Mammals of Gaoligong Mountain in China:Diversity,distribution,and conservation

Gaoligong Mountain(hereafter,GLGM)is located at the intersection of Myanmar and China’s Yunnan Province and Xizang Zizhiqu,and spans three globally significant biodiversity hotspots:the Himalayas,Indo-Burma,and the Mountains of Southwest China.Although surveys of mammals in this ecologically important region have a long history,there is no comprehensive systematic checklist and distribution account of the mammals of GLGM.Here,we compiled a mammal species checklist of GLGM based on thorough field investigations and literature reviews.We also examined specimen collections and applied camera trapping surveys to explore the region’s mammal diversity and distribution patterns.We recorded 212 mammal species in nine orders,33 families,and 119 genera,which accounts for 30.5%of China’s mammal species,and a high proportion of nationally protected(50)and globally threatened(29)species.Mammal species richness showed a symmetrical unimodal curve along the elevation gradient,peaking at intermediate elevations(2000 to 2500 m above sea level(asl)),and increasing generally from south to north,slightly higher in the east slope than in the west.Cluster analysis and non-metric multidimensional scaling revealed three distinct elevational assemblages(<900 m asl.,900-3500 m asl.,and>3500 m asl)and significant south-to-north variation,but no substantial differences between the east and west slopes.The GLGM present a unique conservation value due to the high proportions of rare and endangered mammal species,complex faunal composition,high endemism,and being the distribution boundary for many species.This study is an important phased account of mammal diversity in GLGM and makes a prospect for future research.

Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views

Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and thrombosis.These disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and platelets.In clinical practice,aside from drugs that target abnormal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory disturbances.Natural products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfusion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory disturbances.In recent years,numerous research papers on the improvement of microcirculatory function by natural products have been published in international journals.In 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology&Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural components of compounded Chinese medicine,respectively.This review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPSinduced microcirculatory disturbances and tissue injury.Based on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

A 700 W·h·kg^(-1) Rechargeable Pouch Type Lithium Battery

High-energy-density rechargeable lithium batteries are being pursued by researchers because of their revolutionary potential nature.Current advanced practical lithium-ion batteries have an energy density of around300 W·h·kg^(-1).Continuing to increase the energy density of batteries to a higher level could lead to a major explosion development in some fields,such as electric aviation.Here,we have manufactured practical pouch-type rechargeable lithium batteries with both a gravimetric energy density of 711.3 W·h·kg^(-1)and a volumetric energy density of 1653.65 W·h·L^(-1).This is achieved through the use of high-performance battery materials including high-capacity lithium-rich manganese-based cathode and thin lithium metal anode with high specific energy,combined with extremely advanced process technologies such as high-loading electrode preparation and lean electrolyte injection.In this battery material system,the structural stability of cathode material in a widened charge/discharge voltage range and the deposition/dissolution behavior of interfacial modified thin lithium electrode are studied.

基于sigmoid滤波器的永磁轮毂电机自抗扰控制

相比燃油拖拉机,电动拖拉机具有节能高效、绿色清洁的优点。分布式驱动电动拖拉机结构简单、控制维度多,能进一步提高电动拖拉机的工作效率和作业精度。但是电机检测转速噪声导致轮毂电机速度波动严重,复杂路面及多种作业工况下进一步加剧了上述问题,严重降低了拖拉机的作业质量。针对上述问题,该研究提出一种基于sigmoid滤波器的线性自抗扰控制(linear active disturbance rejection control,LADRC)以提高轮毂电机的转速稳定性和抗扰动能力。该控制策略在传统LADRC的基础上引入sigmoid滤波器至扩张状态观测器(extended state observer,ESO),根据输入噪声信号误差变化改变滤波器带宽,以抑制观测误差中的中高频干扰信号,同时避免滤波器积分环节对轮毂电机速度跟踪快速性的影响,具有较快的收敛性。搭建试验平台对所提出控制策略进行试验验证,结果表明:与传统LADRC策略相比,本文所提控制策略在变速和变载工况下的转速脉动分别减小了32%和41.67%,iq电流脉动分别减小了6.25%和4.17%,可在快速、准确跟踪给定转速的同时,大幅提高轮毂电机驱动系统的噪声抑制性能,为复杂环境下电动拖拉机高精度作业提供技术参考。

