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Infantile bacterial meningitis combined with sepsis caused by Streptococcus gallolyticus subspecies pasteurianus:A case report
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作者 Dan Zou Fen Li +5 位作者 shu-li jiao Jin-Rong Dong Yao-Yao Xiao Xiao-Ling Yan Yan Li Dan Ren 《World Journal of Clinical Cases》 SCIE 2024年第31期6472-6478,共7页
BACKGROUND Streptococcus gallolyticus subspecies pasteurianus(SGSP)is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococ... BACKGROUND Streptococcus gallolyticus subspecies pasteurianus(SGSP)is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal screenings.Hence,we present a case of SGSP-induced infant meningitis and sepsis,accompanied by bronchopneumonia induced by multidrug-resistant Staphylococcus aureus(MRSA),providing insights into the identification,management,and prognosis of this bacterial infection.CASE SUMMARY A 45-day-old female infant presented with two episodes of high fever(maximum temperature:39.5°C)and two generalized grand mal seizure episodes that lasted over ten seconds and self-resolved without concomitant symptoms.Postadmission,the patient’s C-reactive protein level was 40.73 mg/L,white blood cell count was 13.42×10^(9)/L,neutrophil ratio was 78.4%,procalcitonin level was 7.89μg/L,cerebrospinal fluid(CSF)white cell count was 36×10^(6)/L,multinucleated cell ratio was 95.2%,and protein concentration was 0.41 g/L.Blood and CSF culture revealed that the pathogen was SGSP.The bacterium was sensitive to ampicillin,furazolidone,penicillin,lincomycin,moxifloxacin,rifampicin,vancomycin,and levofloxacin but resistant to clindamycin and tetracycline.Sputum culture revealed the presence of MRSA,which was sensitive to vancomycin.The patient was diagnosed with meningitis and sepsis caused by SGSP,accompanied by bronchopneumonia induced by MRSA.Ceftriaxone(100 mg/kg/d)combined with vancomycin(10 mg/kg/dose,q6h)was given as an anti-infective treatment postadmission.After 12 days of treatment,the infant was discharged from the hospital with normal CSF,blood culture,and routine blood test results,and no complications,such as subdural effusion,were observed on cranial computed tomography.No growth retardation or neurological sequelae occurred during follow-up.CONCLUSION SGPSP-induced infant bacterial meningitis and sepsis should be treated with prompt blood and CSF cultures,and a sensitive antibiotic therapy to ensure a favorable prognosis. 展开更多
关键词 Streptococcus gallolyticus subspecies pasteurianus Rare pathogen Bacterial meningitis SEPSIS Multidrugresistant Staphylococcus aureus BRONCHOPNEUMONIA Infant Case report
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病毒性心肌炎患儿血清IMA、h-FABP水平变化及与心肌损害的相关性 被引量:8
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作者 焦书丽 易庆军 任丹 《中国现代医学杂志》 CAS 2020年第20期91-94,共4页
目的探讨病毒性心肌炎患儿血清缺血修饰白蛋白(IMA)、心型脂肪酸结合蛋白(h-FABP)水平变化,并分析血清IMA、h-FABP水平与心肌损害的相关性。方法选取2016年10月-2019年10月在绵阳市中心医院确诊的病毒性心肌炎患儿96例作为观察组,根据... 目的探讨病毒性心肌炎患儿血清缺血修饰白蛋白(IMA)、心型脂肪酸结合蛋白(h-FABP)水平变化,并分析血清IMA、h-FABP水平与心肌损害的相关性。方法选取2016年10月-2019年10月在绵阳市中心医院确诊的病毒性心肌炎患儿96例作为观察组,根据临床表现和相关检查,将观察组分为轻症组(54例)和重症组(42例)。选取同期该院健康体检儿童50例作为对照组。采用白蛋白钴结合试验检测血清IMA浓度,酶联免疫吸附试验检测血清h-FABP水平,化学发光免疫分析法测定血清心肌肌钙蛋白I水平。采用Pearson法分析血清IMA、h-FABP水平与心肌损害的相关性。结果观察组血清IMA、h-FABP水平较对照组高(P<0.05)。重症组血清IMA、h-FABP水平较轻症组高(P<0.05)。病毒性心肌炎患儿血清心肌肌钙蛋白I水平为(0.26±0.12)ng/ml。病毒性心肌炎患儿血清IMA、h-FABP水平与心肌肌钙蛋白I水平呈正相关(r=0.803和0.851,P<0.05)。结论病毒性心肌炎患儿存在血清IMA、h-FABP的高表达,血清IMA、h-FABP水平随病情严重程度的增加而升高,且与心肌损伤程度呈正相关,具有良好的临床早期诊断及病情评估价值。 展开更多
关键词 心肌炎 病毒性疾病 缺血修饰白蛋白/蛋白 心型脂肪酸结合蛋白/蛋白
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