一种电力施工用钢丝绳盘绳机的研制

钢丝绳盘绳机由扭力释放机构、张力保持机构、盘绳机构等组成,扭力释放机构能够充分释放在盘绳作业过程中钢丝绳上所产生的扭力,张力保持机构利用动、定滚轮组合设计,保证钢丝绳在收纳过程中能够保持足够的张力,盘绳机构采用液压动力驱动并结合排绳机构对钢丝绳进行有序盘绳。盘绳机能够实现对多种规格钢丝绳的检测和计长并能配合钢丝绳盘进行钢丝绳的规整收纳,便于仓管人员对钢丝绳进行科学化、规范化、现代化管理。

Geochronology and petrogenesis of the mafic dykes from the Purang ophiolite:Implications for evolution of the western Yarlung-Tsangpo suture zone,southwestern Tibet

The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian terranes.Among the ophiolitic complexes,the Purang ophiolite is the biggest massif in the IYSZ,and many studies have been conducted on this ophiolite.However,previous studies have mainly focused on harzburgite,clinopyroxenite and dunite.Field observations show that mafic dykes were emplaced within the Purang ophiolite.However,petrogenetic evolutions of those mafic dykes are poorly understood.In this study,we present new LA-ICP-MS zircon U-Pb dating results,whole-rock geochemistry and Sr-Nd-Hf isotope analyses for microgabbro,gabbro and dolerite dykes from the Purang ophiolite of the southwestern IYSZ,respectively.Three samples yielded zircon U-Pb ages of144.2±2.1 Ma.127.9±2.3 Ma and 126.5±0.42 Ma,suggesting two different phases of magmatic activities distinctly.Whole-rock geochemical results suggest that the gabbro samples show alkaline features marked by enrichments of light rare earth elements(LREE)and large-ion lithophile elements(LILE),as well as Nb-Ta elements,suggesting an oceanic island basalt-like(OIB-like)geochemical affinity.However,the dolerite and microgabbro samples demonstrate sub-alkaline characteristics with normal mid-oceanic ridge basalt-like(N-MORB-like)geochemical features.Three distinct mafic dykes show significant Rb element depletion.The geochemical data and Sr-Nd-Hf isotopic features suggest that the microgabbro and gabbro rocks were derived from a depleted mantle that had been metasomatized by partial melts of sediments and enriched slab-derived fluids.The dolerite was also originated from a depleted mantle marked by significantly depleted Sr-Nd-Hf compositions,which was not influenced by enriched slab-derived fluids and sediments contamination during subsequent evolution.The isotope and geochemical data and tectonic diagrams suggest a tectonic transition from a within-plate to a midoceanic ridge basalt-like(MORB-like)setting during the period from ca.144 Ma to 127 Ma.Combined with regional background and this study,we propose that these mafic dykes were formed in an oceanic back-arc basin setting.Additionally,integrated with previous studies,we suggest that the geodynamic evolution of the southwestern and central parts of the Neo-Tethys oceanic basin is comparable in Early Cretaceous.

Fault Tolerant Neuro-Robust Position Control of DC Motors

DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model are also addressed to combine with neuro-robust control approach. It is shown that with the proposed control algorithms, external disturbances and coupled dynamics inherent in the system are effectively compensated using neural network unit in which no analytical estimation on the upper bound of the reconstruction error and uncertainties is needed. Simulations on various flight conditions also confirm the effectiveness of the proposed methods.

Combinatorial co-expression of xanthine dehydrogenase and chaperone XdhC from Acinetobacter baumannii and Rhodobacter capsulatus and their applications in decreasing purine content in food

This study investigated the combinatorial expression of xanthine dehydrogenase(XDH)and chaperone XdhC from Acinetobacter baumannii and Rhodobacter capsulatus and their applications in decreasing purine content in the beer,beef and yeast.Naturally occurring xdhABC gene clusters of A.baumannii CICC 10254 and R.capsulatus CGMCC 1.3366 as well as two refactored clusters constructed by exchanging their xdhC genes were overexpressed in Escherichia coli and purified to near homogeneity.RcXDH chaperoned by AbXdhC showed nearly the same catalytic performance as that by RcXdhC,except for the decreased substrate affinity.While the AbXDH co-expressed with RcXdhC displayed enhanced acidic adaptation but weakened catalytic activity.All the XDHs degraded purines in beer,beef and yeast extract effectively,indicating potential applications in low-purine foods to prevent hyperuricemia and gout.The study also presents a method for exploiting the better chaperone XdhC and novel XDHs by functional complement activity using existing XdhCs such as RcXdhC.

Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits

The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described.The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing(ATAC-seq)samples across 11 tissues. An average of 50 ?796open chromatin regions were identified per sample,cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L(active in the duodenum), RCBTB1(muscle and liver), and novel long non-coding RNA ENSGALG00000053256(bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.