Quantitative morphometric analysis of a deep-water channel in the Taranaki Basin, New Zealand

The morphological changes of deep-water channels have an important influence on the distributions of channel sand reservoirs,so it is important to explore the morphological change process of deep-water channel for the exploration and development of deep-water oil and gas.Based on a typical sinuous Quaternary channel(Channel I)in the Taranaki Basin,New Zealand,a variety of seismic interpretation techniques were applied to quantitatively characterize the morphological characteristics of the Channel I,and the relationships between the quantitative parameters and the morphological changes of the Channel I,as well as the controlling factors affecting those morphological changes,were discussed.The results are as follows:(1)in the quantitative analysis,six parameters were selected:the channel depth,width,sinuosity,and aspect ratio(width/depth),the channel swing amplitude(λ)and the channel bend frequency(ω);(2)according to the quantitative morphological parameters of the channel(mainly including three parameters such as channel sinuosity,ωandλ),the Channel I was divided into three types:the low-sinuous channel(LSC),the high-sinuous channel(HSC),the moderate-sinuous channel(MSC).U-shaped channel cross-sections developed in the LSC,V-shaped channel cross-sections developed in the HSC,including inclined-V and symmetric-V cross-sections,and dish-shaped channel cross-sections developed in the MSC;(3)the morphological characteristics of the LSC and MSC were related to their widths and depths,while the morphology of the HSC was greatly affected by the channel width,a change in depth did not affect the HSC morphology;(4)the morphological changes of the Channel I were controlled mainly by the slope gradient,the restricted capacity of the channel and the differential in fluid properties.

Sedimentary elements,evolutions and controlling factors of the Miocene channel system:a case study of the deep-water Taranaki Basin in New Zealand

Deep-water channel systems are important petroleum reservoirs,and many have been discovered worldwide.Understanding deep-water channel sedimentary elements and evolution is helpful for deep-sea petroleum exploration and development.Based on high-resolution 3D seismic data,the Miocene channel system in the deep-water Taranaki Basin,New Zealand,was analyzed by using seismic interpretation techniques such as interlayer attribute extraction and strata slicing.The channel system was divided into five composite channels(CC-I to CC-V)according to four secondary level channel boundaries,and sedimentary elements such as channels,slump deposits,inner levees,mass transport deposits,and hemipelagic drape deposits were identified in the channel system.The morphological characteristics of several composite channels exhibited stark variances,and the overall morphology of the composite channels changed from relatively straight to highly sinuous to relatively straight.The evolution of the composite channels involved a gradual and repeated process of erosion and filling,and the composite channels could be divided into three evolutionary stages:initial erosion-filling,later erosion-filling(multistage),and channel abandonment.The middle Miocene channel system may have formed as a consequence of combined regional tectonic activity and global climatic change,and its intricate morphological alterations may have been influenced by the channel's ability to self-regulate and gravity flow properties.When studying the sedimentary evolution of a large-scale deep-water channel system in the Taranaki Basin during the Oligocene-Miocene,which transitioned from a passive margin to plate convergence,it can be understood how tectonic activity affected the channel and can also provide a theoretical reference for the evolution of the deepwater channels in areas with similar tectonic conversion environments around the world.

Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease

BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the causal relationship between plasma Hcy and COPD by two-sample Mendelian randomization(MR).METHODS:A two-sample MR study was performed to infer the causal link.Genetically predicted plasma Hcy was selected as an instrumental variable(Ⅳ)from published genome-wide association study(GWAS)meta-analyses.COPD with different etiologies was extracted as outcome variables from other GWAS meta-analyses.The main MR analysis was performed using the inversevariance weighted(IVW)method.Additional analyses were further performed using Cochran’s Q-test and MR-Egger regression to evaluate the heterogeneity or horizontal pleiotropy of our findings.RESULTS:MR analysis showed no significant association between plasma Hcy and COPD.The results of the groups were consistent with the sensitivity analysis and repeated analysis,without heterogeneity or horizontal pleiotropy.The IVW results showed COPD hospital admissions(odds ratio[OR]1.06,95%confidence interval[CI]0.91-1.24,P=0.42),asthma/COPD(OR 0.97,95%CI0.89-1.06,P=0.55),COPD-related chronic infection(OR 1.50,95%CI 0.57-3.99,P=0.41),COPDI asthma/interstitial lung disease(ILD)-related pneumonia or pneumonia-derived septicemia(OR 0.93,95%CI 0.86-1.02,P=0.13),and COPD-related respiratory insufficiency(OR 1.00,95%CI 0.7-1.44,P=0.99).CONCLUSION:There is no direct causal relationship between plasma Hcy and COPD in our study.As Hcy is known to have deleterious effects on endothelial function and vascular homeostasis,further studies are needed to investigate whether additional factors mediate the association between Hcy and COPD.

