聚乙二醇/石墨烯复合相变电热膜的制备与性能

文中采用价格低廉的多层石墨烯(MLG)为导电填料,潜热较高的聚乙二醇(PEG)相变材料为基体,通过溶液共混法制备了具有良好电热性能的复合相变电热膜。通过扫描电镜(SEM)、傅里叶变换红外光谱(FT-IR)、X射线衍射仪(XRD)、差示扫描量热分析(DSC)、热重分析(TGA)、升降温实验等分析了相变电热材料的表面形貌、结构性能、相变焓、热稳定性和电热性能。SEM结果表明,MLG与PEG基体中分散较好,并在PEG中构建了MLG杂化网络,其中MLG提供了导热路径,并限制了PEG在相变过程中的泄漏。FT-IR和XRD结果表明,在制备过程中,PEG与MLG之间没有发生化学反应,但PEG的结晶度有所降低。DSC和TGA分析表明,MLG质量分数为7%时,该复合相变材料相变焓为164J/g,开始热失重温度为300℃左右。升降温实验表明电热膜具有可靠的温度调节性能,3gPEG/MLG(7%)样品在20V电压下可升温至91.3℃,并且能在相变温度65℃附近保温280s以上。

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival rate.Evidence suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO databases.Concurrently,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in LUSC.The core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for LUSC.Clinical specimens were examined by immunohistochemical analysis to confirm the diagnostic value in LUSC.Furthermore,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was explored.Results:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for LUSC.GDF10 showed a significant positive correlation with immune cell infiltration and immune checkpoint expression.Conclusion:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

Decomposition of fissile isotope antineutrino spectra using convolutional neural network

Recent reactor antineutrino experiments have observed that the neutrino spectrum changes with the reactor core evolution and that the individual fissile isotope antineutrino spectra can be decomposed from the evolving data,providing valuable information for the reactor model and data inconsistent problems.We propose a machine learning method by building a convolutional neural network based on a virtual experiment with a typical short-baseline reactor antineutrino experiment configuration:by utilizing the reactor evolution information,the major fissile isotope spectra are correctly extracted,and the uncertainties are evaluated using the Monte Carlo method.Validation tests show that the method is unbiased and introduces tiny extra uncertainties.

Effects and translatomics characteristics of a small-molecule inhibitor of METTL3 against non-small cell lung cancer

In non-small cell lung cancer(NSCLC),the heterogeneity promotes drug resistance,and the restricted expression of programmed death-ligand 1(PD-L1)limits the immunotherapy benefits.Based on the mechanisms related to translation regulation and the association with PD-L1 of methyltransferaselike 3(METTL3),the novel small-molecule inhibitor STM2457 is assumed to be useful for the treatment of NSCLC.We evaluated the efficacy of STM2457 in vivo and in vitro and confirmed the effects of its inhibition on disease progression.Next,we explored the effect of STM2457 on METTL3 and revealed its effects on the inhibition of catalytic activity and upregulation of METTL3 protein expression.Importantly,we described the genome-wide characteristics of multiple omics data acquired from RNA sequencing,ribosome profiling,and methylated RNA immunoprecipitation sequencing data under STM2457 treatment or METTL3 knockout.We also constructed a model for the regulation of the translation of METTL3 and PD-L1.Finally,we found PD-L1 upregulation by STM2457 in vivo and in vitro.In conclusion,STM2457 is a potential novel suppressor based on its inhibitory effect on tumor progression and may be able to overcome the heterogeneity based on its impact on the translatome.Furthermore,it can improve the immunotherapy outcomes based on PDL1 upregulation in NSCLC.

Afterpulse measurement of JUNO 20‑inch PMTs

In this study,we present the large photomultiplier tube(PMT)afterpulse measurement results obtained from the Jiangmen underground neutrino observatory(JUNO)experiment.A total of 11 dynode-PMTs(R12860)from the Hamamatsu company(Hamamatsu Photonics K.K.(HPK))and 150 micro-channel plate PMTs(MCP-PMTs,GDB-6201)from the NNVT company(North Night Vision Technology Co.,Ltd.(NNVT))were tested.Subsequently,an afterpulse model was built according to the afterpulse time distribution and the probability of occurrence for these two types of PMTs.The average ratio of the total afterpulse charge with a delay between 0.5μs and 20μs to the primary pulse charge is∼5.7%(13.2%)for the tested MCPPMTs(dynode-PMTs).The JUNO experiment will deploy 20,01220-inch PMTs;this study will benefit detector simulation,event reconstruction,and data analysis regarding the JUNO experiment.

