血浆ET-1水平与老年2型糖尿病下肢血管病变程度的相关性研究

目的:探讨血浆内皮素-1(endothelin-1,ET-1)水平与老年2型糖尿病下肢血管病变程度的相关性。方法:随机选取我院2015年1月至2019年1月收治的老年糖尿病合并下肢血管病变患者136例,依据老年患者踝肱指数(ABI)测定结果将纳入患者分为轻度下肢动脉硬化组84例(0.7≤ABI<0.9),中度下肢动脉硬化组36例(0.5≤ABI<0.7),重度下肢动脉硬化组16例(ABI<0.5),葡萄糖氧化酶法测定空腹血糖(FBG),色谱法测定糖化血红蛋白(HbA1c),全自动生化分析仪测定胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、三酰甘油(TG)等,酶联吸附法测定血浆ET-1,对比三组不同下肢动脉硬化组患者血浆ET-1水平,并分析不同肢大动脉病变程度与血浆ET-1的相关性。结果:2型糖尿病下肢动脉不同病变程度组间的年龄、BMI、TC、TG、LDL、HDL、患者病程、空腹血糖及ET-1对比具有差异性(P<0.05);经多因素Logistic回归分析表明,空腹血糖、糖尿病病程及ET-1均为影响下肢动脉病变程度的独立危险因素。经Spearman等级相关性分析可知糖尿病下肢血管病变程度与ET-1呈正相关关系(r=0.336,P=0.000)。结论:2型糖尿病下肢血管病变程度独立危险因素为空腹血糖、糖尿病病程及ET-1,与ET-1呈正相关关系。

Error-detected single-photon quantum routing using a quantum dot and a double-sided microcavity system

Based on a hybrid system consisting of a quantum dot coupled with a double-sided micropillar cavity, we investigate the implementation of an error-detected photonic quantum routing controlled by the other photon. The computational errors from unexpected experimental imperfections are heralded by single photon detections, resulting in a unit fidelity for the present scheme, so that this scheme is intrinsically robust. We discuss the performance of the scheme with currently achievable experimental parameters. Our results show that the present scheme is efficient. Furthermore, our scheme could provide a promising building block for quantum networks and distributed quantum information processing in the future.

Dynamics of Quantum Fisher Information in Homodyne-Mediated Feedback Control

We investigate the quantum Fisher information(QFI) dynamics of a dissipative two-level system in homodynemediated quantum feedback control. The analytical results demonstrate that the maximum values and stable values of the QFI can be greatly enhanced via feedback control. The quantum feedback plays a more evident role in the improvement of classical Fisher information. The classical part can reach a high stable value, while the quantum part eventually decays to zero whatever the feedback parameter is.

Change-over switch for quantum states transfer with topological channels in a circuit-QED lattice

We propose schemes to realize robust quantum states transfer between distant resonators using the topological edge states of a one-dimensional circuit quantum electrodynamics(QED)lattice.Analyses show that the distribution of edge states can be regulated accordingly with the on-site defects added on the resonators.And we can achieve different types of quantum state transfer without adjusting the number of lattices.Numerical simulations demonstrate that the on-site defects can be used as a change-over switch for high-fidelity single-qubit and two-qubit quantum states transfer.This work provides a viable prospect for flexible quantum state transfer in solid-state topological quantum system.

Topological phase transition in cavity optomechanical system with periodical modulation

We investigate the topological phase transition and the enhanced topological effect in a cavity optomechanical system with periodical modulation.By calculating the steady-state equations of the system,the steady-state conditions of cavity fields and the restricted conditions of effective optomechanical couplings are demonstrated.It is found that the cavity optomechanical system can be modulated to different topological Su–Schrieffer–Heeger(SSH)phases via designing the optomechanical couplings legitimately.Meanwhile,combining the effective optomechanical couplings and the probability distributions of gap states,we reveal the topological phase transition between trivial SSH phase and nontrivial SSH phase via adjusting the decay rates of cavity fields.Moreover,we find that the enhanced topological effect of gap states can be achieved by enlarging the size of system and adjusting the decay rates of cavity fields.

Direct measurement of two-qubit phononic entangled states via optomechanical interactions

We propose schemes of direct concurrence measurement for two-qubit phononic states from quantized mechanical vibration. By combining the Mach–Zehnder interferometer with the optomechanical cross-Kerr nonlinear effect, direct concurrence measurement schemes for two-qubit phononic entangled states are achieved with the help of photon detection with respect to the output of the interferometer. For different types of entangled states, diversified quantum devices and operations are designed accordingly. The final analysis shows reasonable performance under the current parameter conditions.Our schemes may be useful for potential phonon-based quantum computation and information in the future.

