Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrive...Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrived the national Category Ⅱof the water quality standard during this year. In summer in the bay the pollution of PHC was heavy, while relatively light in spring. In the coastal waters in the east and the northeast of the bay, the PHC contents in spring surpassed the national Category Ⅱ, and surpassed the national Category Ⅲ. In the coastal waters, in the northeast of the bay, the change of the PHC contents formed the grads: the contents presented the falling trend from the big one to the small, which unveiled that the PHC souce in the bay mainly came from the discharge of the industrial waste water and living sewage.展开更多
BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer models.It also constitutes an integral component of a compound formulation known as Pien Tze Huang,which...BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer models.It also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver cancer.However,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well understood.AIM To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway modulation.METHODS This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular docking.In vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot analysis.RESULTS This study identified 22 active components in CB,11 of which were detected in the bloodstream.Preclinical investigations have demonstrated the ability of CB to effectively inhibit liver tumor growth.An integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM polarization.In vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway activation.The inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway specificity.CONCLUSION This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.展开更多
The hydrolysis of MgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen supply.However,the formation of a surface passivation Mg(OH)_(2) layer and the large excess of H_(2)O...The hydrolysis of MgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen supply.However,the formation of a surface passivation Mg(OH)_(2) layer and the large excess of H_(2)O required to ensure complete hydrolysis are two key challenges for the MgH_(2) hydrolysis systems.Now,a low-cost method is reported to synthesize MgH_(2)@Mg(BH_(4))_(2) composite via ball-milling MgH_(2) with cheap and widely available B_(2)O_(3)(or B(OH)_(3)).By adding small amounts of B_(2)O_(3),the in-situ formed Mg(BH_(4))_(2) could significantly promote the hydrolysis of MgH_(2).In particular,the MgH_(2)–10 wt%B_(2)O_(3) composite releases 1330.7 mL·g^(−1) H_(2)(close to 80%theoretical hydrogen generation H_(2))in H_(2)O and 1520.4 mL·g^(−1) H_(2)(about 95%)in 0.5 M MgCl_(2) in 60 min at 26℃ with hydrolysis rate of 736.9 mL·g^(−1)·min^(−1) and 960.9 mL·g^(−1)·min^(−1) H_(2) during the first minute of the hydrolysis,respectively.In addition,the MgCl_(2) solution allows repeated use by filtering and exhibits high cycle stability(20 cycles),therefore leading to much reduced capacity loss caused by the excess H_(2)O.We show that by introducing B_(2)O_(3) and recycling the 0.5 M MgCl_(2) solution,the system hydrogen capacity can approach 5.9 wt%,providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.展开更多
OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases mortality.Tenascin-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular injury.The elevation of TN-C in AAS and whether ...OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases mortality.Tenascin-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular injury.The elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains unclear.METHODS We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back pain.Measures to discriminate AAS from acute coronary syndrome(ACS)were compared and calculated.RESULTS From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50–5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of AAS.Of the 166 AAS patients,the peaked level of TN-C was at acute stage(P=0.012),then a slight of decrease was observed at subacute stage.The area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for TN-C.At a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and hs-cTnT.CONCLUSIONS The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and NCV.TN-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain diseases.展开更多
