Ⅱ型(胰岛素非依赖型)糖尿病患者细胞内、外低镁水平状态

尽管镁在细胞内的代谢过程仍不十分清楚,但人们早就观察到,胰岛素能促进细胞对镁的摄取。正因如此,在胰岛素缺乏所致的急性糖尿病酮症酸中毒时,常规出现人体总体镁缺乏。然而,是否慢性稳定性糖尿病,尤其是Ⅱ型糖尿病也存在镁缺乏仍不清楚。我们应用磷-磁共振光谱法、镁离子电极等检测了Ⅱ型糖尿病患者红细胞内、血清离子状态及血清总镁水平及其相关性。

Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over age of forty years and response of a booster dose among nonresponders

AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination. METHODS:A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg,anti-HBc antibody, HBeAg and anti-HBs antibody) received 20μg of recombinant HB vaccine intramuscularly at 0,1,and 6 months.Anti HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days.A booster dose of 20μg HB vaccine was given after 6 months of the 3^(rd) vaccine dose to the 15 non- responders and anti-HBs titers were measured after i month. RESULTS:Seroprotection (anti-HBs GMT^3 10 IU/L) was achieved in 85.3 % (87/102) volunteers.The mean GMT titers of the vaccine responders was 136.1 IU/L.Of the seroprotected individuals,there were 32.4% (33/102) hyporesponders (anti- HBs titers <10-99 mIU/ml) and 52.9% (54/102) were responders (anti-HBs titers >100 IU/L).All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose. CONCLUSION:Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile.A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody titers.However,larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.

Enhanced corrosion resistance of phytic acid coated magnesium by stearic acid treatment

A green chemical conversion coating for magnesium was obtained with a phytic acid solution. The microstructure and corrosion properties of phytic acid conversion coated magnesium were further improved by soaking in stearic acid solution. The phytic acid conversion coated magnesium after soaking in the stearic acid showed no micro-cracks and the surface became very smooth. The corrosion behavior of the uncoated and coated magnesium samples was studied by electrochemical methods. The corrosion resistance of the stearic acid treated sample was much higher than that of phytic acid conversion coated magnesium or uncoated magnesium. The electrochemical results indicated that the stearic acid treated coating provided effective corrosion protection to the magnesium sample.

Spark plasma sintering of a high-energy ball milled Mg-10 wt% Al alloy

The influence of spark plasma sintering(SPS)temperature on microstructure,hardness and corrosion behavior of a high-energy ball milled Mg-10wt%Al alloy was investigated in this work.The holding time and sintering pressure for SPS were kept constant while varying the sintering temperature from 200 to 350℃.The grain size and microstructure were studied using X-ray diffraction analysis,scanning electron microscopy,energy dispersive X-ray spectroscopy,and Archimedes'based density measurement.Corrosion behavior was investigated using potentiodynamic polarization tests.The nanocrystalline regime(grain size<100nm)was maintained even after SPS up to 350℃.The density of the alloy increased with increasing the SPS temperature.Vickers'hardness and corrosion performance improved up to 300℃ followed by a decrease after SPS at 350℃.Possible reasons for densification,strengthening,and corrosion behavior have been discussed in the light of reduced porosity and microstructural changes.

Pitting corrosion behavior and corrosion protection performance of cold sprayed double layered noble barrier coating on magnesium-based alloy in chloride containing solutions

Nitrogen processed, cold sprayed commercially pure(CP)-Al coatings on Mg-based alloys mostly lack acceptable hardness, wear resistance and most importantly are highly susceptible to localized corrosion in chloride containing solutions. In this research, commercially pure α-Ti top coating having good pitting potential(~1293 mV_(SCE)), high microhardness(HV_(0.025): 263.03) and low wear rate was applied on a CP-Al coated Mg-based alloy using high pressure cold spray technology. Potentiodynamic polarization(PDP) curves indicated that the probability of transition from metastable pits to the stable pits for cold spayed(CS) Al coating is considerably higher compared to that with the CS Ti top coating(for Ti/Al/Mg system). In addition, CS Ti top coating was in the passivation region in most pH ranges even after 48 h immersion in 3.5 wt% NaCl solution. The stored energy in the CS Ti top coating(as a passive metal) was presumed to be responsible for the easy passivation. Immersion tests indicated no obvious pits formation on the intact CS Ti top coating surface and revealed effective corrosion protection performance of the CS double layered noble barrier coatings on Mg alloys in 3.5 wt% NaCl solution even after 264 h.

