The mining loss rate and dilution rate are the key indicators for the mining technology and management level of mining enterprises. Aiming at the practical problems such as the large workload but inaccurate data of th...The mining loss rate and dilution rate are the key indicators for the mining technology and management level of mining enterprises. Aiming at the practical problems such as the large workload but inaccurate data of the traditional loss and dilution calculation method, this thesis introduces the operating principle and process of calculating the loss rate and dilution rate at the mining fields by adopting geological models. As an example, authors establishes 3D models of orebody units in the exhausted area and mining fields in Yangshu Gold Mine in Liaoning Province, and conduct Boolean calculation among the models to obtain the calculation parameters of loss and dilution, and thereby calculate out the dilution rate and loss rate of the mining fields more quickly and accurately.展开更多
With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,P...With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more.展开更多
This paper has systematically researched mineral assemble and the characteristics of gold-mercury minerals in Davao Placer in Mindanao Islands, Philippines. The results show that reflection force of gold-mercury miner...This paper has systematically researched mineral assemble and the characteristics of gold-mercury minerals in Davao Placer in Mindanao Islands, Philippines. The results show that reflection force of gold-mercury minerals has a strong-weak-strong of changes features as mercury's content in minerals increased. Otherwise their hardness of gold-mercury minerals reduced. While the hardness of gold-mercury minerals, which have isometric crystal structure, they are gradually become larger, the goldmalgam and r-Goldmalgamite just be found to exist as natural edge of gold-mercury mineral grains. Overall, mercury content is gradually reduced from the edge to the centre of gold-mercury minerals particles, but mercury-bearing in edge of the grains is lower than in the middle. Combination of the background of geological mineralization, this paper suggests that there are mantle-derived deposits such as Platinum, chromium in Philippines, which accompanied ultramafic-mafic magmation. It's most likely to found some large or extra large scale polymetallic deposits of gold and mercury, as well as coastal placers of gold, platinum, etc.展开更多
Calcitonin is a common medicine used in the treatment of osteoporosis,which could restrain the activity of osteoclasts,stop the loss of osteocalcin and reduce the transfer of osteocalcin.Calcitonin can also be used in...Calcitonin is a common medicine used in the treatment of osteoporosis,which could restrain the activity of osteoclasts,stop the loss of osteocalcin and reduce the transfer of osteocalcin.Calcitonin can also be used in the treatment of the pain-caused diseases which usually cause by hypercalcemia and others such like Paget's disease and bone tumors.As is approved by several clinic researches,calcitonin is powerful in adjusting the level of calcium,phosphorus and PTH during the treatment of renal osteodystrophy.In addition,it could improves the life quality of the patients who suffered from chronic kidney disease(CKD)and extending their life period.At present,several studies have shown us Calcitonin could be treated in renal osteodystrophy.However,the treatment experiences of Calcitonin are still lacking.Better understanding of the clinical evaluation for calcitonin in the treatment of renal osteodystrophy will hopefully help us to improve outcomes for these patients.展开更多
Fibroblast growth factor 23(FGF23)is a protein synthesized by bone cell and the osteoblast with endocrine function.The main role of FGF23 is to regulate serum phosphorus and 1,25(OH)2 D3 levels,it also plays an import...Fibroblast growth factor 23(FGF23)is a protein synthesized by bone cell and the osteoblast with endocrine function.The main role of FGF23 is to regulate serum phosphorus and 1,25(OH)2 D3 levels,it also plays an important role in calcium and phosphorus metabolism.The role of FGF23 in renal disease is to inhibit of phosphorus reabsorption,promote urinary phosphorus excretion and maintain a stable blood phosphorus level.Patients with chronic kidney disease(CKD)have more risk to suffer cardiovascular disease(CVD)which is related to the abnormal metabolism of calcium and phosphorus.FGF23,as newly discovered cardiovascular risk marker,several studies have shown that FGF23 level associates with multiple cardiovascular risk factors in CKD patients,especially in CKD patients with vascular calcification.To explore its pathogenesis of vascular calcification in CKD patients is particularly important,and that may help to take appropriate measures to improve the prognosis of CKD patients.展开更多
