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High-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer based on probability density evolution method
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作者 Mingming Wang Linfang Qian +3 位作者 Guangsong Chen Tong Lin Junfei Shi shijie zhou 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期209-221,共13页
This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer.Firstly,the dynamic model of projectile motion is establi... This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer.Firstly,the dynamic model of projectile motion is established considering the flexible deformation of the barrel and the interaction between the projectile and the barrel.Subsequently,the accuracy of the dynamic model is verified based on the external ballistic projectile attitude test platform.Furthermore,the probability density evolution method(PDEM)is developed to high-dimensional uncertainty quantification of projectile motion.The engineering example highlights the results of the proposed method are consistent with the results obtained by the Monte Carlo Simulation(MCS).Finally,the influence of parameter uncertainty on the projectile disturbance at muzzle under different working conditions is analyzed.The results show that the disturbance of the pitch angular,pitch angular velocity and pitch angular of velocity decreases with the increase of launching angle,and the random parameter ranges of both the projectile and coupling model have similar influence on the disturbance of projectile angular motion at muzzle. 展开更多
关键词 Truck-mounted howitzer Projectile motion Uncertainty quantification Probability density evolution method
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新辅助免疫治疗联合化疗在可手术的非小细胞肺癌的初步疗效评估 被引量:14
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作者 周世杰 郝学峰 +11 位作者 于大平 刘树库 曹小庆 苏崇玉 宋小运 肖宁 李云松 杨威 赵丹 王敬慧 刘志东 许绍发 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第6期420-425,共6页
背景与目的初步研究证实新辅助免疫联合化疗对可手术非小细胞肺癌近期疗效显著,但国内相关临床试验较少。本研究回顾性分析应用新辅助免疫治疗联合化疗的可手术Ⅰb期-Ⅲb期非小细胞肺癌的临床病理资料,初步评估新辅助免疫治疗联合化疗... 背景与目的初步研究证实新辅助免疫联合化疗对可手术非小细胞肺癌近期疗效显著,但国内相关临床试验较少。本研究回顾性分析应用新辅助免疫治疗联合化疗的可手术Ⅰb期-Ⅲb期非小细胞肺癌的临床病理资料,初步评估新辅助免疫治疗联合化疗的疗效及安全性。方法回顾性分析2019年11月-2020年12月期间于首都医科大学附属北京胸科医院胸外科治疗的临床分期Ⅰb期-Ⅲb期的非小细胞肺癌患者20例,术前应用免疫联合化疗新辅助治疗,根据影像学和病理学方法分别评估疗效。结果全组患者新辅助治疗后影像学评估疗效,客观有效率(objective responserate,ORR)为85.0%(完全缓解4例,部分缓解13例),疾病稳定1例(5.0%),疾病进展2例(10.0%)。其中17例后续接受手术治疗,16例达到R0(no residual tumor)切除,1例R1(microscopic residual tumor)切除。术后病理评估:主要病理缓解率(major pathologic response,MPR)为47.1%(8/17),其中完全病理缓解率(complete pathologic response,CPR)为29.4%(5/17)。主要不良反应:免疫相关性肺炎(Ⅳ级)1例,Ⅲ级及以上血液学毒性9例(45.0%)。结论新辅助免疫联合化疗对于可手术的非小细胞肺癌近期疗效显著,具有一定的安全性及有效性。但新辅助免疫联合化疗的远期疗效、最佳周期数以及理想预测免疫治疗效果的标记物仍有待研究。 展开更多
关键词 肺肿瘤 免疫治疗 新辅助治疗 手术
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Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation 被引量:1
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作者 Hansong Bai Jiahua Lyu +6 位作者 Xinyu Nie Hao Kuang Long Liang Hongyuan Jia shijie zhou Churong Li Tao Li 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第11期1296-1308,共13页
Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and C... Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis.Bioinformatic molecular docking prediction and following validation by surface plasmon resonance(SPR)technology,cellular thermal shift assay(CETSA),and isothermal titration calorimetry(ITC)were conducted to explore the binding between ginsenoside Rg5 and 90 kD heat shock protein alpha(HSP90a).The effects of ginsenoside Rg5 on HSP90-cell division cycle 37(CDC37)interaction,the client protein stability,and the downstream regulations were further explored.Results showed that ginsenoside Rg5 could induce cell-cycle arrest at the G1 phase and enhance irradiationinduced cell apoptosis.It could bind to HSP90a with a high affinity,but the affinity was drastically decreased by HSP90a Y61A mutation.Co-immunoprecipitation(Co-IP)and ITC assays confirmed that ginsenoside Rg5 disrupts the HSP90-CDC37 