Remote sensing of subtropical tree diversity:The underappreciated roles of the practical definition of forest canopy and phenological variation

Tree species diversity is vital for maintaining ecosystem functions,yet our ability to map the distribution of tree diversity is limited due to difficulties in traditional field-based approaches.Recent developments in spaceborne remote sensing provide unprecedented opportunities to map and monitor tree diversity more efficiently.Here we built partial least squares regression models using the multispectral surface reflectance acquired by Sentinel-2 satellites and the inventory data from 74 subtropical forest plots to predict canopy tree diversity in a national natural reserve in eastern China.In particular,we evaluated the underappreciated roles of the practical definition of forest canopy and phenological variation in predicting tree diversity by testing three different definitions of canopy trees and comparing models built using satellite imagery of different seasons.Our best models explained 42%–63%variations in observed diversities in cross-validation tests,with higher explanation power for diversity indices that are more sensitive to abundant species.The models built using imageries from early spring and late autumn showed consistently better fits than those built using data from other seasons,highlighting the significant role of transitional phenology in remotely sensing plant diversity.Our results suggested that the cumulative diameter(60%–80%)of the biggest trees is a better way to define the canopy layer than using the subjective fixeddiameter-threshold(5–12 cm)or the cumulative basal area(90%–95%)of the biggest trees.Remarkably,these approaches resulted in contrasting diversity maps that call attention to canopy structure in remote sensing of tree diversity.This study demonstrates the potential of mapping and monitoring tree diversity using the Sentinal-2 data in species-rich forests.

Reliable knowledge graph fact prediction via reinforcement learning

Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing approaches largely suffer from unreliable calculations on rule confidences owing to a limited number of obtained reasoning paths,thereby resulting in unreliable decisions on prediction triples.Hence,we propose a new RL-based approach named EvoPath in this study.EvoPath features a new reward mechanism based on entity heterogeneity,facilitating an agent to obtain effective reasoning paths during random walks.EvoPath also incorporates a new postwalking mechanism to leverage easily overlooked but valuable reasoning paths during RL.Both mechanisms provide sufficient reasoning paths to facilitate the reliable calculations of rule confidences,enabling EvoPath to make precise judgments about the truthfulness of prediction triples.Experiments demonstrate that EvoPath can achieve more accurate fact predictions than existing approaches.

Realization of the iSWAP-like gate among the superconducting qutrits

High-dimensional quantum systems, such as qutrits(quantum three-level systems), have multiple accessible energy levels beyond the two-level qubits. Therefore, qutrits can offer a larger state space to improve the efficiency of quantum computation. Here, we demonstrate a high-fidelity iSWAP-like gate operation on a frequency-tunable superconducting qutrits system. The superconducting quantum system consists of two qutrits that are coupled via a resonator with fixed qutrit-resonator coupling strengths. Through designing the frequency pulse profile and optimizing the parameter values,the gate error can be suppressed below 1.5 × 10^(-3). To bear out the feasibility of the proposal, we have conducted our study with experimentally accessible parameters. As the resonator can mediate the interaction between the irrelevant qutrits, the presented approach can also be used to couple multiple qutrits together, providing a good platform for quantum information processing.

Sclerosing odontogenic carcinoma of maxilla:A case report

BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.

Clinicopathological study of malignant peripheral nerve sheath tumors in the head and neck:Case reports and review of literature

BACKGROUND Malignant peripheral nerve sheath tumor(MPNST)is a rare and aggressive soft tissue sarcoma that poses a major diagnostic and therapeutic challenge.CASE SUMMARY We retrospectively reviewed patients with head and neck MPNSTs treated in our hospital from 2000 to 2021.The clinical features,pathological manifestations,treatments,and prognoses were summarized.We also reviewed the literature,focusing on MPNST in the mandible and maxilla.The study population consisted of five women and five men aged 22–75 years(mean age,49 years).Of the 10 patients,7 were initial cases and 3 were recurrent cases.All lesions were sporadic.The most common site was the mandible.The most frequently encountered symptoms were a progressive mass and local swelling.Complete or partial loss of trimethylation at lysine 27 of histone H3(H3K27me3)was evident on staining in four of nine cases(one case was excluded due to lack of tissue for evaluation of loss of H3K27me3).The 2-and 5-year disease-specific survival rates were 86%a nd 43%,respectively.The average survival time was 64 mo.CONCLUSION MPNST is a highly malignant tumor with a poor prognosis,prone to a high risk of recurrence and distant metastasis.Complete surgical resection is the main treatment.

The spatial transcriptomic landscape of human gingiva in health and periodontitis

The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells.

