Structure and Transesterification Reaction of Methyl 3-(Phenyldihalostannyl)propionates

The title compounds, PhX2SnCHECHECO2Me （X = C1, 1a; Br, 1b; I, 1c）, readily underwent transesterification into the corresponding analogues, PhX2SnCH2CH2CO2R when reacted with an alcohol ROH. The structural features of these compounds were described, and the possible mechanism of the novel transesterification was suggested.

Synthesis of a New Chiral Ligand Containing 1, 5-Diazacyclooctane and the Application in Diethyl Zinc Addition to Benzaldehyde

A new chiral tetradentate ligand (S, S)-1, 5-bis (4-benzyloxazolin-2-yl-methyl)-1, 5-diazacyclo-octane 1 has been synthesized and the application of 1 as catalyst in the enantioselective addition of diethyl zinc to benzaldehyde is also described.

A Facile Synthesis of 3,5-Diaryl 1,2,4-Selenadiazoles from Aryl Selenoamides

A facile synthesis of 3,5-diaryl 1,2,4-selenadiazoles was provided by treatment of aryl selenoamides with p-methylphenyl sulfonyl chloride in chloroform.

Synthesis and Pregnancy Terminating Activity of 2-Aryl imidazo [2,1-a] isoquinolines

Two 2-aryl imidazo [2,1-a] isoquinolines were synthesized and tested for pregnancy terminating activities. Both of them are new compounds and their structures were confirmed by IR, (HNMR)-H-1, MS and elemental analysis. They both showed high activities in NIH mice.

Synthesis and Transesterification of the Complexes of Methyl 2-Methyl-3-trichlorostannylpropoinate with Benzylmethylsulfoxide

The title complex, Cl3SnCH2CH(CH3)CO2CH3L (1), was synthesized by the reaction of methyl 2-methyl-3-trichlorostannylpropionate with benzylmethylsulfoxide (L) in solid state at room temperature and readily underwent transesterification into the corresponding analogues Cl3SnCH2CH(CH3)CO2RL when reacted with an alcohol ROH. The structural features of these compounds were described, and the possible mechanism of transesterification was suggested.

Synthesis of (S,S)-1,5-bis(4-alkyl-5-hydroxy-2-oxo-3-azapentyl)-1,5-diazacyclooctane

Synthesis of a series of chiral aza crown ethers ((S,S)-1, 5-bis (4-alkyl-5-hydroxy- 2-oxo-3-azapentyl)-1, 5-diazacyclooctane) are described.

Minor Groove Binding between Norfloxacin and DNA Duplexes in Solution: A Molecular Dynamics Study

Molecular dynamics were used to investigate the interaction between norfloxacin and DNA duplex. The results showed that norfloxacin was situated in the minor groove of DNA, binding to the TCGA region of d [ATATCGATAT] 2- Specific hydrogen bonds were formed between norfloxacin and guanine base of DNA during the 2 ns MD, which may be the reason for the preferentiality of quinolone antibacterial towards the guanine base of DNA duplex.

Synthesis of a New Ligand Containing 1, 7-Diaza-12-crown-4 and the Application in Asymmetric Cyclopropanation Reaction

A new chiral multidenate ligand (S, S)-1,7-bis(4-benzyloxazolin-2-yl-methyl)-1, 7-diaza- 12-crown-4 1 has been synthesized and used as ligand in the copper catalyzed asymmetric cyclopropanation of 1, 1-diphenylethylene.