BACKGROUND Lung abscess found on chest X-ray and computed tomography examinations is rare in infants and young children.Several pathogens can cause lung abscesses,with the most common pathogens being anaerobes,Strepto...BACKGROUND Lung abscess found on chest X-ray and computed tomography examinations is rare in infants and young children.Several pathogens can cause lung abscesses,with the most common pathogens being anaerobes,Streptococci and Staphylococcus aureus.Streptococcus pseudopneumoniae(S.pseudopneumoniae)is a member of the Streptococcaceae family,and is mainly isolated from respiratory tract specimens.There are currently no cases of lung abscess caused by S.pseudopneumoniae in the literature.CASE SUMMARY A 2-year-old boy was admitted to hospital due to persistent cough and fever.Lung computed tomography examination suggested the formation of a lung abscess.His diagnosis was not confirmed by testing for serum respiratory pathogens(6 items),respiratory pathogen nucleic acid(27 items),and laboratory culture.Finally,metagenomic next-generation sequencing of bronchoalveolar lavage fluid revealed the presence of S.pseudopneumoniae,confirming its role in causing the lung abscess.After receiving antibiotic treatment,reexamination with lung computed tomography showed that the abscess was resorbed and the patient’s outcome was good.CONCLUSION This is the first report of a lung abscess in a child caused by S.pseudopneumoniae infection.Metagenomic next-generation sequencing of bronchoalveolar lavage fluid is helpful in achieving rapid and accurate pathogen identification.展开更多
Two-dimensional(2D)transition metal dichalcogenides have been extensively studied due to their fascinating physical properties for constructing high-performance photodetectors.However,their relatively low responsiviti...Two-dimensional(2D)transition metal dichalcogenides have been extensively studied due to their fascinating physical properties for constructing high-performance photodetectors.However,their relatively low responsivities,current on/off ratios and response speeds have hindered their widespread application.Herein,we fabricated a high-performance photodetector based on few-layer MoTe_(2) and CdS_(0.42)Se_(0.58) flake heterojunctions.The photodetector exhibited a high responsivity of 7221 A/W,a large current on/off ratio of 1.73×10^(4),a fast response speed of 90/120μs,external quantum efficiency(EQE)reaching up to 1.52×10^(6)%and detectivity(D*)reaching up to 1.67×10^(15) Jones.The excellent performance of the heterojunction photodetector was analyzed by a photocurrent mapping test and first-principle calculations.Notably,the visible light imaging function was successfully attained on the MoTe_(2)/CdS_(0.42)Se_(0.58) photodetectors,indicating that the device had practical imaging application prospects.Our findings provide a reference for the design of ultrahighperformance MoTe_(2)-based photodetectors.展开更多
In this paper,we investigate the maximization of the differences between a nonnegative monotone diminishing return submodular(DR-submodular)function and a nonnegative linear function on the integer lattice.As it is al...In this paper,we investigate the maximization of the differences between a nonnegative monotone diminishing return submodular(DR-submodular)function and a nonnegative linear function on the integer lattice.As it is almost unapproximable for maximizing a submodular function without the condition of nonnegative,we provide weak(bifactor)approximation algorithms for this problem in two online settings,respectively.For the unconstrained online model,we combine the ideas of single-threshold greedy,binary search and function scaling to give an efficient algorithm with a 1/2 weak approximation ratio.For the online streaming model subject to a cardinality constraint,we provide a one-pass(3-√5)/2 weak approximation ratio streaming algorithm.Its memory complexity is(k log k/ε),and the update time for per element is(log^(2)k/ε).展开更多
In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to prov...In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic efficacy.Moreover,by virtue of various modification strategies,the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic,which is worthy of further study.In this review,we summarize the recent developments in imaging-guided strategies and synergistic cancer therapy based on multifunctional MNPs.Then,we discuss the challenge and perspective of the next generation of MNPs-based imaging-guided cancer therapy,hoping to provide guidance in potential applications.展开更多
