Advancing Brain Tumor Analysis through Dynamic Hierarchical Attention for Improved Segmentation and Survival Prognosis

Gliomas,the most prevalent primary brain tumors,require accurate segmentation for diagnosis and risk assess-ment.In this paper,we develop a novel deep learning-based method,the Dynamic Hierarchical Attention for Improved Segmentation and Survival Prognosis(DHA-ISSP)model.The DHA-ISSP model combines a three-band 3D convolutional neural network(CNN)U-Net architecture with dynamic hierarchical attention mechanisms,enabling precise tumor segmentation and survival prediction.The DHA-ISSP model captures fine-grained details and contextual information by leveraging attention mechanisms at multiple levels,enhancing segmentation accuracy.By achieving remarkable results,our approach surpasses 369 competing teams in the 2020 Multimodal Brain Tumor Segmentation Challenge.With a Dice similarity coefficient of 0.89 and a Hausdorff distance of 4.8 mm,the DHA-ISSP model demonstrates its effectiveness in accurately segmenting brain tumors.We also extract radio mic characteristics from the segmented tumor areas using the DHA-ISSP model.By applying cross-validation of decision trees to the selected features,we identify crucial predictors for glioma survival,enabling personalized treatment strategies.Utilizing the DHA-ISSP model and the desired features,we assess patients’overall survival and categorize survivors into short,mid,in addition to long survivors.The proposed work achieved impressive performance metrics,including the highest accuracy of 0.91,precision of 0.84,recall of 0.92,F1 score of 0.88,specificity of 0.94,sensitivity of 0.92,area under the curve(AUC)value of 0.96,and the lowest mean absolute error value of 0.09 and mean squared error value of 0.18.These results clearly demonstrate the superiority of the proposed system in accurately segmenting brain tumors and predicting survival outcomes,highlighting its significant merit and potential for clinical applications.

Deep Learning with Optimal Hierarchical Spiking Neural Network for Medical Image Classification

Medical image classification becomes a vital part of the design of computer aided diagnosis(CAD)models.The conventional CAD models are majorly dependent upon the shapes,colors,and/or textures that are problem oriented and exhibited complementary in medical images.The recently developed deep learning(DL)approaches pave an efficient method of constructing dedicated models for classification problems.But the maximum resolution of medical images and small datasets,DL models are facing the issues of increased computation cost.In this aspect,this paper presents a deep convolutional neural network with hierarchical spiking neural network(DCNN-HSNN)for medical image classification.The proposed DCNN-HSNN technique aims to detect and classify the existence of diseases using medical images.In addition,region growing segmentation technique is involved to determine the infected regions in the medical image.Moreover,NADAM optimizer with DCNN based Capsule Network(CapsNet)approach is used for feature extraction and derived a collection of feature vectors.Furthermore,the shark smell optimization algorithm(SSA)based HSNN approach is utilized for classification process.In order to validate the better performance of the DCNN-HSNN technique,a wide range of simulations take place against HIS2828 and ISIC2017 datasets.The experimental results highlighted the effectiveness of the DCNN-HSNN technique over the recent techniques interms of different measures.Please type your abstract here.

Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists

Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been thedeliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization,confer antioxidant properties, and impart antimicrobial effects, marking significant contributions tothe field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertaintiesposed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroidhormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects. Thiscomprehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biomaterials acrossall research aspects and dimensionalities (powders, granules, thin films, bulk materials, and porous structures),follows a unified approach rooted in a cohesive conceptual framework, including synthesis, characterization, andtesting protocols. Tangible outcomes [injectable cements, durable implant coatings, and bone graft substitutes(scaffolds) featuring customized porous architectures for implant fixation, osteointegration, accelerated boneregeneration in critical-sized bone defects] were achieved. The manuscript showcases specific biofunctionalexamples of successful biomedical applications and effective translations to the market of bone grafts foradvanced therapies.