interaction in a dose-dependent manner.It reduced irradiation-induced upregulation of the HSP90-CDC37 client proteins,including SRC,CDK4,RAF1,and ULK1 in A549 cell-derived xenograft(CDX)tumors.Ginsenoside Rg5 or MRT67307(an IKKε/TBK1 inhibitor)pretreatment suppressed irradiation-induced elevation of the LC3-II/b ratio and restored irradiation-induced downregulation of p62 expression.In A549 CDX tumors,ginsenoside Rg5 treatment suppressed LC3 expression and enhanced irradiation-induced DNA damage.In conclusion,ginsenoside Rg5 may be a potential radiosensitizer for lung adenocarcinoma.It interacts with HSP90a and reduces the binding between HSP90 and CDC37,thereby increasing the ubiquitin-mediated proteasomal degradation of the HSP90-CDC37 client proteins. 展开更多
关键词 Ginsenoside Rg5 Lung adenocarcinoma RADIOTHERAPY HSP90 CDC37
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Health Data Availability Protection:Delta-XOR-Relay Data Update in Erasure-Coded Cloud Storage Systems
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作者 Yifei Xiao shijie zhou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第4期169-185,共17页
To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottle... To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottlenecked by the constrained cross-rack bandwidth.Various techniques have been proposed in the literature to improve network bandwidth efficiency,including delta transmission,relay,and batch update.These techniques were largely proposed individually previously,and in this work,we seek to use them jointly.To mitigate the cross-rack update traffic,we propose DXR-DU which builds on four valuable techniques:(i)delta transmission,(ii)XOR-based data update,(iii)relay,and(iv)batch update.Meanwhile,we offer two selective update approaches:1)data-deltabased update,and 2)parity-delta-based update.The proposed DXR-DU is evaluated via trace-driven local testbed experiments.Comprehensive experiments show that DXR-DU can significantly improve data update throughput while mitigating the cross-rack update traffic. 展开更多
关键词 Data availability health data data update cloud storage IoT
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Chemokine Ligand 13 Expression is Abundant in the Tumor Microenvironment and Indicates Poor Prognosis of Kidney Clear Cell Carcinoma
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作者 MENGDAN WU MENGYAO SUN +14 位作者 QINHUAI LAI YIN LU YUYIN FU YUJIA PENG WEIRONG LAI LISHI ZENG SHENGYAN ZHAO YUYAN LI ZHIXIONG ZHANG XIAOFENG CHEN FAN QIAO YIWEN ZHANG shijie zhou LANTU GOU JINLIANG YANG 《BIOCELL》 SCIE 2021年第3期589-597,共9页
The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,w... The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME. 展开更多
关键词 CXCL13 Kidney clear cell carcinoma Gamma/delta T cells DNA methylation Unfavorable survival
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远程关联视角下中国碳储量在建设用地流动中的变化及驱动因素分析 被引量:1
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作者 王少剑 周诗洁 方创琳 《科学通报》 EI CAS CSCD 北大核心 2024年第27期4119-4136,共18页
建设用地转变是造成人为碳储量变化的主要原因之一,贸易产品的交换以及资源的流通使得建设用地受到远程关联的影响发生流动,负载其中的碳储量也因此产生流动和变化,因此有必要分析碳储量在建设用地流动中的变化,探明碳储量变化的驱动因... 建设用地转变是造成人为碳储量变化的主要原因之一,贸易产品的交换以及资源的流通使得建设用地受到远程关联的影响发生流动,负载其中的碳储量也因此产生流动和变化,因此有必要分析碳储量在建设用地流动中的变化,探明碳储量变化的驱动因素,为未来区域“双碳”目标实现和绿色可持续发展提供科学依据.本文利用土地利用数据、碳密度数据和投入产出数据,结合生态系统服务和权衡的综合评估模型的碳计算模块、多区域投入产出模型和结构分解分析等方法,揭示了2012~2017年间远程关联视角下中国建设用地碳储量的流动变化格局及在流动变化中碳损失热点,并分析各省份建设用地碳储量远程关联变化的驱动因素.结果表明:(1) 2012和2017年中国区域间建设用地碳储量流动值分别为483.3和580.7 Tg C,研究期内区域流动更为频繁,区域间的远程关联性更强,高频率流动量不仅仅只在经济较为发达的东部沿海地区,而是逐渐覆盖全国,经济发展稍滞后的东北、西南地区的流动量产生大幅度提升.(2)研究期间,中国各省份建设用地碳储量的净流入增长区集中于经济发展较好的中东部地区,净流出增加区集中于欠发达的东北部和西北部地区,发达地区为了满足自身发展建设需求,不仅占用了欠发达地区的土地资源,更进一步转移了对资源侵占所造成的碳储量损失,造成了生态不平等.其中,内蒙古净流出量增加最多,是碳储量损失热点,浙江净流入增加最多,是导致碳损失的重要省份.(3)消费规模和建设用地碳储量负载强度是影响流出量和流入量变化的主要因素,其中江苏等经济基础较好的省份,结构分解中表现出更多的消费规模增加和更多的建设用地碳储量负载强度减少,通过增加单位建设用地产值满足新增的外部规模需求.为了保护碳储量,缓解区域间的生态不平等,政策制定中要注重优化建设用地的管理机制,激活生态用地服务价值,健全生态补偿机制. 展开更多
关键词 远程关联 建设用地 碳储量 MRIO 驱动因素
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不饱和醛选择性加氢高效催化剂的研究