Exploring efficient materials for capturing radioactive iodine in nuclear waste is of great significance for the progress of nuclear energy as well as the protection of ecological environment.Covalent organic framewor...Exploring efficient materials for capturing radioactive iodine in nuclear waste is of great significance for the progress of nuclear energy as well as the protection of ecological environment.Covalent organic frameworks(COFs)have emerged as promising adsorbents because of their predesignable and functionalizable skeleton structures.However,it remains a grand challenge to achieve large scale preparation of COFs.In this work,we developed a mild and efficient microwave irradiation method instead of the traditional solvothermal method to prepare copper phthalocyanine-based covalent organic frameworks(Cu_(x)Pc-COFs)within only 15 min.The nitrogen-rich 1,2,4,5-tetracarbonitrilebenzene(TCNB)was selected as the solely organic ligand to construct copper phthalocyanine-based 2D conjugated COFs.The resultant Cu_(x)Pc-COFs exhibited excellent iodine enrichment with 2.99 g/g for volatile iodine and 492.27 mg/g for iodine-cyclohexane solution,respectively,outperforming that of many porous materials.As indicated by spectroscopic analysis and DFT calculations,this impressive adsorption performance can be attributed to the charge transfer arising from nitrogen-rich phthalocyanine structures and electron-richπ-conjugated systems with iodine molecules.Moreover,the strong electrostatic interaction between Cu(Ⅱ)on chelate centers and polyiodide anions(I_(x)^(-))also play an important role in the firmly trapping radioactive iodine.Therefore,this study provides a facile and intelligent approach to implement metal-based COFs for the remediation of toxic radioactive iodine.展开更多
Polyoxometalates(POMs) are a class of molecular metal oxides, showing numerous applications in various chemical processes due to their unique acid/base and redox features. By adjusting the tunable molecular structures...Polyoxometalates(POMs) are a class of molecular metal oxides, showing numerous applications in various chemical processes due to their unique acid/base and redox features. By adjusting the tunable molecular structures of the anions and counter cations, plenty of POM-based ionic liquids(POM-based ILs) have been fabricated to be used in various fields, such as catalysis, structural chemistry and material science. As a class of excellent catalysts, POM-based ILs have shown advantages in the emerging field of CO_2 utilization such as CO_2 capture, cycloaddition of CO_2 to epoxides, and reduction of CO_2, owing to the efficient activation of CO_2 by POM anions. This review summarizes recent advances in the catalysis of POM-based ILs, and particularly highlights the areas that are related to CO_2 conversion.展开更多
We consider the online scheduling with job rejection to minimize the total weighted completion time of the scheduled jobs plus the total rejection penalty of the rejected jobs.In the problem,a set of independent jobs ...We consider the online scheduling with job rejection to minimize the total weighted completion time of the scheduled jobs plus the total rejection penalty of the rejected jobs.In the problem,a set of independent jobs arriving online over time has to be scheduled with the flexibility of rejecting some of the jobs,where preemption is not allowed and the information of each job,including its processing time,release date,weight,and rejection penalty,is not known in advance.For this problem,using a technique named Greedy-Interval-Rejection,we provide an online algorithm with a competitive ratio of at most 4+εon identical machines and an online algorithm with a competitive ratio of at most 8 on unrelated machines,respectively。展开更多
Selective oxidation of sulfides to sulfoxides was successfully performed by employing readily available Fe(NO3)3-9H2O as the active catalyst with oxygen as the oxidant in 2,2,2-trifluoroethanol (TFE) without the f...Selective oxidation of sulfides to sulfoxides was successfully performed by employing readily available Fe(NO3)3-9H2O as the active catalyst with oxygen as the oxidant in 2,2,2-trifluoroethanol (TFE) without the formation of sulfones. Nitrate anion could play a crucial role in promoting the reaction due to the oxidation capacity under acidic media. High yields of sulfoxides were exclusively obtained from the corresponding sulfides. Furthermore, both aromatic and aliphatic sulfides gave moderate to high yields of sulfoxides with this protocol.展开更多
基金Supported by Corps Guiding Plan Project of Xinjiang Uygur Autonomous Region,China,No.2022ZD031Financial Science and Technology Plan Project of Shihezi,Xinjiang Uygur Autonomous Region of China,No.2022NY01Research Project of Shihezi University of Shihezi,Xinjiang Uygur Autonomous Region of China,No.ZZZC202072A.
