Important challenges must be addressed to make wind turbines sustainable renewable energy sources.A typical problem concerns the design of the foundation.If the pile diameter is larger than that of the jacket platform...Important challenges must be addressed to make wind turbines sustainable renewable energy sources.A typical problem concerns the design of the foundation.If the pile diameter is larger than that of the jacket platform,traditional mechanical models cannot be used.In this study,relying on the seabed soil data of an offshore wind farm,the m-method and the equivalent embedded method are used to address the single-pile wind turbine foundation problem for different pile diameters.An approach to determine the equivalent pile length is also proposed accordingly.The results provide evidence for the effectiveness and reliability of the model based on the equivalent embedded method.展开更多
Antineutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis(AAV)is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood vessels.AAV involves multi...Antineutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis(AAV)is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood vessels.AAV involves multiple organ systems throughout the body.Our knowledge of the pathogenesis of AAV has increased considerably in recent years,involving cellular,molecular and genetic factors.Because of the controlled environment with no other confounding factors,animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side effects.However,the complexity and heterogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in patients.The aim of this review is to overview the current status of animal models for AAV,outline the pros and cons of methods,and propose potential directions for future research.展开更多
Objective: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been obs...Objective: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma (HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion. Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC- 7721, BEL-7402, Huh-7, HepG2, Hep3B and SKHepl were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA (siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells. Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siP, NA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells. Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC.展开更多
Quantitative real-time PCR(qPCR)is an effective and widely used method to analyze expression patterns of target genes.Selection of stable reference genes is a prerequisite for accurate normalization of target gene exp...Quantitative real-time PCR(qPCR)is an effective and widely used method to analyze expression patterns of target genes.Selection of stable reference genes is a prerequisite for accurate normalization of target gene expression by qRT-PCR.In Iris germanica L.,no studies have yet been published regarding the evaluation of potential reference genes.In this study,nine candidate reference genes were assessed at different flower developmental stages and in different tissues by four different algorithms(GeNorm,NormFinder,BestKeeper,and RefFinder).The results revealed that ACT11(Actin 11)and EF1α(Elongation factor 1 alpha)were the most stable reference genes in different tissues,whereas TUA(Tubulin alpha)and UBC9(Ubiquitin-protein ligase 9)were the most stable ones in different flower developmental stages.UBC9 and ACT11 were the most stable reference genes in all of the tested samples,while the SAMDC(S-Adenosylmethionine decarboxylase)showed the least stability.Finally,to validate the suitability of the selected reference genes,the relative expression level of IgTPS(beta-caryophyllene synthase)was assessed and highlighted the importance of suitable reference gene selection.This work constitutes the first systematic evaluation of potential reference genes in I.germanica and provides guidelines for future research on gene function and molecular mechanisms on I.germanica and related species.展开更多
Xiyanping injection,a traditional Chinese medicine injection made of andrographolide sulfonate,consisting of well-defined ingredients with antiviral,antibacterial,anti-inflammatory and antipyretic efficacy,has been wi...Xiyanping injection,a traditional Chinese medicine injection made of andrographolide sulfonate,consisting of well-defined ingredients with antiviral,antibacterial,anti-inflammatory and antipyretic efficacy,has been widely used for treating infectious diseases of respiratory and digestive systems.However,its wide applications may easily lead to unreasonable clinical medication.In order to guide the precise clinical application and rational use of Xiyanping injection,experts in related fields conducted systematically literature review,evaluated and deliberated the application of Xiyanping injection in treating acute infectious diseases using evidence-based medicine method,and jointly drafted the consensus to summarize types of acute infectious diseases in children and adults that can be treated with Xiyanping injection,and recommend the intervention time,usage and dosage,course of treatment and combined medication of the injection.Besides,the consensus elucidates the safety,precautions and contraindications of the injection,so as to provide guidance for clinical use.展开更多
Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times swe...Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs.展开更多
The purpose of underground methane drainage technology is to prevent methane disasters and enable the efficient use of coal mine methane(CMM),and the sealing depth is a key factor that affects the performance of under...The purpose of underground methane drainage technology is to prevent methane disasters and enable the efficient use of coal mine methane(CMM),and the sealing depth is a key factor that affects the performance of underground methane drainage.In this work,the layouts of in-seam and crossing boreholes are considered to analyze the stress distribution and failure characteristics of roadway surrounding rock through a numerical simulation and field stress investigation to determine a reasonable sealing depth.The results show that the depths of the plastic and elastic zones in two experimental coal mines are 16 and 20 m respectively.Borehole sealing minimizes the air leakage through the fractures around the roadway when the sealing material covers the failure and plastic zones,and the field test results for CMM drainage at different sealing depths indicate that the CMM drainage efficiency increases with increasing sealing depth but does not change once the sealing depth exceeds the plastic zone.Moreover,sealing in the high-permeability roadway surrounding rock does not have a strong influence on the borehole sealing performance.Considering these findings,a new CMM drainage system for key sealing in the low-permeability zone was developed that is effective for improving the CMM drainage efficiency and prolonging the high-concentration CMM drainage period.The proposed approach offers a valuable quantitative analysis method for selecting the optimum sealing parameters for underground methane drainage,thereby improving considerably the drainage and utilization rates of CMM.展开更多
An E-type high-precision temperature sensor, which is adopted for upper air meteorology, was proposed in this paper. A computational fluid dynamics(CFD) method was implemented to analyze temperature rise induced by so...An E-type high-precision temperature sensor, which is adopted for upper air meteorology, was proposed in this paper. A computational fluid dynamics(CFD) method was implemented to analyze temperature rise induced by solar radiation at different altitudes and solar radiation intensities. A temperature rise correction equation was obtained by fitting the CFD results using a Broyden-Fletcher-Goldfarb-Shanno(BFGS) method. To verify the performance of the temperature sensor, an experimental platform was constructed. Through simulations and experiments, the relationship among the altitude, solar radiation intensity and radiation temperature rise was obtaned. The root-mean-square error(RMSE) between the temperature rise derived from the correction equation and that derived from the experiments is 0.013 K. The sample determination coefficient r2 of the solar radiation error correction equation is 0.9975.展开更多
Influenza is a serious public health problem that endangers the health of the global human population.Traditional Chinese medicine(TCM)is rich in theory and practical experience regarding the treatment of influenza,an...Influenza is a serious public health problem that endangers the health of the global human population.Traditional Chinese medicine(TCM)is rich in theory and practical experience regarding the treatment of influenza,and TCM treatments have shown good curative effects,but there is a dearth of standardized clinical guidance.It is necessary to formulate a clinical practice guide based on evidence-based medicine.To this end,the Specialty Committee of Emergency,China Association of Chinese Medicine(Beijing,China)organized a team of clinical experts,methodological experts,and other multidisciplinary experts to develop a guideline with integrated research methods in the first place of TCM.This guide includes 23 recommendations.The prescription section contains 16 recommendations,including 5 recommendations for mild cases,5 recommendations for severe cases,3 recommendations for critical cases,and 4 recommendations for the recovery period;the portion covering proprietary Chinese medicines forms a total of 7 recommendations.This guide aims to provide the best evidence for clinicians and related practitioners to make decisions about influenza diagnosis and treatment in Chinese medicine.展开更多
The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and ov...The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths[1].During the past 2 years,global studies on prevention and therapies for COVID-19 have achieved a series of promising findings,including antiviral drugs(Remdesivir,Molnupiravir,Paxlovid)and monoclonal antibodies(Bamlanivimab and Etesevimab,Sotrovimab,Casirivimab and Imdevimab)[2].展开更多
A splashing crown is commonly observed when a high-speed drop impacts a liquid film. The influence of the liquid viscosity on the crown's evolution is not yet clear. We review several existing theories of this proble...A splashing crown is commonly observed when a high-speed drop impacts a liquid film. The influence of the liquid viscosity on the crown's evolution is not yet clear. We review several existing theories of this problem, and carry out a series of numerical simulations. We find that a three-segment model can describe the crown's motion. In the very early stage when the crown is barely visible, the influence of viscosity is small. Later, a shallow water approach used in most existing models is applicable as long as the initial conditions are formulated properly. They depend on viscous dissipation in the intermediate period. Preliminary estimation based on a dissipation function is proposed to characterize the influence of viscosity in this problem.展开更多
Surface water-blooms (SWBs) is usually explained as a buoyant migration of blue-green algae to the water surface under the conditions of reduced turbulence. Wind-induced turbulent mixing can cause considerable heter...Surface water-blooms (SWBs) is usually explained as a buoyant migration of blue-green algae to the water surface under the conditions of reduced turbulence. Wind-induced turbulent mixing can cause considerable heterogeneity in the vertical concentration distribution of algal cells. There exists a criterion below which cell buoyancy can overcome the turbulent mixing. Former researchers regarded a certain wind speed as this criterion, but this wind speed differs in value. In this research, we propose a new criterion, nondimensional entrainment number (En), which represents the ratio of the intrinsic velocity of algal cells relative to the characteristic velocity of wind-induced mixing. Observation in Taihu Lake demonstrates that this new criterion is more suitable for the description of hydrodynamic effect on the formation of surface water-blooms.展开更多
Accurate conditions monitoring and early wrong action warnings of relay protection in the Smart Substation is the basic guarantee to realize the normal operation of primary and secondary system of the power grid.At pr...Accurate conditions monitoring and early wrong action warnings of relay protection in the Smart Substation is the basic guarantee to realize the normal operation of primary and secondary system of the power grid.At present,the traditional operation and maintenance monitoring methods of relay protections have poor timeliness,while some automatic monitoring methods have insufficient early warning performance,and lack the online action deduction function independent of the actual device.In this paper,a design method of integrated action deduction system including protection logic reasoning and software and hardware operation condition is proposed.The system can receive real-time operation information of protection online,simulate different types of faults,and output the recording information of sub modules belongs to the action deduction system.It can realize the online monitoring of device faults such as deducing the correctness of setting values at a certain time in the future,giving the wrong action warnings and predicting the probability of them as well,which effectively improves the operation and maintenance efficiency of the secondary system in the intelligent substation.展开更多
Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by ...Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.展开更多
Atmospheric moisture exploitation is emerging as a promising alternative to relieve the shortage of freshwater and energy.Efforts to exploit hygroscopic materials featuring flexibility,programmability,and accessibilit...Atmospheric moisture exploitation is emerging as a promising alternative to relieve the shortage of freshwater and energy.Efforts to exploit hygroscopic materials featuring flexibility,programmability,and accessibility are crucial to portable and adaptable devices.However,current two-dimensional(2D)or three-dimensional(3D)-based hygroscopic materials are dif-ficult to adapt to diverse irregular surfaces and meet breathability,which severely hinders their wide applications in wearable and programmable devices.Herein,hygroscopic organogel fibers(HOGFs)were designed via a wet-spinning strategy.The achieved fibers were composed of the hydrophilic polymeric network,hygroscopic solvent,and photothermal/antibacterial Ag nanoparticles(AgNPs),enabling hygroscopic capacity,photothermal conversion,and antibacterial.Owing to the good knittable feature,the HOGFs can be readily woven to adjusted 2D textiles to function as an efficient self-sustained solar evaporator of 4-layer woven HOGF device with a saturated moisture capacity of 1.63 kg m^(-2) and water-releasing rate of 1.46 kg m^(-2) h^(-1).Furthermore,the 2D textile can be applied as a wearable dehumidification device to efficiently remove the evaporative moisture from human skin to maintain a comfortable environment.It can reduce the humidity from 90 to 33.4%within 12.5 min.In addition,the introduction of AgNPs can also endow the HOGFs with antibacterial features,demonstrat-ing significant potential in personal healthcare.展开更多
基金supported by the National Natural Science Foundation of China (52071055)the Fundamental Research Funds for the Central Universities (Grant No.DUT22QN237).
文摘Important challenges must be addressed to make wind turbines sustainable renewable energy sources.A typical problem concerns the design of the foundation.If the pile diameter is larger than that of the jacket platform,traditional mechanical models cannot be used.In this study,relying on the seabed soil data of an offshore wind farm,the m-method and the equivalent embedded method are used to address the single-pile wind turbine foundation problem for different pile diameters.An approach to determine the equivalent pile length is also proposed accordingly.The results provide evidence for the effectiveness and reliability of the model based on the equivalent embedded method.
基金the Ethics Committee of Tongji Hospital,Huazhong University of Science and Technology,China(TJ-IRB20191012).
文摘Antineutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis(AAV)is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood vessels.AAV involves multiple organ systems throughout the body.Our knowledge of the pathogenesis of AAV has increased considerably in recent years,involving cellular,molecular and genetic factors.Because of the controlled environment with no other confounding factors,animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side effects.However,the complexity and heterogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in patients.The aim of this review is to overview the current status of animal models for AAV,outline the pros and cons of methods,and propose potential directions for future research.
基金supported by grants from the National Natural Science Foundation of China (81272645 and 81301743)
文摘Objective: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma (HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion. Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC- 7721, BEL-7402, Huh-7, HepG2, Hep3B and SKHepl were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA (siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells. Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siP, NA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells. Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC.
基金The work was supported by the National Natural Science Foundation of China(31801901)the Natural Science Foundation of Jiangsu(BK20180314)+1 种基金the Foundation of Key Laboratory of Landscaping(KF201901),Ministry of Agriculture and Rural Affairs,Chinathe Jiangsu Key Laboratory for the Research and Utilization of Plant Resources(JSPKLB201814).
文摘Quantitative real-time PCR(qPCR)is an effective and widely used method to analyze expression patterns of target genes.Selection of stable reference genes is a prerequisite for accurate normalization of target gene expression by qRT-PCR.In Iris germanica L.,no studies have yet been published regarding the evaluation of potential reference genes.In this study,nine candidate reference genes were assessed at different flower developmental stages and in different tissues by four different algorithms(GeNorm,NormFinder,BestKeeper,and RefFinder).The results revealed that ACT11(Actin 11)and EF1α(Elongation factor 1 alpha)were the most stable reference genes in different tissues,whereas TUA(Tubulin alpha)and UBC9(Ubiquitin-protein ligase 9)were the most stable ones in different flower developmental stages.UBC9 and ACT11 were the most stable reference genes in all of the tested samples,while the SAMDC(S-Adenosylmethionine decarboxylase)showed the least stability.Finally,to validate the suitability of the selected reference genes,the relative expression level of IgTPS(beta-caryophyllene synthase)was assessed and highlighted the importance of suitable reference gene selection.This work constitutes the first systematic evaluation of potential reference genes in I.germanica and provides guidelines for future research on gene function and molecular mechanisms on I.germanica and related species.
文摘Xiyanping injection,a traditional Chinese medicine injection made of andrographolide sulfonate,consisting of well-defined ingredients with antiviral,antibacterial,anti-inflammatory and antipyretic efficacy,has been widely used for treating infectious diseases of respiratory and digestive systems.However,its wide applications may easily lead to unreasonable clinical medication.In order to guide the precise clinical application and rational use of Xiyanping injection,experts in related fields conducted systematically literature review,evaluated and deliberated the application of Xiyanping injection in treating acute infectious diseases using evidence-based medicine method,and jointly drafted the consensus to summarize types of acute infectious diseases in children and adults that can be treated with Xiyanping injection,and recommend the intervention time,usage and dosage,course of treatment and combined medication of the injection.Besides,the consensus elucidates the safety,precautions and contraindications of the injection,so as to provide guidance for clinical use.
基金the National Natural Science Foundation of China(31701497 and 31601371)the Natural Science Foundation of Jiangsu Province(BK20160600 and BK20180312),the Jiangsu Key Laboratory for the Research and Utilization of Plant Resources(JSPKLB201801 and JSPKLB201832).
文摘Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs.
