We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffus...We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.展开更多
We report a 43-year-old man who had been experiencing recurrent attacks of syncope for several years, and a search for the causes behind these lapses in consciousness was fruitless for many years. The patient was admi...We report a 43-year-old man who had been experiencing recurrent attacks of syncope for several years, and a search for the causes behind these lapses in consciousness was fruitless for many years. The patient was admitted to our department of internal medicine because of the symptoms flushing, hypotension and episodes of syncope. After a careful anamnesis and then a comprehensive investigation, we reached the definitive diagnosis of the infrequent disease “systemic mastocytosis”.展开更多
文摘We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.
文摘We report a 43-year-old man who had been experiencing recurrent attacks of syncope for several years, and a search for the causes behind these lapses in consciousness was fruitless for many years. The patient was admitted to our department of internal medicine because of the symptoms flushing, hypotension and episodes of syncope. After a careful anamnesis and then a comprehensive investigation, we reached the definitive diagnosis of the infrequent disease “systemic mastocytosis”.
