Emergence of Multidrug-Resistant Proteus mirabilis Harboring both blaNDM-1 and cfr genes

Proteus mirabilis is abundant in soil and water,and although it is part of the normal human intestinal flora(along with Klebsiella species and Escherichia coli),it is known to cause serious infections in humans,with a fatality rate of 20%-50%[1].Proteus mirabilis is intrinsically resistant to tetracycline,tigecycline,and colistin.The widespread and irregular use of antimicrobial agents,P.mirabilis antimicrobial resistance has mirabilis.They acquire antimicrobial resistance(AMR)by capturing plasmids,transposons,or other mobile elements harboring antimicrobial resistance genes.This mechanism allows the rapid selection and transmission of numerous AMR genes in clinical,veterinary,food production,transportation,and environmental settings.

磁性艾茎活性炭的制备及吸附亚甲基蓝的研究

以艾茎为原材料,以Fe_(3)O_(4)和K_(2)CO_(3)为活化剂制备了磁性艾茎活性炭(MASBAC)。利用扫描电子显微镜、N,吸附脱附及X-射线扫描仪对MASBAC进行了表征。研究了该炭材料投加量、亚甲基蓝初始浓度、反应温度、吸附时间、pH值等因素对MASBAC吸附亚甲基蓝性能的影响。结果显示:MASBAC具有较大的比表面积、较小孔洞,多孔状态且有磁性;溶液pH值对MASBAC吸附性能无明显影响,MASBAC投加量16.0mg、亚甲基蓝初始浓度55.0mg·L^(-1)、反应温度25℃时为最佳吸附条件。MASBAC对亚甲基蓝的吸附遵循准二级动力学模型(R^(2)=0.9998)和Langmuir模型(R=0.9918),吸附量为166.83mg·g^(-1)。本研究为处理染料废水提供方法参考。

基于“阶梯任务驱动+多维度输出”模式的无机化学课程教学设计与实施——以分子间作用力为例

无机化学是大学化学专业一门基础学科,针对知识点分散、教学方式单一、学科思维培养不足等痛点,探索“阶梯任务驱动+多维度输出”模式,以分子间作用力为例进行教学设计与实施,评价方式采用多元交互式并引入Rubrics评价量规。教学实践结果表明,这种模式有助于学生个性化发展,提升学生自主参与意识,增强专业认同感,培养学科素养。

Visual Perception of Incomplete Human-Like Body Postures: A Near-Infrared Spectroscopy Study

Previous studies have reported that the mirror neuron system plays a crucial role in social cognition. We examined whether the higher-order cognitive functions are involved in the activations in the mirror neuron area when we perceive simplified pseudo-postures. We measured 14 participants’ brain activation during the posture-recognition task using near-infrared spectroscopy. The participants’ task was to observe five sequentially presented target pseudo-postures and judge whether a test pseudo-posture was identical to one of the preceding five target pseudo-postures. The results in the majority of participants (n = 10/14) revealed that the activity in the inferior frontal mirror neuron area is modulated by perception of human-likeness, but not in the remaining four participants (n = 4/14). These results suggest that the degree of the activation of higher-order cognitive functions, which may be engaged in the inhibitory and/or facilitative processing of human body or bodily movement, leads to the distinctive activities in the inferior frontal mirror neuron area.

Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology

Objective:To explore the potential antidepressant mechanism of Wenyang Jieyu Granules with multiple targets and components based on network pharmacology,and to verify the cAMP pathway and animal experimental results.Methods:The active components of Aconitum,Guizhi,Glycyrrhiza uralensis,Wumei,Jujube and Ginger in Wenyang Jieyu Granules were searched and screened by TCM System Pharmacology Analysis Platform(TCMSP).Using the Swiss database to predict its target,and then through the UniProt database to query the target corresponding genes;with the use of Gene Cards、OMIM database query depression related target Point and gene mapping to get the potential target of Wenyang Jieyu granule antidepressant.using Cytoscape,String software to plot the"wenyangjieyu granule-active component-potential action target-depression"network and"protein interaction network",and using David database for GO functional enrichment analysis and KEGG pathway enrichment analysis to predict the action mechanism of wenyangjieyu granule in the treatment of depression and verify it with some previous relevant experimental results.Autodock software was used to perform molecular docking experiments on selected components and targets.Results:The topology analysis is effective there are 47 core components of depression,and 40 potential key targets are SLC6A2,SHBG,ACHE,NR3C1,ESR1.they are involved in many biological processes,such as neurotransmitter receptor conduction,ammonium ion binding,postsynaptic neurotransmitter receptor activity,G protein-coupled neurotransmitter receptor activity.they play an antidepressant effect through brain tissue nerve activity ligand-receptor interaction signaling pathway,cAMP,PI3K-Akt,MAPK signaling pathway,ErbB signaling pathway,etc.At the same time,the results of molecular docking show that the core components have good binding force to the key targets.Conclusion:Wenyang Jieyu granule.The active components of the anti-depressant effect are mediated by multiple signaling pathways and multiple targets.