文摘BACKGROUND Lung abscess found on chest X-ray and computed tomography examinations is rare in infants and young children.Several pathogens can cause lung abscesses,with the most common pathogens being anaerobes,Streptococci and Staphylococcus aureus.Streptococcus pseudopneumoniae(S.pseudopneumoniae)is a member of the Streptococcaceae family,and is mainly isolated from respiratory tract specimens.There are currently no cases of lung abscess caused by S.pseudopneumoniae in the literature.CASE SUMMARY A 2-year-old boy was admitted to hospital due to persistent cough and fever.Lung computed tomography examination suggested the formation of a lung abscess.His diagnosis was not confirmed by testing for serum respiratory pathogens(6 items),respiratory pathogen nucleic acid(27 items),and laboratory culture.Finally,metagenomic next-generation sequencing of bronchoalveolar lavage fluid revealed the presence of S.pseudopneumoniae,confirming its role in causing the lung abscess.After receiving antibiotic treatment,reexamination with lung computed tomography showed that the abscess was resorbed and the patient’s outcome was good.CONCLUSION This is the first report of a lung abscess in a child caused by S.pseudopneumoniae infection.Metagenomic next-generation sequencing of bronchoalveolar lavage fluid is helpful in achieving rapid and accurate pathogen identification.
基金This work was supported by the National Natural Science Foundation of China(Nos.11864046 and 11764046)the Basic Research Program of Yunnan Province(Nos.202001AT070064 and 202101AT070124)+1 种基金the Spring City Plan(Highlevel Talent Promotion and Training Project of Kunming)(No.2022SCP005)Yunnan Expert Workstation(No.202205AF150008).
文摘Two-dimensional(2D)transition metal dichalcogenides have been extensively studied due to their fascinating physical properties for constructing high-performance photodetectors.However,their relatively low responsivities,current on/off ratios and response speeds have hindered their widespread application.Herein,we fabricated a high-performance photodetector based on few-layer MoTe_(2) and CdS_(0.42)Se_(0.58) flake heterojunctions.The photodetector exhibited a high responsivity of 7221 A/W,a large current on/off ratio of 1.73×10^(4),a fast response speed of 90/120μs,external quantum efficiency(EQE)reaching up to 1.52×10^(6)%and detectivity(D*)reaching up to 1.67×10^(15) Jones.The excellent performance of the heterojunction photodetector was analyzed by a photocurrent mapping test and first-principle calculations.Notably,the visible light imaging function was successfully attained on the MoTe_(2)/CdS_(0.42)Se_(0.58) photodetectors,indicating that the device had practical imaging application prospects.Our findings provide a reference for the design of ultrahighperformance MoTe_(2)-based photodetectors.
基金supported by the National Natural Science Foundation of China(Nos.12001025 and 12131003)The second author is supported by the Natural Sciences and Engineering Research Council(No.06446),and the National Natural Science Foundation of China(Nos.11771386 and 11728104)+2 种基金The third author is supported by the National Natural Science Foundation of China(Nos.11501171 and 11771251)the Province Natural Science Foundation of Shandong(No.ZR2020MA028)The fourth author is supported by the National Natural Science Foundation of China(No.11701150)。
文摘In this paper,we investigate the maximization of the differences between a nonnegative monotone diminishing return submodular(DR-submodular)function and a nonnegative linear function on the integer lattice.As it is almost unapproximable for maximizing a submodular function without the condition of nonnegative,we provide weak(bifactor)approximation algorithms for this problem in two online settings,respectively.For the unconstrained online model,we combine the ideas of single-threshold greedy,binary search and function scaling to give an efficient algorithm with a 1/2 weak approximation ratio.For the online streaming model subject to a cardinality constraint,we provide a one-pass(3-√5)/2 weak approximation ratio streaming algorithm.Its memory complexity is(k log k/ε),and the update time for per element is(log^(2)k/ε).
基金support from the National Natural Science Foundation of China(52201198,52027801,and 51631001)the National Key R&D Program of China(2017YFA0206301)the China-Germany Collaboration Project(M-0199).
文摘In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic efficacy.Moreover,by virtue of various modification strategies,the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic,which is worthy of further study.In this review,we summarize the recent developments in imaging-guided strategies and synergistic cancer therapy based on multifunctional MNPs.Then,we discuss the challenge and perspective of the next generation of MNPs-based imaging-guided cancer therapy,hoping to provide guidance in potential applications.
