With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic...With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic rate.However,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia patients.Similarly in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive decline.Nitric oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous system.Recently,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular dementia.This review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular dementia.Additionally,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.展开更多
Fracture propagation in shale under in situ conditions is a critical but poorly understood mechanical process in hydraulic fracturing for deep shale gas reservoirs. To address this, hydraulic fracturing experiments we...Fracture propagation in shale under in situ conditions is a critical but poorly understood mechanical process in hydraulic fracturing for deep shale gas reservoirs. To address this, hydraulic fracturing experiments were conducted on hollow double-wing crack specimens of the Longmaxi shale under conditions simulating the ground surface(confining pressure σ_(cp)=0, room temperature(Tr)) and at depths of 1600 m(σ_(cp)=40 MPa, Ti=70 ℃) and 3300 m(σ_(cp)=80 MPa, high temperature Ti=110 ℃) in the study area.High in situ stress was found to significantly increase fracture toughness through constrained microcracking and particle frictional bridging mechanisms. Increasing the temperature enhances rather than weakens the fracture resistance because it increases the grain debonding length, which dissipates more plastic energy and enlarges grains to close microdefects and generate compressive stress to inhibit microcracking. Interestingly, the fracture toughness anisotropy in the shale was found to be nearly constant across burial depths, despite reported variations with increasing confining pressure. Heated water was not found to be as important as the in situ environment in influencing shale fracture. These findings emphasize the need to test the fracture toughness of deep shales under coupled in situ stress and temperature conditions rather than focusing on either in situ stress or temperature alone.展开更多
Granitic veins(GVs)have a significant influence on the mechanical responses of tunnels excavated in granitic strata.Distinguishing the mechanical properties of host granites(HGs),GVs and vein-granite interfaces(VGIs)i...Granitic veins(GVs)have a significant influence on the mechanical responses of tunnels excavated in granitic strata.Distinguishing the mechanical properties of host granites(HGs),GVs and vein-granite interfaces(VGIs)is critical.For this,this paper analyzed the mechanical behaviors and rupture processes of typical HG,GV,and VGI samples under uniaxial compression condition.For the rocks studied,although the linear axial stress‒strain relation can be identified and the deformation modulus can be determined,the transverse deformation developed nonlinearly with axial stress.As a result,the instantaneous Poisson’s ratio increases continuously and may even exceed 0.5,making it extremely difficult to accurately determine the Poisson’s ratio.In addition,the studied GV samples were found to be significantly brittle,indicating that large-scale GVs cannot be ignored when assessing rockburst hazards in granitic strata with brittle GVs.In terms of the rupture process,the HG and GV samples were gradually damaged by the formation of small-scale cracks and then ruptured by large cracks formed from smallscale cracks,whereas the VGI samples ruptured along large cracks with significant energy release.By examining the characteristic stress thresholds of these three granites,it is noted that the crack closure stress scc exceeds both the crack initiation stress sci and the crack damage stress scd for the HG and VGI samples.The transverse damage to a tested sample appears to be significantly greater than the axial damage,which is essentially related to the rock grain size and grain size distribution.展开更多
We present a novel approach for generating stable three-dimensional(3D)spatiotemporal solitons(SSs)within a rotating Bose–Einstein condensate,incorporating spin–orbit coupling(SOC),a weakly anharmonic potential and ...We present a novel approach for generating stable three-dimensional(3D)spatiotemporal solitons(SSs)within a rotating Bose–Einstein condensate,incorporating spin–orbit coupling(SOC),a weakly anharmonic potential and cold Rydberg atoms.This intricate system facilitates the emergence of quasi-stable 3D SSs with topological charges|m|≤3 in two spinor components,potentially exhibiting diverse spatial configurations.Our findings reveal that the Rydberg long-range interaction,spin–orbit coupling,and rotational angular frequency exert significant influence on the domains of existence and stability of these solitons.Notably,the Rydberg interaction contributes to a reduction in the norm of topological solitons,while the SOC plays a key role in stabilizing the SSs with finite topological charges.This research of SSs exhibits potential applications in precision measurement,quantum information processing,and other advanced technologies.展开更多
