Rock failure can cause serious geological disasters,and the non-extensive statistical features of electric potential(EP)are expected to provide valuable information for disaster prediction.In this paper,the uniaxial c...Rock failure can cause serious geological disasters,and the non-extensive statistical features of electric potential(EP)are expected to provide valuable information for disaster prediction.In this paper,the uniaxial compression experiments with EP monitoring were carried out on fine sandstone,marble and granite samples under four displacement rates.The Tsallis entropy q value of EPs is used to analyze the selforganization evolution of rock failure.Then the influence of displacement rate and rock type on q value are explored by mineral structure and fracture modes.A self-organized critical prediction method with q value is proposed.The results show that the probability density function(PDF)of EPs follows the q-Gaussian distribution.The displacement rate is positively correlated with q value.With the displacement rate increasing,the fracture mode changes,the damage degree intensifies,and the microcrack network becomes denser.The influence of rock type on q value is related to the burst intensity of energy release and the crack fracture mode.The q value of EPs can be used as an effective prediction index for rock failure like b value of acoustic emission(AE).The results provide useful reference and method for the monitoring and early warning of geological disasters.展开更多
BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatiti...BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.展开更多
Background:Nutrient resorption is critical for plants toward balancing their nutritional requirements and adapting to environmental variabilities,which further impacts litter quality and nutrient cycling.However,the i...Background:Nutrient resorption is critical for plants toward balancing their nutritional requirements and adapting to environmental variabilities,which further impacts litter quality and nutrient cycling.However,the interannual variability of nutrient resorption under climate change remains unclear.Methods:We investigated the five-year nutrient resorption efficiencies(NuRE,%)of 14 elements in three deciduous oak tree species(Quercus aliena var.acuteserrata,Q.glandulifera,and Q.variabilis)in a warm-temperate forest of Central China and assessed their relationships with interannual climate and soil factors.Results:Nutrient resorption did not differ between species but varied significantly between different years.For each year,N,P,S,K,C,Mg,and Zn were preferentially resorbed in all of the oak species in contrast to Ca,Na,Mn,Ba,Al,Fe,Cu,which were to some extent discriminated.Among the 14 elements,the NuRE of C,N,P,S,Ca,and Mg was more sensitive to interannual climate variations in the three oak species.The carbon resorption efficiency was significantly increased during the driest year of the study(2014);N resorption efficiency was reduced with temperature;whereas N and P resorption efficiency initially decreased and then increased with precipitation.Moreover,the elements with higher NuREs typically had lower coefficient of variation(CV)in all three oak species.Conclusions:Different oak species exhibited analogous nutrient conservation strategies in response to annual climate variabilities,and interannual climate variations strongly impacted plant nutrient resorption.Deciduous plants may establish a tradeoff mechanism to rebalance somatic nutrients for regrowth at the end of the growing season.展开更多
The stress and gas pressure in deep coal seams are very high,and instability and failure rapidly and intensely occur.It is important to study the infrared precursor characteristics of gas-bearing coal instability and ...The stress and gas pressure in deep coal seams are very high,and instability and failure rapidly and intensely occur.It is important to study the infrared precursor characteristics of gas-bearing coal instability and failure.In this paper,a self-developed stress-gas coupling failure infrared experimental system was used to analyse the infrared radiation temperature(IRT)and infrared thermal image precursor characteristics of gas-free coal and gas-bearing coal.The changes in the areas of the infrared temperature anomalous precursor regions and the effect of the gas on the infrared precursors were examined.The results show that high-temperature anomalous precursors arise mainly when the gas-free coal fails under loading,whereas the gas-bearing coal has high-temperature and low-temperature anomalous precursors.The area of the high-temperature anomalous precursor is approximately 30%–40%under gasbearing coal unstable failure,which is lower than the 60%–70%of the gas-free coal.The area of the low-temperature abnormal precursor is approximately 3%–6%,which is higher than the 1%–2%of the gas-free coal.With increasing gas pressure,the area of the high-temperature anomalous precursor gradually decreases,and the area of the low-temperature anomalous precursor gradually increases.The highand low-temperature anomalous precursors of gas-bearing coal are mainly caused by gas desorption,volume expansion,and thermal friction.The presence of gas inhibits the increase in IRT on the coal surface and increases the difficulty of infrared radiation(IR)monitoring and early warning for gas-bearing coal.展开更多