There are 3 kinds of Renal Replacement Therapy:hemodialysis,peritoneal dialysis and kidney transplantation.Although a kidney transplant would be the best solution,organ donations are limited and the transplanted organ...There are 3 kinds of Renal Replacement Therapy:hemodialysis,peritoneal dialysis and kidney transplantation.Although a kidney transplant would be the best solution,organ donations are limited and the transplanted organs can be rejected by the body.Hemodialysis is a widely recognized and near-universally available treatment method,however,the patient must make at least 3 weekly visits to a hospital to undergo treatment,with each session lasting on average around 4 hours.Consequently this can have an impact on the patients’life,including work and travel.Since the clinical populariza-展开更多
Shape-persistent arylene ethynylene molecular cages have been investigated as transmembrane channels for ions and small molecules.The molecular cages were obtained starting from tetrayne monomers through alkyne metath...Shape-persistent arylene ethynylene molecular cages have been investigated as transmembrane channels for ions and small molecules.The molecular cages were obtained starting from tetrayne monomers through alkyne metathesis cyclooligomerization.We found these porphyrin-based rigid molecular cages can insert into the lipid bilayer and efficiently transport ions and small molecules(e.g.,calcein).Our study reveals longer hydrophobic alkyl chains on the cage molecule promote the channeling efficiency,while shorter and/or more polar side chains impair such activity.Kinetic analysis shows linear correlation between the rate of proton transport and the concentration of the cage,suggesting the active species is likely a monomeric cage.We found that C_(70)-encapsulated cages are nearly inactive for transmembrane ion transportation,indicating that ions are likely transported through the internal cavity of the cage.Discrete shape-persistent organic cages represent highly stable synthetic ion channels or pores,which could have interesting applications in biomimetic signaling and drug delivery.展开更多
Covalent organic frameworks(COFs)have garnered increasing attention as promising electrode materials for sodium-ion batteries(SIBs)due to their ordered backbones,uniform pore sizes,and high surface areas.However,they ...Covalent organic frameworks(COFs)have garnered increasing attention as promising electrode materials for sodium-ion batteries(SIBs)due to their ordered backbones,uniform pore sizes,and high surface areas.However,they also face challenges,including low capacity,unsatisfactory rate performance,and limited cycling stability,which pose the primary obstacles to their practical use.Herein,a pyrenoimidazole-based COF,denoted as PyIm-COF,has been synthesized as a novel electrode material for highperformance SIBs using an efficient synthetic strategy.With extended fully conjugated backbones and readily accessible redox-active sites,PyIm-COF demonstrates remarkable high-rate performance,delivering around 250 m Ah g^(−1)and excellent cycling stability,retaining 97.2%of its capacity even after 2500 cycles at 5 A g^(−1),which is higher than that of most previously reported COF-based SIBs.This work provides valuable insights into the development of nitrogen-rich conjugated COF electrode materials for rechargeable SIBs.展开更多
We report a series of highly stable metallophthalocyanine-based covalent organic frameworks(MPc-dxCOFs) linked by robust 1,4-dioxin bonds constructed through nucleophilic aromatic substitution(SNAr)reaction. The chemi...We report a series of highly stable metallophthalocyanine-based covalent organic frameworks(MPc-dxCOFs) linked by robust 1,4-dioxin bonds constructed through nucleophilic aromatic substitution(SNAr)reaction. The chemical structures and crystallinity of the COFs largely remain unchanged even after treating with boiling water(90°C), concentrated acids(12 mol/L HCl) or bases(12 mol/L Na OH), oxidizing(30% H_(2)O_(2)) or reducing agents(1 mol/L NaBH;) for three days due to their stable M-Pc building blocks and resilient dioxin linkers. With metallated phthalocyanine active sites regularly arranged in the stable framework structures, MPc-dx-COFs can be directly used as efficient electrocatalysts for the oxygen reduction reaction(ORR) without pyrolysis treatment that has commonly been used in previous studies.展开更多
文摘The mining loss rate and dilution rate are the key indicators for the mining technology and management level of mining enterprises. Aiming at the practical problems such as the large workload but inaccurate data of the traditional loss and dilution calculation method, this thesis introduces the operating principle and process of calculating the loss rate and dilution rate at the mining fields by adopting geological models. As an example, authors establishes 3D models of orebody units in the exhausted area and mining fields in Yangshu Gold Mine in Liaoning Province, and conduct Boolean calculation among the models to obtain the calculation parameters of loss and dilution, and thereby calculate out the dilution rate and loss rate of the mining fields more quickly and accurately.