Metal matrix self-lubricating materials lie at the core of cutting-edge aerospace,mechanical,and electrical industries,which demand technological performances that cannot be met by traditional liquid lubricants.Rapid ...Metal matrix self-lubricating materials lie at the core of cutting-edge aerospace,mechanical,and electrical industries,which demand technological performances that cannot be met by traditional liquid lubricants.Rapid innovation in nanocarbon materials in recent years enabled rapid development of advanced nanocomposites for applications in structural engineering and functional devices.Carbonous materials(e.g.,graphite,graphene and carbon nanotubes),exhibit a wide range of unique electrical,mechanical,and thermal properties,which are also considered ideal lubricating reinforcements for metal matrix nanocomposites(MMCs)with superior mechanical and tribological properties.In this review,we first showcase the distinctive features of the constituents commonly employed in self-lubricating MMCs,encompassing the high-strength metallic matrix and nano-carbonous reinforcement.Then,we present a comprehensive overview of the recent advancements in preparation techniques for these advanced MMCs,followed by an in-depth discussion on their corresponding tribological properties and wear mechanisms.We close this review by outlining key problems to be solved and the future trend of the development in self-lubricating MMCs.展开更多
Geotectonically, the Shuikou ultrabasic-basic rock mass is located on the western margin of the Yangtze Platform. As revealed by field geological surveys, the Shuikou rock mass intrudes into the quartz sandstones of t...Geotectonically, the Shuikou ultrabasic-basic rock mass is located on the western margin of the Yangtze Platform. As revealed by field geological surveys, the Shuikou rock mass intrudes into the quartz sandstones of the Sinian Chengjiang Formation (Zac). It is dominated by pyroxenites and can be roughly divided into four lithofacies zones, namely gabbros at the outermost periphery and fine-, medium-, and coarse-grained pyroxenites from margin to center. With the transition from pyroxenites to gabbros, the Shuikou rock mass features gradual enrichment in silica and alkali overall, an increase in ΣREE and (La/Yb)<sub>N</sub> ratio, and a decrease in δEu values and Eu/Sm ratio, indicating that the Shuikou rock mass was formed from the continuous differentiation and crystallization of consanguineous magma and that low-degree partial melting occurred meanwhile. According to the U-Pb baddeleyite geochronology, the crystallization age of the Shuikou rock mass is 210.7 ± 3 Ma (MSWD = 1.01). Based on this, as well as the analysis of geochemical characteristics, the Shuikou rock mass occurred in a continental intraplate tensional environment, this is closely related to the activities of the Emeishan mantle plume during the same period.展开更多
The sand layer B of Dongying Formation of CFD oilfield in Bohai offshore belongs to the middle deep layer of buried hill overlap deposit. Its reservoir distribution has the characteristics of large burial depth, thin ...The sand layer B of Dongying Formation of CFD oilfield in Bohai offshore belongs to the middle deep layer of buried hill overlap deposit. Its reservoir distribution has the characteristics of large burial depth, thin thickness and rapidly lateral change. Because of low resolution of seismic data and overlying sand layer. It is difficult to identify and interpret the structure of sand layer accurately. The uncertainty of structure and reservoir restricts the fine development of B sand layer. In order to identify the top surface of reservoir effectively. The seismic data are processed by using the reflection coefficient inversion method. The results show that the inversion resolution of reflection coefficient is significantly higher than that of original data. The top surface of sand layer B and its overlying sand layer can be well identified and traced. Carrying out structural interpretation of B sand layer based on reflection coefficient inversion data and the microstructure and the formation tip extinction point are implemented. Based on the constraint of new interpretation level, the sedimentary facies plane distribution of B sand layer is described and make prediction of dominant reservoir development area in detail combining with sedimentary paleogeomorphology, along layer attribute section and limited drilling data. The research shows that the study area is mainly from the northwest material sources, the slope belt in the northwest is close to the lake shoreline with a gentle slope and shallow water depositional environment, which is located on the main transport and deposition channels. The shallow water gentle slope landform is suitable for forming large-area sand bar deposition, mainly composed of underwater distributary channel and debouch bars facies, which is the dominant reservoir development area. The research conclusion guides the deployment and implementation of the development well location effectively.展开更多