Background:Melanoma is a deadly skin tumor resulting from the malignant transformation of melanocytes.It is highly malignant and invasive,with the highest mortality rate among skin cancers.Acalypha australis L.(AAL),a...Background:Melanoma is a deadly skin tumor resulting from the malignant transformation of melanocytes.It is highly malignant and invasive,with the highest mortality rate among skin cancers.Acalypha australis L.(AAL),a plant with dual medicinal and culinary purposes,is commonly regarded as an edible wild vegetable in southern China.Additionally,AAL has a long history of medicinal use in China,often employed for its hemostatic,anti-diarrheal,and anti-inflammatory properties.Modern pharmacology has demonstrated that AAL possesses functions such as weight loss,antimicrobial activity,antiviral effects,and treatment for ulcerative colitis.However,there is currently no research available regarding its effectiveness and mechanisms of action on melanoma.Methods:In this investigation,we used methyl thiazolyl tetrazolium assay to detect cell viability,transwell assay to detect cell migration and invasion ability,and Western blot assay to detect relevant signaling pathways.Results:The present study reveals that 2 mg/mL AAL effectively suppresses the metastasis of B16 cells,while simultaneously triggering the expression of key apoptosis-related proteins,including Bcl-2,Bax,and cleaved caspased 3.Subsequent investigations demonstrate that AAL exerts this inhibitory effect via the PI3K/AKT signal transduction pathway,as evidenced by the observed deficits in Ras,AKT,p-AKT,and PI3K expression levels.Conclusion:These findings indicated that AAL could be a valuable therapeutic option for reducing the metastatic potential of B16 melanoma cells.展开更多
Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution ...Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between 2000 and 2011.Methods:A total of 22,432 incident cases of CRC between 2000 and 2011 from Guangzhou Cancer Registry were identified.Crude incidence and age-standardized rates(ASRs),using the Segi’s world standard population,were calculated for CRC and CRC subsites.The incidence trend was analyzed and the annual percentage change(APC) in incidence was calculated by using JoinPoint software.Results:The crude incidence increased significantly from 23.4/10~5 in 2000 to 37.4/10~5 in 2011 for males and from20.9/10~5 to 30.5/10~5 for females.The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.The ages at the onset of CRC for both males and females during 2010-2011 were significantly higher compared with those during 2000-2002(males:f = 1.95,P = 0.05;females:f = 6.03,P < 0.01).For males aged50-64 years,the CRC incidence increased by 8.50%annually(P = 0.04) during 2000-2004 and by 1.68%annually(P = 0.03) during 2005-2011.For females aged 65 years and older,the CRC incidence increased by 5.77%annually(P = 0.03) during 2000-2004.There were no significant changes for the CRC incidences in males aged 49 and younger and 65 years and older and females aged 64 years and younger during 2000-2004,or for those in all females as well as males aged 49 years and younger and 65 years and older during 2005-2011.The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.The ASRs of descending colon and sigmoid colon cancer incidences increased significantly for females during 2005-2011(APC,5.51%and 1.08%,respectively,both P < 0.05).Conclusions:The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging,whereas the ASRs kept stable.The percentage of colon cancer in all CRCs increased significantly.Further surveillance,research,and intervention are needed to identify the causes of these changes and to reduce the incidence and mortality of CRC.展开更多
AIM To measure the willingness to pay for colorectal cancer screening in Guangzhou, and to identify those factors associated with it. METHODS A face-to-face questionnaire survey for pre-screening population from free ...AIM To measure the willingness to pay for colorectal cancer screening in Guangzhou, and to identify those factors associated with it. METHODS A face-to-face questionnaire survey for pre-screening population from free and non-free colonoscopy districts was used to collect information on demographic characteristics, health behaviours, the intention of the cancer screenings and willingness to pay for colorectal cancer screening. A total of 1243 participants who took part in the pre-screening for colorectal cancer in Guangzhou were collected in the study. Categorical data were compared using the χ~2 test to analyse significant differences. Non-conditional logistic regression and multi-class