Lie group analysis, numerical and non-traveling wave solutions for the (2+1)-dimensional diffusion–advection equation with variable coefficients

In this paper, the variable-coefficient diffusion-advection （DA） equation, which arises in modeling various physical phenomena, is studied by the Lie symmetry approach. The similarity reductions are derived by determining the complete sets of point symmetries of this equation, and then exact and numerical solutions are reported for the reduced second-order nonlinear ordinary differential equations. Further, an extended （Gl/G）-expansion method is applied to the DA equation to construct some new non-traveling wave solutions.

On certain new exact solutions of the Einstein equations for axisymmetric rotating fields

We investigate the Einstein field equations corresponding to the Weyl-Lewis-Papapetrou form for an axisymmetric rotating field by using the classical symmetry method. Using the invafiance group properties of the governing system of partial differential equations （PDEs） and admitting a Lie group of point transformations with commuting infinitesimal generators, we obtain exact solutions to the system of PDEs describing the Einstein field equations. Some appropriate canonical variables are characterized that transform the equations at hand to an equivalent system of ordinary differential equations and some physically important analytic solutions of field equations are constructed. Also, the class of axially symmetric solutions of Einstein field equations including the Papapetrou solution as a particular case has been found.

New exact solutions of the Einstein-Maxwell equations for magnetostatic fields

The symmetry reduction method based on the Frechet derivative of differential operators is applied to investigate symmetries of the Einstein-Maxwell field equations for magnetostatic fields, which is a coupled system of nonlinear partial differential equations of the second order. The technique yields invariant transformations that reduce the given system of partial differential equations to a system of nonlinear ordinary differential equations. Some of the reduced systems are further studied to obtain the exact solutions.

取向聚合物的结晶动力学(下)

结果和讨论在180至240℃范围,每相隔10℃,做一熔纺实验。图3所示是炉长为0.7米、温度为220℃时,在三个不同的卷绕速度下,实验得到的纤维温度分布,最大的卷绕速度为1500米/分。从图中可以看出,在炉子内部,纤维的温度基本保持在常数。而一离开炉子,便迅速降到玻璃化温度以下。

Corrosion Protective Conversion Coatings on Magnesium Disks Using a Hydrothermal Technique

A uniform, compact, and well adherent conversion coating of magnesium hydroxide has been formed on bioresorbable magnesium disks by means of a hydrothermal technique. Electrochemical results indicate that the coating brings about a significant reduction in magnesium corrosion in phosphate buffered saline （PBS） solution. It is also observed that corrosion resistance of the coating increases with an increase in treatment time, which in turn, increases the coating thickness. The protective behavior of magnesium hydroxide coating is attributed to its chemical inertness in PBS solution. The coatings are found to be free from pores that reduce the direct contact between corroding media and underlying magnesium.

cardiGAN:A generative adversarial network model for design and discovery of multi principal element alloys

Multi-principal element alloys(MPEAs),inclusive of high entropy alloys(HEAs),continue to attract significant research attention owing to their potentially desirable properties.Although MPEAs remain under extensive research,traditional(i.e.empirical)alloy production and testing are both costly and timeconsuming,partly due to the inefficiency of the early discovery process which involves experiments on a large number of alloy compositions.It is intuitive to apply machine learning in the discovery of this novel class of materials,of which only a small number of potential alloys have been probed to date.In this work,a proof-of-concept is proposed,combining generative adversarial networks(GANs)with discriminative neural networks(NNs),to accelerate the exploration of novel MPEAs.By applying the GAN model herein,it was possible to directly generate novel compositions for MPEAs,and to predict their phases.To verify the predictability of the model,alloys designed by the model are presented and a candidate produced-as validation.This suggests that the model herein offers an approach that can significantly enhance the capacity and efficiency of development of novel MPEAs.

Painlev Analysis,Lie Symmetries and Exact Solutions for Variable Coefficients Benjamin-Bona-Mahony-Burger (BBMB) Equation

In this paper, a variable-coefficient Benjarnin-Bona-Mahony-Burger （BBMB） equation arising as a math- ematical model of propagation of small-amplitude long waves in nonlinear dispersive media is investigated. The inte- grability of such an equation is studied with Painlevd analysis. The Lie symmetry method is performed for the BBMB equation and then similarity reductions and exact solutions are obtained based on the optimal system method. Further- more different types of solitary, periodic and kink waves can be seen with the change of variable coefficients.

