The Study and Applications of Sparse Methods Technology in Yunnan Mountain Substation

As one of the divisions in China Southern Power Grid, Yunnan Power Grid Corporation has conducted research and demonstration projects on multiple smart grid technologies to improve the power system reliability, save operation cost and enhance measurement accuracy. In this paper, we will introduce The Study of Yunnan Mountain Substation Data Aggregation Technology based on Sparse Methods. Most substations are built in the mountain, the complex geological conditions and poor natural conditions put forward higher requirements on the substation running and real-time comprehensive monitoring of substation system. Processing and polymerization research of large amounts of the monitoring data and information is studied in this article. This paper introduces the sparse methods and then explains the thinning algorithm, especially new algorithm is proposed. Finally, the substation sparse method architecture is put forward and the simulation experiment was carried out to prove the feasibility and effectiveness of the proposed method.

Nanotechnology:A New Strategy for Lung Cancer Treatment Targeting Pro-Tumor Neutrophils

Primary and metastatic lung cancers are malignant lung tumors each with of which has a different pathogenesis,although both threaten patient lives.Tumor development and progression involve communication between tumor cells and the host microenvironment.Neutrophils are the most abundant immune cells in the tumor microenvironment(TME);they participate in the generation of an inflammatory milieu and influence patient survival through their anti-and pro-tumor abilities.Neutrophils can be classified into various categories according to different criteria;frequent categories include N1 antitumor neutrophils and N2 immunosuppressive neutrophils.The antitumor effects of neutrophils are reported to be mediated through a combination of reactive oxygen species,tumor necrosis factor-related apoptosis-inducing ligand,and receptor for advanced glycation end-products–cathepsin G association,as well as the regulation of the activities of other immune cells.There have also been reports that neutrophils can function as tumor promoters that contribute to lung cancer progression and metastasis by influencing processes including carcinogenesis,angiogenesis,cancer cell proliferation,and invasion ability,as well as having similar roles in the lung metastasis of other cancers.The rapid development of nanotechnology has provided new strategies for cancer treatment targeting neutrophils.

Oncolytic Virus Senecavirus A Inhibits Hepatocellular Carcinoma Proliferation and Growth by Inducing Cell Cycle Arrest and Apoptosis

Background and Aims:Hepatocellular carcinoma(HCC)isa highly aggressive tumor with limited treatment options andhigh mortality.Senecavirus A(SVA)has shown potential inselectively targeting tumors while sparing healthy tissues.This study aimed to investigate the effects of SVA on HCCcells in vitro and in vivo and to elucidate its mechanisms ofaction.Methods:The cell counting kit-8 assay and colonyformation assay were conducted to examine cell proliferation.Flow cytometry and nuclear staining were employed toanalyze cell cycle distribution and apoptosis occurrence.Asubcutaneous tumor xenograft HCC mouse model was createdin vivo using HepG2 cells,and Ki67 expression in thetumor tissues was assessed.The terminal deoxynucleotidyltransferase dUTP nick end labeling assay and hematoxylinand eosin staining were employed to evaluate HCC apoptosisand the toxicity of SVA on mouse organs.Results:In vitro,SVA effectively suppressed the growth of tumor cells by inducingapoptosis and cell cycle arrest.However,it did nothave a notable effect on normal hepatocytes(MIHA cells).In an in vivo setting,SVA effectively suppressed the growthof HCC in a mouse model.SVA treatment resulted in a significantdecrease in Ki67 expression and an increase in apoptosisof tumor cells.No notable histopathological alterationswere observed in the organs of mice during SVA administration.Conclusions:SVA inhibits the growth of HCC cells byinducing cell cycle arrest and apoptosis.It does not causeany noticeable toxicity to vital organs.

Combination Therapy of Multiple Micro Trauma Technology on Hepatocellular Carcinoma

Objective: To compare efficacy of therapy scheme as Transhepatic Artery Chemoembolization (TACE) + Radiofrequency Ablation (RFA) + Introportal Vein Chemotherapy (PVC) + Percutaneous Ethanol Injection (PEI) therapy (quadruplet group) with TACE + RFA combinational therapy (diad group) in treating hepatocellular carcinoma (HCC). Methods: 25 cases in quadruplet group were treated by TACE for 3 weeks, then by RFA, after 2 months, by PVC + PEI;23 cases in diad group were treated by TACE for 3 weeks and then by PEI. After completion of each treatment course in both groups, Alphafetoprotein (AFP) was tested 2 months later;abdomen colorful doppler, CT and AFP were retested 6 months later. Results: AFP was significantly decreased in 23 cases of quadruplet group and 20 cases of diad group among those with AFP positive results. 6 months later, examinations of CT, colorful Doppler and AFP in two groups showed: quadruplet group has significantly decreased (X2 = 6.81, P 0.01) blood supply of cancer tissue and significantly diminished (X2 = 8.29, P 0.01) tumor size, few cases with AFP elevation (X2 = 5.06, P 0.05);lower 1 year relapse rate and two years mortality than that in diad group (X2 = 5.30, P 0.05). Conclusion: TACE + RFA + PVC + PEI combinational therapy is a safe double intervention treatment for HCC scheme with less side effects, which is better than TACE + PEI scheme in killing remnant tumor and reducing relapse.