logistic regression were also performed for multivariate analysis and to estimate the odds ratios.RESULTS The percentage of participants willing to pay for colorectal cancer screening was 91.7%. "Unnecessary" was the dominant reason that participants gave for their unwillingness, accounting for 63.1%. Of those who were willing to pay, 29.2%, 20.7%, 14.8%, 13.0% and 22.4% of participants were willing to pay less than $100, $100-$199, $200-299, $300-$399 and more than $400, respectively. Non-logistic regression analysis showed that respondents who were male, had a high level of education, were from the family with more children/older to raise, and accepted colorectal cancer screening were willing to pay for this screening. Multi-class logistic regression analysis showed that respondents with higher annual household income per capita, from government and private enterprises, government agency/institution and peasants, and less family medical expenditure were willing to pay more.CONCLUSION Willingness to pay for colorectal cancer screening in Guangzhou is high, but the amount of willing to pay is not much.展开更多
目的探讨电子序贯器官衰竭评分(simplified organ dysfunction criteria optimized for electronic health records,eSOFA)对急诊脓毒症患者28、90 d及1年预后的预测价值,并与序贯器官衰竭评分(sequential organ failure assessment,SO...目的探讨电子序贯器官衰竭评分(simplified organ dysfunction criteria optimized for electronic health records,eSOFA)对急诊脓毒症患者28、90 d及1年预后的预测价值,并与序贯器官衰竭评分(sequential organ failure assessment,SOFA)、急性生理学与慢性健康状况Ⅱ评分(acute physiology and chronic health evaluationⅡ,APACHEⅡ)进行比较。方法连续纳入2018年12月1日至2021年1月31日中国康复研究中心急诊重症监护室收治的脓毒症患者。分别绘制eSOFA、SOFA和APACHEⅡ评分对患者28、90 d及1年预后的受试者工作特征(receiver operating characteristic,ROC)曲线,计算相应的曲线下面积(area under curve,AUC),并进行比较。根据eSOFA评分的截断值将患者分为eSOFA评分≤2分和eSOFA评分>2分两组,比较两组的一般临床特点。结果本研究最终纳入197例脓毒症患者,年龄为84(74~88)岁,其中男119例。纳入患者28、90 d及1年的病死率分别为38.6%(76/197)、51.8%(102/197)及58.9%(116/197)。eSOFA、SOFA和APACHEⅡ评分对脓毒症患者28、90 d及1年预后均具有预测能力,但三者差异无统计学意义(P>0.05),eSOFA评分对脓毒症患者1年死亡预测模型的拟和优度差,对1年预后预测效果不佳(P=0.01)。与eSOFA评分≤2分组相比,eSOFA评分>2分组患者死亡风险高(P<0.05),SOFA评分[分:5(4,7)vs.9(7,12)]和APACHEⅡ评分[分:23(18,27)vs.28(23,35)]更差,且更多患者发生急性肾损伤(acute kidney injury,AKI)(61.8%vs.83.6%)及接受血管活性药物(10.3%vs.59.1%)和机械通气(19.1%vs.50.8%)治疗。结论eSOFA、SOFA和APACHEⅡ评分均能有效评估脓毒症患者的中短期预后,优化患者早期治疗策略,但eSOFA评分简便易计算,更适合应用于急诊科。展开更多
To study controlled evolution of nonautonomous matter-wave breathers and rogue waves in spinor Bose–Einstein condensates with spatiotemporal modulation,we focus on a system of three coupled Gross–Pitaevskii equation...To study controlled evolution of nonautonomous matter-wave breathers and rogue waves in spinor Bose–Einstein condensates with spatiotemporal modulation,we focus on a system of three coupled Gross–Pitaevskii equations with spacetime-dependent external potentials and temporally modulated gain-loss distributions.With different external potentials and gain-loss distributions,various solutions for controlled nonautonomous matterwave breathers and rogue waves are derived by the Darboux transformation method,such as breathers and rogue waves on arched and constant backgrounds which have the periodic and parabolic trajectories.Effects of the gain-loss distribution and linear potential on the breathers and rogue waves are studied.Nonautonomous two-breathers on the arched and constant backgrounds are also derived.展开更多
It is inadequate to study the shear failure anisotropy of shale in only 2D space.Aiming at a 3D analysis,a series of direct shear tests was conducted on Longmaxi shale with three typical bedding orientations:arrester,...It is inadequate to study the shear failure anisotropy of shale in only 2D space.Aiming at a 3D analysis,a series of direct shear tests was conducted on Longmaxi shale with three typical bedding orientations:arrester,divider and short-transverse orientations.During testing,acoustic emission(AE)and digital image correlation(DIC)techniques were simultaneously employed to monitor failure development,after testing,X-ray computed tomography(CT)scanning was adopted to acquire and reconstruct the fractures inside typical ruptured samples for more detailed analysis.The results indicated that the shear strength parameters exhibited 3D anisotropies and those of the arrester sample did not have equivalent shear strength parameters to the shale matrix.The maximum(minimum)shear strength and cohesion were obtained with the divider(short-transverse)orientation,and the internal friction angle reached its maximum(minimum)with the divider(arrester)orientation.Combining the AE,DIC and CT techniques,four characteristic stress levels that can capture the progressive shear failure process of shale rocks were identified,and the onset and accelerated development of shear damage-induced dilation were observed at the crack initiation and coalesce stress thresholds,respectively.During the crack coalescence stage,the dominated microcracking mechanism transferred from tensile-mode to shear-mode.For the arrester and divider orientations,more tensile-mode AE events were generated due to the microcracking along the vertical beddings.Compared with the divider samples,a more complex fracture network with a larger fracture area and volume was obtained in the arrester samples,whose strengths were smaller.展开更多
