Wind and wave data are essential in climatological and engineering design applications.In this study,data from 15 buoys located throughout the South China Sea(SCS)were used to evaluate the ERA5 wind and wave data.Appl...Wind and wave data are essential in climatological and engineering design applications.In this study,data from 15 buoys located throughout the South China Sea(SCS)were used to evaluate the ERA5 wind and wave data.Applicability assessment are beneficial for gaining insight into the reliability of the ERA5 data in the SCS.The bias range between the ERA5 and observed wind-speed data was-0.78-0.99 m/s.The result indicates that,while the ERA5 wind-speed data underestimation was dominate,the overestimation of such data existed as well.Additionally,the ERA5 data underestimated annual maximum wind-speed by up to 38%,with a correlation coefficient>0.87.The bias between the ERA5 and observed significant wave height(SWH)data varied from-0.24 to 0.28 m.And the ERA5 data showed positive SWH bias,which implied a general underestimation at all locations,except those in the Beibu Gulf and centralwestern SCS,where overestimation was observed.Under extreme conditions,annual maximum SWH in the ERA5 data was underestimated by up to 30%.The correlation coefficients between the ERA5 and observed SWH data at all locations were greater than 0.92,except in the central-western SCS(0.84).The bias between the ERA5 and observed mean wave period(MWP)data varied from-0.74 to 0.57 s.The ERA5 data showed negative MWP biases implying a general overestimation at all locations,except for B1(the Beibu Gulf)and B7(the northeastern SCS),where underestimation was observed.The correlation coefficient between the ERA5 and observed MWP data in the Beibu Gulf was the smallest(0.56),and those of other locations fluctuated within a narrow range from 0.82 to 0.90.The intercomparison indicates that during the analyzed time-span,the ERA5 data generally underestimated wind-speed and SWH,but overestimated MWP.Under non-extreme conditions,the ERA5 wind-speed and SWH data can be used with confidence in most regions of the SCS,except in the central-western SCS.展开更多
The influence of Typhoon Kalmaegi on internal waves near the Dongsha Islands in the northeastern South China Sea was investigated using mooring observation data.We observed,for the first time,that the phenomenon of re...The influence of Typhoon Kalmaegi on internal waves near the Dongsha Islands in the northeastern South China Sea was investigated using mooring observation data.We observed,for the first time,that the phenomenon of regular variation characteristics of the 14-d spring-neap cycle of diurnal internal tides(ITs)can be regulated by typhoons.The diurnal ITs lost the regular variation characteristics of the 14-d spring-neap cycle during the typhoon period owing to the weakening of diurnal coherent ITs,represented by O_(1)and K_(1),and the strengthening of diurnal incoherent ITs.Results of quantitative analysis showed that during the pre-typhoon period,timeaveraged modal kinetic energy(sum of Modes 1–5)of near-inertial internal waves(NIWs)and diurnal and semidiurnal ITs were 0.62 kJ/m^(2),5.66 kJ/m^(2),and 1.48 kJ/m^(2),respectively.However,during the typhoon period,the modal kinetic energy of NIWs increased 5.11 times,mainly due to the increase in high-mode kinetic energy.At the same time,the modal kinetic energy of diurnal and semidiurnal ITs was reduced by 68.9%and 20%,respectively,mainly due to the decrease in low-mode kinetic energy.The significantly reduced diurnal ITs during the typhoon period could be due to:(1)strong nonlinear interaction between diurnal ITs and NIWs,and(2)a higher proportion of high-mode diurnal ITs during the typhoon period,leading to more energy dissipation.展开更多
Background Brain-derived neurotrophic factor(BDNF)is known to prevent methamphetamine(METH)-induced neurotoxicity and plays a role in various stages of METH addiction.However,there is a lack of research with longitudi...Background Brain-derived neurotrophic factor(BDNF)is known to prevent methamphetamine(METH)-induced neurotoxicity and plays a role in various stages of METH addiction.However,there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.Aims The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.Methods This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure.Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.Results Repeated METH exposure decreased plasma BDNF levels.Additionally,plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.Conclusions These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.展开更多
基金Supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.SML2021SP102)the Key Laboratory of Marine Environmental Survey Technology and Application+2 种基金Ministry of Natural Resources(Nos.MESTA-2020-C003,MESTA-2020-C004)the Key Research and Development Project of Guangdong Province(No.2020B1111020003)the Science and Technology Research Project of Jiangxi Provincial Department of Education(No.GJJ200330)。
