Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate t...Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.展开更多
This article summarized the nursing problems and corresponding nursing strategies of 18 cases of external diaphragm pacemakers in the application of elderly patients with lung cancer after thoracic surgery. Timely psy...This article summarized the nursing problems and corresponding nursing strategies of 18 cases of external diaphragm pacemakers in the application of elderly patients with lung cancer after thoracic surgery. Timely psychological care, correct operation, close observation and infection prevention during treatment can effectively optimize the use of external diaphragm pacemakers, improve respiratory muscle function, and the quality of life after lung cancer surgery in elderly patients.展开更多
Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone hol...Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases.展开更多
An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems.This study investigated dynamic changes in root respiration and the contribution of root...An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems.This study investigated dynamic changes in root respiration and the contribution of root respiration to total soil respiration(R_(r)/R_(t) ratio)during the non-growing season in mine reclaimed soil,with different covering-soil thicknesses.According to the covering-soil thicknesses,the study area was divided into four sites:10-25 cm(site A),25-45 cm(site B),45-55 cm(site C),and 55-65 cm(site D).From November 2017 to April 2018(except February in 2018),the soil respiration,root respiration,temperature at 5 cm,water content,and root biomass were measured.The results show that soil temperature and root respiration exhibited similar diurnal and monthly variations.The root respiration is strongly influenced by soil temperature during the non-growing season,with an exponential and positive relationship(P<0.001).Root respiration varies with the covering-soil thickness and is greatest with a covering-soil thickness of 25-45 cm.The R_(r)/R_(t) ratio also exhibits monthly variations.During the non-growing season,the mean value of the R_(r)/R_(t) ratio is 51.15%in mine reclaimed soil.The study indicates that root respiration is the primary source of soil respiration and is an important factor for estimating the potential emission of soil CO_(2) from mine reclaimed soil at the regional scale.展开更多
Surrounding rock of coal seam was one of the important factors to gas occurrence. The coal seam gas occurrence was studied by the index of roof strata thickness or sand content rate;we found that there were certain sh...Surrounding rock of coal seam was one of the important factors to gas occurrence. The coal seam gas occurrence was studied by the index of roof strata thickness or sand content rate;we found that there were certain shortcomings. In order to reasonably evaluate the influence of coal seam surrounding rock on gas occurrence in Panji mining area, we quantitatively evaluated the effect of coal seam surrounding rock on gas occurrence by influence coefficient of roof strata thickness, and built six mathematical models of the variational gas content in the mining area which is divided into six gas geological units. The results shows that the coal seam gas content is mainly influenced by 20 mroof strata in each gas geological unit, the gas content presents the tendency of increase, and with the influence coefficient of strata thickness increases, they exist a significant linear relationship.展开更多
Tropical cyclones(TCs),including tropical depressions and different categories of typhoons,hurricanes,and cyclonic storms,mostly originate over the oceans in the absence of direct observations.Thus,detailed monitoring...Tropical cyclones(TCs),including tropical depressions and different categories of typhoons,hurricanes,and cyclonic storms,mostly originate over the oceans in the absence of direct observations.Thus,detailed monitoring and analysis of TCs has always been an unsolved problem.In the recent 20 years,great changes have taken place in domestic and foreign TC monitoring techniques,imposing a significant impact on TC operations and research.Some new technologies and products gradually emerge to support operations,with improved monitoring accuracy.In this paper,the progress on TC monitoring and analysis via meteorological satellites,radars,and airplanes in China and the world is reviewed,compared,and summarized,with special focuses on multisatellite fusion observations,in situ aircraft measurements,and some unconventional observation equipment such as rockets,saildrones,and underwater gliders.On this basis,the paper points out future directions for improving TC monitoring and analysis in aid of better TC forecast and early warning.展开更多
Bdellovibrio-and-like organisms （BALOs） are a group of ubiquitous and obligate predatory bacteria and conmlonly used as biocontrol agents. In this study, an efficient, environmental-friendly, and convenient BALOs en...Bdellovibrio-and-like organisms （BALOs） are a group of ubiquitous and obligate predatory bacteria and conmlonly used as biocontrol agents. In this study, an efficient, environmental-friendly, and convenient BALOs encouraged municipal waste sludge biolysis pretreatment technique was developed and investigated for dewaterability enhancement of excess waste sludge. The indigenous predatory BALOs were successfully isolated from the sludge for biolysis treatment. Without any chemical addition or pH adjustment, the sludge specific resistance （SRF） and capillary suction time （CST） were significantly reduced by as high as 53.4% and 23.8%, respectively within 24 h＇s treatment, which would further be lowered with the increase of BALOs input dosage. However, the continuous extension of reaction time would women the sludge dewaterability. The decreases of SRF and CST accompanied with the increases of sludge disintegration degree and soluble chemical oxygen demand, nitrogen, and phosphorus concentrations all emphasized the contributions of BALOs＇ predation activities to sludge disturbance, cell lysis, and consequently the release of sludge intracellular water to finally effectively improve the sludge dewaterability and disposal efficiency.展开更多
Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-...Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described.The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope.It is amenable to gram-scale synthesis and easily transformation.Moreover,this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.展开更多