Realizing single light solitons that are stable in high dimensions is a long-standing goal in research of nonlinear optical physics.Here,we address a scheme to generate stable two-dimensional solitons in a cold Rydber...Realizing single light solitons that are stable in high dimensions is a long-standing goal in research of nonlinear optical physics.Here,we address a scheme to generate stable two-dimensional solitons in a cold Rydberg atomic system with a parity-time(PT) symmetric moiré optical lattice.We uncover the formation,properties,and their dynamics of fundamental and two-pole gap solitons as well as vortical ones.The PT symmetry,lattice strength,and the degrees of local and nonlocal nonlinearity are tunable and can be used to control solitons.The stability regions of these solitons are evaluated in two numerical ways:linear-stability analysis and time evolutions with perturbations.Our results provide an insightful understanding of solitons physics in combined versatile platforms of PT-symmetric systems and Rydberg–Rydberg interaction in cold gases.展开更多
Topological insulator materials,including Bi_(2)Te_(3),Sb_(2)Te_(3),Sb_(2)Te_(3),and Bi_(2)Se_(3),have attracted some attention due to their narrow band gaps,high carrier mobility,wide spectral absorption ranges and o...Topological insulator materials,including Bi_(2)Te_(3),Sb_(2)Te_(3),Sb_(2)Te_(3),and Bi_(2)Se_(3),have attracted some attention due to their narrow band gaps,high carrier mobility,wide spectral absorption ranges and other characteristics.We report a new multi-compound topological insulator material BiSbTeSe_(2) that,compared with the traditional topological insulator composed of two elements,can integrate the physical advantages of each element,helpful to build an experimental platform with rich physical properties.The nonlinear optical characteristics of the quaternary material BiSbTeSe_(2) is obtained in the erbium-doped fiber laser.Using the BiSbTeSe_(2) as a saturable absorber material,the passive Q-switched and mode-locked fiber lasers are achieved.The pulse duration and signal-to-noise ratio(SNR)of the Q-switched fiber laser are 854 ns and 70 dB,respectively.Meanwhile,the pulse duration and SNR of the mode-locked fiber laser are 259 fs and 87.75 dB,respectively.This work proves that the BiSbTeSe_(2) has a considerable application prospect as a saturable absorber in fiber lasers,and provides a new reference for selection of high-performance saturable absorber materials.展开更多
Background:Hepatic fibrosis is a common chronic liver disease in clinic,the purpose of our study is to explore potential biomarkers to provide a theoretical basis for the treatment of liver fibrosis with pirfenidone.M...Background:Hepatic fibrosis is a common chronic liver disease in clinic,the purpose of our study is to explore potential biomarkers to provide a theoretical basis for the treatment of liver fibrosis with pirfenidone.Methods:We downloaded a gene-sequencing dataset and a single-cell dataset from the GEO database and pirfenidone target genes from three different databases.First,we performed GO,KEGG,and DO analysis on pirfenidone target genes.Then,we grouped the liver tissue sequencing data(GSE162694)in the sequencing data set(N-F0 group and F1-F4 group)and performed gene expression differential analysis on these two groups,weighted gene co-expression network analysis and gene Enrichment analysis.Finally,we intersected the significantly upregulated genes in the F1-F4 group with the pirfenidone target genes and performed PPI network analysis.In order to further explore the expression of both pirfenidone drug target genes and liver fibrosis disease genes(PDLFG)in different immune cells of liver tissue,we used the CD45+cell data in the GSE136103 data set for further analysis.Results:A subnetwork consisting of CDC42,HNF4A,BHLHE40,CCDC71L,NR1H3,TNF,MGLL,GPT,SCD and PLIN1 was screened out,and by analysis,we finally identified the SCD as PDLFG.In single-cell sequencing analysis,we found that SCD was highly expressed in M2-polarized macrophages.Conclusion:SCD may be an important target protein to inhibit the progression of liver fibrosis.展开更多
基金supported by the National Key R&D Program of China,No.2019YFE0121200(to LQZ)the National Natural Science Foundation of China,Nos.82325017(to LQZ),82030032(to LQZ),82261138555(to DL)+2 种基金the Natural Science Foundation of Hubei Province,No.2022CFA004(to LQZ)the Natural Science Foundation of Jiangxi Province,No.20224BAB206040(to XZ)Research Project of Cognitive Science and Transdisciplinary Studies Center of Jiangxi Province,No.RZYB202201(to XZ).
