Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was des...Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines.The process presented here is simple,rapid,environmentally welcoming and high yielding.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.展开更多
A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-i have been synthesized by a reaction of tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 3a-d, benzil 4, aromatic amine 5a--c an...A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-i have been synthesized by a reaction of tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 3a-d, benzil 4, aromatic amine 5a--c and ammonium acetate in the presence of iodine through one-pot multi-component reaction (MCR) approach. All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations.展开更多
A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitri...A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs.展开更多
A series of some new quinoline based imidazole-5-one derivatives have been synthesized by the fusion of oxazol-5-ones,various p-substituted anilines and zeolite in pyridine.All the derivatives were subjected to an in ...A series of some new quinoline based imidazole-5-one derivatives have been synthesized by the fusion of oxazol-5-ones,various p-substituted anilines and zeolite in pyridine.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.展开更多
A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and enaminone.All the synthesiz...A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and enaminone.All the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^(13)C NMR data.All the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,B.substilis and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method.展开更多
A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone 3....A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone 3.All the synthesized compounds were screened against six bacterial pathogens,namely B.subtilis,C.tetani,S.pneumoniae,S.typhi,V.cholerae, E.coli and antifungal activity against,two fungal pathogens,A.fumigatus and C.albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains.展开更多
文摘Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines.The process presented here is simple,rapid,environmentally welcoming and high yielding.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.
文摘A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-i have been synthesized by a reaction of tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 3a-d, benzil 4, aromatic amine 5a--c and ammonium acetate in the presence of iodine through one-pot multi-component reaction (MCR) approach. All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations.
文摘A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs.
文摘A series of some new quinoline based imidazole-5-one derivatives have been synthesized by the fusion of oxazol-5-ones,various p-substituted anilines and zeolite in pyridine.All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.
文摘A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and enaminone.All the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^(13)C NMR data.All the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,B.substilis and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method.
文摘A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone 3.All the synthesized compounds were screened against six bacterial pathogens,namely B.subtilis,C.tetani,S.pneumoniae,S.typhi,V.cholerae, E.coli and antifungal activity against,two fungal pathogens,A.fumigatus and C.albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains.