The efficacy study of trinity permeation synergism on anti-aging

Background:More and more consumers are paying attention to skin rejuvenation.However,there is a lack of a non-invasive and efficient solution.Objective:To evaluate the efficacy of a trinity permeation synergism(TPS),which consists of a firming essence,an atomizer and a photoelectric penetrator,for facial anti-aging efficacy.Material and methods:In this work,in vitro cell experiments and human efficacy study were used to evaluate the firming and anti-wrinkle effects.Cell experiments were used to verify the effect of the firming essence on the cell proliferation,migration,and anti-inflammation in keratinocytes(HaCaT),and on the gene expression levels of type I and type III collagen(Col-1 and Col-3)and type I matrix metalloproteinase(MMP-1)in human skin fibroblasts(HSF).After in vitro test,60 women aged 35–60 years were enrolled in the randomized test,of which 30 subjects were randomly selected to be the experimental group and treated with the TPS system,while the left 30 subjects were treated with the firming essence only considered as control.After 28 days,skin elasticity,skin redness value,and skin wrinkles were measured to evaluate the efficacy of the TPS system.Results:Cell experiments showed that the firming essence can significantly improve the proliferation and the migration of HaCaT cells.It also promoted the expression level of Col-1 and Col-3 gene,and inhibited the expression level of MMP-1 gene in HSF cells.After confirming the efficacy of firming essence,the efficacy benefit of the TPS was further studied.The 28-day tests show that combined use firming essence with atomizer and penetrator can significantly increase skin elasticity,reduce skin hemoglobin value and skin wrinkles on Day 28.Moreover,all the mentioned improvements are significantly better than that in the control group.Conclusion:Through efficient delivery in the whole process,TPS boosts the efficacy of active components in the firming essence.TPS offers an efficient,non-invasive,and convenient way for enhanced facial rejuvenation efficacy.

Self-therapeutic metal-based nanoparticles for treating inflammatory diseases

Inflammatory diseases are key contributors to high mortality globally and adversely affect the quality of life.Current treatments include corticosteroids or nonsteroidal anti-inflammatories that may cause systemic toxicity and biologics that may increase the risk of infection.Composite nanoparticles that bear not only the drug payload but also targeting ligands for delivery to inflammation sites at lowered systemic toxicity are established in the nanomedicine field,but their relatively large size often leads to systemic clearance.Metal-based nanoparticles with intrinsic anti-inflammatory properties represent attractive alternatives.They are not only designed to be compact for crossing biological barriers(with the nanoparticle serving as a dual carrier and drug),but also support label-free tracking of their interactions with cells.The review commences with an outline of the common inflammatory diseases,inflammatory pathways involved,and conventional drug-loaded nanoparticles for anti-inflammation.Next,the review features the emerging applications of self-therapeutic metal-based nanoparticles(e.g.,gold,coper oxide,platinum,ceria,and zinc oxide)for managing inflammatory diseases in animals over the past three years,focusing on therapeutic outcomes and anti-inflammatory mechanisms.The review concludes with an outlook on the biodistribution,long-term toxicity,and clinical translation of self-therapeutic metalbased nanoparticles.