Energy consumption forecasting for laser manufacturing of large artifacts based on fusionable transfer learning

This study presents an energy consumption(EC)forecasting method for laser melting manufacturing of metal artifacts based on fusionable transfer learning(FTL).To predict the EC of manufacturing products,particularly from scale-down to scale-up,a general paradigm was first developed by categorizing the overall process into three main sub-steps.The operating electrical power was further formulated as a combinatorial function,based on which an operator learning network was adopted to fit the nonlinear relations between the fabricating arguments and EC.Parallel-arranged networks were constructed to investigate the impacts of fabrication variables and devices on power.Considering the interconnections among these factors,the outputs of the neural networks were blended and fused to jointly predict the electrical power.Most innovatively,large artifacts can be decomposed into timedependent laser-scanning trajectories,which can be further transformed into fusionable information via neural networks,inspired by large language model.Accordingly,transfer learning can deal with either scale-down or scale-up forecasting,namely,FTL with scalability within artifact structures.The effectiveness of the proposed FTL was verified through physical fabrication experiments via laser powder bed fusion.The relative error of the average and overall EC predictions based on FTL was maintained below 0.83%.The melting fusion quality was examined using metallographic diagrams.The proposed FTL framework can forecast the EC of scaled structures,which is particularly helpful in price estimation and quotation of large metal products towards carbon peaking and carbon neutrality.

Study on Community Care Needs and Influencing Factors of the Urban Elderly in Shandong Province, China

Objective: To understand community care needs of the urban elderly in Shandong Province. To analysis the influencing factors and community care needs of the urban elderly in Shandong Province. Methods: Shandong Province was divided into four levels according to the level of economic development, multi-stage stratified cluster random sampling method was used. Each city collected the old aged 60 years or older served by 5 community health service centers. A total of 3390 questionnaires were distributed, the recovery rate was 100%, it had 3363 effective questionnaires, and an effective rate was 99.20%. SPSS17.0 software was used for univariate and multivariate analysis. Results: Analysis results show that, the influencing factors of community care needs of health promotion dimension have medical time (t = 3.239, P = 0.001) and EQ-5D score (t = 9.104, P - 6.239, P - 17.276, P - 3.762, P - 8.341, P Conclusions: Community care needs of the urban elderly in Shandong Province are at a medium level and have many influencing factors, the scores of each dimension from high to low are health promotion, disease care and disease prevention. In community nursing work, we should meet the care needs of the elderly, we need to enhance elderly self-care and safety awareness and promote the physical and mental health of the elderly.

OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice

Although both protein arginine methylation(PRMT)and jasmonate(JA)signaling are crucial for regulating plant development,the relationship between these processes in the control of spikelet development remains unclear.In this study,we used the CRISPR/Cas9 technology to generate two OsPRMT6a loss-of-function mutants that exhibit various abnormal spikelet structures.Interestingly,we found that OsPRMT6a can methylate arginine residues in JA signal repressors OsJAZ1 and OsJAZ7.We showed that arginine methylation of OsJAZ1 enhances the binding affinity of OsJAZ1 with the JA receptors OsCOI1a and OsCOI1b in the presence of JAs,thereby promoting the ubiquitination of OsJAZ1 by the SCF^(OsCOI1a/OsCOI1b) complex and degradation via the 26S proteasome.This process ultimately releases OsMYC2,a core transcriptional regulator in the JA signaling pathway,to activate or repress JA-responsive genes,thereby maintaining normal plant(spikelet)development.However,in the osprmt6a-1 mutant,reduced arginine methylation of OsJAZ1 impaires the interaction between OsJAZ1 and OsCOI1a/OsCOI1b in the presence of JAs.As a result,OsJAZ1 proteins become more stable,repressing JA responses,thus causing the formation of abnormal spikelet structures.Moreover,we discovered that JA signaling reduces the OsPRMT6a mRNA level in an OsMYC2-dependent manner,thereby establishing a negative feedback loop to balance JA signaling.We further found that OsPRMT6a-mediated arginine methylation of OsJAZ1 likely serves as a switch to tune JA signaling to maintain normal spikelet development under harsh environmental conditions such as high temperatures.Collectively,our study establishes a direct molecular link between arginine methylation and JA signaling in rice.

Ivosidenib in Chinese patients with relapsed or refractory isocitrate dehydrogenase 1 mutated acute myeloid leukemia:a registry study

Ivosidenib,an isocitrate dehydrogenase 1(IDH1)inhibitor,has demonstrated clinical benefits in a pivotal study(AG120-C-001)in patients with IDH1-mutated(mIDH1)acute myeloid leukemia(AML).A registry study(CS3010-101:NCT04176393)was conducted to assess the pharmacokinetic(PK)characteristics,safety,and efficacy of ivosidenib in Chinese patients with relapsed or refractory(R/R)mIDH1 AML.Patients received ivosidenib 500 mg once daily for 28-day cycles until disease progression.Ten subjects underwent intensive PK/progressive disease(PD)assessments.All subjects had the clinical response assessed at screening,every 28 days through month 12,and then every 56 days.Between November 12,2019,and April 2,2021,30 patients were enrolled;26(86.7%)had de novo AML and 18(60.0%)were transfusion-dependent at baseline.Following single and repeated doses of ivosidenib,median time to maximum plasma concentration(T_(max))was 4.0 and 2.0 hours,respectively.The inter-individual variability of pharmacokinetic exposure was moderate to high(coefficient of variation[CV],25%–53%).No obvious accumulation was observed after repeated doses at cycle 2 day 1.Regarding the clinical response,the CR+CRh rate was 36.7%(95%confidence interval[CI]:19.9%–56.1%),the median duration of CR+CRh was 19.7 months(95%CI:2.9 months–not reached[NR]),and median duration of response(DoR)was 14.3 months(95%CI:6.4 months–NR).Consistent clinical benefits and safety of ivosidenib were consistently observed at the final data cutoff with median follow-up time 26.0 months,as compared with primary data cutoff,and the data from Chinese R/R mIDH1 AML patients were also consistent with results from pivotal study.

