In this paper,an intelligent reflecting surface(IRS)-and-unmanned aerial vehicle(UAV)-assisted two-way amplify-and-forward(AF)relay network in maritime Internet of Things(IoT)is proposed,where ship1(S1)and ship2(S2)ca...In this paper,an intelligent reflecting surface(IRS)-and-unmanned aerial vehicle(UAV)-assisted two-way amplify-and-forward(AF)relay network in maritime Internet of Things(IoT)is proposed,where ship1(S1)and ship2(S2)can be viewed as data collecting centers.To enhance the message exchange rate between S1 and S2,a problem of maximizing minimum rate is cast,where the variables,namely AF relay beamforming matrix and IRS phase shifts of two time slots,need to be optimized.To achieve a maximum rate,a low-complexity alternately iterative(AI)scheme based on zero forcing and successive convex approximation(LC-ZF-SCA)algorithm is presented.To obtain a significant rate enhancement,a high-performance AI method based on one step,semidefinite programming and penalty SCA(ONSSDP-PSCA)is proposed.Simulation results show that by the proposed LC-ZF-SCA and ONS-SDP-PSCA methods,the rate of the IRS-and-UAV-assisted AF relay network surpass those of with random phase and only AF relay networks.Moreover,ONS-SDP-PSCA perform better than LC-ZF-SCA in aspect of rate.展开更多
针对多分量线性调频(Linear frequency modulated,LFM)信号,提出了一种基于多路欠采样的参数估计方法。采样过程由多个采样速率相同、采样时刻不同的模数转换器实现,总采样率可以低于信号的奈奎斯特采样率。基于欠采样序列乘积型模糊函...针对多分量线性调频(Linear frequency modulated,LFM)信号,提出了一种基于多路欠采样的参数估计方法。采样过程由多个采样速率相同、采样时刻不同的模数转换器实现,总采样率可以低于信号的奈奎斯特采样率。基于欠采样序列乘积型模糊函数的单频特性,可以通过峰值检测实现调频斜率的估计。根据估计出的调频斜率对各路欠采样序列进行解线调处理,可得到多频正弦信号。结合矩保持问题的求解方法以及对超定方程组的求解,可以根据解线调后的各路序列估计出原始LFM信号各分量的初始频率。本文方法能够根据亚奈奎斯特采样样本实现LFM信号的参数估计,并且运算简单、易于实现。仿真实验验证了其有效性和准确性。展开更多
针对多星定位系统对地面静态目标的无源定位误差分析问题,运用Fisher信息矩阵、Taylor级数、矩阵理论和统计理论,综合考虑时差、频差、卫星位置误差以及卫星速度误差,推导了到达时间差(time difference of arrival,TDOA)/到达频率差(fre...针对多星定位系统对地面静态目标的无源定位误差分析问题,运用Fisher信息矩阵、Taylor级数、矩阵理论和统计理论,综合考虑时差、频差、卫星位置误差以及卫星速度误差,推导了到达时间差(time difference of arrival,TDOA)/到达频率差(frequency difference of arrival,FDOA)联合定位误差克拉美·罗界(Cramer-Rao lower bound,CRLB)的简单表达式,以及三星单独TDOA定位误差的CRLB,进而给出了避免TDOA定位盲区的良好卫星构型设计的充分条件.理论分析与仿真结果表明:在单独TDOA定位场景下良好的构型能完全消除定位盲区,定位精度随主星-星下点连线与主星-副星连线的夹角逼近90°而逐渐提高;通过引入FDOA与TDOA联合定位也能有效避免定位盲区,提高定位精度.展开更多
考虑到天线选择(AS)具有实现简单和性能好等优点,通过仿真评估在不同中继策略场景下天线选择的性能。评估方法如下:中继站第1时隙采用最大比合并算法(MRC),第2时隙选择中继处理后具有最大信道增益的单天线进行信号传输。仿真结果表明:...考虑到天线选择(AS)具有实现简单和性能好等优点,通过仿真评估在不同中继策略场景下天线选择的性能。评估方法如下:中继站第1时隙采用最大比合并算法(MRC),第2时隙选择中继处理后具有最大信道增益的单天线进行信号传输。仿真结果表明:与现有的分布式空时码(DSTBC)和最大比合并、最大比合并和匹配滤波(MF)算法相比,最大比合并加天线选择混合方案在转发重传(AF)和译码重传(DF)策略下都能够提供更优的合速率与误码性能;并且在中继站采用译码转发策略时,该方案表现出优于采用放大转发策略的情形。例如,当误码率(SER)等于10-3时,译码转发策略具有1 d B的信噪比(SNR)增益。展开更多
BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis development.HSCs perform aerobic glycolysis to provide energy for their activation.Focal adhesion kinase(FAK)promotes aerobic gl...BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis development.HSCs perform aerobic glycolysis to provide energy for their activation.Focal adhesion kinase(FAK)promotes aerobic glycolysis in cancer cells or fibroblasts,while FAK-related non-kinase(FRNK)inhibits FAK phosphorylation and biological functions.AIM To elucidate the effect of FRNK on liver fibrosis at the level of aerobic glycolytic metabolism in HSCs.METHODS Mouse liver fibrosis models were established by administering CCl4,and the effect of FRNK on the degree of liver fibrosis in the model was evaluated.Transforming growth factor-β1 was used to activate LX-2 cells.Tyrosine phosphorylation at position 397(pY397-FAK)was detected to identify activated FAK,and the expression of the glycolysis-related proteins monocarboxylate transporter 1(MCT-1)and enolase1(ENO1)was assessed.Bioinformatics analysis was performed to predict putative binding sites for c-myc in the ENO1 promoter region,which were validated with chromatin immunoprecipitation(ChIP)and dual luciferase reporter assays.RESULTS The pY397-FAK level was increased in human fibrotic liver tissue.FRNK knockout promoted liver fibrosis in mouse models.It also increased the activation,migration,proliferation and aerobic glycolysis of primary hepatic stellate cells(pHSCs)but inhibited pHSC apoptosis.Nevertheless,opposite trends for these phenomena were observed after exogenous FRNK treatment in LX-2 cells.Mechanistically,the FAK/Ras/c-myc/ENO1 pathway promoted aerobic glycolysis,which was inhibited by exogenous FRNK.CONCLUSION FRNK inhibits aerobic glycolysis in HSCs by inhibiting the FAK/Ras/c-myc/ENO1 pathway,thereby improving liver fibrosis.FRNK might be a potential target for liver fibrosis treatment.展开更多
基金supported in part by the National Natural Science Foundation of China (Nos.U22A2002, and 62071234)the Hainan Province Science and Technology Special Fund (ZDKJ2021022)+1 种基金the Scientific Research Fund Project of Hainan University under Grant KYQD(ZR)-21008the Collaborative Innovation Center of Information Technology, Hainan University (XTCX2022XXC07)
文摘In this paper,an intelligent reflecting surface(IRS)-and-unmanned aerial vehicle(UAV)-assisted two-way amplify-and-forward(AF)relay network in maritime Internet of Things(IoT)is proposed,where ship1(S1)and ship2(S2)can be viewed as data collecting centers.To enhance the message exchange rate between S1 and S2,a problem of maximizing minimum rate is cast,where the variables,namely AF relay beamforming matrix and IRS phase shifts of two time slots,need to be optimized.To achieve a maximum rate,a low-complexity alternately iterative(AI)scheme based on zero forcing and successive convex approximation(LC-ZF-SCA)algorithm is presented.To obtain a significant rate enhancement,a high-performance AI method based on one step,semidefinite programming and penalty SCA(ONSSDP-PSCA)is proposed.Simulation results show that by the proposed LC-ZF-SCA and ONS-SDP-PSCA methods,the rate of the IRS-and-UAV-assisted AF relay network surpass those of with random phase and only AF relay networks.Moreover,ONS-SDP-PSCA perform better than LC-ZF-SCA in aspect of rate.