站城融合理念下高铁站点换乘导视系统优化设计研究

目的本文以重庆建设国际性综合交通枢纽城市为研究背景,满足各类人群高铁出行的适宜性与多样性需求,升级城市形象展示窗口。深入剖析高铁站点导视系统在换乘枢纽中的实际应用情况,紧密关注城市智慧交通导视系统的发展趋势与最新动态,致力于解决用户在换乘过程中可能遇到的视觉困扰和引导不足等核心问题,并在此基础上提出具有针对性的优化设计方案。方法对城市高铁站轨道换乘导视系统的设计要点和布设方法进行举证研究,重点就城市智慧出行、数字导视系统进行分析,结合对乘客空间寻路、安全感、舒适感等心理需求的调研,总结轨道交通换乘站点导视系统的设计思路。综合考虑色彩及应用、字号及对比度、字体及视觉度、布设逻辑与信息分级,把控导视系统的视觉度、布设尺度、色彩材质、技术工艺。结合我国高铁站轨道换乘导视系统的发展现状,提出重庆西站换乘导视系统的优化设计策略。结论在尊重空间动向、用户体验、视觉流程的基础上,以智慧交通导视系统为研究对象,充分探寻高铁站点轨道换乘导视系统的高效性、便捷性,旨在提升枢纽的建设水平、运行效率,以及人民群众的出行体验。

川东南地区中二叠统茅口组三段白云岩成因机理

白云岩是四川盆地海相层系最为重要的天然气储层类型之一,也是深层碳酸盐岩油气勘探的重点,白云岩成因机理的研究是预测深层优质白云岩储层分布的基础。通过川东南地区茅口组三段白云岩露头、岩心、薄片等资料,结合碳氧同位素、锶同位素、稀土元素等研究了白云岩的成因机理。川东南地区茅三段白云岩可分为层状粉晶白云岩、层状细—中晶白云岩以及鞍形白云石胶结物。层状细—中晶白云岩是最主要的白云岩类型,未受热液影响的该类型白云岩δ^(18)O_(VPDB)值为-7.04‰~-6.08‰,与泥晶灰岩相似,^(87)Sr/^(86)Sr比值为0.707 550~0.707 740,处于同期海水范围值内,主要成因为准同生—埋藏期封闭局限海水渗透回流白云岩化;受到热液影响的该类型白云岩δ^(18)O_(VPDB)值为-7.33‰~-7.11‰,与泥晶灰岩相比略微偏负,^(87)Sr/^(86)Sr比值为0.707 950~0.708 171,高于同期海水。层状粉晶白云岩未明显受到热液影响改造,其成因与上述未受热液影响的层状细—中晶白云岩一致。而溶洞、裂缝中的鞍形白云石胶结物则是热液流体直接沉淀或重结晶所形成,具有较高的^(87)Sr/^(86)Sr比值(均值0.707 970)、明显偏负的δ^(18)O_(VPDB)值(均值-7.32‰)以及Eu的正异常。从层状粉晶白云岩、层状细—中晶白云岩到鞍形白云石胶结物,呈现出一种受控于封闭局限海水到热液流体的梯度性变化,研究区内的白云岩是由多期次流体、多次成岩作用的结果。

