province,China(No.2021RC4036).
文摘The impact of cold rolling deformation,which was introduced after solid solution and before aging treatment,on microstructure evolution and mechanical properties of the as-extruded spray formed Al−9.8Zn−2.3Mg−1.73Cu−0.13Cr(wt.%)alloy,was investigated.SEM,TEM,and EBSD were used to analyze the microstructures,and tensile tests were conducted to assess mechanical properties.The results indicate that the D1-T6 sample,subjected to 25%cold rolling deformation,exhibits finer grains(3.35μm)compared to the D0-T6 sample(grain size of 4.23μm)without cold rolling.Cold rolling refines the grains that grow in solution treatment.Due to the combined effects of finer and more dispersed precipitates,higher dislocation density and smaller grains,the yield strength and ultimate tensile strength of the D1-T6 sample can reach 663 and 737 MPa,respectively.In comparison to the as-extruded and D0-T6 samples,the yield strength of the D1-T6 sample increases by 415 and 92 MPa,respectively.
基金Supported by National Key R&D Program of China,No.2022YFC25045001.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYGD23012.
文摘BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.
基金supported by the Postdoctoral Fellowship Program of CPSF(Grant No.GZB20240308)the National Natural Science Foundation of China(Grant No.12273009)。
文摘Fast radio burst(FRB)is a type of extragalactic radio signal characterized by millisecond duration,extremely high brightness temperature,and large dispersion measure.It remains a mystery in the universe.Advancements in instrumentation have led to the discovery of 816 FRB sources and 7622 bursts from 67 repeating FRBs(https://blinkverse.alkaidos.cn/).This field is undergoing rapid development,rapidly advancing our understanding of the physics of FRBs as new observational data accumulates.The accumulation of data has also promoted exploration of our universe.In this review,we summarize the statistical analysis and cosmological applications using large samples of FRBs,including the energy functions,the waiting time distributions of repeating FRBs,probe of missing baryons and circumgalactic medium in the universe,measurements of cosmological parameters,exploration of the epoch of re-ionization history,and research of the gravitational lensing of FRBs.
基金financially supported by the Major Special Projects in Anhui Province,China(No.202003c08020005)the Key Projects in Hunan Province,China(No.2020GK2045)+1 种基金the Science and Technology Innovation Program of Hunan Province,China(No.2021RC4036)Postgraduate Scientific Research Innovation Project of Hunan Province,China(No.CX20211079)。
文摘锂离子电池的健康状态(state of health,SOH)准确估计对于储能电站的稳定高效运行至关重要。为了进一步提高数据驱动方法对SOH估计的精度,本团队提出了一种利用交叉验证训练的线性回归加权融合模型的方法。首先,从放电电压曲线、充电和放电温度曲线中提取了健康特征,并使用Pearson相关系数对所选特征进行了相关性分析,确定了网络模型输入的健康因子参数。随后,通过在LSTM与GRU中加入注意力机制,建立了LSTM-Attention与GRU-Attention模型,分别以NASA电池老化数据集B0005、B0006、B0007和B0018电池的前50%作为模型训练集,用剩余数据对模型进行验证,分别得到了模型对应的ŷ_(L-A)与ŷ_(G-A)估计值,然后使用所提融合模型方法对两个估计值进行线性回归加权,结果显示该方法的最大均方根误差和平均绝对误差分别为0.00291和0.00200。最后,为验证所提模型的抗干扰能力,在输入模型的健康因子中加入不同比例的高斯白噪声,实验结果显示融合模型的抗干扰能力较强,最大均方根误差和平均绝对误差仅为0.03562和0.02889。
基金This work was supported by the National Key R&D Program of China(Grant No.2020YFA0309400)the National Natural Science Foundation of China(Grant No.12174081)the Fundamental Research Funds for the Central Universities(Grant Nos.JZ2021HGTB0126 and PA2021KCPY0052).
文摘Nitrogen-vacancy(NV)centers in a bulk diamond are often employed to realize measurement of multiple physical quantities,which depends on orientation information of NV axis.We report a fast and effective method to determine the orientation of NV axis with the aid of a static magnetic field.By measuring the optically detected magnetic resonance spectra,we can precisely extract the polar angle information between the NV axis and the known magnetic field.Combining with the polar angle information of different kinds of NV centers,we employ the Nelder-Mead algorithm to get the optimal solution of the orientation of NV axis.This method is simple and efficient,and is easily applied in NV-based quantum sensing.
文摘BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes.The condition is typically marked by pruritus(itching)and elevated levels of liver enzymes and bile acids.The standard treatment for ICP has generally been ursodeoxycholic acid and ademetionine 1,4-butanedisulfonate,but the efficacy of this approach remains less than optimal.Recently,polyene phosphatidylcholine has emerged as a promising new therapeutic agent for ICP due to its potential hepatoprotective effects.AIM To evaluate the effect of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate on bile acid levels,liver enzyme indices,and pregnancy outcomes in patients with ICP.METHODS From June 2020 to June 2021,600 patients with ICP who were diagnosed and treated at our hospital were recruited and assigned at a ratio of 1:1 via randomnumber table method to receive either ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate(control group,n=300)or polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate(combined group,n=300).Outcome measures included bile acids levels,liver enzyme indices,and pregnancy outcomes.RESULTS Prior to treatment,no significant differences were observed between the two groups(P>0.05).Post-treatment,patients in both groups had significantly lower pruritus scores,but the triple-drug combination group had lower scores than the dual-drug combination group(P<0.05).The bile acid levels decreased significantly in both groups,but the decrease was more significant in the triple-drug group(P<0.05).The triple-drug group also exhibited a greater reduction in the levels of certain liver enzymes and a lower incidence of adverse pregnancy outcomes compared to the dual-drug group(P<0.05).CONCLUSION Polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate effectively relieves pruritus and reduces bile acid levels and liver enzyme indices in patients with ICP,providing a positive impact on pregnancy outcome and a high safety profile.Further clinical trials are required prior to clinical application.