We experimentally demonstrate an electrically triggered terahertz(THz) dual-band tunable band-pass filter based on Si_3 N_4–VO_2–Si_3 N_4 sandwich-structured hybrid metamaterials. The insulator–metal phase transiti...We experimentally demonstrate an electrically triggered terahertz(THz) dual-band tunable band-pass filter based on Si_3 N_4–VO_2–Si_3 N_4 sandwich-structured hybrid metamaterials. The insulator–metal phase transition of VO_2 film is induced by the Joule thermal effect of the top metal layer. The finite-integration-time-domain(FITD) method and finite element method(FEM) are used for numerical simulations. The sample is fabricated using a surface micromachining process,and characterized by a THz time-domain-spectrometer(TDS). When the bias current is 0.225 A, the intensity modulation depths at two central frequencies of 0.56 THz and 0.91 THz are about 81.7% and 81.3%, respectively. This novel design can achieve dynamically electric–thermo–optic modulation in the THz region, and has potential applications in the fields of THz communications, imaging, sensing, and astronomy exploration.展开更多
Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary rese...Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely accepted.Aim This article will focus on the application of viral vectors in basic and clinical neuropsychiatric research.Methods By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of patients.Perspective Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.展开更多
As a typical non-smooth bifurcation, grazing bifurcation can induce instability of elementary near-grazing impact periodic motion in impact oscillators. In this paper,the stability for near-grazing period-one impact m...As a typical non-smooth bifurcation, grazing bifurcation can induce instability of elementary near-grazing impact periodic motion in impact oscillators. In this paper,the stability for near-grazing period-one impact motion to suppress grazing-induced instabilities is analyzed, based on which, a control strategy is proposed. The commonly-used leading order zero time discontinuity mapping is extended to a higher order one to aid the perturbation analysis of the characteristic equation. It is shown that the degenerate grazing bifurcation can eliminate the singular term in the characteristic equation, leading to bounded eigenvalues. Based on such a precondition, the bounded eigenvalues are further restricted inside the unit circle, and a continuous transition between non-impact and controlled impact motion is observed. One discrete feedback controller that changes the velocity of the oscillator based on the selected Poincar′e sections is adopted to demonstrate the control procedure.展开更多
We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wi...We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wire and four metallic split-ring resonators(SRRs)whose gaps are filled with photosensitive semiconductor gallium arsenide(GaAs)patches.We simulate the PIT effect controlled by external infrared light intensity to change the conductivity of GaAs.In the absence of photo excitation,the conductivity of Ga As is 0,thus the SRR gaps are disconnected,and the PIT effect is not observed since the dark resonator(supported by the hybrid SRRs)cannot be stimulated.When the conductivity of GaAs is increased via photo excitation,the conductivity of Ga As can increase rapidly from 0 S/m to 1×10^(6)S/m and GaAs can connect the metal aluminum SRR gaps,and the dark resonator is excited through coupling with the bright resonator(supported by the cut wire),which leads to the PIT effect.Therefore,the PIT effect can be dynamically tuned between the on and off states by controlling the intensity of the external infrared light.We also discuss couplings between one bright mode(CW)and several dark modes(SRRs)with different sizes.The interference analytically described by the coupled Lorentz oscillator model elucidates the coupling mechanism between one bright mode and two dark modes.The phenomenon can be considered the result of linear superposition of the coupling between the bright mode and each dark mode.The proposed metamaterials are promising for application in the fields of THz communications,optical storage,optical display,and imaging.展开更多
The size and composition of particulate matter(PM)are pivotal in determining its adverse health effects.It is important to understand PM's retention by plants to facilitate its atmospheric removal.However,the dist...The size and composition of particulate matter(PM)are pivotal in determining its adverse health effects.It is important to understand PM's retention by plants to facilitate its atmospheric removal.However,the distinctions between the size and composition of naturally fallen PM(NFPM)and leaf-deposited PM(LDPM)are not well-documented.Here we utilize a single-particle aerosol mass spectrometer,coupled with a PM resuspension chamber,to analyze these differences.We find that LDPM particles are 6.8 e97.3%larger than NFPM.Employing a neural network algorithm based on adaptive resonance theory,we have identified distinct compositional profiles:NFPM predominantly consists of organic carbon(OC;31.2%)and potassium-rich components(19.1%),whereas LDPM are largely composed of crustal species(53.9e60.6%).Interestingly,coniferous species retain higher OC content(11.5e13.7%)compared to broadleaved species(0.5e1.2%),while the levoglucosan content exhibit an opposite trend.Our study highlights the active role of tree leaves in modifying PM composition beyond mere passive capture,advocating for a strategic approach to species selection in urban greening initiatives to enhance PM mitigation.These insights provide guidance for urban planners and environmentalists in implementing nature-based solutions to improve urban air quality.展开更多