Interfacial electron rearrangement: Ni activated Ni(OH)_(2) for efficient hydrogen evolution

The rational modulation of electronic structure is highly desirable to develop an efficient alkaline hydrogen evolution reaction(HER)catalyst for renewable energy applications.Metal hydroxide such as Ni(OH)_(2) has been proven useful for promoting alkaline HER,but the performance remains unsatisfactory.Herein,the electronic structure of Ni(OH)_(2) is modulated by the interfacial electron rearrangement between Ni-Ni(OH)_(2) heterojunction.Combined experiments with DFT simulations,the electrons of Ni species accumulate to the interfacial Ni-Ni(OH)_(2) sites,which modifies the d band center for promoting conversion of hydrogen intermediates and narrows the energy gap for boosting charge transfer in the HER process.Thus,the integrated electrode exhibits an efficient HER performance to drive10 mA cm^(-2) at the overpotential of 72 mV with a low Tafel slope of 43 mV dec^(-1).Our work renders a valuable insight for understanding and rationally designing efficient catalysts in alkaline HER.

信贷扩张如何影响家庭房地产投资?——以信用卡的扩散为例

经济衰退往往伴随着信用收缩,央行一般采用信贷扩张的刺激政策予以应对。然而,如果增加的信贷大量流入房地产,则会削弱相关政策的有效性。本文通过考察城市家庭使用信用卡购买二套房的行为,从家庭微观层面实证检验了信贷扩张对房地产投资行为的可能影响。本文发现,相对于没有信用卡的家庭,2013年持有信用卡的家庭在两年内购买二套房的可能性提高了3.6个百分点。本文的发现意味着,存在房地产升值预期的情况下,提供给家庭的消费信用仍然会流入房地产,这不仅会削弱相关货币政策的有效性,而且可能加剧房地产过热,增加系统性风险。

先天性鼻泪管阻塞首次探通失败再治疗的临床分析

目的:分析我院就诊的28例首次泪道探通失败的先天性鼻泪管阻塞病例资料,总结再治疗策略。方法:回顾性研究,选取2013-02-01/2017-12-31在我院就诊的591例患儿中的28例,均为首次泪道探通失败的先天性鼻泪管阻塞患儿(不包括外伤性和先天性泪道畸形),收集病史、鼻腔情况、首次探通年龄,治疗前后情况等病例资料。结果:患儿28例中,15例经再次泪道探通联合置管术,取管后已治愈;10例患儿经下鼻甲处理后,再次泪道探通联合置管术,取管后已治愈;2例患儿经常发作急性泪囊炎,在全身麻醉下行鼻内窥镜下鼻腔泪囊吻合术;1例骨性鼻泪管狭窄和阻塞患儿,有溢泪不伴溢脓,建议定期随访,13岁后鼻窦发育完全后行鼻内窥镜下鼻腔泪囊吻合术。结论:先天性鼻泪管阻塞首次泪道探通失败再治疗需采取个性化的阶梯治疗方案,合理治疗该疾病。

Tailoring interfacial electron redistribution of Ni/Fe_(3)O_(4) electrocatalysts for superior overall water splitting

Exploring highly active earth-abundant bifu nctional electrocatalysts for water splitting at a high output is essential for the forthcoming hydrogen economy.Non-noble Fe_(3)O_(4) catalyst owns outstanding conductivity and its octahedral Fe sites can markedly promote water dissociation.However,it lacks active centers on the surface,resulting in its poor activity when used as a catalyst for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).Herein,an electron redistribution strategy is proposed by introducing Ni sites onto the surface of Fe_(3)O_(4)(Ni/Fe_(3)O_(4)).The abundant delocalized electrons,derived from the electronic interaction of Ni and Fe_(3)O_(4) species,significantly optimize the electronic structure of the Ni/Fe_(3)O_(4) catalyst,leading to its improved adsorption behavior.This Ni/Fe_(3)O_(4) catalyst exhibits remarkable bifunctional activity,steadily outputting 1000 mA cm^(-2)at the low overpotential of 387 mV for HER and 338 mV for OER,respectively.Using Ni/Fe_(3)O_(4) as a bifunctional catalyst for overall water splitting reaction exhibits the optimal performance with outstanding stability,obtaining a current density of1000 mA cm^(-2)at 1.98 V,much superior to a Pt/C‖IrO_(2)cell.Experimental analysis and theoretical calculations collectively corroborate that the electron redistribution of Fe_(3)O_(4) is activated by coupling Ni species,leading to the promoted HER and OER kinetics.This electron redistribution strategy provides an effective method to activate transition metal-based catalysts which are promising to be utilized as superior electrocatalysts for the industrial overall water splitting reaction.

Elementary Experiences,Problems and Countermeasures of County Forestry Economy

County forestry economy is a strong power for regional green economic development,and an important way to improve farmers' income and promote living environment in urban and rural areas. According to the investigation of ten typical counties or cities with forestry industrial advantage,this paper sums up the elementary experiences of county forestry economy,analyzes its prominent problems. Countermeasures are brought forward to improve the development of county forestry economy.