Development and application of blade-coating technique in organic solar cells

Due to the characteristics of lower material waste,higher crystallinity,roll-to-roll compatibility,and high-throughput continuous processing,blade-coating has been widely applied in the preparation of large-area organic solar cells.In this paper,the technique of blade-coating is introduced,including the effects of blading speed,substrate temperature,and other technological innovations during the process of blade-coating.Besides,the recent progress of blade-coating in organic solar cells is summarized and the active layer prepared by a blade-coating method is introduced in detail,including materials,processing methods,solvents,and additives.The interface layer and electrodes prepared by the blade-coating method are also discussed.Finally,some perspectives on the blade-coating method are proposed.In the foreseeable future,blade-coating will become the core of batch production of large-area organic solar cells,so as to make organic solar cells more competitive.

A silazane additive for CsPbI_(2)Br perovskite solar cells

Adding additives into peroskite precursor solution has been proven as a simple and efficient strategy to improve the quality of peroskite films.In this work,we demonstrate an effective additive strategy to improve the quality of all-inorganic perovskite films by adding a novel silazane additive heptamethyldisilazane(HDMS).The power conversion efficiency(PCE)of the optimized devices is enhanced from 14.55%to 15.31%with an open-circuit voltage over 1.26 V due to the higher quality perovskite films with lower trap density after the incorporation of HDMS.More interestingly,the HDMS devices exhibit superior humidity and thermal stability compared with the control ones.This work provides a simple and efficient strategy to enhance the device performance and stability of all-inorganic perovskite solar cells,which could facilitate its commercialization.

Synthesis and application of green solvent dispersed organic semiconducting nanoparticles

Organic photovoltaic semiconductors have made significant progress and have promising application prospects after decades of development.When compared with traditional semiconductors,the solution method for preparing photovoltaic semiconductors shows the advantages of low cost and convenient preparation.However,because of the extremely poor solubility of the polymers used to prepare semiconductors,toxic solvents must be used when using the solution method,which has significant negative effects on the environment and operators and severely limits its development prospects.Organic nanoparticles(NPs),on the other hand,can avoid these issues.Because NPs are typically water or alcohol-based,no toxic solvents are used.Furthermore,NPs have been used in organic solar cells,hydrogen catalysis,organic light-emitting diodes,and other fields after nearly two decades of development,and their preparation methods have been developed.We describe the preparation,optimization,and application of NPs in photovoltaic semiconductors in this review.

降低全聚合物太阳能电池光伏效率的温度依赖性

全聚合物太阳能电池(All-PSCs)具有良好的机械稳定性和热稳定性,受到人们的广泛关注.目前,提高全聚合物太阳能电池性能的关键是改善活性层的形貌.本文通过逐层(LBL)工艺,优化了薄膜形貌,实现了更好的电荷产生和传输,增加了激子扩散长度,提高了电荷产量,并抑制了复合损失.此外,本文进一步研究了LBL制备的全聚合物太阳能电池中的激子/电荷行为与温度的依赖性关系.详细的原位光谱测量和光电特性表征表明,独特的形态延长了激子寿命,减少了电荷陷阱,并促进了电荷传输和收集.因此,准双层PM6/PYF-T-o器件的能量转换效率(PCE)显著提高(16.70%).此外,与BHJ器件相比,通过LBL工艺制备的器件,实现了增强的分子有序性,降低了能级混乱度,使得器件填充系数和PCE温度依赖性减弱.本工作为太阳能电池在温度可变环境下的电荷传输行为和光伏性能提供了新的认识,也为其实际应用提供了理论依据.

Synergistic Co-doping effect of CNTs and PVP in Na_(4)MnCr(PO_(4))3 cathode as a strategy for improving the electrochemical performance of SIBs

In order to solve the contradiction between the rapidly growing energy demand and the excessive exploitation of fossil fuels,it is urgent to research and develops more environmentally friendly and efficient energy storage technologies.Therefore,the development of high-performance cathode materials to enhance the energy density of SIB is currently one of the most important topics of scientific research.Advanced high-voltage and low-cost cathode material for SIBs,a composite of carbon-coated Na_(4)MnCr(PO_(4))_(3)(NASICON-type),polyvinylpyrrolidone(PVP),and modified carbon nanotubes(CNTs)is prepared by sol-gel and freeze-drying method.Due to the high conductivity of CNTs,the conductivity of the composite is significantly improved,and its initial capacity is increased to 114 mAh/g at 0.5 C and 96 mAh/g at 5 C(Mn^(2+)/Mn^(4+)conversion for voltage windows 1.4-4.3 V).Moreover,the multi-electrons transfer of Cr^(3+)/Cr^(4+) and Mn^(2+)/Mn^(4+) can provide a high capacity of 165 mAh/g at 0.1 C and 102 mAh/g at 5 C in the high voltage window of 1.4-4.6 V.Furthermore,PVP can effectively inhibit the Jahn-Teller effect caused by Mn ion,making the composite have more excellent high-rate performance and stability.In addition,GITT,EIS and CV curves were drawn to better reveal the excellent kinetic properties of Na_(4)MnCr(PO_(4))_(3)@C@PVP@CNT cathode,and the mechanism of its performance improvement is deeply studied and discussed.Accordingly,the co-doping of CNTs and PVP is a simple way to high conductivity and fast charging of cathode materials for SIBs.