文摘With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic rate.However,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia patients.Similarly in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive decline.Nitric oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous system.Recently,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular dementia.This review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular dementia.Additionally,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.
基金supported by the National Natural Science Foundation of China(No.12172240).
文摘Fracture propagation in shale under in situ conditions is a critical but poorly understood mechanical process in hydraulic fracturing for deep shale gas reservoirs. To address this, hydraulic fracturing experiments were conducted on hollow double-wing crack specimens of the Longmaxi shale under conditions simulating the ground surface(confining pressure σ_(cp)=0, room temperature(Tr)) and at depths of 1600 m(σ_(cp)=40 MPa, Ti=70 ℃) and 3300 m(σ_(cp)=80 MPa, high temperature Ti=110 ℃) in the study area.High in situ stress was found to significantly increase fracture toughness through constrained microcracking and particle frictional bridging mechanisms. Increasing the temperature enhances rather than weakens the fracture resistance because it increases the grain debonding length, which dissipates more plastic energy and enlarges grains to close microdefects and generate compressive stress to inhibit microcracking. Interestingly, the fracture toughness anisotropy in the shale was found to be nearly constant across burial depths, despite reported variations with increasing confining pressure. Heated water was not found to be as important as the in situ environment in influencing shale fracture. These findings emphasize the need to test the fracture toughness of deep shales under coupled in situ stress and temperature conditions rather than focusing on either in situ stress or temperature alone.
基金Additionally,the authors appreciate Dr.Zhaopeng Zhang’s assistance in conducting the experiments.This research was funded by the Science and Technology Department of Tibet(Grant No.XZ202201ZY0021G).
文摘Granitic veins(GVs)have a significant influence on the mechanical responses of tunnels excavated in granitic strata.Distinguishing the mechanical properties of host granites(HGs),GVs and vein-granite interfaces(VGIs)is critical.For this,this paper analyzed the mechanical behaviors and rupture processes of typical HG,GV,and VGI samples under uniaxial compression condition.For the rocks studied,although the linear axial stress‒strain relation can be identified and the deformation modulus can be determined,the transverse deformation developed nonlinearly with axial stress.As a result,the instantaneous Poisson’s ratio increases continuously and may even exceed 0.5,making it extremely difficult to accurately determine the Poisson’s ratio.In addition,the studied GV samples were found to be significantly brittle,indicating that large-scale GVs cannot be ignored when assessing rockburst hazards in granitic strata with brittle GVs.In terms of the rupture process,the HG and GV samples were gradually damaged by the formation of small-scale cracks and then ruptured by large cracks formed from smallscale cracks,whereas the VGI samples ruptured along large cracks with significant energy release.By examining the characteristic stress thresholds of these three granites,it is noted that the crack closure stress scc exceeds both the crack initiation stress sci and the crack damage stress scd for the HG and VGI samples.The transverse damage to a tested sample appears to be significantly greater than the axial damage,which is essentially related to the rock grain size and grain size distribution.
基金supported by the National Natural Science Foundation of China(Grant Nos.62275075 and 11975172)the Sci-ence and Technology Research Program of Education De-partment of Hubei Province(Grant No.B2022188)+1 种基金the Natural Science Foundation of Hubei Province(Grant No.2023AFC042)the Training Program of Innova-tion and Entrepreneurship for Undergraduates of Hubei Province(Grant No.S202210927003).
文摘We present a novel approach for generating stable three-dimensional(3D)spatiotemporal solitons(SSs)within a rotating Bose–Einstein condensate,incorporating spin–orbit coupling(SOC),a weakly anharmonic potential and cold Rydberg atoms.This intricate system facilitates the emergence of quasi-stable 3D SSs with topological charges|m|≤3 in two spinor components,potentially exhibiting diverse spatial configurations.Our findings reveal that the Rydberg long-range interaction,spin–orbit coupling,and rotational angular frequency exert significant influence on the domains of existence and stability of these solitons.Notably,the Rydberg interaction contributes to a reduction in the norm of topological solitons,while the SOC plays a key role in stabilizing the SSs with finite topological charges.This research of SSs exhibits potential applications in precision measurement,quantum information processing,and other advanced technologies.