To pre-compress the disk-shaped LY12 samples along the radial direction can be done with the aid of overstress assembly by heating or by mechanical clamping, which can also generate the deviatoric stress fields under ...To pre-compress the disk-shaped LY12 samples along the radial direction can be done with the aid of overstress assembly by heating or by mechanical clamping, which can also generate the deviatoric stress fields under different states. The spallation signals of these pre-compressed samples are measured by VISAR in the light-gas gun shock experiments. The experimental results show that even under the same impact velocity, the pullback amplitudes of the velocity at the free surface of the sam- pies vary significantly. According to the experimental data, we propose a distinct concept that the material spallation strength is closely related to the deviatoric stress fields in the material. Based on the numerical simulation, we develop a damage con- stitutive model, which reveals that the deviatoric stress reduces the tensile threshold of the void growth. The numerical inves- tigations also demonstrate that the spallation strength decreases as pre-compression increases. The experimental idea proposed in this paper can also be used to study the spallation process in other structures.展开更多
In order to improve the existing phosphorus index assessment methods,using the interactive evaluation index(IEI)as an auxiliary variable,the geographically weighted regression(GWR)was adopted as prediction means.A met...In order to improve the existing phosphorus index assessment methods,using the interactive evaluation index(IEI)as an auxiliary variable,the geographically weighted regression(GWR)was adopted as prediction means.A method of regional soil phosphorus risk assessment was constructed by modifying phosphorus index model(MPIM).The GWR-IEI method more accurately predicted available phosphorus(AP)and soil organic matter(SOM),and the prediction precision and goodness of fit were high.Compared with the ordinary least square(OLS)method,the relative improvement of the root mean squared errors(RMSE)with the GWR-IEI method reached 28.95%for available phosphorus predicted,while that of SOM was 21.24%.The phosphorus loss risk of most of the study area(95.29%)was moderate to low.The areas featuring an extremely high phosphorus loss accounted for merely 0.33%of the total research area.Phosphorus loss depends on the effects of many factors.Areas which have strong source or transfer factors are not necessarily high-risk areas for phosphorus loss.Only the co-occurrence of transfer and source factors leads to high risk and greater potential for phosphorus loss.The GWR-IEI-MPIM method accurately reflected the degree of risk for phosphorus at the regional scale,which provides a valuable reference for risk assessment of phosphorus.展开更多
基金supported by grants from the National Natural Science Foundation of China (No. 81901042)the Sichuan Science and Technology Program (No. 2022NSFSC1384)International Team for Implantology (No. 1477_2020)。
文摘Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.
文摘This article summarized the nursing problems and corresponding nursing strategies of 18 cases of external diaphragm pacemakers in the application of elderly patients with lung cancer after thoracic surgery. Timely psychological care, correct operation, close observation and infection prevention during treatment can effectively optimize the use of external diaphragm pacemakers, improve respiratory muscle function, and the quality of life after lung cancer surgery in elderly patients.
基金the National Natural Science Foundation of China(NSFC 81722014,81970913)State Key Laboratory of Oral Diseases(SKLOD202008)West China Hospital of Stomatology(RD-03-202010).
文摘Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases.
基金This work was financially supported by the National Natural Science Foundation of China(41572333,51274013).In addition,we express our sincere gratitude to Ada Zhang for polishing the language of this paper.
文摘An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems.This study investigated dynamic changes in root respiration and the contribution of root respiration to total soil respiration(R_(r)/R_(t) ratio)during the non-growing season in mine reclaimed soil,with different covering-soil thicknesses.According to the covering-soil thicknesses,the study area was divided into four sites:10-25 cm(site A),25-45 cm(site B),45-55 cm(site C),and 55-65 cm(site D).From November 2017 to April 2018(except February in 2018),the soil respiration,root respiration,temperature at 5 cm,water content,and root biomass were measured.The results show that soil temperature and root respiration exhibited similar diurnal and monthly variations.The root respiration is strongly influenced by soil temperature during the non-growing season,with an exponential and positive relationship(P<0.001).Root respiration varies with the covering-soil thickness and is greatest with a covering-soil thickness of 25-45 cm.The R_(r)/R_(t) ratio also exhibits monthly variations.During the non-growing season,the mean value of the R_(r)/R_(t) ratio is 51.15%in mine reclaimed soil.The study indicates that root respiration is the primary source of soil respiration and is an important factor for estimating the potential emission of soil CO_(2) from mine reclaimed soil at the regional scale.
文摘Surrounding rock of coal seam was one of the important factors to gas occurrence. The coal seam gas occurrence was studied by the index of roof strata thickness or sand content rate;we found that there were certain shortcomings. In order to reasonably evaluate the influence of coal seam surrounding rock on gas occurrence in Panji mining area, we quantitatively evaluated the effect of coal seam surrounding rock on gas occurrence by influence coefficient of roof strata thickness, and built six mathematical models of the variational gas content in the mining area which is divided into six gas geological units. The results shows that the coal seam gas content is mainly influenced by 20 mroof strata in each gas geological unit, the gas content presents the tendency of increase, and with the influence coefficient of strata thickness increases, they exist a significant linear relationship.