Nonreciprocal photon blockade in a spinning resonator coupled to two two-level atoms

We propose a scheme to simultaneously achieve nonreciprocal conventional photon blockade(NCPB) and unconventional photon blockade(NUPB) in a spinning resonator coupled to two two-level atoms. We show that, with the unequal frequency detuning of cavity and atoms from the driving laser, the quantum efect of the nonreciprocal photon blockade can be realized based on two regimes under diferent driving strengths. We confirm that, the NUPB results from the quantum destructive interference between distinct pathways when the driving laser is loaded from one side, whereas the destructive interference is broken when the system is driven from the other side. Moreover, the NCPB originates from whether the single excitation resonance condition is satisfied, corresponding to the opposite driving direction in contrast to the former. Besides, we obtain the optimal nonreciprocal results by appropriately choosing the system parameters. Interestingly, the UPB exhibits stronger robustness to thermal noises,and the nonreciprocity still exists up to a high thermal excitation. This work provides an alternative way to achieve nonreciprocal quantum devices based on the nonreciprocal photon blockade, which may help to develop information network processing.

基因组编辑对酿酒酵母DNA的损伤作用及修复响应

【目的】为了研究基因组编辑工具CRISPR/Cas9和CRISPR/Cpf1所产生的DNA双链断裂(DNA doublestrandbreak,DSB)对酿酒酵母DNA的损伤作用及修复响应情况,对比化学物质甲基磺酸甲酯(methyl methanesulfonate,MMS)对酿酒酵母基因组DNA的损伤和修复,阐明编辑细胞在细胞水平和转录水平上的变化。【方法】起始细胞分为两种情况,包括未进行细胞周期同步化和被α-因子同步化细胞周期至G0/G1期。检测CRISPR/Cas9和CRISPR/Cpf1处理后编辑细胞的生长情况。利用流式细胞术检测编辑细胞的细胞周期延滞的情况。利用荧光定量PCR检测编辑细胞和MMS处理细胞后DNA损伤响应关键基因转录表达水平的变化情况。【结果】起始细胞无论是未同步化还是同步化,其生长均受到基因组编辑抑制,细胞存活率降低,细胞周期被滞留在G2/M期,而MMS处理导致细胞周期S期的滞留。此外,随编辑时间的延长,突变率增加,细胞存活率降低。CRISPR/Cpf1编辑细胞的突变率和存活率均低于CRISPR/Cas9,由此可见,CRISPR/Cpf1对细胞的损伤强度高于CRISPR/Cas9。两种编辑均诱导酵母DNA损伤响应关键基因RNR3及HUG1转录水平显著上调,并且CRISPR/Cpf1介导的上调幅度大于CRISPR/Cas9,但两者均低于MMS的处理。【结论】本研究解析了CRISPR/Cas9和CRISPR/Cpf1介导的基因组编辑在细胞水平和转录水平上对DNA损伤作用及修复响应,初步揭示了酿酒酵母应对不同类型的DSB损伤时响应程度的差异,为提高基因组编辑工具的编辑能力和评估基因编辑安全性提供了重要依据。

Qubit-assisted squeezing of mirror motion in a dissipative cavity optomechanical system

In this study, we investigate a hybrid system consisting of an atomic ensemble trapped inside a dissipative optomechanical cavity assisted with perturbative oscillator-qubit coupling. Such a system is generally very suitable for generating stationary squeezing of the mirror motion in the long-time limit under the unresolved sideband regime. Based on the master equation and covariance matrix approaches, we discuss in detail the respective squeezing effects. We also determine that in both approaches, simplifying the system dynamics with adiabatic elimination of the highly dissipative cavity mode is very effective. In the master equation approach, we find that the squeezing is a resulting effect of the cooling process and is robust against thermal fluctuations of the mechanical mode. In the covariance matrix approach, we can approximately obtain the analytical result of the steady-state mechanical position variance from the reduced dynamical equation. Finally, we compare the two approaches and observe that they are completely equivalent for the stationary dynamics. Moreover, the scheme may be useful for possible ultraprecise quantum measurement that involves mechanical squeezing.

Engineering of strong mechanical squeezing via the joint effect between Duffing nonlinearity and parametric pump driving

Previous works for achieving mechanical squeezing focused mainly on the sole squeezing manipulation method.Here we study how to construct strong steady-state mechanical squeezing via the joint effect between Duffing nonlinearity and parametric pump driving. We find that the 3 d B limit of strong mechanical squeezing can be easily overcome from the joint effect of two different below 3 d B squeezing components induced by Duffing nonlinearity and parametric pump driving, respectively, without the need of any extra technologies, such as quantum measurement or quantum feedback. We first demonstrate that, in the ideal mechanical bath, the joint squeezing effect just is the superposition of the two respective independent squeezing components. The mechanical squeezing constructed by the joint effect is fairly robust against the mechanical thermal noise. Moreover, different from previous mechanical squeezing detection schemes, which need to introduce an additional ancillary cavity mode, the joint mechanical squeezing effect in the present scheme can be directly measured by homodyning the output field of the cavity with an appropriate phase. The joint idea opens up a new approach to construct strong mechanical squeezing and can be generalized to realize other strong macroscopic quantum effects.

