BACKGROUND For treatment of hilar cholangiocarcinoma(HCCA),the rate of radical resection is low and prognosis is poor,and preoperative evaluation is not sufficiently accurate.3D visualization has the advantage of givi...BACKGROUND For treatment of hilar cholangiocarcinoma(HCCA),the rate of radical resection is low and prognosis is poor,and preoperative evaluation is not sufficiently accurate.3D visualization has the advantage of giving a stereoscopic view,which makes accurate resection of HCCA possible.AIM To establish precise resection of HCCA based on eOrganmap 3D reconstruction and full quantification technology.METHODS We retrospectively analyzed the clinical data of 73 patients who underwent HCCA surgery.All patients were assigned to two groups.The traditional group received traditional 2D imaging planning before surgery(n=35).The eOrganmap group underwent 3D reconstruction and full quantitative technical planning before surgery(n=38).The preoperative evaluation,anatomical classification of hilar hepatic vessels,indicators associated with surgery,postoperative complications,liver function,and stress response indexes were compared between the groups.RESULTS Compared with the traditional group,the amount of intraoperative blood loss in the eOrganmap group was lower,the operating time and postoperative intestinal ventilation time were shorter,and R0 resection rate and lymph node dissection number were higher(P<0.05).The total complication rate in the eOrganmap group was 21.05%compared with 25.71%in the traditional group(P>0.05).The levels of total bilirubin,Albumin(ALB),aspartate transaminase,and alanine transaminase in the eOrganmap group were significantly different from those in the traditional group(intergroup effect:F=450.400,79.120,95.730,and 13.240,respectively;all P<0.001).Total bilirubin,aspartate transaminase,and alanine transaminase in both groups showed a decreasing trend with time(time effect:F=30.270,17.340,and 13.380,respectively;all P<0.001).There was an interaction between patient group and time(interaction effect:F=3.072,2.965,and 2.703,respectively;P=0.0282,0.032,and 0.046,respectively);ALB levels in both groups tended to increase with time(time effect:F=22.490,P<0.001),and there was an interaction effect between groups and time(interaction effect:F=4.607,P=0.004).In the eOrganmap group,there was a high correlation between the actual volume of intraoperative liver specimen resection and the volume of preoperative virtual liver resection(t=0.916,P<0.001).CONCLUSION The establishment of accurate laparoscopic resection of hilar cholangiocarcinoma based on preoperative eOrganmap 3D reconstruction and full quantization technology can make laparoscopic resection of hilar cholangiocarcinoma more accurate and safe.展开更多
MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are...MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are investigated.The batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mAh g^-1 at a current density of 100 mA g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mAh g^-1 at 5 A g^-1.This study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.展开更多
Improving the cycling stability of metal sulfide-based anode materials at high rate is of great significance for advanced sodium ion batteries.However,the sluggish reaction kinetics is a big obstacle for the developme...Improving the cycling stability of metal sulfide-based anode materials at high rate is of great significance for advanced sodium ion batteries.However,the sluggish reaction kinetics is a big obstacle for the development of high-performance sodium storage electrodes.Herein,we have rationally engineered the heterointerface by designing the Fe1?xS/MoS2 heterostructure with abundant“ion reservoir”to endow the electrode with excellent cycling stability and rate capability,which is proved by a series of in and ex situ electrochemical investigations.Density functional theory calculations further reveal that the heterointerface greatly decreases sodium ion diffusion barrier and facilitates charge-transfer kinetics.Our present findings not only provide a deep analysis on the correlation between the structure and performance,but also draw inspiration for rational heterointerface engineering toward the next-generation high-performance energy storage devices.展开更多
A star-shaped compound of perfluoro-1-octanesulfonated fullerene was synthesized. The measurement of the friction for its spin-coating film by friction force microscopy (FFM) reveals that the films possess lower frict...A star-shaped compound of perfluoro-1-octanesulfonated fullerene was synthesized. The measurement of the friction for its spin-coating film by friction force microscopy (FFM) reveals that the films possess lower friction force compared to that of the star-shaped C-60-polystyrene films.展开更多
Relapse is the most important cause of treatment failure in acute leukemia(AL).Thus,how to predict relapse is critical for improving the survival of patients with AL.Measurable residual diseases(MRDs;previously termed...Relapse is the most important cause of treatment failure in acute leukemia(AL).Thus,how to predict relapse is critical for improving the survival of patients with AL.Measurable residual diseases(MRDs;previously termed minimal resid-ual diseases),refering to the presence of remaining leukemia cells after the declaration of complete remission(CF)detected by morphological analysis,is the most important biomarker forrelapseprediction.'Several methods,including multiparameter flow cytometry(MFC),real-time quantitative polymerase dhain reaction(qPCR),digital PCR(dPCR),and next-generation sequencing(NGS),are used to monitor MRD after treatment,reaching a sensitvityof 10^(-4)to 10^(-6).展开更多