基金This work was supported by the Hunan Education Department Project(NO.20A390)National Innovation and Entrepreneurship Training Program(S202010548007).
文摘Background:Melanoma is a deadly skin tumor resulting from the malignant transformation of melanocytes.It is highly malignant and invasive,with the highest mortality rate among skin cancers.Acalypha australis L.(AAL),a plant with dual medicinal and culinary purposes,is commonly regarded as an edible wild vegetable in southern China.Additionally,AAL has a long history of medicinal use in China,often employed for its hemostatic,anti-diarrheal,and anti-inflammatory properties.Modern pharmacology has demonstrated that AAL possesses functions such as weight loss,antimicrobial activity,antiviral effects,and treatment for ulcerative colitis.However,there is currently no research available regarding its effectiveness and mechanisms of action on melanoma.Methods:In this investigation,we used methyl thiazolyl tetrazolium assay to detect cell viability,transwell assay to detect cell migration and invasion ability,and Western blot assay to detect relevant signaling pathways.Results:The present study reveals that 2 mg/mL AAL effectively suppresses the metastasis of B16 cells,while simultaneously triggering the expression of key apoptosis-related proteins,including Bcl-2,Bax,and cleaved caspased 3.Subsequent investigations demonstrate that AAL exerts this inhibitory effect via the PI3K/AKT signal transduction pathway,as evidenced by the observed deficits in Ras,AKT,p-AKT,and PI3K expression levels.Conclusion:These findings indicated that AAL could be a valuable therapeutic option for reducing the metastatic potential of B16 melanoma cells.
文摘Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between 2000 and 2011.Methods:A total of 22,432 incident cases of CRC between 2000 and 2011 from Guangzhou Cancer Registry were identified.Crude incidence and age-standardized rates(ASRs),using the Segi’s world standard population,were calculated for CRC and CRC subsites.The incidence trend was analyzed and the annual percentage change(APC) in incidence was calculated by using JoinPoint software.Results:The crude incidence increased significantly from 23.4/10~5 in 2000 to 37.4/10~5 in 2011 for males and from20.9/10~5 to 30.5/10~5 for females.The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.The ages at the onset of CRC for both males and females during 2010-2011 were significantly higher compared with those during 2000-2002(males:f = 1.95,P = 0.05;females:f = 6.03,P < 0.01).For males aged50-64 years,the CRC incidence increased by 8.50%annually(P = 0.04) during 2000-2004 and by 1.68%annually(P = 0.03) during 2005-2011.For females aged 65 years and older,the CRC incidence increased by 5.77%annually(P = 0.03) during 2000-2004.There were no significant changes for the CRC incidences in males aged 49 and younger and 65 years and older and females aged 64 years and younger during 2000-2004,or for those in all females as well as males aged 49 years and younger and 65 years and older during 2005-2011.The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.The ASRs of descending colon and sigmoid colon cancer incidences increased significantly for females during 2005-2011(APC,5.51%and 1.08%,respectively,both P < 0.05).Conclusions:The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging,whereas the ASRs kept stable.The percentage of colon cancer in all CRCs increased significantly.Further surveillance,research,and intervention are needed to identify the causes of these changes and to reduce the incidence and mortality of CRC.
基金Supported by the Natural Science Foundation of Guangdong Province,No.2016A030313504Guangzhou Science and Technology Program Key Project,No.201707010205
文摘AIM To measure the willingness to pay for colorectal cancer screening in Guangzhou, and to identify those factors associated with it. METHODS A face-to-face questionnaire survey for pre-screening population from free and non-free colonoscopy districts was used to collect information on demographic characteristics, health behaviours, the intention of the cancer screenings and willingness to pay for colorectal cancer screening. A total of 1243 participants who took part in the pre-screening for colorectal cancer in Guangzhou were collected in the study. Categorical data were compared using the χ~2 test to analyse significant differences. Non-conditional logistic regression and multi-class logistic regression were also performed for multivariate analysis and to estimate the odds ratios.RESULTS The percentage of participants willing to pay for colorectal cancer screening was 91.7%. "Unnecessary" was the dominant reason that participants gave for their unwillingness, accounting for 63.1%. Of those who were willing to pay, 29.2%, 20.7%, 14.8%, 13.0% and 22.4% of participants were willing to pay less than $100, $100-$199, $200-299, $300-$399 and more than $400, respectively. Non-logistic regression analysis showed that respondents who were male, had a high level of education, were from the family with more children/older to raise, and accepted colorectal cancer screening were willing to pay for this screening. Multi-class logistic regression analysis showed that respondents with higher annual household income per capita, from government and private enterprises, government agency/institution and peasants, and less family medical expenditure were willing to pay more.CONCLUSION Willingness to pay for colorectal cancer screening in Guangzhou is high, but the amount of willing to pay is not much.
