This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer.Firstly,the dynamic model of projectile motion is establi...This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer.Firstly,the dynamic model of projectile motion is established considering the flexible deformation of the barrel and the interaction between the projectile and the barrel.Subsequently,the accuracy of the dynamic model is verified based on the external ballistic projectile attitude test platform.Furthermore,the probability density evolution method(PDEM)is developed to high-dimensional uncertainty quantification of projectile motion.The engineering example highlights the results of the proposed method are consistent with the results obtained by the Monte Carlo Simulation(MCS).Finally,the influence of parameter uncertainty on the projectile disturbance at muzzle under different working conditions is analyzed.The results show that the disturbance of the pitch angular,pitch angular velocity and pitch angular of velocity decreases with the increase of launching angle,and the random parameter ranges of both the projectile and coupling model have similar influence on the disturbance of projectile angular motion at muzzle.展开更多
Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and C...Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis.Bioinformatic molecular docking prediction and following validation by surface plasmon resonance(SPR)technology,cellular thermal shift assay(CETSA),and isothermal titration calorimetry(ITC)were conducted to explore the binding between ginsenoside Rg5 and 90 kD heat shock protein alpha(HSP90a).The effects of ginsenoside Rg5 on HSP90-cell division cycle 37(CDC37)interaction,the client protein stability,and the downstream regulations were further explored.Results showed that ginsenoside Rg5 could induce cell-cycle arrest at the G1 phase and enhance irradiationinduced cell apoptosis.It could bind to HSP90a with a high affinity,but the affinity was drastically decreased by HSP90a Y61A mutation.Co-immunoprecipitation(Co-IP)and ITC assays confirmed that ginsenoside Rg5 disrupts the HSP90-CDC37 interaction in a dose-dependent manner.It reduced irradiation-induced upregulation of the HSP90-CDC37 client proteins,including SRC,CDK4,RAF1,and ULK1 in A549 cell-derived xenograft(CDX)tumors.Ginsenoside Rg5 or MRT67307(an IKKε/TBK1 inhibitor)pretreatment suppressed irradiation-induced elevation of the LC3-II/b ratio and restored irradiation-induced downregulation of p62 expression.In A549 CDX tumors,ginsenoside Rg5 treatment suppressed LC3 expression and enhanced irradiation-induced DNA damage.In conclusion,ginsenoside Rg5 may be a potential radiosensitizer for lung adenocarcinoma.It interacts with HSP90a and reduces the binding between HSP90 and CDC37,thereby increasing the ubiquitin-mediated proteasomal degradation of the HSP90-CDC37 client proteins.展开更多
To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottle...To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottlenecked by the constrained cross-rack bandwidth.Various techniques have been proposed in the literature to improve network bandwidth efficiency,including delta transmission,relay,and batch update.These techniques were largely proposed individually previously,and in this work,we seek to use them jointly.To mitigate the cross-rack update traffic,we propose DXR-DU which builds on four valuable techniques:(i)delta transmission,(ii)XOR-based data update,(iii)relay,and(iv)batch update.Meanwhile,we offer two selective update approaches:1)data-deltabased update,and 2)parity-delta-based update.The proposed DXR-DU is evaluated via trace-driven local testbed experiments.Comprehensive experiments show that DXR-DU can significantly improve data update throughput while mitigating the cross-rack update traffic.展开更多
The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,w...The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME.展开更多
Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effec...Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effective and environmentally friendly measure to sequester anthropogenic carbon emissions, which is significant for achieving carbon neutrality and curbing global climate change. This paper uses land use data and carbon density tables with the In VEST model to obtain a carbon storage distribution map of China. It further applies land use response elasticity coefficients, Theil index multi-stage nested decomposition, and spatial autocorrelation analysis to examine the spatial-temporal patterns, causes of changes, and evolution characteristics of carbon storage in terrestrial ecosystems from 1980 to 2020. The results show that the temporal changes in China's carbon storage generally present an inverted S-curve, with an initial rapid decline followed by a slower decrease. Spatially, it features high levels in the northeast, low levels in the northwest, and a uniform distribution in the central and southern regions.The disturbance of land use type changes on terrestrial ecosystem carbon storage has been effectively mitigated. The significant