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芪苈强心胶囊辅助沙库巴曲缬沙坦钠治疗射血分数降低型慢性心力衰竭患者的临床疗效
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作者 张世威 沈志方 常国栋 《四川生理科学杂志》 2024年第6期1226-1229,共4页
目的:研究芪苈强心胶囊辅助沙库巴曲缬沙坦钠治疗射血分数降低型慢性心力衰竭(Heart failure with reduced ejection fraction,HFrEF)患者的临床疗效。方法:选取我院2020年12月至2022年12月收治的HFrEF患者78例,随机分为西药组、中药辅... 目的:研究芪苈强心胶囊辅助沙库巴曲缬沙坦钠治疗射血分数降低型慢性心力衰竭(Heart failure with reduced ejection fraction,HFrEF)患者的临床疗效。方法:选取我院2020年12月至2022年12月收治的HFrEF患者78例,随机分为西药组、中药辅助组,各39例。西药组采用沙库巴曲缬沙坦钠治疗,中药辅助组采用芪苈强心胶囊辅助沙库巴曲缬沙坦钠治疗。治疗3 m后,比较两组临床疗效,四维心脏彩超仪检测心率、左心室射血分数(Left ventricular ejection fraction,LVEF)、左心室后壁厚度(Left ventricular posterior wall thickness,LVWP)、每搏输出量(Stroke volume,SV),24 h动态心电分析系统检测正常窦性心搏间期标准差(Standard deviation of NN intervals,SDNN)、相邻RR间期差值均方根(Root mean square of successive R-R interval differences,RMSSD),酶联免疫吸附法检测血清半乳糖凝集素3(Galectin-3,Gal-3)、心肌肌钙蛋白(Cardiac Troponin T,cTnT)、生长刺激表达基因2蛋白(Soluble growth stimulation expressed gene 2,sST2)、B型利钠肽(Brain natriuretic peptide,BNP)水平;治疗后随访6 m,比较两组主要不良心血管事件(Major adverse cardiovascular events,MACE)发生情况。结果:治疗后,中药辅助组临床总有效率高于西药组(P<0.05);与治疗前相比,两组治疗后心率、LVWP均降低,LVEF、SV均升高,其中中药辅助组改善更为显著(P<0.05);与治疗前相比,两组治疗后RMSSD、SDNN均升高,血清Gal-3、cTnT、sST2、BNP水平均降低,其中中药辅助组改善更为显著(P<0.05);治疗后随访6 m,中药辅助组MACE发生率略低于西药组,但组间比较,差异无统计学意义(P>0.05)。结论:芪苈强心胶囊辅助合沙库巴曲缬沙坦钠治疗HFrEF疗效显著,可改善心率变异性,增强心功能,减轻心肌损伤,改善心室重构,降低MACE发生的风险。 展开更多
关键词 射血分数降低型慢性心力衰竭 芪苈强心胶囊 沙库巴曲缬沙坦钠
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尼可地尔辅助替罗非班治疗急性STEMIPCI术后患者的疗效观察
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作者 张世威 沈志方 常国栋 《四川生理科学杂志》 2023年第7期1205-1208,共4页
目的:探讨尼可地尔辅助替罗非班治疗行经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)的急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者的疗效。方法:收集2019年10月至2021年10月我院收... 目的:探讨尼可地尔辅助替罗非班治疗行经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)的急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者的疗效。方法:收集2019年10月至2021年10月我院收治的急性STEMI患者84例,两组均行PCI治疗,随机分为替罗非班组(n=42)和尼可地尔辅助组(n=42)。替罗非班组接受替罗非班治疗,尼可地尔辅助组在替罗非班组基础上给予尼可地尔辅助治疗。治疗1 m后,比较两组心功能指标、凝血功能指标、心肌梗死溶栓试验血流分级、氧化应激相关指标、心血管不良事件(Major adverse cardiovascular events,MACE)发生率。结果:治疗后,尼可地尔辅助左心室舒张末期的内径、左心室收缩末期的内径、血清纤维蛋白原、丙二醛水平低于替罗非班组,左心室的射血分数、凝血酶时间、活化部分凝血酶时间、凝血酶原时间、超氧化物歧化酶、还原型谷胱甘肽水平高于替罗非班组,血流分级情况优于替罗非班组(P<0.05);尼可地尔辅助组MACE发生率(7.14%)低于替罗非班组(23.81%)(P<0.05)。结论:尼可地尔辅助替罗非班治疗行PCI术的急性STEMI患者可有效改善患者心功能和凝血功能,有效缓解机体的氧化应激状态,减少MACE的发生,有利于患者PCI术后的康复和预后。 展开更多
关键词 尼可地尔 替罗非班 经皮冠状动脉介入术 急性心肌梗死
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冠心病合并Hp感染患者糖脂代谢和斑块特征及miR-146a、IL-33、ST2水平
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作者 崔玉凤 马红岩 +1 位作者 沈志方 常国栋 《中华医院感染学杂志》 CAS CSCD 北大核心 2024年第11期1649-1653,共5页
目的探究冠心病合并幽门螺杆菌(Hp)感染对糖脂代谢和斑块特征及微小RNA-146a(miR-146a)、白细胞介素-33(IL-33)、致瘤性抑制因子2(ST2)的影响.方法选择2018年6月-2022年6月商丘市第一人民医院就诊的单纯冠心病(未合并Hp感染)患者86例作... 目的探究冠心病合并幽门螺杆菌(Hp)感染对糖脂代谢和斑块特征及微小RNA-146a(miR-146a)、白细胞介素-33(IL-33)、致瘤性抑制因子2(ST2)的影响.方法选择2018年6月-2022年6月商丘市第一人民医院就诊的单纯冠心病(未合并Hp感染)患者86例作为未感染组,另选取同期于医院治疗的冠心病合并Hp感染患者60例作为感染组;比较两组糖代谢相关指标[空腹血糖、胰高血糖素、胰高血糖素样肽-1(GLP-1)、生长抑素(SS)、胰岛素]、脂代谢相关指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、斑块特征、miR-146a及血清IL-33、ST2表达水平,对比不同感染程度患者以上指标.结果感染组空腹血糖、胰高血糖素、TG、TC较未感染组高,而SS、HDL-C较未感染组低(P<0.05);感染组颈动脉内膜中层厚度(IMT)、斑块面积比未感染组高(P<0.05);感染组混合斑、硬斑较未感染组少,软斑较未感染组多(P<0.05);感染组miR-146a、血清IL-33、ST2水平均高于较未感染组(P<0.05);随冠心病合并Hp感染者的感染程度增加,miR-146a及血清IL-33、ST2水平均增加(P<0.05).结论Hp感染可导致冠心病患者糖脂代谢出现紊乱,斑块稳定性下降,miR-146a及血清IL-33、ST2水平升高,促进病情进展. 展开更多
关键词 冠心病 幽门螺杆菌 斑块特征 MIR-146A 白细胞介素-33 致瘤性抑制因子2
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Effect of acupuncture and tuina plus rehabilitative therapy on lower limb motor dysfunction in infants with spastic cerebral palsy 被引量:13
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作者 shen zhi-fang Luo Kai-tao Yan Yu-qin 《Journal of Acupuncture and Tuina Science》 CSCD 2017年第1期31-35,共5页