Objective: To investigate the changes of bone auditory thresholds variations in cholesteatoma middle ear surgery and its related factors and its related factors. Methods: 122 cases (122 ears) of unilateral cholesteato...Objective: To investigate the changes of bone auditory thresholds variations in cholesteatoma middle ear surgery and its related factors and its related factors. Methods: 122 cases (122 ears) of unilateral cholesteatoma otitis media were treated by mastoidectomy and/or tympanoplasty plus stage I tympanoplasty, and tragus cartilage ring-cartilage membrane (Referred to as cartilage group, 62 ears) and temporalis muscle fascia (Referred to as fascia group, 60 ears) were used as tympanic membrane grafts respectively. The changes of bone conduction hearing threshold were compared between the two groups before and 1, 3, 6 months and 1, 3 years after operation. And compare the difference in the incidence of ossicular chain fixation or necrosis, vestibular window or cochlear window dysfunction between the two groups of patients with increased (positive) and decreased (negative) bone conduction threshold before operation. Results: Compared with the healthy side, 95 ears of 122 ears in the two groups had higher bone conduction hearing threshold before operation. Among them, 48 ears were in cartilage group and 47 ears were in fascia group;In 72 ears (76.34%) of these cases, the bone conduction hearing threshold decreased after operation, and the difference between the two groups was statistically significant (P Conclusion: The improvement of bone conduction hearing threshold in patients with cholesteatoma otitis media is mainly related to the fixation or necrosis of ossicular chain and the dysfunction of two windows. The tragus cartilage ring-perichondrium tympanoplasty can not only reduce the air-bone conduction difference, but also reduce the bone conduction hearing threshold, which has the advantage of stable and lasting hearing improvement.展开更多
生命与健康多组学数据是生命科学研究和生物医学技术发展的重要基础。然而,我国缺乏生物数据管理和共享平台,不但无法满足国内日益增长的生物医学及相关学科领域的研究发展需求,而且严重制约我国生物大数据整合共享与转化利用。鉴于此,...生命与健康多组学数据是生命科学研究和生物医学技术发展的重要基础。然而,我国缺乏生物数据管理和共享平台,不但无法满足国内日益增长的生物医学及相关学科领域的研究发展需求,而且严重制约我国生物大数据整合共享与转化利用。鉴于此,中国科学院北京基因组研究所于2016年初成立生命与健康大数据中心(BIG Data Center,BIGD),围绕国家人口健康和重要战略生物资源,建立生物大数据管理平台和多组学数据资源体系。本文重点介绍BIGD的生命与健康大数据资源系统,主要包括组学原始数据归档库、基因组数据库、基因组变异数据库、基因表达数据库、甲基化数据库、生物信息工具库和生命科学维基知识库,提供生物大数据汇交、整合与共享服务,为促进我国生命科学数据管理、推动国家生物信息中心建设奠定重要基础。展开更多
文摘Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrived the national Category Ⅱof the water quality standard during this year. In summer in the bay the pollution of PHC was heavy, while relatively light in spring. In the coastal waters in the east and the northeast of the bay, the PHC contents in spring surpassed the national Category Ⅱ, and surpassed the national Category Ⅲ. In the coastal waters, in the northeast of the bay, the change of the PHC contents formed the grads: the contents presented the falling trend from the big one to the small, which unveiled that the PHC souce in the bay mainly came from the discharge of the industrial waste water and living sewage.
基金Supported by National Natural Science Foundation of China,No.82074450Education Department of Hunan Province,No.21A0243,No.21B0374,No.22B0397,and No.22B0392+2 种基金Research Project of"Academician Liu Liang Workstation"of Hunan University of Traditional Chinese Medicine,No.21YS003Hunan Administration of Traditional Chinese Medicine,No.B2023001 and No.B2023009Hunan Provincial Natural Science Foundation of China,No.2023JJ40481。
文摘BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer models.It also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver cancer.However,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well understood.AIM To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway modulation.METHODS This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular docking.In vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot analysis.RESULTS This study identified 22 active components in CB,11 of which were detected in the bloodstream.Preclinical investigations have demonstrated the ability of CB to effectively inhibit liver tumor growth.An integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM polarization.In vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway activation.The inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway specificity.CONCLUSION This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.
基金supported by the Basic and Applied Basic Research Foundation of Guangdong Province(No.2022A1515011832 and 2021A1515110676)supported by GDAS’Project of Science and Technology Development(2022GDASZH-2022010104,2022GDASZH-2022030604-04).