基金Guangdong Obers Blood Purification Aca demician Work station(2013B090400004)Science and technology plan project of Guangdong industrial high and new technology field(2013B010203019)+3 种基金Guangzhou entrepreneurial leader talent/LCY201215Guangdong Inno vation Fund Project(2014A010101123)Guangdong Provincial Center for clinical en gineering of blood purification(507204531040)Guangdong University blood purification technology and Engineering Research Center(GCZX-A1104)
文摘With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more.
文摘This paper has systematically researched mineral assemble and the characteristics of gold-mercury minerals in Davao Placer in Mindanao Islands, Philippines. The results show that reflection force of gold-mercury minerals has a strong-weak-strong of changes features as mercury's content in minerals increased. Otherwise their hardness of gold-mercury minerals reduced. While the hardness of gold-mercury minerals, which have isometric crystal structure, they are gradually become larger, the goldmalgam and r-Goldmalgamite just be found to exist as natural edge of gold-mercury mineral grains. Overall, mercury content is gradually reduced from the edge to the centre of gold-mercury minerals particles, but mercury-bearing in edge of the grains is lower than in the middle. Combination of the background of geological mineralization, this paper suggests that there are mantle-derived deposits such as Platinum, chromium in Philippines, which accompanied ultramafic-mafic magmation. It's most likely to found some large or extra large scale polymetallic deposits of gold and mercury, as well as coastal placers of gold, platinum, etc.
基金Guangzhou Development Zone entrepreneurship leading talent project(2017-L153)Guangdong University blood purification technology and Engineering Research Center(GCZX-A1104)+2 种基金Guangzhou entrepreneurial leader talent/LCY201215Guangdong Provincial Center for clinical engineering of blood purification(507204531040)Guangdong Obers Blood Purification A cademician Work station(2013B090400004)
文摘Calcitonin is a common medicine used in the treatment of osteoporosis,which could restrain the activity of osteoclasts,stop the loss of osteocalcin and reduce the transfer of osteocalcin.Calcitonin can also be used in the treatment of the pain-caused diseases which usually cause by hypercalcemia and others such like Paget's disease and bone tumors.As is approved by several clinic researches,calcitonin is powerful in adjusting the level of calcium,phosphorus and PTH during the treatment of renal osteodystrophy.In addition,it could improves the life quality of the patients who suffered from chronic kidney disease(CKD)and extending their life period.At present,several studies have shown us Calcitonin could be treated in renal osteodystrophy.However,the treatment experiences of Calcitonin are still lacking.Better understanding of the clinical evaluation for calcitonin in the treatment of renal osteodystrophy will hopefully help us to improve outcomes for these patients.
基金Construction of collaborative platform for clin ical re search and clinical research of blood purification(201604020175)Guang dong University blood purification tech nology and Engineering Research Center(GCZX-A1104)+2 种基金Guangdong Obers Blood Purification A ca demi cian Work station(2013B090400004)Guangdong Provincial Center for clinical en gineering of blood purification(507204531040)Guangzhou entrepreneurial leader talent/LCY201215
文摘Fibroblast growth factor 23(FGF23)is a protein synthesized by bone cell and the osteoblast with endocrine function.The main role of FGF23 is to regulate serum phosphorus and 1,25(OH)2 D3 levels,it also plays an important role in calcium and phosphorus metabolism.The role of FGF23 in renal disease is to inhibit of phosphorus reabsorption,promote urinary phosphorus excretion and maintain a stable blood phosphorus level.Patients with chronic kidney disease(CKD)have more risk to suffer cardiovascular disease(CVD)which is related to the abnormal metabolism of calcium and phosphorus.FGF23,as newly discovered cardiovascular risk marker,several studies have shown that FGF23 level associates with multiple cardiovascular risk factors in CKD patients,especially in CKD patients with vascular calcification.To explore its pathogenesis of vascular calcification in CKD patients is particularly important,and that may help to take appropriate measures to improve the prognosis of CKD patients.
