为隔离车载精密仪器承受的多维振动,引入基于并联机构且考虑机构关节间隙的多维被动隔振系统。通过GF集(Generalized Function Set)型综合理论,得到一种具有三平移一转动运动特性的4-PUU(移动副-虎克副-虎克副)并联机构,在主动关节处添...为隔离车载精密仪器承受的多维振动,引入基于并联机构且考虑机构关节间隙的多维被动隔振系统。通过GF集(Generalized Function Set)型综合理论,得到一种具有三平移一转动运动特性的4-PUU(移动副-虎克副-虎克副)并联机构,在主动关节处添加弹簧和黏滞阻尼器,建立考虑关节间隙的多维隔振系统运动学和动力学方程,研究存在关节间隙的多维隔振系统在谐波、随机路面激励下的时域、频域隔振能力。研究结果表明:存在关节间隙的多维隔振系统能够实现多维振动在时域和频域中的有效衰减;随着关节间隙数值逐渐增大,隔振能力沿x轴方向变化最敏感,沿y轴方向变化最不敏感;系统第一阶共振峰对关节间隙变化敏感,向低频区域移动,隔振能力恶化。展开更多
Ferroptosis is a form of non-apoptotic programmed cell death,and its mechanisms mainly involve the accumulation of lipid peroxides,imbalance in the amino acid antioxidant system,and disordered iron metabolism.The prim...Ferroptosis is a form of non-apoptotic programmed cell death,and its mechanisms mainly involve the accumulation of lipid peroxides,imbalance in the amino acid antioxidant system,and disordered iron metabolism.The primary organelle responsible for coordinating external challenges and internal cell demands is the endoplasmic reticulum,and the progression of inflammatory diseases can trigger endoplasmic reticulum stress.Evidence has suggested that ferroptosis may share pathways or interact with endoplasmic reticulum stress in many diseases and plays a role in cell survival.Ferroptosis and endoplasmic reticulum stress may occur after ischemic stroke.However,there are few reports on the interactions of ferroptosis and endoplasmic reticulum stress with ischemic stroke.This review summarized the recent research on the relationships between ferroptosis and endoplasmic reticulum stress and ischemic stroke,aiming to provide a reference for developing treatments for ischemic stroke.展开更多
文摘为隔离车载精密仪器承受的多维振动,引入基于并联机构且考虑机构关节间隙的多维被动隔振系统。通过GF集(Generalized Function Set)型综合理论,得到一种具有三平移一转动运动特性的4-PUU(移动副-虎克副-虎克副)并联机构,在主动关节处添加弹簧和黏滞阻尼器,建立考虑关节间隙的多维隔振系统运动学和动力学方程,研究存在关节间隙的多维隔振系统在谐波、随机路面激励下的时域、频域隔振能力。研究结果表明:存在关节间隙的多维隔振系统能够实现多维振动在时域和频域中的有效衰减;随着关节间隙数值逐渐增大,隔振能力沿x轴方向变化最敏感,沿y轴方向变化最不敏感;系统第一阶共振峰对关节间隙变化敏感,向低频区域移动,隔振能力恶化。
基金supported by the National Natural Science Foundation of China,Nos.82071339 and 82271370(both to LG).
文摘Ferroptosis is a form of non-apoptotic programmed cell death,and its mechanisms mainly involve the accumulation of lipid peroxides,imbalance in the amino acid antioxidant system,and disordered iron metabolism.The primary organelle responsible for coordinating external challenges and internal cell demands is the endoplasmic reticulum,and the progression of inflammatory diseases can trigger endoplasmic reticulum stress.Evidence has suggested that ferroptosis may share pathways or interact with endoplasmic reticulum stress in many diseases and plays a role in cell survival.Ferroptosis and endoplasmic reticulum stress may occur after ischemic stroke.However,there are few reports on the interactions of ferroptosis and endoplasmic reticulum stress with ischemic stroke.This review summarized the recent research on the relationships between ferroptosis and endoplasmic reticulum stress and ischemic stroke,aiming to provide a reference for developing treatments for ischemic stroke.
