Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferati...Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation,differentiation and angiogenesis.These effects by MSCs are mediated by a variety of factors,including growth factors,cytokines and extracellular vesicles(EVs).Among these factors,EVs,containing proteins,mRNA and microRNAs(miRNA),may carry their contents into distant tissues with high stability.Therefore,the treatment with MSC-derived EVs may be promising as‘natural’drug delivery systems(DDS).Especially,the treatment of MSCderived EVs with the manipulation of specific miRNAs expression has been reported to be beneficial under a variety of diseases and tissue injuries.The overexpression of specific miRNAs in the EVs might be through pre-loading method using the gene editing system by plasmid vector or post-loading method to load miRNA mimics into EVs by electroporation or calcium chloride-mediated transfection.Despite current several challenges for clinical use,it should open the next era of regenerative medicine for a variety of diseases.In this article,we highlight the therapeutic potential of MSC-derived EVs as‘natural’DDS and current challenges.展开更多
This paper considers the design of EMAT （Electro-Magnetic Acoustic Transducer） based on numerical simulation. The EMAT consists of an exiting coil and two permanent magnets, which transmits the ultrasonic wave by th...This paper considers the design of EMAT （Electro-Magnetic Acoustic Transducer） based on numerical simulation. The EMAT consists of an exiting coil and two permanent magnets, which transmits the ultrasonic wave by the Lorentz force between the eddy current and the static magnetic field by the magnets. From the experimental result on self-prepared EMATs, the intensity and the directivity of the transmitted wave depend on the widths of the coil and the magnets. By means of EEM analysis the authors attempt to determine the optimal values of the above widths such that both the intensity and the directivity achieve the maximum or allowable performance.展开更多
文摘Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation,differentiation and angiogenesis.These effects by MSCs are mediated by a variety of factors,including growth factors,cytokines and extracellular vesicles(EVs).Among these factors,EVs,containing proteins,mRNA and microRNAs(miRNA),may carry their contents into distant tissues with high stability.Therefore,the treatment with MSC-derived EVs may be promising as‘natural’drug delivery systems(DDS).Especially,the treatment of MSCderived EVs with the manipulation of specific miRNAs expression has been reported to be beneficial under a variety of diseases and tissue injuries.The overexpression of specific miRNAs in the EVs might be through pre-loading method using the gene editing system by plasmid vector or post-loading method to load miRNA mimics into EVs by electroporation or calcium chloride-mediated transfection.Despite current several challenges for clinical use,it should open the next era of regenerative medicine for a variety of diseases.In this article,we highlight the therapeutic potential of MSC-derived EVs as‘natural’DDS and current challenges.
文摘This paper considers the design of EMAT （Electro-Magnetic Acoustic Transducer） based on numerical simulation. The EMAT consists of an exiting coil and two permanent magnets, which transmits the ultrasonic wave by the Lorentz force between the eddy current and the static magnetic field by the magnets. From the experimental result on self-prepared EMATs, the intensity and the directivity of the transmitted wave depend on the widths of the coil and the magnets. By means of EEM analysis the authors attempt to determine the optimal values of the above widths such that both the intensity and the directivity achieve the maximum or allowable performance.
