Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate （NSCL/P） in Northern Chinese people in Shenyang by using genomewide and interaction linkage scan.Methods Two multiplex ...Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate （NSCL/P） in Northern Chinese people in Shenyang by using genomewide and interaction linkage scan.Methods Two multiplex families in Shenyang from North China were ascertained through probands with NSCL/P.Blood of every member was drawn for DNA extraction and analysis.Genotypes were available for 382 autosomal short tandem repeat （STR） markers from the ABI Prism Linkage Mapping Set version 2.5.Linkage between markers and NSCL/P was assessed by 2-point parametric LOD scores,multipoint heterogeneity parametric LOD scores （HLODs）,and multipoint nonparametric linkage score （NPL）.Results The initial scan suggested linkage on Chromosomes 1,2,and 15.In subsequent fine mapping,1q32-q42 showed a maximum multipoint LOD score of 1.9（empirical P=0.013） and an NPL score of 2.35 （empirical P=0.053）.For 2p24-p25,the multipoint NPL increased to 2.94 （empirical P=0.007）.2-locus interaction analysis obtained a maximum NPL score of 3.73 （P=0.00078） and a maximum LOD score of 3 for Chromosome 1 （at 221 cM） and Chromosome 2 （at 29 cM）.Conclusion Both parametric and nonparametric linkage scores greatly increased over the initial linkage scores on 1q32-q42,suggesting a susceptibility locus in this region.Nonparametric linkage gave a strong evidence for a candidate region on chromosome 2p24-p25.The superiority of 2-locus linkage scores compared to single-locus scores gave additional evidence for linkage on 1q32-q42 and 2p24-p25,and suggested that certain genes in the two regions may contribute to NCSL/P risks with interaction.展开更多
In this work,we report the reorientation of magnetization by spin-orbit torque(SOT)in YIG/Pt bilayers.The SOT is investigated by measuring the spin Hall magnetoresistance(SMR),which is highly sensitive to the directio...In this work,we report the reorientation of magnetization by spin-orbit torque(SOT)in YIG/Pt bilayers.The SOT is investigated by measuring the spin Hall magnetoresistance(SMR),which is highly sensitive to the direction of magnetic moment of YIG.An external in-plane rotating magnetic field which is applied to the YIG/Pt bilayers,and the evolutions of SMR under different injected currents in the Pt layer,result in deviation of SMR curve from the standard shape.We conclude that the SOT caused by spin accumulation near the interface between YIG and Pt can effectively reorient the inplane magnetic moment of YIG.This discovery provides an effective way to modulate YIG magnetic moments by electrical methods.展开更多
Background：The optimal ventilated status under total intravenous or inhalation anesthesia in neurosurgical patients with a supratentorial tumor has not been ascertained.The purpose of this study was to intraoperative...Background：The optimal ventilated status under total intravenous or inhalation anesthesia in neurosurgical patients with a supratentorial tumor has not been ascertained.The purpose of this study was to intraoperatively compare the effects of moderate hyperventilation on the jugular bulb oxygen saturation （SjO2）,cerebral oxygen extraction ratio （O2ER）,mean arterial blood pressure （MAP）,and heart rate （HR） in patients with a supratentorial tumor under different anesthetic regimens.Methods：Twenty adult patients suffered from supratentorial tumors were randomly assigned to receive a propofol infusion followed by isoflurane anesthesia after a 30-min stabilization period or isoflurane followed by propofol.The patients were randomized to one of the following two treatment sequences：hyperventilation followed by normoventilation or normoventilation followed by hyperventilation during isoflurane or propofol anesthesia,respectively.The ventilation and end-tidal CO2 tension were maintained at a constant level for 20 min.Radial arterial and jugular bulb catheters were inserted for the blood gas sampling.At the end of each study period,we measured the change in the arterial and jugular bulb blood gases.Results：The mean value of the jugular bulb oxygen saturation （SjO2） significantly decreased,and the oxygen extraction ratio （O2ER） significantly increased under isoflurane or propofol anesthesia during hyperventilation compared with those during normoventilation （SjO2：t =-2.728,P =0.011 or t =-3.504,P =0.001;O2ER：t =2.484,P =0.020 or t =2.892,P =0.009）.The SjO2 significantly decreased,and the O2ER significantly increased under propofol anesthesia compared with those values under isoflurane anesthesia during moderate hyperventilation （SjO2：t =-2.769,P =0.012;O2ER：t =2.719,P =0.013）.In the study,no significant changes in the SjO2 and the O2ER were observed under propofol compared with those values under isoflurane during normoventilation.Conclusions：Our results suggest that the optimal ventilated status under propofol or isoflurane anesthesia in neurosurgical patients varies.Hyperventilation under propofol anesthesia should be cautiously performed in neurosurgery to maintain an improved balance between the cerebral oxygen supply and demand.展开更多