基金Guangdong Obers Blood Purification Aca demician Work station(2013B090400004)Guangzhou entrepreneurial leader talent/LCY201215+3 种基金Science and technology plan project of Guangdong in dustri al high and new technology field(2013B010203019)Construc tion of col laborative platform for clinical research and clinical research of blood purification(201604020175)Guangdong University blood purifi cation tech nology and Engineering Re search Center(GCZX-A1104)Guangdong Innovation Fund Project(2014A010101123)
文摘There are 3 kinds of Renal Replacement Therapy:hemodialysis,peritoneal dialysis and kidney transplantation.Although a kidney transplant would be the best solution,organ donations are limited and the transplanted organs can be rejected by the body.Hemodialysis is a widely recognized and near-universally available treatment method,however,the patient must make at least 3 weekly visits to a hospital to undergo treatment,with each session lasting on average around 4 hours.Consequently this can have an impact on the patients’life,including work and travel.Since the clinical populariza-
基金financial support by the Summer Graduate School Fellowship from University of Colorado Boulder。
文摘Shape-persistent arylene ethynylene molecular cages have been investigated as transmembrane channels for ions and small molecules.The molecular cages were obtained starting from tetrayne monomers through alkyne metathesis cyclooligomerization.We found these porphyrin-based rigid molecular cages can insert into the lipid bilayer and efficiently transport ions and small molecules(e.g.,calcein).Our study reveals longer hydrophobic alkyl chains on the cage molecule promote the channeling efficiency,while shorter and/or more polar side chains impair such activity.Kinetic analysis shows linear correlation between the rate of proton transport and the concentration of the cage,suggesting the active species is likely a monomeric cage.We found that C_(70)-encapsulated cages are nearly inactive for transmembrane ion transportation,indicating that ions are likely transported through the internal cavity of the cage.Discrete shape-persistent organic cages represent highly stable synthetic ion channels or pores,which could have interesting applications in biomimetic signaling and drug delivery.
基金the Natural Science Foundation of Liaoning province(grant no.2019-MS-046)W.Zhang thanks the University of Colorado Boulder for financial support of this work+1 种基金W.Huang acknowledges the support from the National Natural Science Foundation of China(grant no.21875206)The authors acknowledge the assistance of the Dalian University of Technology Instrumental Analysis Center.
文摘Covalent organic frameworks(COFs)have garnered increasing attention as promising electrode materials for sodium-ion batteries(SIBs)due to their ordered backbones,uniform pore sizes,and high surface areas.However,they also face challenges,including low capacity,unsatisfactory rate performance,and limited cycling stability,which pose the primary obstacles to their practical use.Herein,a pyrenoimidazole-based COF,denoted as PyIm-COF,has been synthesized as a novel electrode material for highperformance SIBs using an efficient synthetic strategy.With extended fully conjugated backbones and readily accessible redox-active sites,PyIm-COF demonstrates remarkable high-rate performance,delivering around 250 m Ah g^(−1)and excellent cycling stability,retaining 97.2%of its capacity even after 2500 cycles at 5 A g^(−1),which is higher than that of most previously reported COF-based SIBs.This work provides valuable insights into the development of nitrogen-rich conjugated COF electrode materials for rechargeable SIBs.
基金supported by University of Colorado Boulder and K. C. Wong Education Foundationfinancial support by the Koch Graduate fellowship。
文摘We report a series of highly stable metallophthalocyanine-based covalent organic frameworks(MPc-dxCOFs) linked by robust 1,4-dioxin bonds constructed through nucleophilic aromatic substitution(SNAr)reaction. The chemical structures and crystallinity of the COFs largely remain unchanged even after treating with boiling water(90°C), concentrated acids(12 mol/L HCl) or bases(12 mol/L Na OH), oxidizing(30% H_(2)O_(2)) or reducing agents(1 mol/L NaBH;) for three days due to their stable M-Pc building blocks and resilient dioxin linkers. With metallated phthalocyanine active sites regularly arranged in the stable framework structures, MPc-dx-COFs can be directly used as efficient electrocatalysts for the oxygen reduction reaction(ORR) without pyrolysis treatment that has commonly been used in previous studies.