康柏西普联合EX-PRESS青光眼引流器植入对NVG患者视力及并发症的影响

目的:探讨玻璃体腔注射康柏西普联合EX-PRESS青光眼引流器植入对新生血管性青光眼(NVG)患者视力及并发症的影响。方法:选取2016-02/2018-10我院眼科收治的NVG患者128例,依据患者的治疗方法分为EX-PRESS组(n=66)和小梁切除术组(n=62),两组患者接受玻璃体腔注射康柏西普治疗,EX-PRESS组患者加行EX-PRESS青光眼引流器植入术治疗,小梁切除术组患者则加行小梁切除术治疗。比较两组手术疗效及术后眼压变化、视力改善情况及并发症发生情况。结果:术后12mo时,EX-PRESS组、小梁切除术组手术治疗总成功率分别为81.8%(54/66)、72.6%(45/62)(P>0.05);术后1、7d,1、3、6、12mo,两组患者眼压均显著低于术前(P<0.05),但两组患者眼压无差异(P>0.05);术后6mo,EX-PRESS组患者视力改善情况显著优于小梁切除术组患者(P<0.05);EX-PRESS组、小梁切除术组术后并发症总发生率分别为27.3%(18/66)、37.1%(23/62)(P>0.05)。结论:玻璃体腔注射康柏西普联合EX-PRESS青光眼引流器植入术与联合小梁切除术治疗NVG的有效性、安全性相似,而前者在改善视力方面更具优势。

miR-302c靶向CREB1基因通过P53信号通路影响肺癌的侵袭和迁移

目的:探讨微小RNA-302c(miR-302c)在肺癌组织中的表达,以及对肺癌侵袭和迁移的影响和作用机制。方法:在线分析GEO数据库中GSE19945和GSE136043两组肺癌数据集中miR-302c的表达情况,通过Human Protein Atlas数据库研究CREB1表达情况;双荧光素酶实验证明miR-302c和CREB1的关系。正常组细胞不加任何药物,对照组细胞转染miR-302cmimic-NC,实验组细胞转染miR-302c-mimic。通过Transwell小室检测细胞的侵袭与迁移能力,通过小管形成检测细胞的血管生成能力,通过Western blot检测各组细胞中CREB1、p-P53、p-P21的表达水平。结果:生物信息分析显示,与正常组织相比,miR-302c在肺癌组织、肺癌淋巴转移组织中的表达明显降低,肺癌组织中CREB1的表达明显升高;双荧光素酶实验证明miR-302c靶向调控CREB1的表达;与正常组相比,实验组迁移和侵袭的细胞数量、小管生成的数量明显下降,实验组中CREB1的表达明显下降,p-P53、p-P21的表达明显升高(均P<0.05)。结论:miR-302c在肺癌组织表达降低,过表达miR-302c后能明显抑制肺癌细胞的侵袭与转移,这可能与抑制靶基因CREB1的表达,以及激活P53信号通路有关。

醇硫基丙烷磺酸钠对电解高性能锂电铜箔的影响

电解铜箔因其工艺简单、经济价值高,已广泛应用于印制线路板和锂离子电池领域。研究表明在电解制箔过程中,加入微量添加剂即可大幅度提高电解铜箔性能。因此,在基础电解液(312.5 g·L^(-1)CuSO_(4)·5H_(2)O,100 g·L^(-1)H_(2)SO_(4),50 mg·L^(-1)Cl^(-))基础上,加入添加剂考察了电解液的电化学行为以及对铜箔表面形貌、结构以及性能的影响。实验选取了醇硫基丙烷磺酸钠(HP)、水解蛋白(HVP)和N,N-二甲基硫代甲酰胺丙烷磺酸钠(DPS)作为组合添加剂,利用扫描电镜(SEM)、X射线洐射(XRD)以及电化学分析等方法,重点考察了组合添加中HP对铜箔表面形貌和物理性能的影响。研究结果表明,在组合添加剂体系中HP具有较强的去极化作用,可以加速铜核的生长,且具有增强铜(200)晶面的择优生长取向。HP与DPS、HVP的协同作用可以进一步减小电解铜箔的晶粒尺寸,降低表面粗糙,提高铜箔力学性能和耐腐蚀性能。所制备的电解铜箔均匀致密,平均晶粒尺寸为29.2 nm、平均粗糙度为1.12μm、平均抗拉强度为399.5 MPa且耐蚀性能优越,是锂离子电池负极集流体的理想材料,具有较高的商业价值。

后囊膜切开在糖尿病视网膜病变硅油取出联合白内障术中的应用

目的:探讨后囊膜切开在糖尿病视网膜病变硅油取出联合白内障术中的临床疗效。方法:收集我院2019-01/2020-02诊治的糖尿病视网膜病变硅油填充眼合并白内障患者83例83眼的临床资料进行回顾性分析。根据手术方式不同分为试验组(硅油取出同期行后囊膜切开联合白内障手术)41眼,对照组(硅油取出联合白内障手术)42眼。术后6mo对两组的最佳矫正视力、后发性白内障的发生、眼前黑影飘动等项目进行评估,以证实后囊膜切开在糖尿病视网膜病变硅油取出联合白内障手术中的优势。结果:术后6mo,最佳矫正视力试验组优于对照组(P<0.05);后发性白内障的发生、眼前黑影飘动试验组低于对照组(P<0.05);两组眼压、术后视网膜脱离、玻璃体积血、人工晶状体偏位比较均无差异(P>0.05)。结论:后囊膜切开在糖尿病视网膜病变硅油取出联合白内障手术中的应用安全可靠,可有效地避免后发性白内障的发生。

MTT Detection of the Toxicity on CdTe Quantum Dots

Objective: The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. Methods: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. Result: Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. Conclusion: The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent.

Passively Q-Switched Erbium-Doped Fiber Laser Based on GeSe Saturable Absorber

GeSe nanosheets were prepared by ultrasonic-assisted liquid phase exfoliation (LPE), and the nonlinear saturated absorption performance was experimentally studied. The modulation depth and saturation intensity of the prepared GeSe saturable absorber (SA) were 15% and 1.44 MW/cm2, respectively. Using the saturated absorption characteristics of GeSe SA, a passively Q-switched erbium-doped fiber laser was systematically demonstrated. As the pump power increases, the pulse repetition frequency increases from 22.8 kHz to 77.59 kHz. The shortest pulse duration is 1.51 μs, and the corresponding pulse energy is 46.14 nJ. Experimental results show that GeSe nanosheets can be used as high-efficiency SA in fiber lasers. Our results will provide a useful reference for demonstrating pulsed fiber lasers based on GeSe equipment.

强化抑酸方案对行内镜止血术的老年ANVUGIB患者手术相关临床指标、再出血率及实验室指标的影响

目的探讨强化抑酸方案对行内镜止血术的老年急性非静脉曲张性上消化道大出血(ANVUGIB)患者手术相关临床指标、再出血率及实验室指标的影响。方法研究对象选取该院2015年6月-2017年6月收治的行内镜止血术老年ANVUGIB患者共150例,以随机数字表法分为对照组(75例)和观察组(75例),分别给予常规剂量和强化剂量泮托拉唑辅助治疗,比较两组患者临床疗效、呕血和黑便消失时间、止血时间、总输血量、住院时间、再出血率、中转开腹率、治疗后24和72 h实验室指标水平及不良反应发生率。结果观察组患者治疗总有效率明显高于对照组(P<0.05);观察组患者呕血和黑便消失时间、止血时间、总输血量及住院时间均明显优于对照组(P<0.05);观察组患者再出血率和中转手术率均明显低于对照组(P<0.05);观察组患者治疗后24和72 h实验室指标水平均明显优于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论强化抑酸方案用于行内镜止血术老年ANVUGIB患者可有效实现早期止血,缓解症状体征,减少围手术期失血量,降低中转开腹风险,并有助于改善红细胞压积(PCV)和尿素氮(BUN)水平。

猪附红细胞体感染

猪附红细胞体病是由寄生于猪红细胞或血浆中的附红细胞体引起的一种人畜共患传染病。猪感染以后会导致猪的生长发育不良,可以使呼吸道和肠道疾病的发病率增加,还能导致母猪生殖系统的损伤,使孕育后代的效率降低。由于附红细胞体感染使动物受到的影响越来越大,受到了全球各国的重视,尤其最近几年我国的畜牧养殖业受附红细胞体感染的影响日益严重。但是截至目前,该病没有标准的疾病诊断方法和特效治疗药物,因此,建立一种适合于临床快速诊断该病的检测方法,减少该病对人畜的健康危害,保障人畜的安全,对该病的控制及预防都具有重要意义。

Hybrid Precoder and Combiner Design with Finite Resolution PSs for mmWave MIMO Systems

Hybrid precoding and combining have been considered as a promising technology, which can provide a compromise between hardware complexity and system performance in millimeter wave multiple-input multiple-output systems. However, most existing hybrid precoder and combiner designs generally assume that infinite resolution phase shifters(PSs) are used to produce the analog beamformers. In a practical scene, the design with accurate PSs can lead to high hardware cost and power consumption. In this paper, we investigate the hybrid precoder and combiner design with finite resolution PSs in millimeter wave systems. We employ alternate optimization as the main strategy to jointly design analog precoder and combiner. In addition, we propose a low complexity algorithm, where the analog beamformers are implemented only by finite resolution PSs to maximize spectral efficiency. Then, the digital precoder and combiner are designed based on the obtained analog beamformers to improve the spectral efficiency. Finally, simulation results and mathematical analysis show that the proposed algorithm with low-resolution PSs can achieve near-optimal performance and have low complexity.