A marked increase in the incidence of autoimmune diseases in the past half-a-century has been observed. MS （multiple sclerosis） is one of the most common chronic immune-mediated inflammatory diseases of the central ...A marked increase in the incidence of autoimmune diseases in the past half-a-century has been observed. MS （multiple sclerosis） is one of the most common chronic immune-mediated inflammatory diseases of the central nervous system in young adults which is characterized by inflammatory demyelination and neurodegeneration with unpredictable effects lasting for the rest of their lives. The aim of the MS treatment is to prevent the demyelination and the reduction of axonal loss. Drugs approved for use in MS which reduce the frequency of exacerbations or slow disability progression are referred as DMDs （disease-modifying drugs）. Additional treatments of MS include： dietary supplementation, herbal medicine intake, vitamin D3 and vitamin B supplementation and relaxation techniques. However, little is known about the environmental factors that directly influence Th1 7 cells. Increased salt （sodium chloride） concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human Th 17 cells. Pathogenic IL-23-dependent Th 17 cells have been shown to be critical for the development of EAE （experimental autoimmune encephalomyelitis） along with some genetic risk factors.展开更多
文摘A marked increase in the incidence of autoimmune diseases in the past half-a-century has been observed. MS （multiple sclerosis） is one of the most common chronic immune-mediated inflammatory diseases of the central nervous system in young adults which is characterized by inflammatory demyelination and neurodegeneration with unpredictable effects lasting for the rest of their lives. The aim of the MS treatment is to prevent the demyelination and the reduction of axonal loss. Drugs approved for use in MS which reduce the frequency of exacerbations or slow disability progression are referred as DMDs （disease-modifying drugs）. Additional treatments of MS include： dietary supplementation, herbal medicine intake, vitamin D3 and vitamin B supplementation and relaxation techniques. However, little is known about the environmental factors that directly influence Th1 7 cells. Increased salt （sodium chloride） concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human Th 17 cells. Pathogenic IL-23-dependent Th 17 cells have been shown to be critical for the development of EAE （experimental autoimmune encephalomyelitis） along with some genetic risk factors.
