In this paper, we propose the nonconforming virtual element method (NCVEM) discretization for the pointwise control constraint optimal control problem governed by elliptic equations. Based on the NCVEM approximation o...In this paper, we propose the nonconforming virtual element method (NCVEM) discretization for the pointwise control constraint optimal control problem governed by elliptic equations. Based on the NCVEM approximation of state equation and the variational discretization of control variables, we construct a virtual element discrete scheme. For the state, adjoint state and control variable, we obtain the corresponding prior estimate in H<sup>1</sup> and L<sup>2</sup> norms. Finally, some numerical experiments are carried out to support the theoretical results.展开更多
Diagnosability of a multiprocessor system G is one important measure of the reliability of interconnection networks. In 2016, Zhang et al. proposed the g-extra diagnosability of G, which restrains that every component...Diagnosability of a multiprocessor system G is one important measure of the reliability of interconnection networks. In 2016, Zhang et al. proposed the g-extra diagnosability of G, which restrains that every component of G – S has at least (g + 1) vertices. The locally twisted cube LTQn is applied widely. In this paper, we show that LTQn is tightly (4n – 9) super 3-extra connected for n ≥ 6 and the 3-extra diagnosability of LTQn under the PMC model and MM* model is 4n - 6 for n ≥ 5 and n ≥ 7, respectively.展开更多
Diagnosability of a multiprocessor system is one important study topic. In 2015, Zhang et al. proposed a new measure for fault diagnosis of the system, namely, g-extra diagnosability, which restrains that every fault-...Diagnosability of a multiprocessor system is one important study topic. In 2015, Zhang et al. proposed a new measure for fault diagnosis of the system, namely, g-extra diagnosability, which restrains that every fault-free component has at least (g + 1) fault-free nodes. As a favorable topology structure of interconnection networks, the n-dimensional alternating group graph AGn has many good properties. In this paper, we give that the 2-extra diagnosability of AGn is 6n - 17 for n≥ 5 under the PMC model and MM* model.展开更多
Diagnosability of a multiprocessor system is one important study topic. In 2012, Peng et al. proposed a measure for fault tolerance of the system, which is called the g-good-neighbor diagnosability that restrains ever...Diagnosability of a multiprocessor system is one important study topic. In 2012, Peng et al. proposed a measure for fault tolerance of the system, which is called the g-good-neighbor diagnosability that restrains every fault-free node containing at least g fault-free neighbors. In 2015, Zhang et al. proposed a measure for fault diagnosis of the system, namely, g-extra diagnosability, which restrains that every fault-free component has at least g+1 fault-free nodes. In this paper, we obtain some properties of the g-good-neighbor (g-extra) diagnosability of the system and give the g-good-neighbor (g-extra) diagnosability of some graphs under the PMC model and MM<sup>*</sup> model.展开更多
In this report, we describe radiation-induced difficult airway management in a patient with nasopharyngeal carcinoma. The patient was presented to receive laparoscopic cholecystectomy for gallbladder stone. He had bee...In this report, we describe radiation-induced difficult airway management in a patient with nasopharyngeal carcinoma. The patient was presented to receive laparoscopic cholecystectomy for gallbladder stone. He had been diagnosed to have nasopharyngeal cancer about 2 years ago. In operation, after sleeping, the patient was manual controlled ventilation. However, we subsequently found that his neck campaign was limited and mask ventilation was obstructed. We immediately performed oropharyngeal airway, then mask ventilation improved. Fully surface anesthesia with tetracaine atomizing to the root of tongue, larynx wall and piriform recess, the patient was endotracheal intubated with fiberoptic bronchoscope. After intubation, the patient inhaled 2.5% sevoflurane, then esmeron (50 mg) and remifentanyl (0.1 μg/kg every minute) were administrated by intravenous. After the treatment, the patient's life indexes were normal and steady. In conclusion, patients with nasopharyngeal carcinoma (NPC) after radiation therapy should be based on comprehensive evaluation of upper airway and obstructive condition before operation, then perform safe and effective tracheal intubation methods under spontaneous breathing.展开更多