Neighborhood gardens serve as sensitive sites for human microbial encounters,with phyllosphere microbes directly impacting our respiratory health.Yet,our understanding remains limited on how factors like season,garden...Neighborhood gardens serve as sensitive sites for human microbial encounters,with phyllosphere microbes directly impacting our respiratory health.Yet,our understanding remains limited on how factors like season,garden age,and land use shape the risk of respiratory diseases(RDs)tied to these garden microbes.Here we examined the microbial communities within the phyllosphere of 72 neighborhood gardens across Shanghai,spanning different seasons(warm and cold),garden ages(old and young),and locales(urban and rural).We found a reduced microbial diversity during the cold season,except for Gammaproteobacteria which exhibited an inverse trend.While land use influenced the microbial composition,urban and rural gardens had strikingly similar microbial profiles.Alarmingly,young gardens in the cold season hosted a substantial proportion of RDs-associated species,pointing towards increased respiratory inflammation risks.In essence,while newer gardens during colder periods show a decline in microbial diversity,they have an increased presence of RDs-associated microbes,potentially escalating respiratory disease prevalence.This underscores the pivotal role the garden age plays in enhancing both urban microbial diversity and respiratory health.展开更多
The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power density.The bipolar Cockcroft-W...The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power density.The bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant converter.However,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)phenomenon.The oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency operation.The authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be implemented.To facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with ease.The relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH phenomenon.Finally,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.展开更多
Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.M...Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality.展开更多
基金supported by National Key R&D Program of China(2022YFC3004705)the National Natural Science Foundation of China(Nos.52074280,52227901 and 52204249)+1 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX24_2913)the Graduate Innovation Program of China University of Mining and Technology(No.2024WLKXJ139).
文摘Rock failure can cause serious geological disasters,and the non-extensive statistical features of electric potential(EP)are expected to provide valuable information for disaster prediction.In this paper,the uniaxial compression experiments with EP monitoring were carried out on fine sandstone,marble and granite samples under four displacement rates.The Tsallis entropy q value of EPs is used to analyze the selforganization evolution of rock failure.Then the influence of displacement rate and rock type on q value are explored by mineral structure and fracture modes.A self-organized critical prediction method with q value is proposed.The results show that the probability density function(PDF)of EPs follows the q-Gaussian distribution.The displacement rate is positively correlated with q value.With the displacement rate increasing,the fracture mode changes,the damage degree intensifies,and the microcrack network becomes denser.The influence of rock type on q value is related to the burst intensity of energy release and the crack fracture mode.The q value of EPs can be used as an effective prediction index for rock failure like b value of acoustic emission(AE).The results provide useful reference and method for the monitoring and early warning of geological disasters.
基金Supported by the National Natural Science Foundation of China,No.81570535 and No.81770587Key Projects in the National Science and Technology Pillar Program during the Thirteenth Five-year Plan Period,No.2017ZX10203201-008,No.2018ZX09206005-003,and 2017ZX10202202-005-004+4 种基金the Shanghai Three-Year Plan of the Clinical Skills and Innovations,No.16CR1002Athe Shanghai Municipal Key Clinical Specialty,No.shslczdzk01103the Shanghai Three-Year Plan of the Key Subjects Construction in Public Health-Infectious Diseases and Pathogenic Microorganism,No.15GWZK0102the Suzhou Expert Team of Clinical Medicine,No.SZYJTD201717the Joint Research Initiative-Shanghai Jiao Tong University School of Medicine,No.YW20190002
文摘BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.