基于PI3K/AKT信号通路探讨PRDX4对食管鳞状细胞癌细胞增殖和凋亡的影响

目的:分析过氧化物还原酶4(peroxiredoxin4,PRDX4)对食管鳞状细胞癌(esophagealcarcinoma,ESCC)细胞增殖和凋亡能力的调控作用及相关蛋白表达。方法:结合UALCAN、GEPIA和TCGA数据库预测PRDX4在ESCC中的表达及与病理特征及预后的关系。选取2010年8月至2023年8月潍坊医学院附属医院行食管癌(esophagealcarcinoma,EC)根治术治疗的60例ESCC患者的癌组织及癌旁组织为研究样本,分析组织样本中的PRDX4的表达水平。通过实时荧光定量PCR和免疫印迹法分析ESCC细胞中PRDX4的mRNA和相关信号分子蛋白的表达水平;此外,结合CCK-8实验、流式细胞术实验分析PRDX4对细胞的增殖和凋亡活动的影响。最终将体外实验结果通过裸鼠皮下瘤模型进行验证。结果:GEPIA和UALCAN数据库的数据表明,PRDX4在ESCC中表达异常增高,且与病理分期、分级和患者的生存率等有关。对ESCC细胞系PRDX4进行敲低和过表达后,PRDX4、p-PI3K、p-AKT、Cyclin D1、Survivin蛋白表达分别表达降低和增高,细胞增殖和凋亡能力均受正相关调控;相较于sh-NC组、sh-PRDX4组裸鼠肿瘤的体积和质量降低。结论:PRDX4可基于P13K/AKT信号通路的激活对ESCC细胞的增殖和凋亡能力进行调控。

大型钢结构多向钢节点电弧增材制造工艺

多向钢节点作为连接大型钢结构的关键构件,承载钢结构建筑各方向的力,对其安全性起至关重要的作用。基于七向钢节点结构特点,文中研究了电弧增材制造钢结构建筑的七向钢节点,采用分区成形、平曲面切片及摆动填充的路径规划方法,将其分为直臂圆管区、相贯区和支管延长区3个区域,相贯区包括两管相贯、三管相贯和四管相贯3种类型。直臂圆管区和支管延长区采用摆动工艺进行堆积,两管相贯、三管相贯和四管相贯区分别采用曲面切片的路径规划进行堆积。对堆积完成的构件进行成形精度检测、微观组织的观测和力学性能的测量。结果表明,七向钢节点构件成形尺寸偏差为±1.32 mm,成形精度较高。微观组织为铁素体和珠光体,构件的抗拉强度和屈服强度相对于同成分铸件分别提高了约30%和105%,电弧增材制造的七向钢节点满足使用要求。

When quantum dots meet blue phase liquid crystal elastomers:visualized full-color and mechanically-switchable circularly polarized luminescence

Polymer-based circularly polarized luminescence(CPL)materials with the advantage of diversified structure,easy fabrication,high thermal stability,and tunable properties have garnered considerable attention.However,adequate and precise tuning over CPL in polymer-based materials remains challenging due to the difficulty in regulating chiral structures.Herein,visualized full-color CPL is achieved by doping red,green,and blue quantum dots(QDs)into reconfigurable blue phase liquid crystal elastomers(BPLCEs).In contrast to the CPL signal observed in cholesteric liquid crystal elastomers(CLCEs),the chiral 3D cubic superstructure of BPLCEs induces an opposite CPL signal.Notably,this effect is entirely independent of photonic bandgaps(PBGs)and results in a high glum value,even without matching between PBGs and the emission bands of QDs.Meanwhile,the lattice structure of the BPLCEs can be reversibly switched via mechanical stretching force,inducing on-off switching of the CPL signals,and these variations can be further fixed using dynamic disulfide bonds in the BPLCEs.Moreover,the smart polymer-based CPL systems using the BPLCEs for anti-counterfeiting and information encryption have been demonstrated,suggesting the great potential of the BPLCEs-based CPL active materials.

Advanced Lung Adenocarcinoma with EGFR 19-del Mutation Transformed into SCC after EGFR-tyrosine Kinase inhibitors Treatment:A Case report

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung cancer(NSCLC).CASE SUMMARY A 67-year-old female patient in advanced lung adenocarcinoma suffered from drug resistance after EGFR-TKIs treatment.Secondary pathological tissue biopsy confirmed squamous cell carcinoma(SCC)transformation.Patients inevitably encountered drug resistance issues after receiving EGFR-TKIs treatment for a certain period of time,while EGFR-TKIs can significantly improve the survival of patients with EGFR-sensitive mutations in NSCLC.Notably,EGFR-TKIs resistance includes primary and acquired.Pathological transformation is one of the mechanisms of acquired resistance in EGFR-TKIs,with SCC transformation being relatively rare.Our results provide more detailed results of the patient’s diagnosis and treatment process on SCC transformation after EGFR-TKIs treatment for lung adenocarcinoma.CONCLUSION Squamous cell carcinoma transformation is one of the acquired resistance mechanisms of EGFR-TKIs in advanced lung adenocarcinoma with EGFR mutations.

Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

Geochemical characteristics and origins of natural gases in the eastern Cote d’Ivoire Basin,West Africa

The gas sources in the eastern Cote d’Ivoire Basin(Tano Basin)are seldom reported and remain controversial due to multiple sets of potential source rocks and poorly documented geochemical characteristics of natural gases.The marine source rock potential from the Upper Albian to Turonian as well as the molecular composition and the stable carbon isotope composition of natural gases in the eastern Cote d’Ivoire Basin were studied in detail to investigate the origins of natural gases.The total organic carbon(TOC),hydrogen index(HI),and generation potential(S_(1)+S_(2))of source rocks indicate that both sapropelic source rocks and humic source rocks developed during the late Albian,whereas sapropelic source rocks developed during the Cenomanian and the Turonian.The normal order ofδ^(13)CH_(4)<δ^(13)C_(2)H6<δ^(13)C_(3)H_(8)(δ^(13)C_(1)<δ^(13)C_(2)<δ^(13)C_(3)),the relationship between C_(2)/C_(3)molar ratio andδ^(13)C_(2)-δ^(13)C_(3),and the plot ofδ^(13)C_(1)versus C_(1)/(C_(2)+C_(3))collectively show that the natural gases are thermogenic due to the primary cracking of kerogen,including the typical oil-associated gases from Well D-1,the mixed oil-associated gases and coal-derived gases from Well G-1 and Well L-1.Based on the plot ofδ^(13)C_(1)versusδ^(13)C_(2)and the established relationship betweenδ^(13)C_(1)and equivalent vitrinite reflectance(Ro),we proposed that the natural gases are in a mature stage(Ro generally varies from 1.0%to 1.3%).Combined with results of basin modelling and oil-to-source correlation,the transitional to marine source rocks during the late Albian were thought to have made a great contribution to the natural gases.Our study will make a better understanding on petroleum system in the eastern Cote d’Ivoire Basin.

基于同步挤压S变换的谐振接地系统单相接地故障区段定位方法

谐振接地系统单相接地的故障特征微弱,故障区段难以定位。根据健全与故障区段电流低频能量差异大的特点,利用同步挤压S变换挤压、重组低频区段电流,增强故障特征辨识度;计算各区段能量比值,将能量比值最大的判为故障区段,提出基于同步挤压S变换的故障区段定位方法。以全频区段电流重组信号的峭度因子构建保护启动判据。不同故障条件影响下,大量PSCAD仿真测试了所提启动和区段定位方法的性能及可行性,现场数据验证了所提方法的有效性。

森林火灾风险下的配电线路单相断线放电发展过程研究

随着台风、暴雪等极端恶劣环境的不断常态化,单相接地故障(如单相断线、单相击穿等)频繁发生,严重危害了电网安全。单相断线故障是引发森林火灾的常见故障之一,导线断线坠落至地面附近,在极短间隙内对地放电引燃地表附着的易燃物,最终引发森林火灾,对社会经济和自然环境危害严重。针对森林火灾风险下的配电线路单相断线对地放电发展过程研究建立短间隙放电模型,可以获得断口对地放电过程中的电场分布、电子平均能量分布、电子密度分布,以及不同断口外形对放电过程的影响机理。研究结果表明,随着断口半径从0.5 mm降至0.3 mm,流注头部的电场强度从80 kV/cm升高到110 kV/cm,电子平均能量从10 eV升高到11 eV,流注贯穿间隙时电子密度的最大值由1.5×10~(20)m~(-3)升高到2.7×10~(20) m~(-3)。断口半径越小、曲率越大,导致流注头部的电场强度和电子平均能量升高,流注头部电子密度和放电电流增加,更容易导致流注贯穿间隙。而断口不规则时由于具有更大半径,间隙击穿需要更长时间,因此放电电流峰值由9 A升高至15 A。如果考虑松针等含油量较高的地表附着物影响,该放电电流极易点燃地表附着物并形成电弧、引发火灾。该研究结果对于极端天气下的配电线路安全防护、预防森林火灾具有重要意义。