The diagnosability of a multiprocessor system or an interconnection network is an important research topic. The system and an interconnection network have an underlying topology, which is usually presented by a graph....The diagnosability of a multiprocessor system or an interconnection network is an important research topic. The system and an interconnection network have an underlying topology, which is usually presented by a graph. In this paper, we show proof for the g-good-neighbor diagnosability of the exchanged hypercube EH (s,t) under the PMC model and MM* model.展开更多
Background:Understanding the clinical implications of autoimmune manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to reduce its consequences. This study was aime...Background:Understanding the clinical implications of autoimmune manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to reduce its consequences. This study was aimed at determining the activities of new-onset primary Sjögren syndrome (pSS) since the emergence of SARS-CoV-2.Methods:This retrospective cohort study included data from 471 participants with dry mouths and eyes who had been attending Nanjing Drum Tower Hospital since December 2019. By April 2023, patients diagnosed with pSS were sequentially assigned to vaccinated group ( n = 24) or vaccinated and infected group based on exposure ( n = 20). Patients diagnosed with pSS within 3 months of vaccination against SARS-CoV-2 were assigned to a vaccinated group, and those who had been vaccinated and then developed pSS within 3 months of follow up after direct exposure to SARS-CoV-2 were assigned to a vaccinated and infected group. The controls comprised age- and sex-matched patients who had not been exposed to SARS-CoV-2 before December 2019 ( n = 21). We then compared data among the three groups. Results:The vaccinated and infected patients had more fever, malaise, splenomegaly, and weight loss before diagnosis and a higher European Alliance of Associations for Rheumatology Sjögren's syndrome disease activity index at the time of onset than the other two groups. Vaccinated patients had a higher frequency of anti-nuclear antibody (ANA) titers > 1:320 ( n = 12;50%) and anti-phospholipid antibodies (aPL) ( n = 7;29%) than the controls. The frequency of anti-Ro/SSA antibodies (13, 65%), ANA titers > 1:320 ( n = 16;80%), and aPLs ( n = 7;29%) ( n = 5;25%) were all significantly higher in vaccinated patients with infection than those in the controls. Higher doses of glucocorticoids, cyclosporin A, and tacrolimus were administered to the vaccinated and infected than the vaccinated and control groups ( p < 0.05, for all). Conclusions:Patients with new-onset pSS and a history of vaccination and SARS-CoV-2 infection might have more active disease. Further strengthening the assessment of people with a clear history of SARS-CoV infection and the monitoring of potential populations for autoimmune screening should not be overlooked.展开更多
Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of ...Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus.展开更多
Although the development of titanium alloys with working temperatures above 600?C faces enormous difficulties and challenges,the related research has not stopped.In the present work,detailed analyses on microstructure...Although the development of titanium alloys with working temperatures above 600?C faces enormous difficulties and challenges,the related research has not stopped.In the present work,detailed analyses on microstructure evolution and hot deformation behavior of a new temperature resistant 650?C titanium alloy Ti65 were investigated from micrometer scale to nanometer scale.The results revealed that lamellarαgrains gradually fragmentized and spheroidized during theα+βphase region compression and the orientation of the c-axis ofαgrains gradually aligned to radial directions,forming two high Schmid factors(SFs)value texture eventually with the increase of strain to 0.7.Moreover,there were some strengthening characters in theα+βphase region such as lenticularαsand nano silicide(TiZr)6 Si3.In theβphase region,fine equiaxed dynamic recrystallized(DRX)βgrains were formed.Besides,the variant selection ofαm′artensite followed Burgers orientation relationship during the compression process.The main deformation mechanisms of theα+βphase region were dislocation slip and orientation dependent spheroidization.Whereas,the deformation process in theβphase region was controlled byβgrain DRX.Interestingly,many nano scale FCC twins were generated at the interface ofαl′ath during deforming in theβphase region,which was firstly observed in Ti65 alloy.展开更多
