It is highly demanded to steer the charge flow in semiconductor for efficient photocatalytic environmental remediation.Herein,we designed an interfacial contact Ti_(3)C_(2) MXene/ZnIn_(2)S_(4) nanosheets(TC/ZISNS) Sch...It is highly demanded to steer the charge flow in semiconductor for efficient photocatalytic environmental remediation.Herein,we designed an interfacial contact Ti_(3)C_(2) MXene/ZnIn_(2)S_(4) nanosheets(TC/ZISNS) Schottky heterostructure which could greatly enhance photogenerated charge separation of ZnIn_(2)S_(4) (ZIS).Through TEM and XPS measurement,the strong interface coupling between 2D ZnIn_(2)S_(4) nanosheets and 2D Ti_(3)C_(2) MXene were explained,and the formation of Schottky heterostructure was demonstrated by electrochemical method.To investigate the photocatalytic activity of as-prepared samples,the photocatalytic reduction of Cr(VI) and photocatalytic oxidation degradation tetracycline hydrochloride(TC-H) experiments were carried out.The results showed that the Schottky catalyst(10%-TC/ZISNS) possessed the optimum photocatalytic efficiency.Especially,the apparent rate constant of Cr(VI) reduction with 10%-TC/ZISNS was 3.9 times than that of pure ZIS.The photocatalytic performance of 10%-TC/ZISNS toward degradation rate of TC-H was 1.8 times than that of pure ZIS.Finally,a possible mechanism for great enhancement of visible-light driven photocatalytic activity in the TC/ZISNS system was provided.On the whole,this work provided a new insight on 2D/2D contact Schottky heterostructure for enhancing photocatalytic activity.展开更多
Exposure to maternal stress during prenatal life is associated with an increased risk of neuropsychiatric disorders, such as depression and anxiety, in offspring. It has also been increasingly observed that prenatal s...Exposure to maternal stress during prenatal life is associated with an increased risk of neuropsychiatric disorders, such as depression and anxiety, in offspring. It has also been increasingly observed that prenatal stress alters the phenotype of offspring via immunological mechanisms and that immunological dysfunction, such as elevated interleukin-18 levels, has been reported in cultures of microglia. Prenatal restraint stress(PRS) in rats permits direct experimental investigation of the link between prenatal stress and adverse outcomes. However, the majority of studies have focused on the consequences of PRS delivered in the second half of pregnancy, while the effects of early prenatal stress have rarely been examined. Therefore, pregnant rats were subjected to PRS during early/middle and late gestation(days 8–14 and 15–21, respectively). PRS comprised restraint in a round plastic transparent cylinder under bright light(6500 lx) three times per day for 45 minutes. Differences in interleukin-18 expression in the hippocampus and in behavior were compared between offspring rats and control rats on postnatal day 75. We found that adult male offspring exposed to PRS during their late prenatal periods had higher levels of anxiety-related behavior and depression than control rats, and both male and female offspring exhibited higher levels of depression-related behavior, impaired recognition memory and diminished exploration of novel objects. Moreover, an elevated level of interleukin-18 was observed in the dorsal and ventral hippocampus of male and female early-and late-PRS offspring rats. The results indicate that PRS can cause anxiety and depression-related behaviors in adult offspring and affect the expression of interleukin-18 in the hippocampus. Thus, behavior and the molecular biology of the brain are affected by the timing of PRS exposure and the sex of the offspring. All experiments were approved by the Animal Experimentation Ethics Committee at Kunming Medical University, China(approval No. KMMU2019074) in January 2019.展开更多
Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we co...Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 days.The complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),respectively.With a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),respectively.The most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of treatment.Tumor proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab treatment.In conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage NKTCL.Dysregulated lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.展开更多
The four-level active neutral point clamped(ANPC)inverter has become increasingly widely used in the renewable energy indus-try since it offers one more voltage level without increasing the total number of active swit...The four-level active neutral point clamped(ANPC)inverter has become increasingly widely used in the renewable energy indus-try since it offers one more voltage level without increasing the total number of active switches compared to the three-level ANPC inverter.The model predictive current control(MPCC)is a promising control method for multi-level inverters.However,the conven-tional MPCC suffers from high computational complexity and tedious weighting factor tuning in multi-level inverter applications.A low-complexity MPCC without weighting factors for a four-level ANPC inverter is proposed in this paper.The computational burden and voltage vector candidate set are reduced according to the relationship between voltage vector and neutral point voltage balance.The proposed MPCC shows excellent steady-state and dynamics performances while ensuring the neutral point voltage balancing.The efficacy of the proposed MPCC is verified by simulation and experimental results.展开更多
基金supported by the National Natural Science Foundation of China(nos.51672077,51872089)Hunan Provincial Natural Science Foundation of China(no.2017JJ2026)。