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作者 杨星月 周石杰 +1 位作者 杨宇森 卫敏 《化学进展》 SCIE CAS CSCD 北大核心 2024年第3期297-318,共22页
不饱和醛的选择性加氢作为一类重要的精细化学品加工转化过程,在香精香料、药物食品生产、农产品加工等领域具有广泛应用。但是目前所应用催化剂的反应活性仍有待提高,需对催化剂进行进一步调控。本文总结了提高催化剂加氢选择性的三种... 不饱和醛的选择性加氢作为一类重要的精细化学品加工转化过程,在香精香料、药物食品生产、农产品加工等领域具有广泛应用。但是目前所应用催化剂的反应活性仍有待提高,需对催化剂进行进一步调控。本文总结了提高催化剂加氢选择性的三种策略,包括:改变金属活性位点的电子性质、增强金属活性位点与亲电位点之间的协同作用和利用结构效应来改变催化剂对于C=O键或C=C键的吸附能力和加氢活性。概括了氢源种类、反应溶剂、反应温度和氢气压力等反应条件对催化性能的影响。并归纳了不饱和醛选择性加氢有关的密度泛函理论计算、反应的动力学模型及反应中的构效关系。最后,讨论了不饱和醛选择性加氢催化剂面临的问题和挑战,并提出了可行的解决方案。 展开更多
关键词 选择性加氢 不饱和醛 动力学研究 构效关系 结构设计
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Spatial-temporal patterns and evolution of carbon storage in China's terrestrial ecosystems from 1980 to 2020
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作者 Shaojian WANG shijie zhou Chuanglin FANG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第10期3270-3287,共18页
Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effec... Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effective and environmentally friendly measure to sequester anthropogenic carbon emissions, which is significant for achieving carbon neutrality and curbing global climate change. This paper uses land use data and carbon density tables with the In VEST model to obtain a carbon storage distribution map of China. It further applies land use response elasticity coefficients, Theil index multi-stage nested decomposition, and spatial autocorrelation analysis to examine the spatial-temporal patterns, causes of changes, and evolution characteristics of carbon storage in terrestrial ecosystems from 1980 to 2020. The results show that the temporal changes in China's carbon storage generally present an inverted S-curve, with an initial rapid decline followed by a slower decrease. Spatially, it features high levels in the northeast, low levels in the northwest, and a uniform distribution in the central and southern regions.The disturbance of land use type changes on terrestrial ecosystem carbon storage has been effectively mitigated. The significant reduction in grassland area in the Southwest region is the main source of carbon storage loss during the study period, and the encroachment of construction land on arable land in large urban agglomerations is one of the important causes of carbon storage loss. The Theil index multi-stage nested decomposition results indicate that the overall difference in carbon storage in China has decreased, while differences among cities within provinces and among counties within cities have increased. The influence of natural factors on the distribution of carbon storage is weakening, whereas the impact of human activities is becoming more profound, enhancing its influence on the spatial distribution of carbon storage in China. From 1980 to 2000, the carbon density in coastal metropolises generally showed a declining trend. From 2000 to 2020, the carbon density in the central urban areas of eastern coastal city clusters gradually showed an upward trend and continued to expand outward, revealing to some extent the“Environmental Kuznets Curve” characteristic in the development process of urban carbon storage. Therefore, in future ecological construction, the government should fully consider the impact of land management planning on carbon storage in different regions, promote the efficient use and standardized management of land, and strive to cross the “Environmental Kuznets Curve” inflection point of carbon storage as soon as possible. 展开更多
关键词 Terrestrial ecosystem carbon storage Carbon density Land use change InVEST model Spatiotemporal pattern
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Targeting fibrosis: mechanisms and clinical trials 被引量:15
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作者 Manyu Zhao Liqun Wang +10 位作者 Mengzhu Wang shijie zhou Ying Lu Huijie Cui Alexandra C.Racanelli Ling Zhang Tinghong Ye Bisen Ding Ben Zhang Jinliang Yang Yuqin Yao 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第7期2469-2489,共21页
Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung... Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung.Fibrosis such as liver cirrhosis,idiopathic pulmonary fibrosis,and cystic fibrosis caused substantial disease burden.Persistent abnormal activation of myofibroblasts mediated by various signals,such as transforming growth factor,platelet-derived growth factor,and fibroblast growh factor,has been recongized as a major event in the occurrence and progression of fibrosis.Although the mechanisms driving organ-specific fibrosis have not been fully elucidated,drugs targeting these identified aberrant signals have achieved potent anti-fibrotic efficacy in clinical trials.In this review,we briefly introduce the aetiology and epidemiology of several fibrosis diseases,including liver fibrosis,kidney fibrosis,cardiac fibrosis,and pulmonary fibrosis.Then,we summarise the abnormal cells(epithelial cells,endothelial cells,immune cells,and fibroblasts)and their interactions in fibrosis.In addition,we also focus on the aberrant signaling pathways and therapeutic targets that regulate myofibroblast activation,extracellular matrix cross-linking,metabolism,and inflammation in fibrosis.Finally,we discuss the anti-fibrotic drugs based on their targets and clinical trials.This review provides reference for further research on fibrosis mechanism,drug development,and clinical trials. 展开更多
关键词 DRUGS EPIDEMIOLOGY ORGANS
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一种兼具程序性缓释双氢青蒿素和Fe^(2+)自供应能力的智能纳米药物用于肿瘤协同治疗
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作者 赵莹 王樱蕙 +8 位作者 曹悦 周仕杰 刘洋 牛瑞 徐博 张松涛 王大广 宋术岩 张洪杰 《Science China Materials》 SCIE EI CAS CSCD 2023年第10期4071-4078,共8页
双氢青蒿素(DHA)作为一种新型的抗癌药物引起了全世界的广泛关注.然而,DHA的固有缺陷降低了其在血液系统中的运输效率,而肿瘤细胞中铁含量不足进一步导致疗效不佳.因此,构建一个可同时负载DHA和Fe^(3+)并在肿瘤微环境中特异性释放出DHA... 双氢青蒿素(DHA)作为一种新型的抗癌药物引起了全世界的广泛关注.然而,DHA的固有缺陷降低了其在血液系统中的运输效率,而肿瘤细胞中铁含量不足进一步导致疗效不佳.因此,构建一个可同时负载DHA和Fe^(3+)并在肿瘤微环境中特异性释放出DHA/Fe的纳米药物具有重大意义.本文报道了一种智能纳米药物CaCO_(3)@DHA@Fe^(3+)-TA@PEG(CDFP NPs)用于肿瘤协同治疗.Fe^(3+)-TA壳层的包覆赋予CDFP NPs良好的光热性能.此外,CDFP NPs在酸性的肿瘤微环境中可以快速降解并释放出TA,Fe^(3+),DHA和Ca^(2+).Fe^(3+)与TA反应生成Fe^(2+),Fe^(2+)与DHA相互作用生成高毒性的自由基.此外,在氧化应激状态下,Ca^(2+)过载导致线粒体功能紊乱,最终诱导肿瘤细胞死亡.在光热治疗,活性氧,Ca^(2+)过载的协同作用下,CDFP NPs在体内外均表现出良好的治疗效果. 展开更多
关键词 DIHYDROARTEMISININ self-supply Fe^(2+) Ca^(2+)overloading synergistic therapy
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Varying contributions of fast and slow responses cause asymmetric tropical rainfall change between CO_(2) ramp-up and ramp-down
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作者 shijie zhou Ping Huang +2 位作者 Shang-Ping Xie Gang Huang Lin Wang 《Science Bulletin》 SCIE EI CAS CSCD 2022年第16期1702-1711,M0004,共11页
Tropical rainfall is important for regional climate around the globe.In a warming climate forced by rising CO_(2),the tropical rainfall will increase over the equatorial Pacific where sea surface warming is locally en... Tropical rainfall is important for regional climate around the globe.In a warming climate forced by rising CO_(2),the tropical rainfall will increase over the equatorial Pacific where sea surface warming is locally enhanced.Here,we analyze an idealized CO_(2) removal experiment from the Carbon Dioxide Removal Model Intercomparison Project(CDRMIP)and show that the tropical rainfall change features a stronger pattern during CO_(2) ramp-down than ramp-up,even under the same global mean temperature increase,such as the 2℃ goal of the Paris Agreement.The tropical rainfall during CO_(2) ramp-down increases over the equatorial Pacific with a southward extension,and decreases over the Pacific intertropical convergence zone and South Pacific convergence zone.The asymmetric rainfall changes between CO_(2) ramp-down and ramp-up result from time-varying contributions of the fast and slow oceanic responses to CO_(2) forcing,defined as the responses to abrupt CO_(2) forcing in the first 10 years and thereafter,respectively,in the