在机器阅读理解任务中,由于中文实词的组合性和隐喻性,且缺乏有关中文实词辨析的数据集,因此传统方法对中文实词的理解程度和辨析能力仍然有限.为此,构建了一个大规模(600k)的中文实词辨析数据集(Chinese notional word discrimination ...在机器阅读理解任务中,由于中文实词的组合性和隐喻性,且缺乏有关中文实词辨析的数据集,因此传统方法对中文实词的理解程度和辨析能力仍然有限.为此,构建了一个大规模(600k)的中文实词辨析数据集(Chinese notional word discrimination cloze data set,CND).在数据集中,一句话中的一个实词被替换成了空白占位符,需要从提供的两个候选实词中选择正确答案.设计了一个基线模型RoBERTa-ND(RoBERTa-based notional word discrimination model)来对候选词进行选择.模型首先利用预训练语言模型提取语境中的语义信息.其次,融合候选实词语义并通过分类任务计算候选词得分.最后,通过增强模型对位置及方向信息的感知,进一步加强了模型的中文实词的辨析能力.实验表明,该模型在CND上准确率达到90.21%,战胜了DUMA(87.59%),GNN-QA(84.23%)等主流的完形填空模型.该工作填补了中文隐喻语义理解研究的空白,可以在提高中文对话机器人认知能力等方向开发更多实用价值.数据集CND及RoBERTa-ND代码均已开源:https://github.com/2572926348/CND-Large-scale-Chinese-National-word-discrimination-dataset.展开更多
The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves(BCE) in type 2 diabetic mellitus(T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg^(-1),...The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves(BCE) in type 2 diabetic mellitus(T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg^(-1),to the normal rats and the high-fat-diet-and streptozotocin-induced T2 DM rats were carried out.Effects of BCE on blood glucose,body weight,and a range of serum biochemical parameters were tested,and histopathological observation of pancreatic tissues was also performed.HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin,isoorientin,vitexin,isomangiferin,isovitexin,quercetin hexoside,2'-trans-O-cumaroyl mangiferin,and nigricanside.BCE caused a significant decrease in the concentrations of fasting blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,low density lipoprotein-cholesterol,serum insulin,and malondialdehyde,and increases in oral glucose tolerance,high density lipoprotein-cholesterol,and superoxide dismutase in the T2 DM model rats.Moreover,considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment.The results indicated that BCE exhibited an excellent hypoglycemic activity,and alleviated dyslipidemia which is associated with T2 DM.Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.展开更多
The present study was designed to explore the mechanism by which ethanol extract of Bombax ceiba leaves(BCE) and its main constituent mangiferin(MGF) affect diabetic nephropathy by combating oxidative stress. Oral adm...The present study was designed to explore the mechanism by which ethanol extract of Bombax ceiba leaves(BCE) and its main constituent mangiferin(MGF) affect diabetic nephropathy by combating oxidative stress. Oral administration of BCE and MGF to normal and streptozotocin(STZ)-induced diabetic mice were carried out. Fasting blood glucose, 24-h urinary albumin, serum creatinine, and blood urea nitrogen were tested, histopathology, and immunohistochemical analysis of kidney tissues were performed. Moreover, mesangial cells were treated with BCE and MGF for 48 h with or without 25 mmol·L^(-1) of glucose. Immunofluorescence, Western blot and apoptosis analyses were used to investigate their regulation of oxidative stress and mitochondrial function. BCE and MGF ameliorated biochemical parameters and restored STZ-induced renal injury in the model mice. In vitro study showed that high glucose stimulation increased oxidative stress and cell apoptosis in mesangial cells. BCE and MGF limited mitochondrial membrane potential(Δψm) collapse by inhibiting Nox4, mitochondrially bound hexokinase II dissociation, and subsequent ROS production, which effectively reduced oxidative stress, cleaved caspase-3 expression and cell apoptosis. Our work indicated that BCE and MGF had protective effects on diabetic caused kidney injury and prevented oxidative stress in mesangial cells by regulation of hexokinase II binding and Nox4 oxidase signaling.展开更多
文摘在机器阅读理解任务中,由于中文实词的组合性和隐喻性,且缺乏有关中文实词辨析的数据集,因此传统方法对中文实词的理解程度和辨析能力仍然有限.为此,构建了一个大规模(600k)的中文实词辨析数据集(Chinese notional word discrimination cloze data set,CND).在数据集中,一句话中的一个实词被替换成了空白占位符,需要从提供的两个候选实词中选择正确答案.设计了一个基线模型RoBERTa-ND(RoBERTa-based notional word discrimination model)来对候选词进行选择.模型首先利用预训练语言模型提取语境中的语义信息.其次,融合候选实词语义并通过分类任务计算候选词得分.最后,通过增强模型对位置及方向信息的感知,进一步加强了模型的中文实词的辨析能力.实验表明,该模型在CND上准确率达到90.21%,战胜了DUMA(87.59%),GNN-QA(84.23%)等主流的完形填空模型.该工作填补了中文隐喻语义理解研究的空白,可以在提高中文对话机器人认知能力等方向开发更多实用价值.数据集CND及RoBERTa-ND代码均已开源:https://github.com/2572926348/CND-Large-scale-Chinese-National-word-discrimination-dataset.
文摘The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves(BCE) in type 2 diabetic mellitus(T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg^(-1),to the normal rats and the high-fat-diet-and streptozotocin-induced T2 DM rats were carried out.Effects of BCE on blood glucose,body weight,and a range of serum biochemical parameters were tested,and histopathological observation of pancreatic tissues was also performed.HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin,isoorientin,vitexin,isomangiferin,isovitexin,quercetin hexoside,2'-trans-O-cumaroyl mangiferin,and nigricanside.BCE caused a significant decrease in the concentrations of fasting blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,low density lipoprotein-cholesterol,serum insulin,and malondialdehyde,and increases in oral glucose tolerance,high density lipoprotein-cholesterol,and superoxide dismutase in the T2 DM model rats.Moreover,considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment.The results indicated that BCE exhibited an excellent hypoglycemic activity,and alleviated dyslipidemia which is associated with T2 DM.Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.
基金supported by the Preponderant Discipline Construction Project for Traditional Chinese Medicines of Jiangsu Province
文摘The present study was designed to explore the mechanism by which ethanol extract of Bombax ceiba leaves(BCE) and its main constituent mangiferin(MGF) affect diabetic nephropathy by combating oxidative stress. Oral administration of BCE and MGF to normal and streptozotocin(STZ)-induced diabetic mice were carried out. Fasting blood glucose, 24-h urinary albumin, serum creatinine, and blood urea nitrogen were tested, histopathology, and immunohistochemical analysis of kidney tissues were performed. Moreover, mesangial cells were treated with BCE and MGF for 48 h with or without 25 mmol·L^(-1) of glucose. Immunofluorescence, Western blot and apoptosis analyses were used to investigate their regulation of oxidative stress and mitochondrial function. BCE and MGF ameliorated biochemical parameters and restored STZ-induced renal injury in the model mice. In vitro study showed that high glucose stimulation increased oxidative stress and cell apoptosis in mesangial cells. BCE and MGF limited mitochondrial membrane potential(Δψm) collapse by inhibiting Nox4, mitochondrially bound hexokinase II dissociation, and subsequent ROS production, which effectively reduced oxidative stress, cleaved caspase-3 expression and cell apoptosis. Our work indicated that BCE and MGF had protective effects on diabetic caused kidney injury and prevented oxidative stress in mesangial cells by regulation of hexokinase II binding and Nox4 oxidase signaling.