文摘The hydrolysis of MgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen supply.However,the formation of a surface passivation Mg(OH)_(2) layer and the large excess of H_(2)O required to ensure complete hydrolysis are two key challenges for the MgH_(2) hydrolysis systems.Now,a low-cost method is reported to synthesize MgH_(2)@Mg(BH_(4))_(2) composite via ball-milling MgH_(2) with cheap and widely available B_(2)O_(3)(or B(OH)_(3)).By adding small amounts of B_(2)O_(3),the in-situ formed Mg(BH_(4))_(2) could significantly promote the hydrolysis of MgH_(2).In particular,the MgH_(2)–10 wt%B_(2)O_(3) composite releases 1330.7 mL·g^(−1) H_(2)(close to 80%theoretical hydrogen generation H_(2))in H_(2)O and 1520.4 mL·g^(−1) H_(2)(about 95%)in 0.5 M MgCl_(2) in 60 min at 26℃ with hydrolysis rate of 736.9 mL·g^(−1)·min^(−1) and 960.9 mL·g^(−1)·min^(−1) H_(2) during the first minute of the hydrolysis,respectively.In addition,the MgCl_(2) solution allows repeated use by filtering and exhibits high cycle stability(20 cycles),therefore leading to much reduced capacity loss caused by the excess H_(2)O.We show that by introducing B_(2)O_(3) and recycling the 0.5 M MgCl_(2) solution,the system hydrogen capacity can approach 5.9 wt%,providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.
基金supported by the National Natural Science Foundation of China(No.81970401,No.82270346,No.82170496)Jiangsu Provincial Key Medical Discipline(ZD2021023)+1 种基金Nanjing Municipal Health Science and Education Key Project(ZKX 21021)Nanjing Science and Technology Bureau Medical and Health International Joint Project(No.202002052).
文摘OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases mortality.Tenascin-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular injury.The elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains unclear.METHODS We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back pain.Measures to discriminate AAS from acute coronary syndrome(ACS)were compared and calculated.RESULTS From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50–5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of AAS.Of the 166 AAS patients,the peaked level of TN-C was at acute stage(P=0.012),then a slight of decrease was observed at subacute stage.The area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for TN-C.At a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and hs-cTnT.CONCLUSIONS The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and NCV.TN-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain diseases.
基金support by the National Key Research and Development Program of China(2022YFB3809000)the Natural Science Foundation of China(No.52175188)+2 种基金Key Research and Development Program of Shaanxi Province(2023-YBGY-434)the Open Fund of Liaoning Provincial Key Laboratory of Aero-engine Materials Tribology(Grant No.LKLAMTF202301)State Key Laboratory for Mechanical Behavior of Materials(20222412).
文摘Metal matrix self-lubricating materials lie at the core of cutting-edge aerospace,mechanical,and electrical industries,which demand technological performances that cannot be met by traditional liquid lubricants.Rapid innovation in nanocarbon materials in recent years enabled rapid development of advanced nanocomposites for applications in structural engineering and functional devices.Carbonous materials(e.g.,graphite,graphene and carbon nanotubes),exhibit a wide range of unique electrical,mechanical,and thermal properties,which are also considered ideal lubricating reinforcements for metal matrix nanocomposites(MMCs)with superior mechanical and tribological properties.In this review,we first showcase the distinctive features of the constituents commonly employed in self-lubricating MMCs,encompassing the high-strength metallic matrix and nano-carbonous reinforcement.Then,we present a comprehensive overview of the recent advancements in preparation techniques for these advanced MMCs,followed by an in-depth discussion on their corresponding tribological properties and wear mechanisms.We close this review by outlining key problems to be solved and the future trend of the development in self-lubricating MMCs.
文摘Geotectonically, the Shuikou ultrabasic-basic rock mass is located on the western margin of the Yangtze Platform. As revealed by field geological surveys, the Shuikou rock mass intrudes into the quartz sandstones of the Sinian Chengjiang Formation (Zac). It is dominated by pyroxenites and can be roughly divided into four lithofacies zones, namely gabbros at the outermost periphery and fine-, medium-, and coarse-grained pyroxenites from margin to center. With the transition from pyroxenites to gabbros, the Shuikou rock mass features gradual enrichment in silica and alkali overall, an increase in ΣREE and (La/Yb)<sub>N</sub> ratio, and a decrease in δEu values and Eu/Sm ratio, indicating that the Shuikou rock mass was formed from the continuous differentiation and crystallization of consanguineous magma and that low-degree partial melting occurred meanwhile. According to the U-Pb baddeleyite geochronology, the crystallization age of the Shuikou rock mass is 210.7 ± 3 Ma (MSWD = 1.01). Based on this, as well as the analysis of geochemical characteristics, the Shuikou rock mass occurred in a continental intraplate tensional environment, this is closely related to the activities of the Emeishan mantle plume during the same period.
