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Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage 被引量:1
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作者 Guoqiang Zhang Jianan Lu +7 位作者 Jingwei Zheng Shuhao Mei Huaming Li Xiaotao Zhang An Ping shiqi gao Yuanjian Fang Jun Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期161-170,共10页
Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related t... Preclinical and clinical studies have shown that microglia and macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage.The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment and maturation.However,the effect of Spi1 on intracerebral hemorrhage remains unclear.In this study,we found that Spi1 may regulate recovery from the neuroinflammation and neurofunctional damage caused by intracerebral hemorrhage by modulating the microglial/macrophage transcriptome.We showed that high Spi1expression in microglia/macrophages after intracerebral hemorrhage is associated with the activation of many pathways that promote phagocytosis,glycolysis,and autophagy,as well as debris clearance and sustained remyelination.Notably,microglia with higher levels of Soil expression were chara cterized by activation of pathways associated with a variety of hemorrhage-related cellular processes,such as complement activation,angiogenesis,and coagulation.In conclusion,our results suggest that Spi1 plays a vital role in the microglial/macrophage inflammatory response following intracerebral hemorrhage.This new insight into the regulation of Spi1 and its target genes may advance our understanding of neuroinflammation in intracerebral hemorrhage and provide therapeutic targets for patients with intracerebral hemorrhage. 展开更多
关键词 intracerebral hemorrhage MACROPHAGE microglia neuroinflammation PHAGOCYTOSIS PI3K/AKT/mTOR signaling pathway Spi1 TRANSCRIPTOMICS
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Magnetic wrinkled organosilica-based metal-enzyme integrated catalysts for enhanced chemoenzymatic catalysis
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作者 Yunting Liu Na Guo +5 位作者 Weixi Kong shiqi gao Guanhua Liu Liya Zhou Jing gaoa Yanjun Jiang 《Green Synthesis and Catalysis》 2024年第2期122-125,共4页
Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral am... Core-shell structured magnetic wrinkled organosilica-based metal-enzyme integrated catalysts were synthesized,and their catalytic performances were studied in the chemoenzymatic dynamic kinetic resolution of chiral amines in an organic solvent,as well as in the chemoenzymatic synthesis of chiral alcohols in water.Structureperformance studies revealed the important influence of their tunable structure and composition on the optimization of activity,stability,and recyclability in chemoenzymatic catalysis. 展开更多
关键词 Magnetic wrinkled organosilica Chemoenzymatic catalysis CO-IMMOBILIZATION Asymmetric synthesis Chiral amines/alcohols Dynamic kinetic resolution Nanomaterials
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TaSRT2 recognizes a viral protein to activate host immunity byincreasing histone acetylation
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作者 Kaili Zhong Yaoyao Jiang +17 位作者 Haichao Hu Bowen Yuan Mila Wu Aizhu Tu Gecheng Xu Linna Cai Tingting Liu shiqi gao Linzhi Li Qiansheng Liao Lidan Guo Ye Xia Peng Liu Ye Cheng Lin Lin Chuanxi Zhang Jianping Chen Jian Yang 《Science Bulletin》 SCIE EI CAS CSCD 2024年第20期3206-3211,共6页
Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent informat... Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent information regulator 2(SIR2) family of proteins were initially described as nuclear proteins with histone deacetylase activity that causes chromatin compaction and gene silencing[2]. 展开更多
关键词 IMMUNITY initially ACETYLATION
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Transonic buffet control research with two types of shock control bump based on RAE2822 airfoil 被引量:5
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作者 Yun TIAN shiqi gao +1 位作者 Peiqing LIU Jinjun WANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2017年第5期1681-1696,共16页
Current research shows that the traditional shock control bump(SCB) can weaken the intensity of shock and better the transonic buffet performance. The author finds that when SCB is placed downstream of the shock, it... Current research shows that the traditional shock control bump(SCB) can weaken the intensity of shock and better the transonic buffet performance. The author finds that when SCB is placed downstream of the shock, it can decrease the adverse pressure gradient. This may prevent the shock foot separation bubble to merge with the trailing edge separation and finally improve the buffet performance. Based on RAE2822 airfoil, two types of SCB are designed according to the two different mechanisms. By using Reynolds-averaged Navier-Stokes(RANS) and unsteady Reynolds-averaged Navier-Stokes(URANS) methods to analyze the properties of RAE2822 airfoil with and without SCB, the results show that the downstream SCB can better the buffet performance under a wide range of freestream Mach number and the steady aerodynamics characteristic is similar to that of RAE2822 airfoil. The traditional SCB can only weaken the intensity of the shock under the design condition. Under the off-design conditions, the SCB does not do much to or even worsen the buffet performance. Indeed, the use of backward bump can flatten the leeward side of the airfoil, and this is similar to the mechanism that supercritical airfoil can weaken the recompression of shock wave. 展开更多
关键词 AERODYNAMICS Buffet control RAE2822 airfoil Shock control bump TRANSONIC
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