文摘目的探讨电子序贯器官衰竭评分(simplified organ dysfunction criteria optimized for electronic health records,eSOFA)对急诊脓毒症患者28、90 d及1年预后的预测价值,并与序贯器官衰竭评分(sequential organ failure assessment,SOFA)、急性生理学与慢性健康状况Ⅱ评分(acute physiology and chronic health evaluationⅡ,APACHEⅡ)进行比较。方法连续纳入2018年12月1日至2021年1月31日中国康复研究中心急诊重症监护室收治的脓毒症患者。分别绘制eSOFA、SOFA和APACHEⅡ评分对患者28、90 d及1年预后的受试者工作特征(receiver operating characteristic,ROC)曲线,计算相应的曲线下面积(area under curve,AUC),并进行比较。根据eSOFA评分的截断值将患者分为eSOFA评分≤2分和eSOFA评分>2分两组,比较两组的一般临床特点。结果本研究最终纳入197例脓毒症患者,年龄为84(74~88)岁,其中男119例。纳入患者28、90 d及1年的病死率分别为38.6%(76/197)、51.8%(102/197)及58.9%(116/197)。eSOFA、SOFA和APACHEⅡ评分对脓毒症患者28、90 d及1年预后均具有预测能力,但三者差异无统计学意义(P>0.05),eSOFA评分对脓毒症患者1年死亡预测模型的拟和优度差,对1年预后预测效果不佳(P=0.01)。与eSOFA评分≤2分组相比,eSOFA评分>2分组患者死亡风险高(P<0.05),SOFA评分[分:5(4,7)vs.9(7,12)]和APACHEⅡ评分[分:23(18,27)vs.28(23,35)]更差,且更多患者发生急性肾损伤(acute kidney injury,AKI)(61.8%vs.83.6%)及接受血管活性药物(10.3%vs.59.1%)和机械通气(19.1%vs.50.8%)治疗。结论eSOFA、SOFA和APACHEⅡ评分均能有效评估脓毒症患者的中短期预后,优化患者早期治疗策略,但eSOFA评分简便易计算,更适合应用于急诊科。
基金supported by the National Natural Science Foundation of China (Grant Nos.11975172 and 12261131495)。
文摘To study controlled evolution of nonautonomous matter-wave breathers and rogue waves in spinor Bose–Einstein condensates with spatiotemporal modulation,we focus on a system of three coupled Gross–Pitaevskii equations with spacetime-dependent external potentials and temporally modulated gain-loss distributions.With different external potentials and gain-loss distributions,various solutions for controlled nonautonomous matterwave breathers and rogue waves are derived by the Darboux transformation method,such as breathers and rogue waves on arched and constant backgrounds which have the periodic and parabolic trajectories.Effects of the gain-loss distribution and linear potential on the breathers and rogue waves are studied.Nonautonomous two-breathers on the arched and constant backgrounds are also derived.
基金This research was funded by the National Natural Science Foundation of China(No.12172240 and No.51704198)Department of Science and Technology of Sichuan Province(No.2021YFH0030).