基金This research was supported by the National Natural Science Foundation of China(51974300)the Fundamental Research Funds for the Central Universities(2021YCPY0206 and 2020ZDPY0224)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX21_2467),and as a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘The purpose of underground methane drainage technology is to prevent methane disasters and enable the efficient use of coal mine methane(CMM),and the sealing depth is a key factor that affects the performance of underground methane drainage.In this work,the layouts of in-seam and crossing boreholes are considered to analyze the stress distribution and failure characteristics of roadway surrounding rock through a numerical simulation and field stress investigation to determine a reasonable sealing depth.The results show that the depths of the plastic and elastic zones in two experimental coal mines are 16 and 20 m respectively.Borehole sealing minimizes the air leakage through the fractures around the roadway when the sealing material covers the failure and plastic zones,and the field test results for CMM drainage at different sealing depths indicate that the CMM drainage efficiency increases with increasing sealing depth but does not change once the sealing depth exceeds the plastic zone.Moreover,sealing in the high-permeability roadway surrounding rock does not have a strong influence on the borehole sealing performance.Considering these findings,a new CMM drainage system for key sealing in the low-permeability zone was developed that is effective for improving the CMM drainage efficiency and prolonging the high-concentration CMM drainage period.The proposed approach offers a valuable quantitative analysis method for selecting the optimum sealing parameters for underground methane drainage,thereby improving considerably the drainage and utilization rates of CMM.
文摘An E-type high-precision temperature sensor, which is adopted for upper air meteorology, was proposed in this paper. A computational fluid dynamics(CFD) method was implemented to analyze temperature rise induced by solar radiation at different altitudes and solar radiation intensities. A temperature rise correction equation was obtained by fitting the CFD results using a Broyden-Fletcher-Goldfarb-Shanno(BFGS) method. To verify the performance of the temperature sensor, an experimental platform was constructed. Through simulations and experiments, the relationship among the altitude, solar radiation intensity and radiation temperature rise was obtaned. The root-mean-square error(RMSE) between the temperature rise derived from the correction equation and that derived from the experiments is 0.013 K. The sample determination coefficient r2 of the solar radiation error correction equation is 0.9975.
基金funded by the National Key Research and Development Program of China(2020YFC0861000)the National Science and Technology Major Project of the National Health Commission(2017ZX10305501).
文摘Influenza is a serious public health problem that endangers the health of the global human population.Traditional Chinese medicine(TCM)is rich in theory and practical experience regarding the treatment of influenza,and TCM treatments have shown good curative effects,but there is a dearth of standardized clinical guidance.It is necessary to formulate a clinical practice guide based on evidence-based medicine.To this end,the Specialty Committee of Emergency,China Association of Chinese Medicine(Beijing,China)organized a team of clinical experts,methodological experts,and other multidisciplinary experts to develop a guideline with integrated research methods in the first place of TCM.This guide includes 23 recommendations.The prescription section contains 16 recommendations,including 5 recommendations for mild cases,5 recommendations for severe cases,3 recommendations for critical cases,and 4 recommendations for the recovery period;the portion covering proprietary Chinese medicines forms a total of 7 recommendations.This guide aims to provide the best evidence for clinicians and related practitioners to make decisions about influenza diagnosis and treatment in Chinese medicine.
基金This work was supported by the National Natural Science Foundation of China(A study on the correlation between TCM syndromes and disease outcome of COVID-19,No.82004505)National Key Research and Development Program of China(Real-world study of traditional Chinese medicine for COVID-19,No.2021YFC0863200).
文摘The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths[1].During the past 2 years,global studies on prevention and therapies for COVID-19 have achieved a series of promising findings,including antiviral drugs(Remdesivir,Molnupiravir,Paxlovid)and monoclonal antibodies(Bamlanivimab and Etesevimab,Sotrovimab,Casirivimab and Imdevimab)[2].