reduction in grassland area in the Southwest region is the main source of carbon storage loss during the study period, and the encroachment of construction land on arable land in large urban agglomerations is one of the important causes of carbon storage loss. The Theil index multi-stage nested decomposition results indicate that the overall difference in carbon storage in China has decreased, while differences among cities within provinces and among counties within cities have increased. The influence of natural factors on the distribution of carbon storage is weakening, whereas the impact of human activities is becoming more profound, enhancing its influence on the spatial distribution of carbon storage in China. From 1980 to 2000, the carbon density in coastal metropolises generally showed a declining trend. From 2000 to 2020, the carbon density in the central urban areas of eastern coastal city clusters gradually showed an upward trend and continued to expand outward, revealing to some extent the“Environmental Kuznets Curve” characteristic in the development process of urban carbon storage. Therefore, in future ecological construction, the government should fully consider the impact of land management planning on carbon storage in different regions, promote the efficient use and standardized management of land, and strive to cross the “Environmental Kuznets Curve” inflection point of carbon storage as soon as possible.展开更多
Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung...Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung.Fibrosis such as liver cirrhosis,idiopathic pulmonary fibrosis,and cystic fibrosis caused substantial disease burden.Persistent abnormal activation of myofibroblasts mediated by various signals,such as transforming growth factor,platelet-derived growth factor,and fibroblast growh factor,has been recongized as a major event in the occurrence and progression of fibrosis.Although the mechanisms driving organ-specific fibrosis have not been fully elucidated,drugs targeting these identified aberrant signals have achieved potent anti-fibrotic efficacy in clinical trials.In this review,we briefly introduce the aetiology and epidemiology of several fibrosis diseases,including liver fibrosis,kidney fibrosis,cardiac fibrosis,and pulmonary fibrosis.Then,we summarise the abnormal cells(epithelial cells,endothelial cells,immune cells,and fibroblasts)and their interactions in fibrosis.In addition,we also focus on the aberrant signaling pathways and therapeutic targets that regulate myofibroblast activation,extracellular matrix cross-linking,metabolism,and inflammation in fibrosis.Finally,we discuss the anti-fibrotic drugs based on their targets and clinical trials.This review provides reference for further research on fibrosis mechanism,drug development,and clinical trials.展开更多
Tropical rainfall is important for regional climate around the globe.In a warming climate forced by rising CO_(2),the tropical rainfall will increase over the equatorial Pacific where sea surface warming is locally en...Tropical rainfall is important for regional climate around the globe.In a warming climate forced by rising CO_(2),the tropical rainfall will increase over the equatorial Pacific where sea surface warming is locally enhanced.Here,we analyze an idealized CO_(2) removal experiment from the Carbon Dioxide Removal Model Intercomparison Project(CDRMIP)and show that the tropical rainfall change features a stronger pattern during CO_(2) ramp-down than ramp-up,even under the same global mean temperature increase,such as the 2℃ goal of the Paris Agreement.The tropical rainfall during CO_(2) ramp-down increases over the equatorial Pacific with a southward extension,and decreases over the Pacific intertropical convergence zone and South Pacific convergence zone.The asymmetric rainfall changes between CO_(2) ramp-down and ramp-up result from time-varying contributions of the fast and slow oceanic responses to CO_(2) forcing,defined as the responses to abrupt CO_(2) forcing in the first 10 years and thereafter,respectively,in the abrupt-4xCO_(2) experiment.The fast response follows the CO_(2) evolution,but the slow response does not peak until 60 years after the CO_(2) peak.The slow response features a stronger El Niño-like pattern,as the ocean dynamical thermostat effect is suppressed under stronger subsurface warming.The delayed and stronger slow response leads to stronger tropical rainfall changes during CO_(2) ramp-down.Our results indicate that returning the global mean temperature increase to below a certain goal,such as 2℃,by removing CO_(2),may fail to restore tropical convection distribution,with potentially devastating effects on climate worldwide.展开更多
