There are two major protective methods against lightning outages on overhead distribution lines.One is a surge arrester,and the other is an overhead ground wire.The surge arresters have rather constant effect regardle...There are two major protective methods against lightning outages on overhead distribution lines.One is a surge arrester,and the other is an overhead ground wire.The surge arresters have rather constant effect regardless of the cause of the lightning outage.On the other hand,the effect of an overhead ground wire is quite different in two major causes,the direct lightning hit and the induced overvoltage.It is sufficient to provide surge arresters with an interval of 300 m for protection against the induced overvoltage caused by the nearby lightning stroke.Use of an overhead ground wire together with surge arresters is effective for lightning protection against the direct lightning hit to a distribution line.Puncture of surge arresters is the popular outage when the outage caused by the insulation break decreases sufficiently.Also,the existence of nearby trees leads to the line break due to the side flash from a tree.Advanced lightning protection equipment with ZnO arrester components is popular in Japan.Modeling of a pole transformer and application of an electromagnetic analysis method,such as FDTD method,to surge phenomena is considerably advanced.展开更多
Autoantibody against neuronal nicotinic acetylcholine receptor (nAChR) α3 subunit is implicated in severe autonomic dysfunction in the patients with autoimmune autonomic ganglionopathy (AAG). Although this autoantibo...Autoantibody against neuronal nicotinic acetylcholine receptor (nAChR) α3 subunit is implicated in severe autonomic dysfunction in the patients with autoimmune autonomic ganglionopathy (AAG). Although this autoantibody has been revealed to impair fast excitatory synaptic transmission in autonomic ganglia, its precise mechanism remains unknown. Here, we show that antibody-induced reduction of cell-surface α3 subunits result in impairment of nicotine-evoked Ca2+ influx in stably transfected human embryonic kidney cells. These effects of the antibody were remarkably inhibited by interfering with the endocytic machinery at low-temperature. We conclude that reduction of nAChR in autonomic ganglia can be mediated by the endocytosis of α3 subunits, and resulted in autonomic failure in AAG patients.展开更多
文摘There are two major protective methods against lightning outages on overhead distribution lines.One is a surge arrester,and the other is an overhead ground wire.The surge arresters have rather constant effect regardless of the cause of the lightning outage.On the other hand,the effect of an overhead ground wire is quite different in two major causes,the direct lightning hit and the induced overvoltage.It is sufficient to provide surge arresters with an interval of 300 m for protection against the induced overvoltage caused by the nearby lightning stroke.Use of an overhead ground wire together with surge arresters is effective for lightning protection against the direct lightning hit to a distribution line.Puncture of surge arresters is the popular outage when the outage caused by the insulation break decreases sufficiently.Also,the existence of nearby trees leads to the line break due to the side flash from a tree.Advanced lightning protection equipment with ZnO arrester components is popular in Japan.Modeling of a pole transformer and application of an electromagnetic analysis method,such as FDTD method,to surge phenomena is considerably advanced.
文摘Autoantibody against neuronal nicotinic acetylcholine receptor (nAChR) α3 subunit is implicated in severe autonomic dysfunction in the patients with autoimmune autonomic ganglionopathy (AAG). Although this autoantibody has been revealed to impair fast excitatory synaptic transmission in autonomic ganglia, its precise mechanism remains unknown. Here, we show that antibody-induced reduction of cell-surface α3 subunits result in impairment of nicotine-evoked Ca2+ influx in stably transfected human embryonic kidney cells. These effects of the antibody were remarkably inhibited by interfering with the endocytic machinery at low-temperature. We conclude that reduction of nAChR in autonomic ganglia can be mediated by the endocytosis of α3 subunits, and resulted in autonomic failure in AAG patients.