Acutemyeloid leukemia(AML),which is the most common form of acute leukemia in adults,is a heterogeneous,clonal hematopoietic disorder characterized by the accumulation of immature myeloid progenitors.This heterogeneit...Acutemyeloid leukemia(AML),which is the most common form of acute leukemia in adults,is a heterogeneous,clonal hematopoietic disorder characterized by the accumulation of immature myeloid progenitors.This heterogeneity is especially obvious in the“intermediate-risk group”as defined by international criteria such as those of the European LeukemiaNet,Medical Research Council(MRC),and National Comprehensive Cancer Network.展开更多
To assess the influence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) on the environment in the vicinity of municipal solid waste incinerators(MSWIs), we determined the levels of ...To assess the influence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) on the environment in the vicinity of municipal solid waste incinerators(MSWIs), we determined the levels of PCDD/Fs in air and soil samples collected around a MSWI, which is the largest in China. The International Toxicity Equivalency Quantity(I-TEQ) concentrations of PCDD/Fs in air samples were from 0.0300 to 1.03 pg I-TEQ/m^3(0.445–13.6 pg/m^3), with an average of 0.237 pg I-TEQ/m^3, while in soil samples they ranged from 0.520 to 3.40 pg I-TEQ/g(2.41–88.7 pg/g) with an average of1.49 pg I-TEQ/g. The concentrations of PCDD/Fs in air and soil samples were comparable to other areas, and Pe CDFs were the dominant contributors, which was different from stack gas homologue patterns. Multivariate statistical analysis showed that PCDD/Fs emission from the MSWI did not directly affect the profiles of PCDD/Fs in air and soils, so that vehicles and unidentified emission sources should be considered. The daily inhalation levels of PCDD/Fs for children(0.0110 to 0.392 pg I-TEQ/(kg·day) and adults(0.00600 to 0.221 pg I-TEQ/(kg·day) near the MSWI were lower than the tolerable daily intake of 1.00 to 4.00 pg WHO-TEQ/(kg·day), but in winter the values were higher than in summer. These results can be used as basic data for assessing the risk of PCDD/Fs exposure in residents living around this MSWI, and more monitoring programs and studies should be carried out around MSWIs.展开更多
基金Key R&D Program of Hebei Province,No.223777101D.
文摘BACKGROUND For treatment of hilar cholangiocarcinoma(HCCA),the rate of radical resection is low and prognosis is poor,and preoperative evaluation is not sufficiently accurate.3D visualization has the advantage of giving a stereoscopic view,which makes accurate resection of HCCA possible.AIM To establish precise resection of HCCA based on eOrganmap 3D reconstruction and full quantification technology.METHODS We retrospectively analyzed the clinical data of 73 patients who underwent HCCA surgery.All patients were assigned to two groups.The traditional group received traditional 2D imaging planning before surgery(n=35).The eOrganmap group underwent 3D reconstruction and full quantitative technical planning before surgery(n=38).The preoperative evaluation,anatomical classification of hilar hepatic vessels,indicators associated with surgery,postoperative complications,liver function,and stress response indexes were compared between the groups.RESULTS Compared with the traditional group,the amount of intraoperative blood loss in the eOrganmap group was lower,the operating time and postoperative intestinal ventilation time were shorter,and R0 resection rate and lymph node dissection number were higher(P<0.05).The total complication rate in the eOrganmap group was 21.05%compared with 25.71%in the traditional group(P>0.05).The levels of total bilirubin,Albumin(ALB),aspartate transaminase,and alanine transaminase in the eOrganmap group were significantly different from those in the traditional group(intergroup effect:F=450.400,79.120,95.730,and 13.240,respectively;all P<0.001).Total bilirubin,aspartate transaminase,and alanine transaminase in both groups showed a decreasing trend with time(time effect:F=30.270,17.340,and 13.380,respectively;all P<0.001).There was an interaction between patient group and time(interaction effect:F=3.072,2.965,and 2.703,respectively;P=0.0282,0.032,and 0.046,respectively);ALB levels in both groups tended to increase with time(time effect:F=22.490,P<0.001),and there was an interaction effect between groups and time(interaction effect:F=4.607,P=0.004).In the eOrganmap group,there was a high correlation between the actual volume of intraoperative liver specimen resection and the volume of preoperative virtual liver resection(t=0.916,P<0.001).CONCLUSION The establishment of accurate laparoscopic resection of hilar cholangiocarcinoma based on preoperative eOrganmap 3D reconstruction and full quantization technology can make laparoscopic resection of hilar cholangiocarcinoma more accurate and safe.
基金the National Natural Science Foundation of China(Grant Nos.51602200,61874074)Science and Technology Project of Shenzhen(JCYJ20170817101100705)the(Key)Project of Department of Education of Guangdong Province(Grant No.2016KZDXM008).Y.Z.thanks the support from Science and Technology Project of Shenzhen(ZDSYS201707271014468).L.S.thanks the support from Shenzhen Science and Technology Project Program(JCYJ20170817094552356).
文摘MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are investigated.The batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mAh g^-1 at a current density of 100 mA g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mAh g^-1 at 5 A g^-1.This study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.