基金financially supported by the National Natural Science Foundation of China(52201198,52027801,and 92263203)the Beijing Natural Science Foundation-Haidian Primitive Innovation Joint Fund(L232015)+1 种基金the National Key R&D Program of China(2022YFA1203902)the China-Germany Collaboration Project(M-0199).
基金the financial support from the National Key Research and Development Program of China(No.2018YFC1900105)the National Natural Science Foundation of China(Nos.U2067215,22076044)+1 种基金Science Challenge Project(No.TZ2016004)Beijing Outstanding Young Scientist Program。
文摘Exploring efficient materials for capturing radioactive iodine in nuclear waste is of great significance for the progress of nuclear energy as well as the protection of ecological environment.Covalent organic frameworks(COFs)have emerged as promising adsorbents because of their predesignable and functionalizable skeleton structures.However,it remains a grand challenge to achieve large scale preparation of COFs.In this work,we developed a mild and efficient microwave irradiation method instead of the traditional solvothermal method to prepare copper phthalocyanine-based covalent organic frameworks(Cu_(x)Pc-COFs)within only 15 min.The nitrogen-rich 1,2,4,5-tetracarbonitrilebenzene(TCNB)was selected as the solely organic ligand to construct copper phthalocyanine-based 2D conjugated COFs.The resultant Cu_(x)Pc-COFs exhibited excellent iodine enrichment with 2.99 g/g for volatile iodine and 492.27 mg/g for iodine-cyclohexane solution,respectively,outperforming that of many porous materials.As indicated by spectroscopic analysis and DFT calculations,this impressive adsorption performance can be attributed to the charge transfer arising from nitrogen-rich phthalocyanine structures and electron-richπ-conjugated systems with iodine molecules.Moreover,the strong electrostatic interaction between Cu(Ⅱ)on chelate centers and polyiodide anions(I_(x)^(-))also play an important role in the firmly trapping radioactive iodine.Therefore,this study provides a facile and intelligent approach to implement metal-based COFs for the remediation of toxic radioactive iodine.
基金supported by the National Natural Science Foundation of China (21472103)the Specialized Research Fund for the Doctoral Program of Higher Education (20130031110013)+1 种基金the Ministry of Education Innovation Team (IRT13022) of Chinathe "111" Project of Ministry of Education of China (B06005)
文摘Polyoxometalates(POMs) are a class of molecular metal oxides, showing numerous applications in various chemical processes due to their unique acid/base and redox features. By adjusting the tunable molecular structures of the anions and counter cations, plenty of POM-based ionic liquids(POM-based ILs) have been fabricated to be used in various fields, such as catalysis, structural chemistry and material science. As a class of excellent catalysts, POM-based ILs have shown advantages in the emerging field of CO_2 utilization such as CO_2 capture, cycloaddition of CO_2 to epoxides, and reduction of CO_2, owing to the efficient activation of CO_2 by POM anions. This review summarizes recent advances in the catalysis of POM-based ILs, and particularly highlights the areas that are related to CO_2 conversion.
基金the National Natural Science Foundation of China(Nos.11271338,11171313 and 11301528).
文摘We consider the online scheduling with job rejection to minimize the total weighted completion time of the scheduled jobs plus the total rejection penalty of the rejected jobs.In the problem,a set of independent jobs arriving online over time has to be scheduled with the flexibility of rejecting some of the jobs,where preemption is not allowed and the information of each job,including its processing time,release date,weight,and rejection penalty,is not known in advance.For this problem,using a technique named Greedy-Interval-Rejection,we provide an online algorithm with a competitive ratio of at most 4+εon identical machines and an online algorithm with a competitive ratio of at most 8 on unrelated machines,respectively。
基金the National Natural Science Foundation of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education(No.20130031110013)MOE Innovation Team (No.IRT13022) of China for financial support
文摘Selective oxidation of sulfides to sulfoxides was successfully performed by employing readily available Fe(NO3)3-9H2O as the active catalyst with oxygen as the oxidant in 2,2,2-trifluoroethanol (TFE) without the formation of sulfones. Nitrate anion could play a crucial role in promoting the reaction due to the oxidation capacity under acidic media. High yields of sulfoxides were exclusively obtained from the corresponding sulfides. Furthermore, both aromatic and aliphatic sulfides gave moderate to high yields of sulfoxides with this protocol.