The influence of spark plasma sintering temperatures on the microstructure,hardness,and elastic modulus of the nanocrystalline Al-xV alloys produced by high-energy ball milling

Al-xV alloys(x=2 at.%,5 at.%,10 at.%)with nanocrystalline structure and high solid solubility of V were produced in powder form by high-energy ball milling(HEBM).The alloy powders were consolidated by spark plasma sintering(SPS)employing a wide range of temperatures ranging from 200 to 400°C.The microstructure and solid solubility of V in Al were investigated using X-ray diffraction analysis,scanning electron microscope and transmission electron microscope.The microstructure was influenced by the SPS temperature and V content of the alloy.The alloys exhibited high solid solubility of V–six orders of magnitude higher than that in equilibrium state and grain size<50 nm at all the SPS temperatures.The formation of Al3V intermetallic was detected at 400℃.Formation of a V-lean phase and bimodal grain size was observed during SPS,which increased with the increase in SPS temperature.The hardness and elastic modulus,measured using nanoindentation,were significantly higher than commercial alloys.For example,Al-V alloy produced by SPS at 200℃ exhibited a hardness of 5.21 GPa along with elastic modulus of 96.21 GPa.The evolution of the microstructure and hardness with SPS temperatures has been discussed.

Age-hardening behavior,corrosion mechanisms,and passive film structure of nanocrystalline Al-V supersaturated solid solution

The effect of age-hardening on microstructure,hardness,and corrosion of an Al-5at.%V alloy,produced us-ing high-energy ball milling and subsequent cold compaction,has been investigated.The alloy exhibited a grain size below 100 nm and extremely high solid solubility of V in Al(3.1 at.%).The age-hardening was carried out at 150,200,and 250℃.The peak-aged condition of 150℃ demonstrated the highest hardness-transpired from grain refinement,precipitation,and solid solution hardening.The corrosion re-sistance of the Al-5at.%V alloy was studied as a function of aging conditions.The peak-aged condition retained the corrosion resistance while it deteriorated in the over-aged condition.Nonetheless,the cor-rosion resistance of the ball-milled Al alloys in all the aging conditions was superior to that of pure Al.The passive film structure and origin of corrosion were studied using scanning/transmission electron mi-croscopy(S/TEM).The high corrosion resistance of the alloy was attributed to the V enrichment at the film/metal interface and deposition of V on the cathodic phases,which suppresses the dissolution of Al within the pit and therefore promotes repassivation in the early stages of corrosion.

Corrosion Behavior and Hardness of Al-M (M:Mo,Si,Ti,Cr) Alloys

The corrosion behavior of Al-5 at.% Cr, A1-5 at.% Si, Al-5 at.% Mo and Al-5 at.% Ti produced via casting and Al-5 at.% Cr produced by high-energy ball milling and subsequent consolidation by cold pressing was studied using potentiodynamic polarization and surface analysis following constant immersion tests. Alloys were characterized using a scanning electron microscope coupled with the energy-dispersive X-ray spectroscopy and X-ray diffraction analysis. Hardness, a representative of the strength, was also measured. The alloys produced by casting contained coarse intermetallics and therefore exhibited poor corrosion resistance. Al-5 at.% Cr alloy produced by high-energy ball milling exhibited a significantly improved corrosion resistance and hardness, which was attributed to the grain refinement to nanoscale and extended solid solubility of Cr in AL The study indicated that the high-energy ball milling was capable of producing Al alloys with improved corrosion behavior and hardness.

Effect of Pressure and Temperature on Phase Transformation and Properties of Titanium Aluminide Obtained through Reaction Synthesis

Reaction synthesis process has been used to develop γ titanium aluminide using elemental powders. Powder mixture of Ti-48 at. pct AI was prepared in ball mill and reaction synthesis was carried out in hot press with varying temperature and pressure. Titanium aluminide synthesized under high pressure and temperature resulted in better properties with respect to densification, homogenization response, mechanical properties and oxidation resistance as compared to that synthesized under low pressure and temperature. AI rich phases were observed in as-synthesized condition in all the experiments. However, some Ti rich phases were also found in high pressure-temperature synthesized samples. Density, hardness and tensile strength have been correlated with applied pressure through empirical relations. Variation in density with pressure is found to be logarithmic whereas hardness and tensile strength variation with pressure is polynomial.

聚合物提高采收率技术的现场实施

本文介绍了印度Sanand油田采用聚合物驱技术提高采收率的具体做法，详细阐明了聚合物驱机理，在广泛的室内试验的基础上，筛选出了适合于Sanand油田的聚合物类型和最佳浓度。通过先进的先导性试验、先导性扩大试验，最后转入油田规模应用的方法。保证了聚合物驱的经济性。应得结果表明，采收率水平大大提高，增产效果非常明显。