基金Project supported by the National Natural Science Foundation of China(Nos.11672310 and 11372326)the National Basic Research Program of China(No.2014CB04680202)
文摘A splashing crown is commonly observed when a high-speed drop impacts a liquid film. The influence of the liquid viscosity on the crown's evolution is not yet clear. We review several existing theories of this problem, and carry out a series of numerical simulations. We find that a three-segment model can describe the crown's motion. In the very early stage when the crown is barely visible, the influence of viscosity is small. Later, a shallow water approach used in most existing models is applicable as long as the initial conditions are formulated properly. They depend on viscous dissipation in the intermediate period. Preliminary estimation based on a dissipation function is proposed to characterize the influence of viscosity in this problem.
基金supported by the National Natural Science Funds of China for Distinguished Young Scholar(10825211)Hundred Talents Program of the Chinese Academy of Sciencesthe National Natural Science Foundation of China (11202217)
文摘Surface water-blooms (SWBs) is usually explained as a buoyant migration of blue-green algae to the water surface under the conditions of reduced turbulence. Wind-induced turbulent mixing can cause considerable heterogeneity in the vertical concentration distribution of algal cells. There exists a criterion below which cell buoyancy can overcome the turbulent mixing. Former researchers regarded a certain wind speed as this criterion, but this wind speed differs in value. In this research, we propose a new criterion, nondimensional entrainment number (En), which represents the ratio of the intrinsic velocity of algal cells relative to the characteristic velocity of wind-induced mixing. Observation in Taihu Lake demonstrates that this new criterion is more suitable for the description of hydrodynamic effect on the formation of surface water-blooms.
基金supported by the Science and Technology Program of State Grid Corporation of China(No.kj2020–056).
文摘Accurate conditions monitoring and early wrong action warnings of relay protection in the Smart Substation is the basic guarantee to realize the normal operation of primary and secondary system of the power grid.At present,the traditional operation and maintenance monitoring methods of relay protections have poor timeliness,while some automatic monitoring methods have insufficient early warning performance,and lack the online action deduction function independent of the actual device.In this paper,a design method of integrated action deduction system including protection logic reasoning and software and hardware operation condition is proposed.The system can receive real-time operation information of protection online,simulate different types of faults,and output the recording information of sub modules belongs to the action deduction system.It can realize the online monitoring of device faults such as deducing the correctness of setting values at a certain time in the future,giving the wrong action warnings and predicting the probability of them as well,which effectively improves the operation and maintenance efficiency of the secondary system in the intelligent substation.
文摘Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.
基金supported by the Natural Science Foundation of China(52073295)Ningbo Science and Technology Bureau(2021Z127)+4 种基金Ningbo Public Welfare Science and Technology Plan Project(2021S150)The Sino-German Mobility Program(M-0424)Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-SLH036)Bureau of International Cooperation,Chinese Academy of Sciences(174433KYSB20170061)K.C.Wong Education Foundation(GJTD-2019-13).
文摘Atmospheric moisture exploitation is emerging as a promising alternative to relieve the shortage of freshwater and energy.Efforts to exploit hygroscopic materials featuring flexibility,programmability,and accessibility are crucial to portable and adaptable devices.However,current two-dimensional(2D)or three-dimensional(3D)-based hygroscopic materials are dif-ficult to adapt to diverse irregular surfaces and meet breathability,which severely hinders their wide applications in wearable and programmable devices.Herein,hygroscopic organogel fibers(HOGFs)were designed via a wet-spinning strategy.The achieved fibers were composed of the hydrophilic polymeric network,hygroscopic solvent,and photothermal/antibacterial Ag nanoparticles(AgNPs),enabling hygroscopic capacity,photothermal conversion,and antibacterial.Owing to the good knittable feature,the HOGFs can be readily woven to adjusted 2D textiles to function as an efficient self-sustained solar evaporator of 4-layer woven HOGF device with a saturated moisture capacity of 1.63 kg m^(-2) and water-releasing rate of 1.46 kg m^(-2) h^(-1).Furthermore,the 2D textile can be applied as a wearable dehumidification device to efficiently remove the evaporative moisture from human skin to maintain a comfortable environment.It can reduce the humidity from 90 to 33.4%within 12.5 min.In addition,the introduction of AgNPs can also endow the HOGFs with antibacterial features,demonstrat-ing significant potential in personal healthcare.