文摘Wind and wave data are essential in climatological and engineering design applications.In this study,data from 15 buoys located throughout the South China Sea(SCS)were used to evaluate the ERA5 wind and wave data.Applicability assessment are beneficial for gaining insight into the reliability of the ERA5 data in the SCS.The bias range between the ERA5 and observed wind-speed data was-0.78-0.99 m/s.The result indicates that,while the ERA5 wind-speed data underestimation was dominate,the overestimation of such data existed as well.Additionally,the ERA5 data underestimated annual maximum wind-speed by up to 38%,with a correlation coefficient>0.87.The bias between the ERA5 and observed significant wave height(SWH)data varied from-0.24 to 0.28 m.And the ERA5 data showed positive SWH bias,which implied a general underestimation at all locations,except those in the Beibu Gulf and centralwestern SCS,where overestimation was observed.Under extreme conditions,annual maximum SWH in the ERA5 data was underestimated by up to 30%.The correlation coefficients between the ERA5 and observed SWH data at all locations were greater than 0.92,except in the central-western SCS(0.84).The bias between the ERA5 and observed mean wave period(MWP)data varied from-0.74 to 0.57 s.The ERA5 data showed negative MWP biases implying a general overestimation at all locations,except for B1(the Beibu Gulf)and B7(the northeastern SCS),where underestimation was observed.The correlation coefficient between the ERA5 and observed MWP data in the Beibu Gulf was the smallest(0.56),and those of other locations fluctuated within a narrow range from 0.82 to 0.90.The intercomparison indicates that during the analyzed time-span,the ERA5 data generally underestimated wind-speed and SWH,but overestimated MWP.Under non-extreme conditions,the ERA5 wind-speed and SWH data can be used with confidence in most regions of the SCS,except in the central-western SCS.
基金The National Key Research and Development Program under contract No.2021YFC3101300the CAS Key Laboratory of Science and Technology on Operational Oceanography under contract No.OOST2021-07the fund supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract No.SML2021SP102.
文摘The influence of Typhoon Kalmaegi on internal waves near the Dongsha Islands in the northeastern South China Sea was investigated using mooring observation data.We observed,for the first time,that the phenomenon of regular variation characteristics of the 14-d spring-neap cycle of diurnal internal tides(ITs)can be regulated by typhoons.The diurnal ITs lost the regular variation characteristics of the 14-d spring-neap cycle during the typhoon period owing to the weakening of diurnal coherent ITs,represented by O_(1)and K_(1),and the strengthening of diurnal incoherent ITs.Results of quantitative analysis showed that during the pre-typhoon period,timeaveraged modal kinetic energy(sum of Modes 1–5)of near-inertial internal waves(NIWs)and diurnal and semidiurnal ITs were 0.62 kJ/m^(2),5.66 kJ/m^(2),and 1.48 kJ/m^(2),respectively.However,during the typhoon period,the modal kinetic energy of NIWs increased 5.11 times,mainly due to the increase in high-mode kinetic energy.At the same time,the modal kinetic energy of diurnal and semidiurnal ITs was reduced by 68.9%and 20%,respectively,mainly due to the decrease in low-mode kinetic energy.The significantly reduced diurnal ITs during the typhoon period could be due to:(1)strong nonlinear interaction between diurnal ITs and NIWs,and(2)a higher proportion of high-mode diurnal ITs during the typhoon period,leading to more energy dissipation.
基金Funding for this study was provided by Brain Science and Brain-Like Intelligence Technology(2021ZD0202105)Shanghai‘the Hospital Garden Star’funding for the training of young medical professionals(20224Z0017)+7 种基金the National Natural Science Foundation of China(82171483),(82130041)Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)Shanghai Municipal Health Commission Talent Project(2022YQ048)Lingang Lab(Grant LG202106-03-01),(Grant LG202106-03-03)these fundings had no further role in study designin the collection,analysis and interpretation of datain the writing of the reportin the decision to submit the paper for publication.
文摘Background Brain-derived neurotrophic factor(BDNF)is known to prevent methamphetamine(METH)-induced neurotoxicity and plays a role in various stages of METH addiction.However,there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.Aims The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.Methods This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure.Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.Results Repeated METH exposure decreased plasma BDNF levels.Additionally,plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.Conclusions These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.