中国学者如何进行国际创业研究——读《动荡时代下的国际创业》的体会

Zahra教授对近三十年的国际创业研究进行梳理,并对中国国际创业的研究提出展望。本文围绕Zahra教授的观点进行分析,认为研究中国企业的国际创业应该做到以下两个方面:一是构建跨学科的理论框架来研究,二是结合经济新常态来发现新规律。本文还分析了当前中国的国际创业研究可能存在的问题,提出了中国的国际创业研究可行的方向,对中国管理学者如何做好中国自己的国际创业研究提出有益建议。

Kinematics and dynamics of a particle on a non-simple harmonic vibrating screen

The motion of a particle on a screen is directly affected by the motion of the screen if airflow and inter- granular friction are ignored. To study this effect, a mathematical model was established to analyze the motion of a planar reciprocating vibrating screen, and a matrix method was employed to derive its equa- tion of motion. The motion of the screen was simulated numerically and analyzed using MATLAB. The results show that the screen undergoes non-simple harmonic motion and the law of motion of each point in the screen is different. The tilt angle of the screen during screening is not constant but varies according to a specific periodic function. The results of numerical simulations were verified through experiments. A high-speed camera was used to track the motion of three points in the longitudinal direction of the screen. The balance equation for forces acting on a single particle on the screen was derived based on the non-simple harmonic motion of the screen, These forces were simulated using MATLAB. Different types of particle motion like slipping forward, moving backward, and being tossed to different parts of the screen were analyzed. A vibro-impact motion model for a particle on the non-simple harmonic vibrating screen was established based on the nonlinear law of motion of the particle. The stability of fixed points of the map is discussed. Regimes of different particle behaviors such as stable periodic motion, period-doubling bifurcation motion, Hopf bifurcation motion, and chaotic motion were obtained. With the actual law of motion of the screen and the behavior of a particle on the screen, a theoretical basis for design optimization of the screen is provided.

Unsteady aerodynamic performance of a maglev train:the effect of the ground condition

The effect of ground condition on unsteady aerodynamic performance of a maglev train was numerically investigated with an IDDES(Improved Delayed Detached Eddy Simulation) method. The accuracy of the numerical method has been validated by wind tunnelexperiments. The flow structure, slipstream and aerodynamic force around the train under stationary and moving ground conditionswere compared. Track and ground play a leading role in the influence of wake vortex structure;the flow structure around the trainis more complex under the stationary ground boundary condition. Near the nose point of the head and tail vehicles, the peak valueof the slipstream under the condition of moving ground is slightly higher than that under stationary ground. In the wake area, theeffect of themain vortex structure on both sides of the tail vehicle and the trackmakes the vortex structure in the wake area strongerthan that under moving ground, the slipstream peak is larger and the locus thereof is further forward. In the horizontal direction, thevortex desorption energy near the nose tip of the train is higher on stationary ground, while the vortex desorption energy far fromthe nose tip of the train is higher on moving ground. Compared with the static ground boundary condition, the resistance coefficientof the head and tail of a maglev train increases by 3.45% and 3.31% respectively under the moving ground boundary condition. Thelift coefficient decreases by 157.78% and 5.13%, respectively.

Chinese Pathogen Identification Net:A Laboratory Network for Surveillance and Response of Bacterial Infectious Diseases

Infectious diseases are a sustained threat to social development and public health.Bacterial infectious diseases,including plague,cholera,anthrax,brucellosis,typhoid fever,meningitis,and even those caused by antimicrobial-resistant bacteria,have been prevalent around the world for a long time,and still trigger outbreaks and long-term epidemics in different countries or regions nowadays(1),and trans-regional spread of diseases has frequently exhibited epidemic patterns.

The Effect of Concave Size on the Aerodynamics of a Maglev Train

Inspired by shark’s skin in nature,a non-smooth surface could be an ideal model for changing the flow characteristics of fluids on the object surface.To analyze the effect of a non-smooth surface with concaves on the maglev train aerodynamic performances and to investigate how the concave size affects the aerodynamic forces and flow structure of a maglev train,four 1/10th scaled maglev train models are simulated using an Improved Delayed Detached Eddy Simulation(IDDES)method.The numerical strategy used in this study is verified by comparison with the wind tunnel test results,and the comparison shows that the difference was in a reasonable range.The results demonstrate that the concaves could effectively reduce the tail car pressure drag,thus reducing the total drag,and that the smaller the concave size was,the better the drag reduction effect would be.The change in the lift with the concave size was more significant than that of the drag,and the tail car lift of R1(0.0012H),R2(0.0024H),and R3(0.0036H)train models was 30.1%,43.0%,and 44.5%less than that of the prototype,respectively.In addition,different flow topologies of the wake are analyzed.The width and height of the vortex core of the counter-rotating vortices tended to decrease with the concave size.Thus,from the point of view of ensuring the operating safety of a maglev train,a non-smooth surface with small-size concaves is recommended.