Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading...Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer electronics.These applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic applications.Recently,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting materials.Silicon(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible electronics.Consequently,the research on ultra-thin Si in the context of flexible electronics is studied rigorously nowadays.The thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional properties.This review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.展开更多
Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Tradition...Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.展开更多
Implantable deep brain stimulation(DBS)systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic pain.However,long-term efficacy of DBS is limited,and chronic neuroplastic cha...Implantable deep brain stimulation(DBS)systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic pain.However,long-term efficacy of DBS is limited,and chronic neuroplastic changes and associated therapeutic mechanisms are not well understood.Fundamental and mechanistic investigation,typically accomplished in small animal models,is difficult because of the need for chronic stimulators that currently require either frequent handling of test subjects to charge battery-powered systems or specialized setups to manage tethers that restrict experimental paradigms and compromise insight.To overcome these challenges,we demonstrate a fully implantable,wireless,battery-free platform that allows for chronic DBS in rodents with the capability to control stimulation parameters digitally in real time.The devices are able to provide stimulation over a wide range of frequencies with biphasic pulses and constant voltage control via low-impedance,surface-engineered platinum electrodes.The devices utilize off-the-shelf components and feature the ability to customize electrodes to enable broad utility and rapid dissemination.Efficacy of the system is demonstrated with a readout of stimulation-evoked neural activity in vivo and chronic stimulation of the medial forebrain bundle in freely moving rats to evoke characteristic head motion for over 36 days.展开更多
Continued research on the epidermal electronic sensor aims to develop sophisticated platforms that reproduce key multimodal responses in human skin,with the ability to sense various external stimuli,such as pressure,s...Continued research on the epidermal electronic sensor aims to develop sophisticated platforms that reproduce key multimodal responses in human skin,with the ability to sense various external stimuli,such as pressure,shear,torsion,and touch.The development of such applications utilizes algorithmic interpretations to analyze the complex stimulus shape,magnitude,and various moduli of the epidermis,requiring multiple complex equations for the attached sensor.In this experiment,we integrate silicon piezoresistors with a customized deep learning data process to facilitate in the precise evaluation and assessment of various stimuli without the need for such complexities.With the ability to surpass conventional vanilla deep regression models,the customized regression and classification model is capable of predicting the magnitude of the external force,epidermal hardness and object shape with an average mean absolute percentage error and accuracy of<15 and 96.9%,respectively.The technical ability of the deep learning-aided sensor and the consequent accurate data process provide important foundations for the future sensory electronic system.展开更多
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. RS-2024-00353768)the Yonsei Fellowship, funded by Lee Youn Jae. This study was funded by the KIST Institutional Program Project No. 2E31603-22-140 (K J Y). S M W acknowledges the support by National Research Foundation of Korea (NRF) grant funded by the Korea government (Grant Nos. NRF-2021R1C1C1009410, NRF2022R1A4A3032913 and RS-2024-00411904)
文摘Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high durability.These unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer electronics.These applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic applications.Recently,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting materials.Silicon(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible electronics.Consequently,the research on ultra-thin Si in the context of flexible electronics is studied rigorously nowadays.The thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional properties.This review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.
基金This work utilized Northwestern University Micro/Nano Fabrication Facility(NUFAB)which is partially supported by Soft and Hybrid Nanotechnology Experimental(SHyNE)Resource(NSF ECCS-1542205)+3 种基金the Materials Research Science and Engineering Center(DMR-1720139)the State of Illinois,and Northwestern University.Y.H.acknowledges the support from the National Science Foundation,USA(grant no.CMMI1635443)supported by Querrey Simpson Institute for Bioelectronicssupported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute awarded to the Robert H.Lurie Comprehensive Cancer Center.
文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.
基金support from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health T32EB000809(A.B.)the ARCS Foundation(A.B.).The University of Arizona Department of Biomedical Engineering startup funds(P.G.)and Core Facilities Pilot Program(CA-CFPP NANO-3310342)(P.G.).5.M.W.acknowledges the support by the MSIT(Ministry of Science and IC〇,Korea,under the ICT Creative Consilience program(IITP-2020-0-01821)+2 种基金by Nano Material Technology Development Program(2020M3H4A1A03084600)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT of KoreaThe Eunice Kennedy Shriver National Institute of Child Health&Human Development(K12HD073945,F.V.).University of Pennsylvania Department of Neurosurgery startup funds(A.G.R.).
文摘Implantable deep brain stimulation(DBS)systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic pain.However,long-term efficacy of DBS is limited,and chronic neuroplastic changes and associated therapeutic mechanisms are not well understood.Fundamental and mechanistic investigation,typically accomplished in small animal models,is difficult because of the need for chronic stimulators that currently require either frequent handling of test subjects to charge battery-powered systems or specialized setups to manage tethers that restrict experimental paradigms and compromise insight.To overcome these challenges,we demonstrate a fully implantable,wireless,battery-free platform that allows for chronic DBS in rodents with the capability to control stimulation parameters digitally in real time.The devices are able to provide stimulation over a wide range of frequencies with biphasic pulses and constant voltage control via low-impedance,surface-engineered platinum electrodes.The devices utilize off-the-shelf components and feature the ability to customize electrodes to enable broad utility and rapid dissemination.Efficacy of the system is demonstrated with a readout of stimulation-evoked neural activity in vivo and chronic stimulation of the medial forebrain bundle in freely moving rats to evoke characteristic head motion for over 36 days.
基金support of the MSIT (Ministry of Science and ICT),Korea,under the ICT Creative Consilience program (IITP-2020-0-01821)support by a National Research Foundation of Korea (NRF)grant funded by the Korea government (MSIP+5 种基金Ministry of Science,ICT&Future Planninggrant no.NRF-2021R1C1C1009410,and NRF2022R1A4A3032913)support by the Nano Material Technology Development Program (2020M3H4A1A03084600)through the National Research Foundation of Korea (NRF)funded by the Ministry of Science and ICT of Koreasupported by the Institute of Information&communications Technology Planning&Evaluation (IITP)grant funded by the Korea government (IITP-2021-0-02068)supported by the National Research Foundation of Korea (NRF)grant funded by the Korea government (MSITNRF-2018M3A7B4071110).
文摘Continued research on the epidermal electronic sensor aims to develop sophisticated platforms that reproduce key multimodal responses in human skin,with the ability to sense various external stimuli,such as pressure,shear,torsion,and touch.The development of such applications utilizes algorithmic interpretations to analyze the complex stimulus shape,magnitude,and various moduli of the epidermis,requiring multiple complex equations for the attached sensor.In this experiment,we integrate silicon piezoresistors with a customized deep learning data process to facilitate in the precise evaluation and assessment of various stimuli without the need for such complexities.With the ability to surpass conventional vanilla deep regression models,the customized regression and classification model is capable of predicting the magnitude of the external force,epidermal hardness and object shape with an average mean absolute percentage error and accuracy of<15 and 96.9%,respectively.The technical ability of the deep learning-aided sensor and the consequent accurate data process provide important foundations for the future sensory electronic system.