文摘针对多分量线性调频(Linear frequency modulated,LFM)信号,提出了一种基于多路欠采样的参数估计方法。采样过程由多个采样速率相同、采样时刻不同的模数转换器实现,总采样率可以低于信号的奈奎斯特采样率。基于欠采样序列乘积型模糊函数的单频特性,可以通过峰值检测实现调频斜率的估计。根据估计出的调频斜率对各路欠采样序列进行解线调处理,可得到多频正弦信号。结合矩保持问题的求解方法以及对超定方程组的求解,可以根据解线调后的各路序列估计出原始LFM信号各分量的初始频率。本文方法能够根据亚奈奎斯特采样样本实现LFM信号的参数估计,并且运算简单、易于实现。仿真实验验证了其有效性和准确性。
文摘方向调制(Directional modulation,DM)作为无线物理层安全传输的关键技术能够很好地提升系统的安全性能。然而,由于在角度测量过程中存在误差,因此需要在设计有用信号波束成形向量和人工噪声(Artificial noise,AN)投影矩阵时考虑角度误差,从而提升系统安全性能。本文首先描述了DM系统模型,然后介绍了到达角(Direction of arrival,DOA)估计技术、稳健波束成形设计的3种算法及功率分配技术。仿真表明:稳健波束成形合成方法的性能明显要优于非稳健合成方法,且有用信号和AN之间最优功率分配能明显提高安全速率性能。最后,对DM未来新的发展方向与所面临的挑战性等开放问题进行展望与总结。
文摘针对多星定位系统对地面静态目标的无源定位误差分析问题,运用Fisher信息矩阵、Taylor级数、矩阵理论和统计理论,综合考虑时差、频差、卫星位置误差以及卫星速度误差,推导了到达时间差(time difference of arrival,TDOA)/到达频率差(frequency difference of arrival,FDOA)联合定位误差克拉美·罗界(Cramer-Rao lower bound,CRLB)的简单表达式,以及三星单独TDOA定位误差的CRLB,进而给出了避免TDOA定位盲区的良好卫星构型设计的充分条件.理论分析与仿真结果表明:在单独TDOA定位场景下良好的构型能完全消除定位盲区,定位精度随主星-星下点连线与主星-副星连线的夹角逼近90°而逐渐提高;通过引入FDOA与TDOA联合定位也能有效避免定位盲区,提高定位精度.
文摘考虑到天线选择(AS)具有实现简单和性能好等优点,通过仿真评估在不同中继策略场景下天线选择的性能。评估方法如下:中继站第1时隙采用最大比合并算法(MRC),第2时隙选择中继处理后具有最大信道增益的单天线进行信号传输。仿真结果表明:与现有的分布式空时码(DSTBC)和最大比合并、最大比合并和匹配滤波(MF)算法相比,最大比合并加天线选择混合方案在转发重传(AF)和译码重传(DF)策略下都能够提供更优的合速率与误码性能;并且在中继站采用译码转发策略时,该方案表现出优于采用放大转发策略的情形。例如,当误码率(SER)等于10-3时,译码转发策略具有1 d B的信噪比(SNR)增益。
基金the National Natural Science Foundation of China,No.81860115,No.82060116 and No.81960118the Science and Technology Support Project of Guizhou Province,No.[2021]094.
文摘BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis development.HSCs perform aerobic glycolysis to provide energy for their activation.Focal adhesion kinase(FAK)promotes aerobic glycolysis in cancer cells or fibroblasts,while FAK-related non-kinase(FRNK)inhibits FAK phosphorylation and biological functions.AIM To elucidate the effect of FRNK on liver fibrosis at the level of aerobic glycolytic metabolism in HSCs.METHODS Mouse liver fibrosis models were established by administering CCl4,and the effect of FRNK on the degree of liver fibrosis in the model was evaluated.Transforming growth factor-β1 was used to activate LX-2 cells.Tyrosine phosphorylation at position 397(pY397-FAK)was detected to identify activated FAK,and the expression of the glycolysis-related proteins monocarboxylate transporter 1(MCT-1)and enolase1(ENO1)was assessed.Bioinformatics analysis was performed to predict putative binding sites for c-myc in the ENO1 promoter region,which were validated with chromatin immunoprecipitation(ChIP)and dual luciferase reporter assays.RESULTS The pY397-FAK level was increased in human fibrotic liver tissue.FRNK knockout promoted liver fibrosis in mouse models.It also increased the activation,migration,proliferation and aerobic glycolysis of primary hepatic stellate cells(pHSCs)but inhibited pHSC apoptosis.Nevertheless,opposite trends for these phenomena were observed after exogenous FRNK treatment in LX-2 cells.Mechanistically,the FAK/Ras/c-myc/ENO1 pathway promoted aerobic glycolysis,which was inhibited by exogenous FRNK.CONCLUSION FRNK inhibits aerobic glycolysis in HSCs by inhibiting the FAK/Ras/c-myc/ENO1 pathway,thereby improving liver fibrosis.FRNK might be a potential target for liver fibrosis treatment.