文摘The sand layer B of Dongying Formation of CFD oilfield in Bohai offshore belongs to the middle deep layer of buried hill overlap deposit. Its reservoir distribution has the characteristics of large burial depth, thin thickness and rapidly lateral change. Because of low resolution of seismic data and overlying sand layer. It is difficult to identify and interpret the structure of sand layer accurately. The uncertainty of structure and reservoir restricts the fine development of B sand layer. In order to identify the top surface of reservoir effectively. The seismic data are processed by using the reflection coefficient inversion method. The results show that the inversion resolution of reflection coefficient is significantly higher than that of original data. The top surface of sand layer B and its overlying sand layer can be well identified and traced. Carrying out structural interpretation of B sand layer based on reflection coefficient inversion data and the microstructure and the formation tip extinction point are implemented. Based on the constraint of new interpretation level, the sedimentary facies plane distribution of B sand layer is described and make prediction of dominant reservoir development area in detail combining with sedimentary paleogeomorphology, along layer attribute section and limited drilling data. The research shows that the study area is mainly from the northwest material sources, the slope belt in the northwest is close to the lake shoreline with a gentle slope and shallow water depositional environment, which is located on the main transport and deposition channels. The shallow water gentle slope landform is suitable for forming large-area sand bar deposition, mainly composed of underwater distributary channel and debouch bars facies, which is the dominant reservoir development area. The research conclusion guides the deployment and implementation of the development well location effectively.
文摘Objective: To investigate the changes of bone auditory thresholds variations in cholesteatoma middle ear surgery and its related factors and its related factors. Methods: 122 cases (122 ears) of unilateral cholesteatoma otitis media were treated by mastoidectomy and/or tympanoplasty plus stage I tympanoplasty, and tragus cartilage ring-cartilage membrane (Referred to as cartilage group, 62 ears) and temporalis muscle fascia (Referred to as fascia group, 60 ears) were used as tympanic membrane grafts respectively. The changes of bone conduction hearing threshold were compared between the two groups before and 1, 3, 6 months and 1, 3 years after operation. And compare the difference in the incidence of ossicular chain fixation or necrosis, vestibular window or cochlear window dysfunction between the two groups of patients with increased (positive) and decreased (negative) bone conduction threshold before operation. Results: Compared with the healthy side, 95 ears of 122 ears in the two groups had higher bone conduction hearing threshold before operation. Among them, 48 ears were in cartilage group and 47 ears were in fascia group;In 72 ears (76.34%) of these cases, the bone conduction hearing threshold decreased after operation, and the difference between the two groups was statistically significant (P Conclusion: The improvement of bone conduction hearing threshold in patients with cholesteatoma otitis media is mainly related to the fixation or necrosis of ossicular chain and the dysfunction of two windows. The tragus cartilage ring-perichondrium tympanoplasty can not only reduce the air-bone conduction difference, but also reduce the bone conduction hearing threshold, which has the advantage of stable and lasting hearing improvement.
文摘生命与健康多组学数据是生命科学研究和生物医学技术发展的重要基础。然而,我国缺乏生物数据管理和共享平台,不但无法满足国内日益增长的生物医学及相关学科领域的研究发展需求,而且严重制约我国生物大数据整合共享与转化利用。鉴于此,中国科学院北京基因组研究所于2016年初成立生命与健康大数据中心(BIG Data Center,BIGD),围绕国家人口健康和重要战略生物资源,建立生物大数据管理平台和多组学数据资源体系。本文重点介绍BIGD的生命与健康大数据资源系统,主要包括组学原始数据归档库、基因组数据库、基因组变异数据库、基因表达数据库、甲基化数据库、生物信息工具库和生命科学维基知识库,提供生物大数据汇交、整合与共享服务,为促进我国生命科学数据管理、推动国家生物信息中心建设奠定重要基础。