基金supported by the National Key Technology Research and Development Program of China(2017YFC0505501,2016YFD0600206,and 2013BAD11B01)the National Natural Science Foundation of China(NSFC 31270640 and 31770746)the China Postdoctoral Science Foundation(20Z102060010).
文摘Background:Nutrient resorption is critical for plants toward balancing their nutritional requirements and adapting to environmental variabilities,which further impacts litter quality and nutrient cycling.However,the interannual variability of nutrient resorption under climate change remains unclear.Methods:We investigated the five-year nutrient resorption efficiencies(NuRE,%)of 14 elements in three deciduous oak tree species(Quercus aliena var.acuteserrata,Q.glandulifera,and Q.variabilis)in a warm-temperate forest of Central China and assessed their relationships with interannual climate and soil factors.Results:Nutrient resorption did not differ between species but varied significantly between different years.For each year,N,P,S,K,C,Mg,and Zn were preferentially resorbed in all of the oak species in contrast to Ca,Na,Mn,Ba,Al,Fe,Cu,which were to some extent discriminated.Among the 14 elements,the NuRE of C,N,P,S,Ca,and Mg was more sensitive to interannual climate variations in the three oak species.The carbon resorption efficiency was significantly increased during the driest year of the study(2014);N resorption efficiency was reduced with temperature;whereas N and P resorption efficiency initially decreased and then increased with precipitation.Moreover,the elements with higher NuREs typically had lower coefficient of variation(CV)in all three oak species.Conclusions:Different oak species exhibited analogous nutrient conservation strategies in response to annual climate variabilities,and interannual climate variations strongly impacted plant nutrient resorption.Deciduous plants may establish a tradeoff mechanism to rebalance somatic nutrients for regrowth at the end of the growing season.
基金supported by the National Natural Science Foundation of China(No.52074280)the National Natural Science Foundation of China(No.52004016)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions。
文摘The stress and gas pressure in deep coal seams are very high,and instability and failure rapidly and intensely occur.It is important to study the infrared precursor characteristics of gas-bearing coal instability and failure.In this paper,a self-developed stress-gas coupling failure infrared experimental system was used to analyse the infrared radiation temperature(IRT)and infrared thermal image precursor characteristics of gas-free coal and gas-bearing coal.The changes in the areas of the infrared temperature anomalous precursor regions and the effect of the gas on the infrared precursors were examined.The results show that high-temperature anomalous precursors arise mainly when the gas-free coal fails under loading,whereas the gas-bearing coal has high-temperature and low-temperature anomalous precursors.The area of the high-temperature anomalous precursor is approximately 30%–40%under gasbearing coal unstable failure,which is lower than the 60%–70%of the gas-free coal.The area of the low-temperature abnormal precursor is approximately 3%–6%,which is higher than the 1%–2%of the gas-free coal.With increasing gas pressure,the area of the high-temperature anomalous precursor gradually decreases,and the area of the low-temperature anomalous precursor gradually increases.The highand low-temperature anomalous precursors of gas-bearing coal are mainly caused by gas desorption,volume expansion,and thermal friction.The presence of gas inhibits the increase in IRT on the coal surface and increases the difficulty of infrared radiation(IR)monitoring and early warning for gas-bearing coal.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11574059,61565004,and 11774288)the National Technology Major Special Project,China(Grant No.2017ZX02101007-003)+2 种基金the Natural Science Foundation of Guangxi,China(Grant Nos.2015GXNSFDA139039 and2017GXNSFBA198116)the Foundation from Guangxi Key Laboratory of Automatic Detection Technology and Instrument,China(Grant No.YQ16101)the Innovation of Guangxi Graduate Education,China(Grant Nos.2018YJCX70,2018YJCX67,and 2018YJCX74)
文摘We experimentally demonstrate an electrically triggered terahertz(THz) dual-band tunable band-pass filter based on Si_3 N_4–VO_2–Si_3 N_4 sandwich-structured hybrid metamaterials. The insulator–metal phase transition of VO_2 film is induced by the Joule thermal effect of the top metal layer. The finite-integration-time-domain(FITD) method and finite element method(FEM) are used for numerical simulations. The sample is fabricated using a surface micromachining process,and characterized by a THz time-domain-spectrometer(TDS). When the bias current is 0.225 A, the intensity modulation depths at two central frequencies of 0.56 THz and 0.91 THz are about 81.7% and 81.3%, respectively. This novel design can achieve dynamically electric–thermo–optic modulation in the THz region, and has potential applications in the fields of THz communications, imaging, sensing, and astronomy exploration.