Spatial information network(SIN)is a network with high speed and periodicity of node operation.In recent days,China will build a complete asteroid monitoring and warning system and a near-Earth asteroid defense system...Spatial information network(SIN)is a network with high speed and periodicity of node operation.In recent days,China will build a complete asteroid monitoring and warning system and a near-Earth asteroid defense system.This requires launching more low-Earth orbit satellites.In order to adapt to the increase in the number of near-Earth satellites,the dynamic optimization of space informa-tion network topology between satellites will have research significance.Consid-ering the visibility of satellite networking,the connectivity of satellite nodes,and the number of links connected to the whole network,with the goal of minimizing the end-to-end delay between satellite nodes in the network as the optimization goal,a network topology optimization model that meets multiple constraints is constructed,and the model is solved using greedy algorithm and simulated anneal-ing algorithm.In the process of simulated annealing,the networkflow algorithm is innovatively proposed for neighborhood solution.Experiments show that the simulated annealing hybrid neighborhood algorithm is significantly better than the simulated annealing random neighborhood algorithm.展开更多
Spatial information network is a kind of satellite network with high speed node movement and fast dynamic topology change.With the increasing number of low-orbit satellites,the research on the subnets topology and dyn...Spatial information network is a kind of satellite network with high speed node movement and fast dynamic topology change.With the increasing number of low-orbit satellites,the research on the subnets topology and dynamic optimization of space information networks has become an important direction to study the destructibility of spatial information network.In this paper,two common objective functions in inter-satellite link assignment,network observation position and network communication factor are studied,and a multi-objective optimization model is constructed.Depth first search,simulated annealing,NSGA-II and adaptive optimization simulated annealing were used to analyze and solve the model.By comparing the solving efficiency of the model through simulation experiments,the difference of the results caused by the four algorithms is verified.展开更多
基金the National Natural Science Foundation of China(Grant No.11472137).
文摘This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer.Firstly,the dynamic model of projectile motion is established considering the flexible deformation of the barrel and the interaction between the projectile and the barrel.Subsequently,the accuracy of the dynamic model is verified based on the external ballistic projectile attitude test platform.Furthermore,the probability density evolution method(PDEM)is developed to high-dimensional uncertainty quantification of projectile motion.The engineering example highlights the results of the proposed method are consistent with the results obtained by the Monte Carlo Simulation(MCS).Finally,the influence of parameter uncertainty on the projectile disturbance at muzzle under different working conditions is analyzed.The results show that the disturbance of the pitch angular,pitch angular velocity and pitch angular of velocity decreases with the increase of launching angle,and the random parameter ranges of both the projectile and coupling model have similar influence on the disturbance of projectile angular motion at muzzle.
基金supported by grants from the Project of Sichuan Science and Technology Department,China(Grant No.:2021YJ0010).
文摘Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects.This study aimed to explore its radio-sensitizing effects and the underlying mechanisms.Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis.Bioinformatic molecular docking prediction and following validation by surface plasmon resonance(SPR)technology,cellular thermal shift assay(CETSA),and isothermal titration calorimetry(ITC)were conducted to explore the binding between ginsenoside Rg5 and 90 kD heat shock protein alpha(HSP90a).The effects of ginsenoside Rg5 on HSP90-cell division cycle 37(CDC37)interaction,the client protein stability,and the downstream regulations were further explored.Results showed that ginsenoside Rg5 could induce cell-cycle arrest at the G1 phase and enhance irradiationinduced cell apoptosis.It could bind to HSP90a with a high affinity,but the affinity was drastically decreased by HSP90a Y61A mutation.Co-immunoprecipitation(Co-IP)and ITC assays confirmed that ginsenoside Rg5 disrupts the HSP90-CDC37 interaction in a dose-dependent manner.It reduced irradiation-induced upregulation of the HSP90-CDC37 client proteins,including SRC,CDK4,RAF1,and ULK1 in A549 cell-derived xenograft(CDX)tumors.Ginsenoside Rg5 or MRT67307(an IKKε/TBK1 inhibitor)pretreatment suppressed irradiation-induced elevation of the LC3-II/b ratio and restored irradiation-induced downregulation of p62 expression.In A549 CDX tumors,ginsenoside Rg5 treatment suppressed LC3 expression and enhanced irradiation-induced DNA damage.In conclusion,ginsenoside Rg5 may be a potential radiosensitizer for lung adenocarcinoma.It interacts with HSP90a and reduces the binding between HSP90 and CDC37,thereby increasing the ubiquitin-mediated proteasomal degradation of the HSP90-CDC37 client proteins.