Objective: To observe the effect of acupuncture, tuina plus rehabilitative therapy on lower limb motor dysfunction in infants with spastic cerebral palsy. Methods: A total of 60 infants with spastic cerebral palsy w... Objective: To observe the effect of acupuncture, tuina plus rehabilitative therapy on lower limb motor dysfunction in infants with spastic cerebral palsy. Methods: A total of 60 infants with spastic cerebral palsy were randomly divided into a treatment group and a control group by random digital table, 30 cases in each group. The treatment group was treated with acupuncture, tuina therapy plus rehabilitative therapy of Western medicine. The control group was simply treated with rehabilitative therapy of Western medicine, as same as that for the treatment group. The assessment was respectively given to the sick infants before the treatment and after the treatment of six months, to evaluate lying and rolling scores in dimension A, to evaluate sitting score in dimension B, to evaluate crawling and kneeling scores in dimension C, and evaluate standing score in dimension D in the gross motor functions and determine the muscle tone of the gastrocnemius muscle by modified Ashworth scale (MAS). Results: The differences were not statistically significant in comparison of the gross motor functions and the muscle tone of the gastrocnemius muscle between the two groups of sick infants before the treatment (P〉O.OS); after the treatment of six months, the above items were obviously improved in the two groups (P〈O.01), better in the treatment group than in the control group, with the statistical significance in the differences between the groups (P〈O.01). Conclusion: Acupuncture, tuina plus rehabilitative therapy of Western medicine are remarkable in the therapeutic effects in the treatment of motor disorders of the lower limbs in the sick infants with spastic cerebral palsy. This therapeutic method is safe, simple and convenient and needs to be clinically popularized and applied. 展开更多
关键词 Acupuncture Therapy TUINA MASSAGE Rehabilitation Cerebral Palsy Myospasm Movement Disorders INFANT
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Therapeutic Efficacy Observation on Combining Intermittent Traction with Warm Needling for Cervical Radiculopathy 被引量:16
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作者 Ni Chun-chu Yao Li-mei +2 位作者 shen zhi-fang Yan Yu-qin Han Chou-ping 《Journal of Acupuncture and Tuina Science》 2013年第6期367-370,共4页
Objective:To observe the clinical effect of combined intermittent traction with warm needling for cervical radiculopathy.Methods:A total of 100 cases with cervical radiculopathy were randomly allocated into an observa... Objective:To observe the clinical effect of combined intermittent traction with warm needling for cervical radiculopathy.Methods:A total of 100 cases with cervical radiculopathy were randomly allocated into an observation group and a control group.Cases in the observation group were treated with intermittent traction coupled with warm needling,whereas cases in the control group were treated with warm needling alone.The therapeutic efficacy was observed after 20-day treatment.Results:The markedly effective rate in total was 90.0%in the observation group,versus 78.0%in the control group,showing a statistically significant difference(P<0.05).Conclusion:Combining intermittent traction with warm needling is safe,convenient and significantly effective for cervical radiculopathy.It is worth further popularization in clinical practice. 展开更多
关键词 TRACTION Warm Needling Therapy Acupuncture Therapy Moxibustion Therapy Neck Pain SPONDYLOSIS
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Clinical observation on warm needling moxibustion plus tuina for cervical spondylosis of vertebral artery type 被引量:11
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作者 Xu Jia shen zhi-fang +1 位作者 Wu Yin-jun Bian Xiao-dong 《Journal of Acupuncture and Tuina Science》 CSCD 2019年第2期111-115,共5页