Co-Frequency Interference Analysis Between Ultra-Large-Scale NGSO Constellations and GSO Systems

The rejuvenation of non-geostationary orbit(NGSO)satellite communication holds the promise of seamless and ubiquitous broadband access from the space.However,the NGSO constellations must share the scarce radio spectrum resources with geostationary orbit(GSO)satellite systems,which results in dynamically changing and unevenly distributed interference to GSO systems.In this context,the ultra-large-scale NGSO constellation incurs a more complicated interference environment with GSO systems,which raises urgent demands on inter-system interference evaluation.In this case,we investigate the inter-system downlink interference from a NGSO satellite mega-constellation to a GSO earth station.Specifically,we consider the scenario where the NGSO and GSO earth stations are co-located,and apply a novel visibility analysis method in the interference modeling to reduce computation redundancy.The interference evaluation is then performed through comprehensive simulations,in which the Starlink constellation with more than 4000 satellites is examined for the first time.The simulation results demonstrate various states of interference on the GSO earth station at different deployment locations.It reveals that the number of visible satellites could influence the angle between the main lobe directions of NGSO satellites and the GSO earth station antenna,which further affects the interference level.

Macrophage Phenotypes and Hepatitis B Virus Infection

Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the liver, contribute to HBV infection in various aspects. These cells play an important role not only in the anti-HBV immunity including virus recognition, cytokine production to directly inhibit viral replication and recruitment and activation of other immune cells involved in virus clearance but also in HBV outcome and progression, such as persistent infection and development of end-stage liver diseases. Since liver macrophages play multiple roles in HBV infection, they are directly targeted by HBV to benefit its life cycle. In the present review, we briefly outline the current advances of research of macrophages, especially the studies of their phenotypes, in chronic HBV infection.

Surface structure change properties:Auto-soft bionic fibrous membrane in reducing postoperative adhesion

Peritoneal adhesion is the most common adverse effect following abdominal surgery or inflammation.The occurrence in clinical trials has been successfully reduced using barriers.However,the shortcomings of frequently used adhesion barriers,such as rapid degradation rate of gel barrier and inadequate operation ability of solid barrier,cannot be ignored.In this study,a fibrous membrane with an ECM-like structure was prepared.The adhesion properties were reduced significantly by changing the surface structure.The fibrous membrane caused less inflammatory response and much less peripheral adhesion and intestinal obstruction compared to the casting film and the commercial film with smooth surface,though with the same components.Because of the auto-soft bionic structure and similarity in the mechanical modulus of the tissues,the fibrous membrane was more flexible when it adhered to the tissues,showed excellent effectiveness and biocompatibility.In addition to the rat and miniature pig models,a randomized,placebo-controlled,and multicenter clinical pilot study with 150 patients confirmed that because of its flexibility,biodegradability,and similarity to mechanical modulus and structure with tissues involved,the fibrous membrane served as a favorable implant for preventing post-operation adhesion.

The Evaluation of Insertion and Deletion Polymorphism in Population and Personal Identification Amidst Chinese Populations

For comprehensive understanding of practical application and evaluation on the power of30 commonly used InDeis(Qiagen Investigator DIPplex®kit),we captured population data from 25 Chinese populations and employed F-statistics for population genetics analysis.The results indicated that the distributions of allelic frequencies among populations were in different levels.Furthermore,the phylogeny confoiming pairwise FST distances showed that the difierentiation of majority populations were consistent with their geographic locations and historic dispersals.We conduct the comprehensive correlation analysis between FST and heterozygosity of30 InDel loci and provided strong evidence for ongoing InDei loci selection.The Fst values of 30 InDels were calculated within 25 Chinese populations,and then,these loci were characterized definitely based on their roles in population genetics or individual identification.Data indicated that 17 InDels with FST<0.01 could be utilized regarding Chinese individual identification(total discrimination power=0.999985 and cumulative matching probability=0.00000009).We comprehensively reconstructed the population structure and filled the gap of evaluating the ability of InDels in personal as well as population identification.The application of InDel loci in the forensic area would convincingly promote the development matter of forensic population identification and personal discrimination.