Simulation and detection of the topological properties of a modulated Rice-Mele model in a one-dimensional circuit-QED lattice

Here, we propose a simple scheme to realize a one-dimensional （1D） modulated Rice-Mele model （RMM） and investigate its topological properties with a 1D circuit quantum electrodynamics （QED） lattice. The system can be mapped into a Chern insulator model by introducing a period parameter. Interestingly and surprisingly, we found that the circuit-QED lattice system always exhibits topologically nonttrvial phases if both the nearest-neighbor hopping strength between two resonators and the qubitassisted on-site potentials are alternately changed in the direction of the lattice. The numerical results show that the topological phases can be obtained by introducing an additional modulation parameter and both the edge state and topological invariant can be unambiguously seen with the existence of decay and disorders, even with few resonators in the lattice.

Dissipation-induced topological phase transition and periodic-driving-induced photonic topological state transfer in a small optomechanical lattice

We propose a scheme to investigate the topological phase transition and the topological state transfer based on the small optomechanical lattice under the realistic parameters regime.We find that the optomechanical lattice can be equivalent to a topologically nontrivial Su-Schrieffer Heeger(SSH)model via designing the effective optomechanical coupling.Especially,the optomechanical lattice experiences the phase transition between topologically nontrivial SSH phase and topologically trivial SSH phase by controlling the decay of the cavity field and the opto mechanical coupling.We stress that the to pological phase transition is mainly induced by the decay of the cavity field,which is counter-intuitive since the dissipation is usually detrimental to the system.Also,we investigate the photonic state transfer between the two cavity fields via the topologically protected edge channel based on the small optomechanical lattice.We find that the quantum st ate transfer assisted by the topological zero energy mode can be achieved via implying the external lasers with the periodical driving amplitudes into the cavity fields.Our scheme provides the fundamental and the insightful explanations towards the mapping of the photonic topological insulator based on the micro-nano optomechanical quantum optical platform.

Engineering multipartite steady entanglement of distant atoms via dissipation

We propose a scheme for generating an entangled state for three atoms trapped in separate optical cavities that are coupled to each other through two optical fibers based on coherent driving and dissi- pation, which are induced by the classical fields and the decay of non-local bosonic modes, respectively. In our scheme, the interaction time need not be controlled strictly in the overall dynamics process, and the cavity field decay can be changed into a vital resource. The numerical simulation shows that the fidelity of the target state is insensitive to atomic spontaneous emission, and our scheme is good enough to generate the W state of distant atoms with a high fidelity and purity. In addition, the present scheme can also be generalized to prepare the N-partite W state of distant atoms.

Manipulation of multi-transparency windows and fast-slow light transitions in a hybrid cavity optomechanical system

We study the generation of quadruple-transparency windows and the implementation of a conversion between slow and fast light in a hybrid optomechanical system. By demonstrating the generation of these transparency windows one by one, we analyze the physical mechanism through which each transparency window forms in detail. Additionally, we discuss how the system parameters affect the formation of transparency windows and conclude that the location, width, and absorption of each transparency window can be arbitrarily manipulated by varying the appropriate parameters. Moreover, when the pump field is changed from red to blue detuning, conversions between slow and fast light occur in the output field. These interesting properties of the output field can be applied to achieve the coherent control and manipulation of light pulses using cavity optomechanical system.

Special modes induced by inter-chain coupling in a non-Hermitian ladder system

We explore some interesting phenomena in a simple non-Hermitian ladder system.Special modes with energy eigenvalues closely related to the inter-chain-coupling strength appear in the non-Hermitian ladder system.We show that a phase transition occurs whereby special modes with pure real eigenvalues can switch to special modes with pure imaginary eigenvalues,when the inter-chain-coupling strength changes from symmetric to asymmetric.We find that the density profiles of all the special modes are completely identical under certain conditions,even if the inter-chain-coupling strength is added into the non-Hermitian ladder system in different ways.Moreover,we also demonstrate that the different inter-chain couplings are fundamentally equivalent to adding different on-site potential energies into the non-Hermitian ladder system.

Ground state cooling of magnomechanical resonator in PT-symmetric cavity magnomechanical system at room temperature

We propose to realize the ground state cooling of magnomechanical resonator in a parity-time(PT).symmetric cavity magnomechanical system composed of a loss ferromagnetic sphere and a gain microwave cavity.In the scheme,the magnomechanical resonator can be cooled close to its ground state via the magnomechanical interaction,and it is found that the cooling effect in PT-symmetric system is much higher than that in non-PT-symmetric system.Resorting to the magnetic force noise spectrum,we investigate the final mean phonon number with experimentally feasible parameters and find surprisingly that the ground state cooling of magnomechanical resonator can be directly achieved at room temperature.Furthermore,we also illustrate that the ground state cooling can be flexibly controlled via the external magnetic field.