基金supported by Major Special Project of Sichuan Science and Technology Department(2020YFG0460)Central University Project of China(ZYGX2020ZB020,ZYGX2020ZB019).
文摘To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottlenecked by the constrained cross-rack bandwidth.Various techniques have been proposed in the literature to improve network bandwidth efficiency,including delta transmission,relay,and batch update.These techniques were largely proposed individually previously,and in this work,we seek to use them jointly.To mitigate the cross-rack update traffic,we propose DXR-DU which builds on four valuable techniques:(i)delta transmission,(ii)XOR-based data update,(iii)relay,and(iv)batch update.Meanwhile,we offer two selective update approaches:1)data-deltabased update,and 2)parity-delta-based update.The proposed DXR-DU is evaluated via trace-driven local testbed experiments.Comprehensive experiments show that DXR-DU can significantly improve data update throughput while mitigating the cross-rack update traffic.
基金funded by the National Science and Technology Major Project for Major New Drug Innovation and Development(2017ZX09302010).
文摘The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME.
基金supported by the National Natural Science Foundation of China (Grant Nos.42121001,42371207)。
文摘Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effective and environmentally friendly measure to sequester anthropogenic carbon emissions, which is significant for achieving carbon neutrality and curbing global climate change. This paper uses land use data and carbon density tables with the In VEST model to obtain a carbon storage distribution map of China. It further applies land use response elasticity coefficients, Theil index multi-stage nested decomposition, and spatial autocorrelation analysis to examine the spatial-temporal patterns, causes of changes, and evolution characteristics of carbon storage in terrestrial ecosystems from 1980 to 2020. The results show that the temporal changes in China's carbon storage generally present an inverted S-curve, with an initial rapid decline followed by a slower decrease. Spatially, it features high levels in the northeast, low levels in the northwest, and a uniform distribution in the central and southern regions.The disturbance of land use type changes on terrestrial ecosystem carbon storage has been effectively mitigated. The significant reduction in grassland area in the Southwest region is the main source of carbon storage loss during the study period, and the encroachment of construction land on arable land in large urban agglomerations is one of the important causes of carbon storage loss. The Theil index multi-stage nested decomposition results indicate that the overall difference in carbon storage in China has decreased, while differences among cities within provinces and among counties within cities have increased. The influence of natural factors on the distribution of carbon storage is weakening, whereas the impact of human activities is becoming more profound, enhancing its influence on the spatial distribution of carbon storage in China. From 1980 to 2000, the carbon density in coastal metropolises generally showed a declining trend. From 2000 to 2020, the carbon density in the central urban areas of eastern coastal city clusters gradually showed an upward trend and continued to expand outward, revealing to some extent the“Environmental Kuznets Curve” characteristic in the development process of urban carbon storage. Therefore, in future ecological construction, the government should fully consider the impact of land management planning on carbon storage in different regions, promote the efficient use and standardized management of land, and strive to cross the “Environmental Kuznets Curve” inflection point of carbon storage as soon as possible.
基金supported by the National Science Foundation of China(No.81773375)the National Major Scientific and Technological Special Project(No.2019ZX09201001)。
文摘Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung.Fibrosis such as liver cirrhosis,idiopathic pulmonary fibrosis,and cystic fibrosis caused substantial disease burden.Persistent abnormal activation of myofibroblasts mediated by various signals,such as transforming growth factor,platelet-derived growth factor,and fibroblast growh factor,has been recongized as a major event in the occurrence and progression of fibrosis.Although the mechanisms driving organ-specific fibrosis have not been fully elucidated,drugs targeting these identified aberrant signals have achieved potent anti-fibrotic efficacy in clinical trials.In this review,we briefly introduce the aetiology and epidemiology of several fibrosis diseases,including liver fibrosis,kidney fibrosis,cardiac fibrosis,and pulmonary fibrosis.Then,we summarise the abnormal cells(epithelial cells,endothelial cells,immune cells,and fibroblasts)and their interactions in fibrosis.In addition,we also focus on the aberrant signaling pathways and therapeutic targets that regulate myofibroblast activation,extracellular matrix cross-linking,metabolism,and inflammation in fibrosis.Finally,we discuss the anti-fibrotic drugs based on their targets and clinical trials.This review provides reference for further research on fibrosis mechanism,drug development,and clinical trials.