基金supported by National Natural Science Foundation of China (the research to identify susceptibility genes of nonsyndromic cleft lip and/or palates, 30600676)Program for New Century Excellent Talents of the Ministry of Education of China (NCET-07-0034)
文摘Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate （NSCL/P） in Northern Chinese people in Shenyang by using genomewide and interaction linkage scan.Methods Two multiplex families in Shenyang from North China were ascertained through probands with NSCL/P.Blood of every member was drawn for DNA extraction and analysis.Genotypes were available for 382 autosomal short tandem repeat （STR） markers from the ABI Prism Linkage Mapping Set version 2.5.Linkage between markers and NSCL/P was assessed by 2-point parametric LOD scores,multipoint heterogeneity parametric LOD scores （HLODs）,and multipoint nonparametric linkage score （NPL）.Results The initial scan suggested linkage on Chromosomes 1,2,and 15.In subsequent fine mapping,1q32-q42 showed a maximum multipoint LOD score of 1.9（empirical P=0.013） and an NPL score of 2.35 （empirical P=0.053）.For 2p24-p25,the multipoint NPL increased to 2.94 （empirical P=0.007）.2-locus interaction analysis obtained a maximum NPL score of 3.73 （P=0.00078） and a maximum LOD score of 3 for Chromosome 1 （at 221 cM） and Chromosome 2 （at 29 cM）.Conclusion Both parametric and nonparametric linkage scores greatly increased over the initial linkage scores on 1q32-q42,suggesting a susceptibility locus in this region.Nonparametric linkage gave a strong evidence for a candidate region on chromosome 2p24-p25.The superiority of 2-locus linkage scores compared to single-locus scores gave additional evidence for linkage on 1q32-q42 and 2p24-p25,and suggested that certain genes in the two regions may contribute to NCSL/P risks with interaction.
基金Project supported by the Natural Science Foundation of Shaanxi Province,China(Grant No.2020JM-088)the National Natural Science Foundation of China(Grant Nos.51572222,51701158,and 51872241)the Fundamental Research Funds for the Central Universities,China(Grant Nos.3102017jc01001 and 310201911cx044).
文摘In this work,we report the reorientation of magnetization by spin-orbit torque(SOT)in YIG/Pt bilayers.The SOT is investigated by measuring the spin Hall magnetoresistance(SMR),which is highly sensitive to the direction of magnetic moment of YIG.An external in-plane rotating magnetic field which is applied to the YIG/Pt bilayers,and the evolutions of SMR under different injected currents in the Pt layer,result in deviation of SMR curve from the standard shape.We conclude that the SOT caused by spin accumulation near the interface between YIG and Pt can effectively reorient the inplane magnetic moment of YIG.This discovery provides an effective way to modulate YIG magnetic moments by electrical methods.
文摘Background：The optimal ventilated status under total intravenous or inhalation anesthesia in neurosurgical patients with a supratentorial tumor has not been ascertained.The purpose of this study was to intraoperatively compare the effects of moderate hyperventilation on the jugular bulb oxygen saturation （SjO2）,cerebral oxygen extraction ratio （O2ER）,mean arterial blood pressure （MAP）,and heart rate （HR） in patients with a supratentorial tumor under different anesthetic regimens.Methods：Twenty adult patients suffered from supratentorial tumors were randomly assigned to receive a propofol infusion followed by isoflurane anesthesia after a 30-min stabilization period or isoflurane followed by propofol.The patients were randomized to one of the following two treatment sequences：hyperventilation followed by normoventilation or normoventilation followed by hyperventilation during isoflurane or propofol anesthesia,respectively.The ventilation and end-tidal CO2 tension were maintained at a constant level for 20 min.Radial arterial and jugular bulb catheters were inserted for the blood gas sampling.At the end of each study period,we measured the change in the arterial and jugular bulb blood gases.Results：The mean value of the jugular bulb oxygen saturation （SjO2） significantly decreased,and the oxygen extraction ratio （O2ER） significantly increased under isoflurane or propofol anesthesia during hyperventilation compared with those during normoventilation （SjO2：t =-2.728,P =0.011 or t =-3.504,P =0.001;O2ER：t =2.484,P =0.020 or t =2.892,P =0.009）.The SjO2 significantly decreased,and the O2ER significantly increased under propofol anesthesia compared with those values under isoflurane anesthesia during moderate hyperventilation （SjO2：t =-2.769,P =0.012;O2ER：t =2.719,P =0.013）.In the study,no significant changes in the SjO2 and the O2ER were observed under propofol compared with those values under isoflurane during normoventilation.Conclusions：Our results suggest that the optimal ventilated status under propofol or isoflurane anesthesia in neurosurgical patients varies.Hyperventilation under propofol anesthesia should be cautiously performed in neurosurgery to maintain an improved balance between the cerebral oxygen supply and demand.