abrupt-4xCO_(2) experiment.The fast response follows the CO_(2) evolution,but the slow response does not peak until 60 years after the CO_(2) peak.The slow response features a stronger El Niño-like pattern,as the ocean dynamical thermostat effect is suppressed under stronger subsurface warming.The delayed and stronger slow response leads to stronger tropical rainfall changes during CO_(2) ramp-down.Our results indicate that returning the global mean temperature increase to below a certain goal,such as 2℃,by removing CO_(2),may fail to restore tropical convection distribution,with potentially devastating effects on climate worldwide. 展开更多
关键词 Tropical rainfall Fast and slow responses Sea surface warming pattern CDRMIP
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Optimization of a Network Topology Generation Algorithm Based on Spatial Information Network
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作者 Peng Yang shijie zhou Xiangyang zhou 《国际计算机前沿大会会议论文集》 EI 2023年第1期246-255,共10页
Spatial information network(SIN)is a network with high speed and periodicity of node operation.In recent days,China will build a complete asteroid monitoring and warning system and a near-Earth asteroid defense system... Spatial information network(SIN)is a network with high speed and periodicity of node operation.In recent days,China will build a complete asteroid monitoring and warning system and a near-Earth asteroid defense system.This requires launching more low-Earth orbit satellites.In order to adapt to the increase in the number of near-Earth satellites,the dynamic optimization of space informa-tion network topology between satellites will have research significance.Consid-ering the visibility of satellite networking,the connectivity of satellite nodes,and the number of links connected to the whole network,with the goal of minimizing the end-to-end delay between satellite nodes in the network as the optimization goal,a network topology optimization model that meets multiple constraints is constructed,and the model is solved using greedy algorithm and simulated anneal-ing algorithm.In the process of simulated annealing,the networkflow algorithm is innovatively proposed for neighborhood solution.Experiments show that the simulated annealing hybrid neighborhood algorithm is significantly better than the simulated annealing random neighborhood algorithm. 展开更多
关键词 Spatial Information Network Dynamic Optimization of Network Topology Network Flow Algorithm Simulated Annealing Algorithm
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Optimization of multi-state generation problem based on spatial information network topology
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作者 Peng Yang JiaYing Zhang +1 位作者 shijie zhou Jinyu zhou 《High-Confidence Computing》 2023年第1期58-65,共8页
Spatial information network is a kind of satellite network with high speed node movement and fast dynamic topology change.With the increasing number of low-orbit satellites,the research on the subnets topology and dyn... Spatial information network is a kind of satellite network with high speed node movement and fast dynamic topology change.With the increasing number of low-orbit satellites,the research on the subnets topology and dynamic optimization of space information networks has become an important direction to study the destructibility of spatial information network.In this paper,two common objective functions in inter-satellite link assignment,network observation position and network communication factor are studied,and a multi-objective optimization model is constructed.Depth first search,simulated annealing,NSGA-II and adaptive optimization simulated annealing were used to analyze and solve the model.By comparing the solving efficiency of the model through simulation experiments,the difference of the results caused by the four algorithms is verified. 展开更多
关键词 Spatial information network Simulated annealing NSGA-II
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