文摘It is highly demanded to steer the charge flow in semiconductor for efficient photocatalytic environmental remediation.Herein,we designed an interfacial contact Ti_(3)C_(2) MXene/ZnIn_(2)S_(4) nanosheets(TC/ZISNS) Schottky heterostructure which could greatly enhance photogenerated charge separation of ZnIn_(2)S_(4) (ZIS).Through TEM and XPS measurement,the strong interface coupling between 2D ZnIn_(2)S_(4) nanosheets and 2D Ti_(3)C_(2) MXene were explained,and the formation of Schottky heterostructure was demonstrated by electrochemical method.To investigate the photocatalytic activity of as-prepared samples,the photocatalytic reduction of Cr(VI) and photocatalytic oxidation degradation tetracycline hydrochloride(TC-H) experiments were carried out.The results showed that the Schottky catalyst(10%-TC/ZISNS) possessed the optimum photocatalytic efficiency.Especially,the apparent rate constant of Cr(VI) reduction with 10%-TC/ZISNS was 3.9 times than that of pure ZIS.The photocatalytic performance of 10%-TC/ZISNS toward degradation rate of TC-H was 1.8 times than that of pure ZIS.Finally,a possible mechanism for great enhancement of visible-light driven photocatalytic activity in the TC/ZISNS system was provided.On the whole,this work provided a new insight on 2D/2D contact Schottky heterostructure for enhancing photocatalytic activity.
基金supported by the National Natural Science Foundation of China,No.81260296(to LJA)and 81300987(to QLi)
文摘Exposure to maternal stress during prenatal life is associated with an increased risk of neuropsychiatric disorders, such as depression and anxiety, in offspring. It has also been increasingly observed that prenatal stress alters the phenotype of offspring via immunological mechanisms and that immunological dysfunction, such as elevated interleukin-18 levels, has been reported in cultures of microglia. Prenatal restraint stress(PRS) in rats permits direct experimental investigation of the link between prenatal stress and adverse outcomes. However, the majority of studies have focused on the consequences of PRS delivered in the second half of pregnancy, while the effects of early prenatal stress have rarely been examined. Therefore, pregnant rats were subjected to PRS during early/middle and late gestation(days 8–14 and 15–21, respectively). PRS comprised restraint in a round plastic transparent cylinder under bright light(6500 lx) three times per day for 45 minutes. Differences in interleukin-18 expression in the hippocampus and in behavior were compared between offspring rats and control rats on postnatal day 75. We found that adult male offspring exposed to PRS during their late prenatal periods had higher levels of anxiety-related behavior and depression than control rats, and both male and female offspring exhibited higher levels of depression-related behavior, impaired recognition memory and diminished exploration of novel objects. Moreover, an elevated level of interleukin-18 was observed in the dorsal and ventral hippocampus of male and female early-and late-PRS offspring rats. The results indicate that PRS can cause anxiety and depression-related behaviors in adult offspring and affect the expression of interleukin-18 in the hippocampus. Thus, behavior and the molecular biology of the brain are affected by the timing of PRS exposure and the sex of the offspring. All experiments were approved by the Animal Experimentation Ethics Committee at Kunming Medical University, China(approval No. KMMU2019074) in January 2019.
基金supported,in part,by research funding from the National Natural Science Foundation of China (82130004 and 82270194)National key research and development program (2022YFC2502600)+4 种基金Chang Jiang Scholars Program,Shanghai Rising-Star Program (23QA1406100)Shanghai Municipal Commission of Science and Technology Project (23141903100)Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support (20152206,20152208,and 20161303)Clinical Research Plan of Shanghai Hospital Development Center (SHDC 2020CR1032B)Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine (DLY201601)。
文摘Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 days.The complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),respectively.With a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),respectively.The most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of treatment.Tumor proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab treatment.In conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage NKTCL.Dysregulated lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFB4201602)the National Natural Science Foundation of China(Grant No.52002409).
文摘The four-level active neutral point clamped(ANPC)inverter has become increasingly widely used in the renewable energy indus-try since it offers one more voltage level without increasing the total number of active switches compared to the three-level ANPC inverter.The model predictive current control(MPCC)is a promising control method for multi-level inverters.However,the conven-tional MPCC suffers from high computational complexity and tedious weighting factor tuning in multi-level inverter applications.A low-complexity MPCC without weighting factors for a four-level ANPC inverter is proposed in this paper.The computational burden and voltage vector candidate set are reduced according to the relationship between voltage vector and neutral point voltage balance.The proposed MPCC shows excellent steady-state and dynamics performances while ensuring the neutral point voltage balancing.The efficacy of the proposed MPCC is verified by simulation and experimental results.