Objective: To observe the clinical effect of warm needling moxibustion plus Kai Qing Long Suo tuina therapy (opening the Qing Long lock, one type of 'Eight and a Half Locks' tuina therapy) for cervical spondyl... Objective: To observe the clinical effect of warm needling moxibustion plus Kai Qing Long Suo tuina therapy (opening the Qing Long lock, one type of 'Eight and a Half Locks' tuina therapy) for cervical spondylosis of vertebral artery type (CSA). Methods: Sixty patients with CSA were randomly allocated into an observation group or a control group, with 30 cases in each group. The observation group was treated with warm needling moxibustion plus Kai Qing Long Suo tuina therapy, while the control group was treated with warm needling moxibustion alone. Warm needling moxibustion was conducted once every other day and tuina was con ducted once a day, 7-day treatme nts for one course. The clin ical efficacy and vertebral artery blood flow was observed after one course of treatment. Results: After treatment, the total effective rate was 93.3% in the observation group versus 80.0% in the control group, and there was a significant differenee between the two groups (P<0.05). After treatment, the systolic blood flow velocity of vertebral artery increased in both groups, with statistical significanee compared with that before treatment (both P<0.05), and the blood flow velocity in the observation group was faster than that in the control group, with statistical significanee between the two groups (P<0.05). Conclusion: Both warm needling moxibustion plus Kai Qing Long Suo tuina therapy and warm needling moxibustion alone are both effective for CSA, can improve the systolic blood flow velocity of vertebral artery. The curative effect of warm needling moxibusiton plus Kai Qing Long Suo tuina therapy is better than that of warm needling moxibustion alone. 展开更多
关键词 Acup un cture Therapy Warm Needling Moxibusit on TUINA Massage Vertebrobasilar In sufficiency VERTIGO Cervical Spondylosis
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Yi Jin Jing (Sinew-transforming Qigong Exercises) for primary osteoporosis in the elderly: a clinical trial 被引量:10
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作者 shen zhi-fang Zhu Gao-feng +1 位作者 Qian Li-feng Fu Yuan-xin 《Journal of Acupuncture and Tuina Science》 CSCD 2018年第2期104-108,共5页
Objective:To observe the clinical efficacy of Yi Jin Jing (Sinew-transforming Qigong Exercises) for primary osteoporosis in the elderly.Methods:Eighty old patients with primary osteoporosis were randomized into a ... Objective:To observe the clinical efficacy of Yi Jin Jing (Sinew-transforming Qigong Exercises) for primary osteoporosis in the elderly.Methods:Eighty old patients with primary osteoporosis were randomized into a Yi Jin Jing group and a medication group,40 cases in each group.The Yi Jin Jing group was intervened by Yi Jin Jing (Sinew-transforming Qigong Exercises) training,while the medication group was intervened by oral administration of alendronate sodium tablet.Prior to and after 6-month intervention,the bone mineral density (BMD) of the proximal femur,visual analog scale (VAS) and activities of daily living (ADL) were estimated.Results:There were no significant differences in the BMD of the proximal femur,and VAS and ADL scores between the two groups before the intervention (P〉0.05).After 6-month intervention,the above items all improved significantly in both groups (both P〈0.01);the improvements in VAS and ADL scores in Yi Jin Jing group were more significant than those in the medication group (P〈0.01),while the between-group difference in the BMD of the proximal femur was statistically insignificant (P〉0.05).Conclusion:Practice of Yi Jin Jing (Sinew-transforming Qigong Exercises) can effectively ameliorate the BMD in the elderly with primary osteoporosis,and it can reduce the pain and improve ADL,with a better general effect compared to oral administration of alendronate sodium tablet. 展开更多
关键词 Yi Jin Jing Physical and Breathing Exercises Exercise Osteoporosis Bone Density Pain Activities of Daily Living Aged
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Effect of Yi Jin Jing(Sinew-transforming Qigong Exercises) on skeletal muscle strength in the elderly 被引量:8
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作者 Zhu Gao-feng shen zhi-fang +2 位作者 shen Qing-he Jin Yue-qin Lou Zhi-yong 《Journal of Acupuncture and Tuina Science》 CSCD 2017年第6期434-439,共6页
