Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell lymphomas.However,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A...Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell lymphomas.However,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased medicine.This evidence-based expert consensus was formulated using an evidence-based approach and the Delphi method.The Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,respectively.This consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special populations.This multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.展开更多
To the editor:Since the onset of COVID-19,several new treatments have been studied,but only a few have received approval for clinical use.However,a challenge we still face is that in real-world medical practice,the pa...To the editor:Since the onset of COVID-19,several new treatments have been studied,but only a few have received approval for clinical use.However,a challenge we still face is that in real-world medical practice,the patient population may differ from those in clinical trials.For instance,prolonged viral elimination has become an issue in immunocompromised patients[1,2]展开更多
A hardware/software field programmable gate array （FPGA）-based driver system was proposed and demonstrated for the KAF-39000 large area high resolution charge coupled device （CCD）. The requirements of the KAF-3900...A hardware/software field programmable gate array （FPGA）-based driver system was proposed and demonstrated for the KAF-39000 large area high resolution charge coupled device （CCD）. The requirements of the KAF-39000 driver system were analyzed. The structure of ＂microprocessor with application specific integrated circuit （ASIC） chips＂ was implemented to design the driver system. The system test results showed that dual channels of imaging analog data were obtained with a frame rate of 0.87frame/s. The frequencies of horizontal timing and vertical timing were 22.9MHz and 28.7kHz, respectively, which almost reached the theoretical value of 24 MHz and 30kHz, respectively.展开更多
To the Editor:Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has spread rapidly throughout the world.It has already posed a great threat to global public health...To the Editor:Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has spread rapidly throughout the world.It has already posed a great threat to global public health security.Angiotensin-converting enzyme 2(ACE2)has been identified as the major receptor of SARS-Co V-2.展开更多
基金supported by the National Natural Science Foundation of China(NSFC)(No.72074005 and No.72304007)the special fund of the National Clinical Key Specialty Construction Program,P.R.China(2023).
文摘Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell lymphomas.However,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased medicine.This evidence-based expert consensus was formulated using an evidence-based approach and the Delphi method.The Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,respectively.This consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special populations.This multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.
基金Peking University Third Hospital,BYSYDL2023001-05,BYSYDL2023001-08,BMU2023XY019.
文摘To the editor:Since the onset of COVID-19,several new treatments have been studied,but only a few have received approval for clinical use.However,a challenge we still face is that in real-world medical practice,the patient population may differ from those in clinical trials.For instance,prolonged viral elimination has become an issue in immunocompromised patients[1,2]
文摘A hardware/software field programmable gate array （FPGA）-based driver system was proposed and demonstrated for the KAF-39000 large area high resolution charge coupled device （CCD）. The requirements of the KAF-39000 driver system were analyzed. The structure of ＂microprocessor with application specific integrated circuit （ASIC） chips＂ was implemented to design the driver system. The system test results showed that dual channels of imaging analog data were obtained with a frame rate of 0.87frame/s. The frequencies of horizontal timing and vertical timing were 22.9MHz and 28.7kHz, respectively, which almost reached the theoretical value of 24 MHz and 30kHz, respectively.
基金support from the National Natural Science Foundation of China(91939301,81820108031,91539123,and 81471893)Beijing Municipal Natural Science Foundation(7172235,China)
文摘To the Editor:Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has spread rapidly throughout the world.It has already posed a great threat to global public health security.Angiotensin-converting enzyme 2(ACE2)has been identified as the major receptor of SARS-Co V-2.
