The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore th...The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis （PTB）. Methods： A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science （Version 13.0） and Review Manager （Version 4.2, The Cochrane Collaboration） were used to analyze the data reported in studies. Results： A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility （allele f vs F： OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF： OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff＋FF： OR=1.39, 95%CI=[1.12, 1.71]）. No significant associations were observed between TaqI （15 studies with 3 031 cases and 3 132 controls）, ApaI （7 studies with 1 495 cases and 1 922 controls）, BsmI （6 studies with 919 cases and 1 250 controls） variants and PTB susceptibility. Conclusion： We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.展开更多
目的:对中医护理质量评价指标相关文献进行范围综述,明确中医护理质量评价指标的类别、名称及内容。方法:以范围综述方法学为指导,系统检索PubMed、Cochrane Library、CINAHL、Web of Science、中国知网、万方数据库、中国生物医学文献...目的:对中医护理质量评价指标相关文献进行范围综述,明确中医护理质量评价指标的类别、名称及内容。方法:以范围综述方法学为指导,系统检索PubMed、Cochrane Library、CINAHL、Web of Science、中国知网、万方数据库、中国生物医学文献数据库。检索时限为建库到2023年2月26日;对纳入文献进行汇总和分析。结果:纳入26篇文献,根据三维质量结构模型对评价指标进行归类,各项评价指标累计出现521次,其中结构质量相关指标168次(32.25%)、过程质量相关指标138次(26.49%)、结果质量相关指标215次(41.27%)。出现频次排名前5的二级指标为护士培训与考核、中医护理操作不良事件、满意度、中医护理人力资源、中医护理组织管理。出现频次排名前5的三级指标为中医护理操作意外与差错、患者对中医护理满意度、护士中医理论与技能培训、护士中医理论与技能考核、辨证施护。各研究较关注护士培训与考核、中医护理临床实践和中医护理操作不良事件等指标,对政策支持条件、延续护理及护理风险等指标关注较少。结论:目前,国内中医护理质量评价指标有待完善,建议在规范和完善评价指标名称和内容的基础上,兼顾科学性验证及临床应用,以保证其科学性和可行性。展开更多
基金Supported by the National Natural Science Foundation of China (30700685)the Medical Science and Technology Research Project of Chongqing Municipal Health Bureau (2009-1-06)
文摘The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis （PTB）. Methods： A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science （Version 13.0） and Review Manager （Version 4.2, The Cochrane Collaboration） were used to analyze the data reported in studies. Results： A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility （allele f vs F： OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF： OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff＋FF： OR=1.39, 95%CI=[1.12, 1.71]）. No significant associations were observed between TaqI （15 studies with 3 031 cases and 3 132 controls）, ApaI （7 studies with 1 495 cases and 1 922 controls）, BsmI （6 studies with 919 cases and 1 250 controls） variants and PTB susceptibility. Conclusion： We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.
文摘目的:对中医护理质量评价指标相关文献进行范围综述,明确中医护理质量评价指标的类别、名称及内容。方法:以范围综述方法学为指导,系统检索PubMed、Cochrane Library、CINAHL、Web of Science、中国知网、万方数据库、中国生物医学文献数据库。检索时限为建库到2023年2月26日;对纳入文献进行汇总和分析。结果:纳入26篇文献,根据三维质量结构模型对评价指标进行归类,各项评价指标累计出现521次,其中结构质量相关指标168次(32.25%)、过程质量相关指标138次(26.49%)、结果质量相关指标215次(41.27%)。出现频次排名前5的二级指标为护士培训与考核、中医护理操作不良事件、满意度、中医护理人力资源、中医护理组织管理。出现频次排名前5的三级指标为中医护理操作意外与差错、患者对中医护理满意度、护士中医理论与技能培训、护士中医理论与技能考核、辨证施护。各研究较关注护士培训与考核、中医护理临床实践和中医护理操作不良事件等指标,对政策支持条件、延续护理及护理风险等指标关注较少。结论:目前,国内中医护理质量评价指标有待完善,建议在规范和完善评价指标名称和内容的基础上,兼顾科学性验证及临床应用,以保证其科学性和可行性。