Objective: To observe the effect of Yi Jin Jing(Sinew-transforming Qigong Exercises) on the muscle strength in senile sarcopenia. Methods: Sixty-five old people with sarcopenia were randomized into Yi Jin Jing gro... Objective: To observe the effect of Yi Jin Jing(Sinew-transforming Qigong Exercises) on the muscle strength in senile sarcopenia. Methods: Sixty-five old people with sarcopenia were randomized into Yi Jin Jing group and a blank control group. Thirty-three patients in Yi Jin Jing group practiced Yi Jin Jing(Sinew-transforming Qigong Exercises), while 32 patients in the blank control group didn't receive any interventions. The muscle strength was measured before and after 12-week training. Results: During the study, each group had 1 dropout. The muscle strength was improved after 12-week training in Yi Jin Jing group, and the difference was statistically significant(P〈0.05); there was no significant difference in the blank control group(P〈0.05). After the intervention, there was a significant difference between Yi Jin Jing group and the blank control group in comparing the muscle strength(P〈0.05). Conclusion: Constant Yi Jin Jing(Sinew-transforming Qigong Exercises) training can notably improve skeletal muscle strength in senile sarcopenia. 展开更多
关键词 YiJin Jing Physical and Breathing Exercises QIGONG Exercise SARCOPENIA Muscle Strength Aged
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Clinical Observation of Chinese Herbal Fumigation plus Mulberry Stick Beating for Heel Pain 被引量:1
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作者 shen Qing-he shen zhi-fang +2 位作者 Yan Yu-qin Zhu Gao-feng Hong Jue 《Journal of Acupuncture and Tuina Science》 2014年第6期350-353,共4页
Objective: To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods: Sixty patients with heel pain were randomized into a treatment group and a c... Objective: To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods: Sixty patients with heel pain were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by Chinese herbal fumigation plus beating with mulberry stick, and the control group was by orally taking Diclofenac Sodium Sustained Release Tablets plus external use of She Xiong Zhen Tong Gao (Moschus Analgesic Plaster). After one treatment course, the visual analogue scale (VAS) was used to observe the change of pain, and the clinical efficacies were also evaluated. Results: After intervention, the improvement of VAS score in the treatment group was more significant than that in the control group (P〈0.01). The total effective rate of the treatment group was significantly higher than that of the control group (P〈0.01). Conclusion: Chinese herbal fumigation plus beating with mulberry stick can produce a higher clinical efficacy than orally taking Diclofenac Sodium Sustained Release Tablets in treating heel pain. 展开更多
关键词 Drugs Chinese Herbal FUMIGATION Flapping Therapy TUINA Massage Points Ashi Heel Pain
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Tuina plus Ultrasonic Therapy for Infantile Muscular Torticollis 被引量:1
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作者 shen zhi-fang Luo Kai-tao +2 位作者 Zhu Gao-feng Jin Yue-qin Hong Jue 《Journal of Acupuncture and Tuina Science》 2014年第6期389-392,共4页
Objective: To observe the clinical efficacy of tuina plus ultrasonic therapy in treating infantile muscular torticollis. Methods: Seventy kids with muscular torticollis were intervened by tuina plus ultrasonic therapy... Objective: To observe the clinical efficacy of tuina plus ultrasonic therapy in treating infantile muscular torticollis. Methods: Seventy kids with muscular torticollis were intervened by tuina plus ultrasonic therapy, and the efficacy was evaluated after 8-month treatment. Results: After 8-month treatment, 41 subjects were cured, accounting for 58.6%, 27 were improved, occupying 38.6%, 2 failed, occupying 2.8%, and the total effective rate was 97.2%. Conclusion: Tuina plus ultrasonic therapy can produce a significant efficacy in treating infantile muscular torticollis, without adverse effects. 展开更多
关键词 TUINA MASSAGE Ultrasonic Therapy TORTICOLLIS INFANT
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