The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacki...The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacking fault energy(SFE).The yield strength,ultimate tensile strength,and elongation of(CoCrNi)_(97)Mo_(3)alloy are 475 MPa,983 MPa and 69%,respectively.The yield strength is increased by~30%and high ductility is maintained,in comparison with CoCrNi alloy.Besides the nano-twins and dislocations,the higher density of stacking faults is induced during the tensile deformation for(CoCrNi)_(97)Mo_(3)alloy.Ab initio calculation results indicate the mean square atomic displacement(MSAD)and SFE value of(CoCrNi)_(97)Mo_(3)alloy is 42.6 pm^(2)and-40.4 mJ/m^(2)at 0 K,respectively.The relationship between mechanical properties and MSAD,SFE for various multiple principal element alloys is discussed.展开更多
Diagnosability of a multiprocessor system is an important study topic. S. L. Peng, C. K. Lin, J. J. M. Tan, and L. H. Hsu [Appl. Math. Comput., 2012, 218（21）： 10406-10412] proposed a new measure for fault diagnosis...Diagnosability of a multiprocessor system is an important study topic. S. L. Peng, C. K. Lin, J. J. M. Tan, and L. H. Hsu [Appl. Math. Comput., 2012, 218（21）： 10406-10412] proposed a new measure for fault diagnosis of the system, which is called the 9-good-neighbor conditional diagnosability that restrains every fault-free node containing at least 9 fault-free neighbors. As a famous topological structure of intereonnection networks, the n-dimensional star graph Sn has many good properties. In this paper, we establish the 9_good-neighbor conditional diagnosability of Sn under the PMC model and MM＊ model.展开更多
Diagnosability of a multiprocessor system is one important study topic.Cayley graph network Cay（Tn,Sn） generated by transposition trees Tnis one of the attractive underlying topologies for the multiprocessor system....Diagnosability of a multiprocessor system is one important study topic.Cayley graph network Cay（Tn,Sn） generated by transposition trees Tnis one of the attractive underlying topologies for the multiprocessor system.In this paper,it is proved that diagnosability of Cay（Tn,Sn） is n-1 under the comparison diagnosis model for n ≥ 4.展开更多
文摘In this paper, we propose the nonconforming virtual element method (NCVEM) discretization for the pointwise control constraint optimal control problem governed by elliptic equations. Based on the NCVEM approximation of state equation and the variational discretization of control variables, we construct a virtual element discrete scheme. For the state, adjoint state and control variable, we obtain the corresponding prior estimate in H<sup>1</sup> and L<sup>2</sup> norms. Finally, some numerical experiments are carried out to support the theoretical results.
文摘Diagnosability of a multiprocessor system G is one important measure of the reliability of interconnection networks. In 2016, Zhang et al. proposed the g-extra diagnosability of G, which restrains that every component of G – S has at least (g + 1) vertices. The locally twisted cube LTQn is applied widely. In this paper, we show that LTQn is tightly (4n – 9) super 3-extra connected for n ≥ 6 and the 3-extra diagnosability of LTQn under the PMC model and MM* model is 4n - 6 for n ≥ 5 and n ≥ 7, respectively.
文摘Diagnosability of a multiprocessor system is one important study topic. In 2015, Zhang et al. proposed a new measure for fault diagnosis of the system, namely, g-extra diagnosability, which restrains that every fault-free component has at least (g + 1) fault-free nodes. As a favorable topology structure of interconnection networks, the n-dimensional alternating group graph AGn has many good properties. In this paper, we give that the 2-extra diagnosability of AGn is 6n - 17 for n≥ 5 under the PMC model and MM* model.