基金co-supported by National Natural Science Foundation of China(81571326,81501153)
文摘Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely accepted.Aim This article will focus on the application of viral vectors in basic and clinical neuropsychiatric research.Methods By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of patients.Perspective Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.
基金Project supported by the National Natural Science Foundation of China(Nos.11672104 and11832009)the Natural Science Foundation of Hunan Province of China(Nos.XJT2015408 and2016JJ4027)
文摘As a typical non-smooth bifurcation, grazing bifurcation can induce instability of elementary near-grazing impact periodic motion in impact oscillators. In this paper,the stability for near-grazing period-one impact motion to suppress grazing-induced instabilities is analyzed, based on which, a control strategy is proposed. The commonly-used leading order zero time discontinuity mapping is extended to a higher order one to aid the perturbation analysis of the characteristic equation. It is shown that the degenerate grazing bifurcation can eliminate the singular term in the characteristic equation, leading to bounded eigenvalues. Based on such a precondition, the bounded eigenvalues are further restricted inside the unit circle, and a continuous transition between non-impact and controlled impact motion is observed. One discrete feedback controller that changes the velocity of the oscillator based on the selected Poincar′e sections is adopted to demonstrate the control procedure.
基金supported by the National Science and Technology Major Project(Grant No.2017ZX02101007-003)the National Natural Science Foundation of China(Grant No.61965005)+4 种基金the National Natural Science Foundation of China(Grant No.62105187)the Natural Science Foundation of Guangxi Province(Grant No.2019GXNSFDA185010)Guangxi Distinguished Expert Project,Foundation of Guangxi Key Laboratory of Optoelectronic Information Processing(Grant No.GD20104)the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QF010)the Innovation Project of Guang Xi Graduate Education(Grant No.YCSW2020158)。
文摘We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wire and four metallic split-ring resonators(SRRs)whose gaps are filled with photosensitive semiconductor gallium arsenide(GaAs)patches.We simulate the PIT effect controlled by external infrared light intensity to change the conductivity of GaAs.In the absence of photo excitation,the conductivity of Ga As is 0,thus the SRR gaps are disconnected,and the PIT effect is not observed since the dark resonator(supported by the hybrid SRRs)cannot be stimulated.When the conductivity of GaAs is increased via photo excitation,the conductivity of Ga As can increase rapidly from 0 S/m to 1×10^(6)S/m and GaAs can connect the metal aluminum SRR gaps,and the dark resonator is excited through coupling with the bright resonator(supported by the cut wire),which leads to the PIT effect.Therefore,the PIT effect can be dynamically tuned between the on and off states by controlling the intensity of the external infrared light.We also discuss couplings between one bright mode(CW)and several dark modes(SRRs)with different sizes.The interference analytically described by the coupled Lorentz oscillator model elucidates the coupling mechanism between one bright mode and two dark modes.The phenomenon can be considered the result of linear superposition of the coupling between the bright mode and each dark mode.The proposed metamaterials are promising for application in the fields of THz communications,optical storage,optical display,and imaging.
基金the National Key Technology Research and Development Program of China(2021YFD2200405 to Z.C.)the National Natural Science Foundation of China(31270640and 31070532 to C.L.)the China Postdoctoral Science Foundation(2019M661489 to B.D.).
基金supported by the National Key Research and Development Project(2022YFF1301104)the National Natural Science Foundation of China(3217186542271096)。
文摘The size and composition of particulate matter(PM)are pivotal in determining its adverse health effects.It is important to understand PM's retention by plants to facilitate its atmospheric removal.However,the distinctions between the size and composition of naturally fallen PM(NFPM)and leaf-deposited PM(LDPM)are not well-documented.Here we utilize a single-particle aerosol mass spectrometer,coupled with a PM resuspension chamber,to analyze these differences.We find that LDPM particles are 6.8 e97.3%larger than NFPM.Employing a neural network algorithm based on adaptive resonance theory,we have identified distinct compositional profiles:NFPM predominantly consists of organic carbon(OC;31.2%)and potassium-rich components(19.1%),whereas LDPM are largely composed of crustal species(53.9e60.6%).Interestingly,coniferous species retain higher OC content(11.5e13.7%)compared to broadleaved species(0.5e1.2%),while the levoglucosan content exhibit an opposite trend.Our study highlights the active role of tree leaves in modifying PM composition beyond mere passive capture,advocating for a strategic approach to species selection in urban greening initiatives to enhance PM mitigation.These insights provide guidance for urban planners and environmentalists in implementing nature-based solutions to improve urban air quality.