17α-methyltestosterone induced hepatocyte apoptosis through endoplasmic reticulum stress in Takifugu fasciatus

17α-methyltestosterone(17α-MT)is an emerging pollutant,which is harmful to the endocrine system and reproduction of fish.We investigated the effects of different concentrations of 17α-MT(0,5,30,60,and 100 mg/kg)on endoplasmic reticulum stress(ERS)and apoptosis in the liver of Takifugu fasciatus.Results show that:(1)with the increase of 17α-MT treatment concentration,liver transaminases(alanine aminotransferase;aspartate aminotransferase)and the mRNA expression of ERS marker genes(glucose-regulated protein 78;calreticulin)of T.fasciatus were significantly increased compared with the control group(P<0.05);(2)the activity of succinate dehydrogenase(SDH),Caspase3 and Caspase9 in the liver of T.fasciatus increased with the increase of 17α-MT concentration compared with the control group(P<0.05);(3)by using 4-phenylbutyricacid(4-PBA)inhibitors to stimulate ERS through in vitro experiments,the expression of ERS and apoptosis-related genes significantly decreased(P<0.05),and the apoptosis rate of T.fasciatus hepatocytes was significantly inhibited(P<0.05)under 17α-MT treatment.This study confirmed that ERS played an important role in the induction of apoptosis in the hepatocytes of T.fasciatus,which enriched the ecotoxicological information of environmental androgens.

Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice

Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation.

吸力式五筒型基础水动力特性的数值模拟分析

多筒型基础具有气浮运输的特性,这一特性省去了驳船运输以及特种作业设备的费用,能够显著降低海上能源开发的成本。该文采用水动力分析软件MOSES建立了吸力式五筒型基础结构的数值分析模型,对不同吃水、不同水深以及不同间距情况下,结构的水动力系数和幅频响应特性进行了研究。研究结果表明:随着水深、吃水和筒间距的增加,结构垂荡和纵摇运动的水动力系数幅值呈下降的趋势;各个浪向角对垂荡的响应幅值算子的影响差异较小;结构间距的增大能够显著改善结构的摇摆运动,但是却增大了结构的垂荡运动。

清代虎门炮台遗址三合土材料科技研究

通过利用体视显微镜、硬度测试、微聚焦X射线荧光光谱仪、蛋白质酶联免疫吸附等实验方法,对清代虎门炮台部分遗址的三合土样品进行测试分析发现:虎门炮台各遗址三合土在其主量元素Si、Al、Ca上表现出不同的特征,如早期三合土中硅元素的量很高而钙元素的量很低,晚期三合土样品钙含量明显比早期三合土样品要高出许多。建造年代较早的炮台样品中蛋白含量较高,晚期的含量较低或者检测不出来。这一测试分析结果,对于研究虎门炮台的建筑材料发展过程以及虎门炮台遗址的保护提供了科技依据。

Real space characterization of nonlinear hall effect in confined directions

The nonlinear Hall effect(NLHE)is a phenomenon which could produce a transverse Hall voltage in a time-reversal-invariant material.Here,we report the real space characterizations of NLHE evaluated through quantum transport in TaIrTe4 nanoribbon without the explicit Berry curvature dipole(BCD)information.We first characterize the NLHE in both transverse confined directions in global-level measurement.The impact of quantum confinement in NLHE is evaluated by adjusting the width of nanoribbons.Then,the probing area is trimmed to the atomic scale to evaluate the local texture,where we discover its patterns differ among the probed neighboring atomic groups.The analysis of charge distribution reveals the connections between NLHE’s local patterns and its non-centrosymmetric nature,rendering nearly an order of Hall voltage enhancement through probe positioning.Our work paves the way to expand the range of NLHE study and unveil its physics in more versatile material systems.

Surface-dominated conductance scaling in Weyl semimetal NbAs

Protected surface states arising fromnon-trivial bandstructure topology in semimetals can potentially enable advanced device functionalities in compute,memory,interconnect,sensing,and communication.This necessitates a fundamental understanding of surface-state transport in nanoscale topological semimetals.Here,we investigate quantum transport in a prototypical topological semimetal NbAs to evaluate the potential of this class of materials for beyond-Cu interconnects in highly-scaled integrated circuits.Using density functional theory(DFT)coupled with non-equilibrium Green’s function(NEGF)calculations,we show that the resistance-areaRAproduct in NbAs films decreases with decreasing thickness at the nanometer scale,in contrast to a nearly constant RA product in ideal Cu films.This anomalous scaling originates from the disproportionately large number of surface conduction states which dominate the ballistic conductance by up to 70%in NbAs thin films.We also show that this favorable RA scaling persists even in the presence of surface defects,in contrast to RA sharply increasing with reducing thickness for films of conventional metals,such as Cu,in the presence of surface defects.These results underscore the potential of topological semimetals as future back-end-of-line(BEOL)interconnect metals.