文摘Diagnosability of a multiprocessor system is one important study topic. In 2012, Peng et al. proposed a measure for fault tolerance of the system, which is called the g-good-neighbor diagnosability that restrains every fault-free node containing at least g fault-free neighbors. In 2015, Zhang et al. proposed a measure for fault diagnosis of the system, namely, g-extra diagnosability, which restrains that every fault-free component has at least g+1 fault-free nodes. In this paper, we obtain some properties of the g-good-neighbor (g-extra) diagnosability of the system and give the g-good-neighbor (g-extra) diagnosability of some graphs under the PMC model and MM<sup>*</sup> model.
文摘In this report, we describe radiation-induced difficult airway management in a patient with nasopharyngeal carcinoma. The patient was presented to receive laparoscopic cholecystectomy for gallbladder stone. He had been diagnosed to have nasopharyngeal cancer about 2 years ago. In operation, after sleeping, the patient was manual controlled ventilation. However, we subsequently found that his neck campaign was limited and mask ventilation was obstructed. We immediately performed oropharyngeal airway, then mask ventilation improved. Fully surface anesthesia with tetracaine atomizing to the root of tongue, larynx wall and piriform recess, the patient was endotracheal intubated with fiberoptic bronchoscope. After intubation, the patient inhaled 2.5% sevoflurane, then esmeron (50 mg) and remifentanyl (0.1 μg/kg every minute) were administrated by intravenous. After the treatment, the patient's life indexes were normal and steady. In conclusion, patients with nasopharyngeal carcinoma (NPC) after radiation therapy should be based on comprehensive evaluation of upper airway and obstructive condition before operation, then perform safe and effective tracheal intubation methods under spontaneous breathing.
文摘The diagnosability of a multiprocessor system or an interconnection network is an important research topic. The system and an interconnection network have an underlying topology, which is usually presented by a graph. In this paper, we show proof for the g-good-neighbor diagnosability of the exchanged hypercube EH (s,t) under the PMC model and MM* model.
基金Jiangsu Provincial Key Research and Development Program,Grant/Award Number:BE2020621.
文摘Background:Understanding the clinical implications of autoimmune manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to reduce its consequences. This study was aimed at determining the activities of new-onset primary Sjögren syndrome (pSS) since the emergence of SARS-CoV-2.Methods:This retrospective cohort study included data from 471 participants with dry mouths and eyes who had been attending Nanjing Drum Tower Hospital since December 2019. By April 2023, patients diagnosed with pSS were sequentially assigned to vaccinated group ( n = 24) or vaccinated and infected group based on exposure ( n = 20). Patients diagnosed with pSS within 3 months of vaccination against SARS-CoV-2 were assigned to a vaccinated group, and those who had been vaccinated and then developed pSS within 3 months of follow up after direct exposure to SARS-CoV-2 were assigned to a vaccinated and infected group. The controls comprised age- and sex-matched patients who had not been exposed to SARS-CoV-2 before December 2019 ( n = 21). We then compared data among the three groups. Results:The vaccinated and infected patients had more fever, malaise, splenomegaly, and weight loss before diagnosis and a higher European Alliance of Associations for Rheumatology Sjögren's syndrome disease activity index at the time of onset than the other two groups. Vaccinated patients had a higher frequency of anti-nuclear antibody (ANA) titers > 1:320 ( n = 12;50%) and anti-phospholipid antibodies (aPL) ( n = 7;29%) than the controls. The frequency of anti-Ro/SSA antibodies (13, 65%), ANA titers > 1:320 ( n = 16;80%), and aPLs ( n = 7;29%) ( n = 5;25%) were all significantly higher in vaccinated patients with infection than those in the controls. Higher doses of glucocorticoids, cyclosporin A, and tacrolimus were administered to the vaccinated and infected than the vaccinated and control groups ( p < 0.05, for all). Conclusions:Patients with new-onset pSS and a history of vaccination and SARS-CoV-2 infection might have more active disease. Further strengthening the assessment of people with a clear history of SARS-CoV infection and the monitoring of potential populations for autoimmune screening should not be overlooked.
