“Curriculum ideology and politics”is a new concept and model of education as well as teaching innovation in colleges and universities.Focusing on the fundamental task of strengthening moral education and cultivating...“Curriculum ideology and politics”is a new concept and model of education as well as teaching innovation in colleges and universities.Focusing on the fundamental task of strengthening moral education and cultivating people along with the nursing curriculum,this article analyzes the main problems existing in the“curriculum ideology and politics”in nursing education,takes the nursing course as the starting point,and proposes suggestions for the teaching reform of“curriculum ideology and politics”in nursing education.展开更多
To the Editor: Liver fibrosis was characterized by the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition. The pathogenesis of liver fibrosis involved many aspects. Studies have found that...To the Editor: Liver fibrosis was characterized by the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition. The pathogenesis of liver fibrosis involved many aspects. Studies have found that endoplasmic reticulum stress (ERS) in HSCs could lead to HSC activation and aggravate liver fibrosis.[1] Although liver fibrosis has been extensively studied, effective anti-fibrotic drugs are lacking at present. Tetrahydropalmatine (THP) was the active ingredient of Chinese herbs Corydalis yanhusuo. Previous studies have found the hepatoprotective effect of THP. Our study aimed to investigate the effects of THP on liver fibrosis and the underlying mechanisms.展开更多
Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinf...Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-Co V-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-Co V-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-Co V-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.展开更多
基金the Hunan Academic Degree and Graduate Education Reform Research Project(Number:2020JGYB216)the Hunan Ordinary Colleges and Universities Teaching Reform Research Project(HNJG-2020-0537)the Teaching Reform Research Project of Hunan Province Ordinary Colleges and Universities of 2018(Item Number:398).
文摘“Curriculum ideology and politics”is a new concept and model of education as well as teaching innovation in colleges and universities.Focusing on the fundamental task of strengthening moral education and cultivating people along with the nursing curriculum,this article analyzes the main problems existing in the“curriculum ideology and politics”in nursing education,takes the nursing course as the starting point,and proposes suggestions for the teaching reform of“curriculum ideology and politics”in nursing education.
基金National Natural Science Foundation of China (No. 81870420)。
文摘To the Editor: Liver fibrosis was characterized by the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition. The pathogenesis of liver fibrosis involved many aspects. Studies have found that endoplasmic reticulum stress (ERS) in HSCs could lead to HSC activation and aggravate liver fibrosis.[1] Although liver fibrosis has been extensively studied, effective anti-fibrotic drugs are lacking at present. Tetrahydropalmatine (THP) was the active ingredient of Chinese herbs Corydalis yanhusuo. Previous studies have found the hepatoprotective effect of THP. Our study aimed to investigate the effects of THP on liver fibrosis and the underlying mechanisms.
基金supported by the National Natural Science Foundation of China(21890753,21988101 to Dehui Deng,91853101 to Fangjun Wang,and 91845106 to Liang Yu)the Strategic PriorityResearch Program of the Chinese Academy of Sciences(XDB36030200 to Dehui Deng)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y201936 to Dehui Deng,Y201750 to Yangbo Hu)。
文摘Fully inactivating SARS-Co V-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-Co V-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-Co V-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-Co V-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.