ATP13A2 protects dopaminergic neurons in Parkinson's disease:from biology to pathology

As a late endosomal/lysosomal transport protein of the P5-type, ATP13A2 is capable of removing the abnormal accumulation of α-synuclein, which maintains the homeostasis of metal ions and polyamines in the central nervous system. Furthermore, ATP13A2 regulates the normal function of several organelles such as lysosomes, endoplasmic reticulum (ER) and mitochondria, and maintains the normal physiological activity of neural cells. Especially, ATP13A2 protects dopaminergic (DA) neurons against environmental or genetically induced Parkinson's disease (PD). As we all know, PD is a neurodegenerative disease characterized by the loss of DA neurons in the substantia nigra pars compacta. An increasing number of studies have reported that the loss-of- function of ATP13A2 affects normal physiological processes of various organelles, leading to abnormalities and the death of DA neurons. Previous studies in our laboratory have also shown that ATP13A2 deletion intensifies the neuroinflammatory response induced by astrocytes, thus inducing DA neuronal injury. In addition to elucidating the normal structure and function of ATP13A2, this review summarized the pathological mechanisms of ATP13A2 mutations leading to PD in existing literature studies, deepening the understanding of ATP13A2 in the pathological process of PD and other related neurodegenerative diseases. This review provides inspiration for investigators to explore the essential regulatory role of ATP13A2 in PD in the future.

Liver injury in COVID-19:A minireview

Coronavirus disease 2019(COVID-19),caused by infection with the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has escalated into a global tragedy afflicting human health,life,and social governance.Through the increasing depth of research and a better understanding of this disease,it has been ascertained that,in addition to the lungs,SARS-CoV-2 can also induce injuries to other organs including the liver.Liver injury is a common clinical manifestation of COVID-19,particularly in severe cases,and is often associated with a poorer prognosis and higher severity of COVID-19.This review focuses on the general existing information on liver injury caused by COVID-19,including risk factors and subpopulations of liver injury in COVID-19,the association between preexisting liver diseases and the severity of COVID-19,and the potential mechanisms by which SARS-CoV-2 affects the liver.This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.

Database system for managing 20,00020-inch PMTs at JUNO

A database system,known as the large PMT characterization and instrumentation database system(LPMT-CIDS),was designed and implemented for the Jiangmen Underground Neutrino Observatory(JUNO).The system is based on a Linux+Apache+MySQL+PHP(LAMP)server and focuses on modularization and architecture separation.It covers all the testing stages for the 20-inch photomultiplier tubes(PMTs)at JUNO and provides its users with data storage,analysis,and visualization services.Based on the successful use of the system in the 20-inch PMT testing program,its design approach and construction elements can be extended to other projects.

Sun-burn induced upper limb lymphedema 11 years following breast cancer surgery: A case report

BACKGROUND Upper arm lymphedema is a common complication one year after breast cancer surgery,which profoundly impacts patients'quality of life.CASE SUMMARY We reported a case of lymphedema induced by prolonged sun exposure 11 years after breast cancer surgery.CONCLUSION Breast screening,patient education and follow-up after hospital discharge could help to prevent upper-arm lymphedema.

CC-chemokine receptor 7 and its ligand CCL 19 promote mitral valve interstitial cell migration and repair

The effect of CC-chemokine receptor 7 （CCR7） and CC-chemokine ligand 19 （CCL19） on rheumatic mitral ste- nosis is unknown. This study aimed to explore the roles of CCR7 and CCL19 in rheumatic mitral stenosis by mea- suring the expression of CCR7 and CCL19 in human mitral valves from rheumatic mitral stenosis patients. Additionally, we examined their effects on human mitral valve interstitial cells （hMVICs） proliferation, apoptosis and wound repair. CCR7 and CCL19 expression was measured in the mitral valves from rheumatic mitral stenosis patients （n= 10） and compared to normal mitral valves （n=5）. CCR7 was measured in cultured hMVICs from rheu- matic mitral stenosis patients and normal donors by RT-PCR and immunofluorescence. The cells were also treated with exogenous CCL19, and the effects on wound healing, proliferation and apoptosis were assayed. In the rheu- matic mitral valves, valve interstitial cells expressed CCR7, while mononuclear cells and the endothelium expressed CCL19. Healthy mitral valves did not stain positive for CCR7 or CCL19. CCR7 was also detected in cultured rheu- matic hMVICs or in normal hMVICs treated with CCL19. In a wound healing experiment, wound closure rates of both rheumatic and normal hMVICs were significantly accelerated by CCL19. These effects were abrogated by a CCR7 neutralizing antibody. The CCR7/CCL19 axis did not influence the proliferation or apoptosis of hMVICs, indicating that wound healing was due to increased migration rates rather than increased proliferation. In conclu- sion, CCR7 and CCL19 were expressed in rheumatic mitral valves. The CCR7/CCL19 axis may regulate remodel- ing of rheumatic valve injury through promoting migratory ability of hMVICs.