基金the support from the Thousand Young Talents Program of Chinathe National Natural Science Foundation of China(Nos.51602200,61874074,21603192)+3 种基金Science and Technology Project of Shenzhen(JCYJ20170817101100705,JCYJ20170817100111548,ZDSYS201707271014468)the(Key)Project of Department of Education of Guangdong Province(No.2016KZDXM008)supported by Shenzhen Peacock Plan(No.KQTD2016053112042971)Singapore Ministry of Education Academic Research Fund Tier 2(MOE2018-T2-2-178).
文摘Improving the cycling stability of metal sulfide-based anode materials at high rate is of great significance for advanced sodium ion batteries.However,the sluggish reaction kinetics is a big obstacle for the development of high-performance sodium storage electrodes.Herein,we have rationally engineered the heterointerface by designing the Fe1?xS/MoS2 heterostructure with abundant“ion reservoir”to endow the electrode with excellent cycling stability and rate capability,which is proved by a series of in and ex situ electrochemical investigations.Density functional theory calculations further reveal that the heterointerface greatly decreases sodium ion diffusion barrier and facilitates charge-transfer kinetics.Our present findings not only provide a deep analysis on the correlation between the structure and performance,but also draw inspiration for rational heterointerface engineering toward the next-generation high-performance energy storage devices.
基金This project is financially supported by the National Natural Science Foundation of China (No. 50173001)
文摘A star-shaped compound of perfluoro-1-octanesulfonated fullerene was synthesized. The measurement of the friction for its spin-coating film by friction force microscopy (FFM) reveals that the films possess lower friction force compared to that of the star-shaped C-60-polystyrene films.
基金suppor ted by the National Key Research and Development Plan of China(grant numbers 2019YFF01014402 and 2022YFC2502606)the CAMS Innovation Fund for Medical Sc ences(CIFMS)(grant numbers 202212MC&T-B-121 and 2019 I2M 5034)+2 种基金the Program of the National Natural Science Foundation of China(grant numbers 11875079 and 82170208Peking University People's Hospital Scentfic Research Development Funds(grant number RZ202202)the State KeyLaboratory of Nuclear Physics and Technal ogy,PKU(grant numbers NPT2020KFY19 and NPT2020KF.J04)。
文摘Relapse is the most important cause of treatment failure in acute leukemia(AL).Thus,how to predict relapse is critical for improving the survival of patients with AL.Measurable residual diseases(MRDs;previously termed minimal resid-ual diseases),refering to the presence of remaining leukemia cells after the declaration of complete remission(CF)detected by morphological analysis,is the most important biomarker forrelapseprediction.'Several methods,including multiparameter flow cytometry(MFC),real-time quantitative polymerase dhain reaction(qPCR),digital PCR(dPCR),and next-generation sequencing(NGS),are used to monitor MRD after treatment,reaching a sensitvityof 10^(-4)to 10^(-6).
基金supported by the National Key Research and Development Program of China(2022YFC2502600,2022YFC2502606)the National Natural Science Foundation of China(82170206,82170208)+3 种基金the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-034,2022-I2M-C&T-B-121)Peking University People’s Hospital Research and Development Funds(RZ2022-02)National High Level Hospital Clinical Research Funding(BJ-2022-169)ShanghaiMunicipal Health Commission Project of Disciplines of Excellence(20234Z0002).
文摘Acutemyeloid leukemia(AML),which is the most common form of acute leukemia in adults,is a heterogeneous,clonal hematopoietic disorder characterized by the accumulation of immature myeloid progenitors.This heterogeneity is especially obvious in the“intermediate-risk group”as defined by international criteria such as those of the European LeukemiaNet,Medical Research Council(MRC),and National Comprehensive Cancer Network.
基金supported by a special grant from the State Environmental Protection Administration, research and public service industry (Grant No. 201309029)
文摘To assess the influence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) on the environment in the vicinity of municipal solid waste incinerators(MSWIs), we determined the levels of PCDD/Fs in air and soil samples collected around a MSWI, which is the largest in China. The International Toxicity Equivalency Quantity(I-TEQ) concentrations of PCDD/Fs in air samples were from 0.0300 to 1.03 pg I-TEQ/m^3(0.445–13.6 pg/m^3), with an average of 0.237 pg I-TEQ/m^3, while in soil samples they ranged from 0.520 to 3.40 pg I-TEQ/g(2.41–88.7 pg/g) with an average of1.49 pg I-TEQ/g. The concentrations of PCDD/Fs in air and soil samples were comparable to other areas, and Pe CDFs were the dominant contributors, which was different from stack gas homologue patterns. Multivariate statistical analysis showed that PCDD/Fs emission from the MSWI did not directly affect the profiles of PCDD/Fs in air and soils, so that vehicles and unidentified emission sources should be considered. The daily inhalation levels of PCDD/Fs for children(0.0110 to 0.392 pg I-TEQ/(kg·day) and adults(0.00600 to 0.221 pg I-TEQ/(kg·day) near the MSWI were lower than the tolerable daily intake of 1.00 to 4.00 pg WHO-TEQ/(kg·day), but in winter the values were higher than in summer. These results can be used as basic data for assessing the risk of PCDD/Fs exposure in residents living around this MSWI, and more monitoring programs and studies should be carried out around MSWIs.