基金Supported by the National Natural Science Foundation of China(41930972)。
文摘Tropical cyclones(TCs),including tropical depressions and different categories of typhoons,hurricanes,and cyclonic storms,mostly originate over the oceans in the absence of direct observations.Thus,detailed monitoring and analysis of TCs has always been an unsolved problem.In the recent 20 years,great changes have taken place in domestic and foreign TC monitoring techniques,imposing a significant impact on TC operations and research.Some new technologies and products gradually emerge to support operations,with improved monitoring accuracy.In this paper,the progress on TC monitoring and analysis via meteorological satellites,radars,and airplanes in China and the world is reviewed,compared,and summarized,with special focuses on multisatellite fusion observations,in situ aircraft measurements,and some unconventional observation equipment such as rockets,saildrones,and underwater gliders.On this basis,the paper points out future directions for improving TC monitoring and analysis in aid of better TC forecast and early warning.
基金Acknowledgements This study was supported by the National Natural Science Foundation of China （Grant No. 51208092） and Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Human Resources and Social Security of the People＇s Republic China （2014）.
文摘Bdellovibrio-and-like organisms （BALOs） are a group of ubiquitous and obligate predatory bacteria and conmlonly used as biocontrol agents. In this study, an efficient, environmental-friendly, and convenient BALOs encouraged municipal waste sludge biolysis pretreatment technique was developed and investigated for dewaterability enhancement of excess waste sludge. The indigenous predatory BALOs were successfully isolated from the sludge for biolysis treatment. Without any chemical addition or pH adjustment, the sludge specific resistance （SRF） and capillary suction time （CST） were significantly reduced by as high as 53.4% and 23.8%, respectively within 24 h＇s treatment, which would further be lowered with the increase of BALOs input dosage. However, the continuous extension of reaction time would women the sludge dewaterability. The decreases of SRF and CST accompanied with the increases of sludge disintegration degree and soluble chemical oxygen demand, nitrogen, and phosphorus concentrations all emphasized the contributions of BALOs＇ predation activities to sludge disturbance, cell lysis, and consequently the release of sludge intracellular water to finally effectively improve the sludge dewaterability and disposal efficiency.
基金the National Natural Sci-ence Foundation of China(No.21772001)the Anhui Provincial Natural Science Foundation(No.1808085MB41)the Cultiva-tion Project for University Outstanding Talents of Anhui Province(2019).
文摘Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described.The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope.It is amenable to gram-scale synthesis and easily transformation.Moreover,this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.
基金supported by the National Natural Science Foundation of China (Grant No. 10772165)the CAEP Foundation for Basic Research (Grant No. 2005R0802)
文摘To pre-compress the disk-shaped LY12 samples along the radial direction can be done with the aid of overstress assembly by heating or by mechanical clamping, which can also generate the deviatoric stress fields under different states. The spallation signals of these pre-compressed samples are measured by VISAR in the light-gas gun shock experiments. The experimental results show that even under the same impact velocity, the pullback amplitudes of the velocity at the free surface of the sam- pies vary significantly. According to the experimental data, we propose a distinct concept that the material spallation strength is closely related to the deviatoric stress fields in the material. Based on the numerical simulation, we develop a damage con- stitutive model, which reveals that the deviatoric stress reduces the tensile threshold of the void growth. The numerical inves- tigations also demonstrate that the spallation strength decreases as pre-compression increases. The experimental idea proposed in this paper can also be used to study the spallation process in other structures.
基金This research was funded by the National Key Research and Development Program of China(2016YFD0300801,2020YFC1908601)the National Natural Science Foundation of China(41471186).
文摘In order to improve the existing phosphorus index assessment methods,using the interactive evaluation index(IEI)as an auxiliary variable,the geographically weighted regression(GWR)was adopted as prediction means.A method of regional soil phosphorus risk assessment was constructed by modifying phosphorus index model(MPIM).The GWR-IEI method more accurately predicted available phosphorus(AP)and soil organic matter(SOM),and the prediction precision and goodness of fit were high.Compared with the ordinary least square(OLS)method,the relative improvement of the root mean squared errors(RMSE)with the GWR-IEI method reached 28.95%for available phosphorus predicted,while that of SOM was 21.24%.The phosphorus loss risk of most of the study area(95.29%)was moderate to low.The areas featuring an extremely high phosphorus loss accounted for merely 0.33%of the total research area.Phosphorus loss depends on the effects of many factors.Areas which have strong source or transfer factors are not necessarily high-risk areas for phosphorus loss.Only the co-occurrence of transfer and source factors leads to high risk and greater potential for phosphorus loss.The GWR-IEI-MPIM method accurately reflected the degree of risk for phosphorus at the regional scale,which provides a valuable reference for risk assessment of phosphorus.