Modeling Neuromorphic Persistent Firing Networks

Neurons are believed to be the brain computational engines of the brain. A recent discovery in neurophysiology reveals that interneurons can slowly integrate spiking, share the output across a coupled network of axons and respond with persistent firing even in the absence of input to the soma or dendrites, which has not been understood and could be very important for exploring the mechanism of human cognition. The conventional models are incapable of simulating the important newly-discovered phenomenon of persistent firing induced by axonal slow integration. In this paper, we propose a computationally efficient model of neurons through modeling the axon as a slow leaky integrator, which captures almost all-known neural behaviors. The model controls the switching of axonal firing dynamics between passive conduction mode and persistent firing mode. The interplay between the axonal integrated potential and its multiple thresholds in axon precisely determines the persistent firing dynamics of neurons. We also present a persistent firing polychronous spiking network which exhibits asynchronous dynamics indicating that this computationally efficient model is not only bio-plausible, but also suitable for large scale spiking network simulations. The implications of this network and the analog circuit design for exploring the relationship between working memory and persistent firing enable developing a spiking network-based memory and bio-inspired computer systems.

Effect of Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy on the malignant degree of cervical cancer

Objective:To study the effect of Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy on the malignant degree of cervical cancer.Methods: Patients with cervical cancer who accepted neoadjuvant chemotherapy in Nanchong Central Hospital and Suining Central Hospital between March 2015 and June 2017 were selected and randomly divided into two groups, the observation group received neoadjuvant chemotherapy combined with Zhenwu decoction therapy, and the control group received neoadjuvant chemotherapy. Before chemotherapy and after 2 courses of chemotherapy, the serum was collected to detect the contents of tumor markers;after chemotherapy, the surgically removed cervical cancer lesion was collected to detect the mRNA expression of proliferation genes, tumor suppressor genes and invasion genes.Results: After 2 course of chemotherapy, CA12-5, bFGF and SCC-Ag levels in serum of both groups were lower than those before treatment, and CA12-5, bFGF and SCC-Ag levels in serum as well as Ki-67, TK-1, SOX-2, CyclinD1, S100A6, N-cadherin, Gal-3, CatL and CatD mRNA expression in cervical cancer lesion of observation group were lower than those of control group whereas p53, p16, FHIT, NF2-1 and LATS1 mRNA expression in cervical cancer lesions were higher than those of control group.Conclusion:Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy can be more effective than neoadjuvant chemotherapy alone to kill cervical cancer cells and reduce the malignancy of cervical cancer.

Effect of the adjuvant Baogan Jiangzhi decoction therapy on liver function and insulin sensitivity in patients with nonalcoholic fatty liver disease

Objective:To study the effect of the adjuvant Baogan Jiangzhi decoction therapy on liver function and insulin sensitivity in patients with nonalcoholic fatty liver disease.Methods: Patients who were newly diagnosed with nonalcoholic fatty liver disease in Nanchong Central Hospital and Suining Central Hospital between March 2015 and October 2017 were selected and randomly divided into the observation group who accepted Baogan Jiangzhi decoction combined with conventional western medicine treatment and the control group who accepted conventional western medicine treatment. The contents of liver damage indexes, inflammatory response markers and oxidative stress markers in serum as well as the expression of insulin signaling molecules in peripheral blood were measured before treatment and 2 weeks after treatment.Results:ALT, AST,γ-GT, TBIL, Chemerin, Wnt5a,β-catenin, MDA and NO contents in serum of both groups 2 weeks after treatment were lower than those before treatment whereas APN, Ghrelin, T-AOC and SOD contents in serum as well as IRS1, IRS2 and GLUT4 expression in peripheral blood were higher than those before treatment, and compared with those of control group, ALT, AST,γ-GT, TBIL, Chemerin, Wnt5a,β-catenin, MDA and NO contents in serum of observation group 2 weeks after treatment were lower whereas APN, Ghrelin, T-AOC and SOD contents in serum as well as IRS1, IRS2 and GLUT4 expression in peripheral blood were higher.Conclusion: Adjuvant Baogan Jiangzhi decoction therapy for nonalcoholic fatty liver disease can reduce liver function injury and improve insulin sensitivity.

Corrigendum to"Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors"[Genes Dis 10(2023)389-392]

We're very sorry for missing a funding program in funding section.Here,we would like to add this program:The Natural Science Foundation of Tianjin(China)(No.21JCQNJCO1890)from Tianjin Science and Technology in the first place.The authors would liketo apologise forany inconvenience caused.