基金supported by the National Key Research and Development Program of China(2020YFA0712102)the National Natural Science Foundation of China(52022094,22020102003,and 52072142)+1 种基金the Program of Science and Technology Development Plan of Jilin Province of China(20210101111JC and 20230508071RC)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232)。
基金supported by the National Key Research&Development Program of China(2019YFA0606703)the National Natural Science Foundation of China(41975116 and 42105027)+2 种基金the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y202025)the China Postdoctoral Science Foundation(BX20200329 and 2020M680646)the Special Research Assistant Project of Chinese Academy of Sciences。
文摘Tropical rainfall is important for regional climate around the globe.In a warming climate forced by rising CO_(2),the tropical rainfall will increase over the equatorial Pacific where sea surface warming is locally enhanced.Here,we analyze an idealized CO_(2) removal experiment from the Carbon Dioxide Removal Model Intercomparison Project(CDRMIP)and show that the tropical rainfall change features a stronger pattern during CO_(2) ramp-down than ramp-up,even under the same global mean temperature increase,such as the 2℃ goal of the Paris Agreement.The tropical rainfall during CO_(2) ramp-down increases over the equatorial Pacific with a southward extension,and decreases over the Pacific intertropical convergence zone and South Pacific convergence zone.The asymmetric rainfall changes between CO_(2) ramp-down and ramp-up result from time-varying contributions of the fast and slow oceanic responses to CO_(2) forcing,defined as the responses to abrupt CO_(2) forcing in the first 10 years and thereafter,respectively,in the abrupt-4xCO_(2) experiment.The fast response follows the CO_(2) evolution,but the slow response does not peak until 60 years after the CO_(2) peak.The slow response features a stronger El Niño-like pattern,as the ocean dynamical thermostat effect is suppressed under stronger subsurface warming.The delayed and stronger slow response leads to stronger tropical rainfall changes during CO_(2) ramp-down.Our results indicate that returning the global mean temperature increase to below a certain goal,such as 2℃,by removing CO_(2),may fail to restore tropical convection distribution,with potentially devastating effects on climate worldwide.
基金Supported by Sichuan Science and Technology Program(2023YFG0155).
文摘Spatial information network(SIN)is a network with high speed and periodicity of node operation.In recent days,China will build a complete asteroid monitoring and warning system and a near-Earth asteroid defense system.This requires launching more low-Earth orbit satellites.In order to adapt to the increase in the number of near-Earth satellites,the dynamic optimization of space informa-tion network topology between satellites will have research significance.Consid-ering the visibility of satellite networking,the connectivity of satellite nodes,and the number of links connected to the whole network,with the goal of minimizing the end-to-end delay between satellite nodes in the network as the optimization goal,a network topology optimization model that meets multiple constraints is constructed,and the model is solved using greedy algorithm and simulated anneal-ing algorithm.In the process of simulated annealing,the networkflow algorithm is innovatively proposed for neighborhood solution.Experiments show that the simulated annealing hybrid neighborhood algorithm is significantly better than the simulated annealing random neighborhood algorithm.
基金This work was supported by the Science and Technology Department of Sichuan Province,China(2023YFG0155).
文摘Spatial information network is a kind of satellite network with high speed node movement and fast dynamic topology change.With the increasing number of low-orbit satellites,the research on the subnets topology and dynamic optimization of space information networks has become an important direction to study the destructibility of spatial information network.In this paper,two common objective functions in inter-satellite link assignment,network observation position and network communication factor are studied,and a multi-objective optimization model is constructed.Depth first search,simulated annealing,NSGA-II and adaptive optimization simulated annealing were used to analyze and solve the model.By comparing the solving efficiency of the model through simulation experiments,the difference of the results caused by the four algorithms is verified.