Ⅰ~Ⅲ期结直肠癌病人神经/脉管浸润风险因素分析并构建列线图预测模型

目的建立预测Ⅰ~Ⅲ期结直肠癌病人神经/脉管浸润(perineural or lymphovascular invasion,PNI/LVI)的列线图预测模型,验证和预测其效能。方法回顾性分析2017年1月至2022年9月徐州医科大学附属医院行结直肠癌根治术治疗的结直肠癌病人684例的临床病理资料,利用R软件采用随机数种子的方式将上述资料按7∶3分成训练组(479例)和验证组(205例)。通过单因素相关分析,把P<0.1的参数纳入到多因素logistic回归分析,筛选影响结直肠恶性肿瘤PNI/LVI的危险因素,建立列线图模型。通过受试者操作特征曲线(ROC曲线)评估风险模型的预测价值,然后通过一致性指数、校准曲线和临床决策曲线分析(DCA)评估预测模型识别、校准和临床实用性方面的有效性。结果糖尿病、肿瘤长径、组织学分级、癌结节、T分期、N分期、血小板计数/淋巴细胞计数(PLR)、血小板计数×中性粒细胞计数/淋巴细胞(SII)、纤维蛋白原(g/L)/前白蛋白(g/L)(FPR)、癌胚抗原(CEA)、糖类抗原(CA)199在单因素分析中P<0.1。而多因素分析结果表明,CA199、T分期和N分期与Ⅰ~Ⅲ期结直肠癌病人PNI/LVI的发生独立相关因素。训练组和验证组的一致性指数分别为0.88[95%CI:(0.85,0.91)]和0.84[95%CI:(0.78,0.89)],同样校准曲线和DCA表明该模型具有良好的准确度和临床实用性。结论以CA199、T分期和N分期为基础建立的列线图模型有助于预测Ⅰ~Ⅲ期结直肠癌病人的PNI/LVI风险,该风险评价模型在临床上具有较好的预测效果。

Experimental and clinical study of influence of high-frequency electric surgical knives on healing of abdominal incision

AIM： To study the influence of high-frequency electric surgical knives on healing of abdominal incision. METHODS： Two hundred and forty white rats were divided into 10^0, 10^2, 10^5, and 10^8 groups and rat models of abdominal operation were induced by using electric surgical knives and common lancets respectively. Then they were respectively given hypodermic injections of normal saline and 0.2 mL quantitative mixture of Escherichia coil, Staphylococcus aureus and Pseudornonas aeruginosa at a concentration of 10^2, 10^5 and 10^8. On the basis of the animal experiment, 220 patients undergoing abdominal operations （above type Ⅱ） were randomly allocated into one of following three groups： electric knife （EK, 93 cases）, electro-coagulation （EC, 55 cases） and control （72 cases）. High-frequency electric surgical knives were used to dissect abdominal tissues and electro-coagulation for hemostasis in EK group. Common lancets and electro-coagulation were applied in EC group. Common lancets and tieing silk suture were used in the controls. RESULTS： In all the groups except group 10^0, infection rate of incisional wounds made by electric surgical knives were remarkably higher than that with common lancets. Furthermore, there were significant differences in groups 10^2, 10^5, and 10^8 （P 〈 0.05）, but not in group 10^0 （P 〉 0.05） between EK and EC groups. Clinical studies showed a delayed wound healing in 16 cases （17.20%） in EK, 11 cases （16.36%） in EC and 2 cases （2.86%）in the control groups. A significant difference between EK and the control groups （χ^2= 8.57, P 〈 0.01）, and between EC and the control groups （χ^2 = 5.66, P 〈 0.05） was observed, but not between EK and EC （χ^2= 0.017, P 〉 0.05）. CONCLUSION： High-frequency electric knives may remarkably delay abdominal incision healing. Its application should be minimized so as to reduce the possibility of postoperative complications.

Adapter Based on Pre-Trained Language Models for Classification of Medical Text

We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract information from medical text,facilitating more accurate classification while minimizing the number of trainable parameters.Extensive experiments conducted on various datasets demonstrate the effectiveness of our approach.