基金by the Major International(Regional)Joint Research Project(No.81720108020)National Natural Science Foundation of China(No.81373199,81501347 and 81370730,81273304)+2 种基金National Natural Science Foundation of Jiangsu(BK20150098)Jiangsu Province Major Research and Development Program(BE2015602)Jiangsu Province 333 Talant Grant(BRA2016001).
文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus.
基金the Major State Research Development Program of China(No.2016YFB0701305)the National Natural Science Foundation of China(No.51801156)the Natural Science Basic Research Plan in Shaanxi Province of China(Nos.2018JQ5035 and 2019JM-584)for the financial support.
文摘Although the development of titanium alloys with working temperatures above 600?C faces enormous difficulties and challenges,the related research has not stopped.In the present work,detailed analyses on microstructure evolution and hot deformation behavior of a new temperature resistant 650?C titanium alloy Ti65 were investigated from micrometer scale to nanometer scale.The results revealed that lamellarαgrains gradually fragmentized and spheroidized during theα+βphase region compression and the orientation of the c-axis ofαgrains gradually aligned to radial directions,forming two high Schmid factors(SFs)value texture eventually with the increase of strain to 0.7.Moreover,there were some strengthening characters in theα+βphase region such as lenticularαsand nano silicide(TiZr)6 Si3.In theβphase region,fine equiaxed dynamic recrystallized(DRX)βgrains were formed.Besides,the variant selection ofαm′artensite followed Burgers orientation relationship during the compression process.The main deformation mechanisms of theα+βphase region were dislocation slip and orientation dependent spheroidization.Whereas,the deformation process in theβphase region was controlled byβgrain DRX.Interestingly,many nano scale FCC twins were generated at the interface ofαl′ath during deforming in theβphase region,which was firstly observed in Ti65 alloy.
基金supported financially by the National Natural Science Foundation of China(Nos.51701061 and 51601020)the Natural Science Foundation of Hebei Province(No.E2019202059)。
文摘The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacking fault energy(SFE).The yield strength,ultimate tensile strength,and elongation of(CoCrNi)_(97)Mo_(3)alloy are 475 MPa,983 MPa and 69%,respectively.The yield strength is increased by~30%and high ductility is maintained,in comparison with CoCrNi alloy.Besides the nano-twins and dislocations,the higher density of stacking faults is induced during the tensile deformation for(CoCrNi)_(97)Mo_(3)alloy.Ab initio calculation results indicate the mean square atomic displacement(MSAD)and SFE value of(CoCrNi)_(97)Mo_(3)alloy is 42.6 pm^(2)and-40.4 mJ/m^(2)at 0 K,respectively.The relationship between mechanical properties and MSAD,SFE for various multiple principal element alloys is discussed.
基金This work was supported by the National Natural Science Foundation of China （Grant No. 61370001）.
文摘Diagnosability of a multiprocessor system is an important study topic. S. L. Peng, C. K. Lin, J. J. M. Tan, and L. H. Hsu [Appl. Math. Comput., 2012, 218（21）： 10406-10412] proposed a new measure for fault diagnosis of the system, which is called the 9-good-neighbor conditional diagnosability that restrains every fault-free node containing at least 9 fault-free neighbors. As a famous topological structure of intereonnection networks, the n-dimensional star graph Sn has many good properties. In this paper, we establish the 9_good-neighbor conditional diagnosability of Sn under the PMC model and MM＊ model.
基金supported by the National Natural Science Foundation of China(61370001,U1304601)
文摘Diagnosability of a multiprocessor system is one important study topic.Cayley graph network Cay（Tn,Sn） generated by transposition trees Tnis one of the attractive underlying topologies for the multiprocessor system.In this paper,it is proved that diagnosability of Cay（Tn,Sn） is n-1 under the comparison diagnosis model for n ≥ 4.