文摘It is inadequate to study the shear failure anisotropy of shale in only 2D space.Aiming at a 3D analysis,a series of direct shear tests was conducted on Longmaxi shale with three typical bedding orientations:arrester,divider and short-transverse orientations.During testing,acoustic emission(AE)and digital image correlation(DIC)techniques were simultaneously employed to monitor failure development,after testing,X-ray computed tomography(CT)scanning was adopted to acquire and reconstruct the fractures inside typical ruptured samples for more detailed analysis.The results indicated that the shear strength parameters exhibited 3D anisotropies and those of the arrester sample did not have equivalent shear strength parameters to the shale matrix.The maximum(minimum)shear strength and cohesion were obtained with the divider(short-transverse)orientation,and the internal friction angle reached its maximum(minimum)with the divider(arrester)orientation.Combining the AE,DIC and CT techniques,four characteristic stress levels that can capture the progressive shear failure process of shale rocks were identified,and the onset and accelerated development of shear damage-induced dilation were observed at the crack initiation and coalesce stress thresholds,respectively.During the crack coalescence stage,the dominated microcracking mechanism transferred from tensile-mode to shear-mode.For the arrester and divider orientations,more tensile-mode AE events were generated due to the microcracking along the vertical beddings.Compared with the divider samples,a more complex fracture network with a larger fracture area and volume was obtained in the arrester samples,whose strengths were smaller.
基金supported by the National Natural Science Foundation of China(Grant Nos.62275075,11975172,and 12261131495)the Shanghai Outstanding Academic Leaders Plan (Grant No.20XD1402000)the Training Program of Innovation and Entrepreneurship for Undergraduates of Hubei Province (Grant No.S202210927036)。
文摘Realizing single light solitons that are stable in high dimensions is a long-standing goal in research of nonlinear optical physics.Here,we address a scheme to generate stable two-dimensional solitons in a cold Rydberg atomic system with a parity-time(PT) symmetric moiré optical lattice.We uncover the formation,properties,and their dynamics of fundamental and two-pole gap solitons as well as vortical ones.The PT symmetry,lattice strength,and the degrees of local and nonlocal nonlinearity are tunable and can be used to control solitons.The stability regions of these solitons are evaluated in two numerical ways:linear-stability analysis and time evolutions with perturbations.Our results provide an insightful understanding of solitons physics in combined versatile platforms of PT-symmetric systems and Rydberg–Rydberg interaction in cold gases.
基金the Beijing Natural Science Foundation(Grant No.JQ21019)the National Natural Science Foundation of China(Grant Nos.12075034 and 11974003)。
文摘Topological insulator materials,including Bi_(2)Te_(3),Sb_(2)Te_(3),Sb_(2)Te_(3),and Bi_(2)Se_(3),have attracted some attention due to their narrow band gaps,high carrier mobility,wide spectral absorption ranges and other characteristics.We report a new multi-compound topological insulator material BiSbTeSe_(2) that,compared with the traditional topological insulator composed of two elements,can integrate the physical advantages of each element,helpful to build an experimental platform with rich physical properties.The nonlinear optical characteristics of the quaternary material BiSbTeSe_(2) is obtained in the erbium-doped fiber laser.Using the BiSbTeSe_(2) as a saturable absorber material,the passive Q-switched and mode-locked fiber lasers are achieved.The pulse duration and signal-to-noise ratio(SNR)of the Q-switched fiber laser are 854 ns and 70 dB,respectively.Meanwhile,the pulse duration and SNR of the mode-locked fiber laser are 259 fs and 87.75 dB,respectively.This work proves that the BiSbTeSe_(2) has a considerable application prospect as a saturable absorber in fiber lasers,and provides a new reference for selection of high-performance saturable absorber materials.
文摘Background:Hepatic fibrosis is a common chronic liver disease in clinic,the purpose of our study is to explore potential biomarkers to provide a theoretical basis for the treatment of liver fibrosis with pirfenidone.Methods:We downloaded a gene-sequencing dataset and a single-cell dataset from the GEO database and pirfenidone target genes from three different databases.First,we performed GO,KEGG,and DO analysis on pirfenidone target genes.Then,we grouped the liver tissue sequencing data(GSE162694)in the sequencing data set(N-F0 group and F1-F4 group)and performed gene expression differential analysis on these two groups,weighted gene co-expression network analysis and gene Enrichment analysis.Finally,we intersected the significantly upregulated genes in the F1-F4 group with the pirfenidone target genes and performed PPI network analysis.In order to further explore the expression of both pirfenidone drug target genes and liver fibrosis disease genes(PDLFG)in different immune cells of liver tissue,we used the CD45+cell data in the GSE136103 data set for further analysis.Results:A subnetwork consisting of CDC42,HNF4A,BHLHE40,CCDC71L,NR1H3,TNF,MGLL,GPT,SCD and PLIN1 was screened out,and by analysis,we finally identified the SCD as PDLFG.In single-cell sequencing analysis,we found that SCD was highly expressed in M2-polarized macrophages.Conclusion:SCD may be an important target protein to inhibit the progression of liver fibrosis.