基金supported by the Natural Science Foundation of China(Project number:32371843)the Science and Technology Commission of Shanghai Municipality(Project number:22230713300).
文摘Neighborhood gardens serve as sensitive sites for human microbial encounters,with phyllosphere microbes directly impacting our respiratory health.Yet,our understanding remains limited on how factors like season,garden age,and land use shape the risk of respiratory diseases(RDs)tied to these garden microbes.Here we examined the microbial communities within the phyllosphere of 72 neighborhood gardens across Shanghai,spanning different seasons(warm and cold),garden ages(old and young),and locales(urban and rural).We found a reduced microbial diversity during the cold season,except for Gammaproteobacteria which exhibited an inverse trend.While land use influenced the microbial composition,urban and rural gardens had strikingly similar microbial profiles.Alarmingly,young gardens in the cold season hosted a substantial proportion of RDs-associated species,pointing towards increased respiratory inflammation risks.In essence,while newer gardens during colder periods show a decline in microbial diversity,they have an increased presence of RDs-associated microbes,potentially escalating respiratory disease prevalence.This underscores the pivotal role the garden age plays in enhancing both urban microbial diversity and respiratory health.
基金Major Science and Technology Special Projects of Sichuan Province,Grant/Award Number:2021ZDZX0006。
文摘The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power density.The bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant converter.However,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)phenomenon.The oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency operation.The authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be implemented.To facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with ease.The relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH phenomenon.Finally,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.
基金supported by the Key Program of the National Natural Science Foundation of China(Grant No.11832009)the National Natural Science Foundation of China(Grant No.12122206).
基金supported by the National Natural Science Foundation of China (Grant Nos.11832009 and 12102132)China Postdoctoral Science Foundation (Grant No.2020M682545)Science and Technology Innovation Program of Hunan Province (Grant No.2020RC2027).
基金Clinical Research Plan of SHDC,Grant/Award Number:SHDC2020CR1037BShanghai Municipal Key Clinic Specialty,Grant/Award Number:shslczdzk00602+16 种基金National Key R&D Program of China,Grant/Award Number:2017YFC0908100National Science and Technology Major Project,Grant/Award Numbers:2018ZX10302206,2018ZX10723203,2017ZX10202202Shanghai Municipal Education Commission–Guofeng Clinical Medicine Grant Support,Grant/Award Number:20152213National Natural Science Foundation of China,Grant/Award Numbers:82170629,81930061,81900579,81970550,82070613,82070650,81972265,81870425,81774234Shanghai Hospital Development Commission,Grant/Award Number:16CR1024BChongqing Natural Science Foundation,Grant/Award Number:CSTC2019jcyjzdxmX0004Beijing Municipal Science&Technology Commission,Grant/Award Number:Z191100006619033Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program,Grant/Award Number:2017BT01S131Clinical Research Program of Nanfang Hospital,Southern Medical University,Grant/Award Numbers:2018CR037,2020CR026Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education,Grant/Award Number:LC2019ZD006President Foundation of Nanfang Hospital,Southern Medical University,Grant/Award Number:2019Z003Foundation for Innovative Research Groups of Hubei Provincial Natural Science Foundation,Grant/Award Number:2018CFA031Hubei Province's Outstanding Medical Academic Leader Program and Project of Hubei University of Medicine,Grant/Award Numbers:FDFR201902,2020XGFYZR05Fundamental Research Funds for the Central Universities,Grant/Award Number:2021FZZX001-41Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2020A1515010052Natural Fund of Guangdong Province,Grant/Award Number:2016A030313237Guangzhou City Science and Technology Project,Grant/Award Number:201607010064。
文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality.