Effects of vitamin family members on insulin resistance and diabetes complications

The following letter to the editor highlights the article“Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance”in World J Diabetes 2023 Oct 15;14(10):1514-1523.It is necessary to explore the role of vitamin family members in insulin resistance and diabetes complications.

Separation of alumina and silica from metakaolinite by reduction roasting-alkaline leaching process: Effect of CaSO_(4) and CaO

Limestone(CaCO3),which could promote sulfur fixation,was added to coal gangue during roasting in a circulating fluidized bed(CFB)boiler.CaO and CaSO_(4) were the main Ca-bearing minerals while metakaolinite was the major Al-bearing mineral in CFB slag.The effect of CaSO_(4) and CaO on the separation of alumina and silica from metakaolinite by reduction roasting−alkaline leaching process was studied.Results showed that metakaolinite was completely converted into hercynite and silica solid solutions(i.e.,quartz and cristobalite solid solutions)by reduction roasting with hematite.More than 95%of silica in the reduced specimen was removed by alkaline leaching.The addition of CaSO_(4) and CaO remarkably decreased the separation efficiency of alumina and silica in metakaolinite,which could be attributed to the formation of Si-bearing minerals:(1)Fayalite and anorthite were formed during the reduction roasting process;(2)Fayalite was stable while anorthite was converted into sodalite and wollastonite during the alkaline leaching process.This study demonstrates that sulfur in coal gangue should be fixed by treating the exhaust gas instead of controlling the combustion process of CFB to achieve the comprehensive recovery of silica and alumina from the CFB slag.

Adsorption mechanism of styryl phosphonate ester as collector in ilmenite flotation

A styryl phosphonate ester(SPE) collector was used to improve the flotation performance of ilmenite, and the adsorption mechanism and model were revealed and established, respectively. Microflotation tests showed that SPE exhibited a stronger collecting ability for ilmenite than the traditional collector styrene phosphonic acid(SPA). Zeta potential measurements revealed that both SPE and SPA could negatively shift the zeta potential of ilmenite, while SPE had more effects than SPA, suggesting the stronger adsorption of SPE. The analysis of X-ray photoelectron spectroscopy confirmed the chemisorption of SPA and SPE onto the Fe/Ti sites of ilmenite. According to frontier orbital theory, the chemical activities of SPE are greater than those of SPA. The partial densities of states analysis indicated that the PO—H groups of the collectors could interact with the Ti/Fe atoms of the ilmenite surface to generate a stable four-membered ring. The bonding model of the collector and(104) ilmenite surface showed that the adsorption energy of SPE was higher than that of SPA. Overall, SPE presented a better collecting ability and interaction effect for ilmenite flotation than SPA, and had the potential to replace SPA in the industry.

Effectiveness of probiotics in irritable bowel syndrome: methodological quality of meta-analyses and systematic reviews

Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessment scale AMSTAR and explored the factors that influenced the quality of methodology. It was designed to provide a reference for future research and systematic reviews/metaanalysis. Methods: The methodological quality of existing systematic reviews/meta-analysis was evaluated using the AMSTAR scale. Influencing factors of methodological quality were statistically analyzed using RevMan 5.3 software. The included systematic reviews/metaanalysis must include the following characteristics:(1) methods using systematic evaluation/meta-analysis,(2) probiotic intervention, and (3) language limitation to Chinese and English. Results: The AMSTAR score was 5-9 (7.42 ± 1.22), and the quality is above average. The factors affecting the methodological quality are the number of authors and whether they cooperate with the institution. Conclusions: Studies have shown that current systematic reviews/meta-analysis of the effectiveness of probiotics on IBS does not fully comply with methodological quality standards, and therefore the methodological quality of research in this area needs to be strengthened. To better clarify how probiotics affect IBS, future systematic reviews and meta-analyses should not only follow methodological quality standards but also include more effective outcome measures, and they should focus more on the discussion of research results. We look forward to the development of higher-quality randomized controlled trials in the future.

Metaplastic breast cancer with chondrosarcomatous differentiation combined with concurrent bilateral breast cancer:A case report

BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and mortality.CASE SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast mass.The patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical mastectomy.Postoperative pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right breast.As the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine treatment.Then the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable condition.However,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is sporadic.CONCLUSION Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus.

Kangfuxin Fluid on the Treatment of Ulcerative Colitis with Retention Enema： a Systematic Review

Objective： To systematically evaluate the effectiveness of Kangfuxin Fluid （KFX） in Ulcerative Colitis （UC） with retention enema. Methods： We searched The Cochanrane Library, Pubmed, EMbase, VIP, CNKI, CBM and WanFang Data from inception to December.2017, and retrospectively incorporated into the literature reference. And a systematic review of randomized controlled trials was performed. Meta-analysis was performed with RevMan5.3 software. Results： A total of 18 randomized controlled trials and 1417 patients were enrolled, among which 731 cases were in experimental group and 686 cases were in control group. The meta-analysis results revealed that the effectiveness of KFX on UC with retention enema was significantly superior to the controlled treatment （RR=1.22 95%CI： [1.16,1.27], Z=8.14, p〈0.00001）. And, the score of quality of life was significantly increased after KFX treatment （MD=11.12, 95% CI [7.00, 15.23], Z=5.30, p〈0.00001）. Conclusion： KFX on the treatment of UC with retention enema is potentially effective to improve patient＇s quality of life, and it is worth being popularized clinically. Depth researches and high quality randomized controlled trials on the efficacy of UC are necessary.

Effect of blood gas analysis in patients with bed rest and blood sampling through the dorsal artery:A meta-analysis

Objective:To systematic evaluation by the dorsalis pedis artery puncture for bed patients blood gas analysis of application effect of impact.Methods:A randomized controlled trial of the effect of arterial blood extraction on blood gas analysis in PubMed,CNKI,Wanfang database and VIP database.After selecting the literature,extracting the data and evaluating the quality of the literature.Meta- analysis was carried out by RevMan 5.3 software.Results:Twelve randomized controlled trials were included and 1696 patients were enrolled.After meta-analysis,the arterial puncture can effectively improve the success of arterial puncture in patients with bed [Z = 5.78,95%CI(1.90,3.66),P<0.001],reduce the occurrence of hematoma [Z = 4.27,95%CI(0.19,0.54),P<0.001],reduce the mistaken into the vein [Z = 4.60,95%CI(0.08,0.36),P<0.001],reduce cyanosis [Z = 2.84,95%CI(0.23,0.81),P<0.008],the difference was statistically significant.Conclusion:Dorsalis pedis artery puncture can improve the success rate of blood gas analysis in bedridden patients,reduce the incidence of hematoma and the incidence of venous leakage,and can be widely used in clinical practice.

Effects of midwife-led psychological intervention on delivery outcomes:a meta-analysis

Objective:To systematically review the influence of psychological intervention of midwives on the delivery mode and outcomes.Methods:Databases including Cochrane Library,PubMed,Medline,EMBASE,CINAHL,CNKI,Wangfang,and VIP were searched for randomized controlled trials studying the effects of midwife-led psychological nursing on puerpera.Two evaluators independently searched and screened the papers,extracted relevant data,and quality assessment of the included studies,followed by a meta-analysis of the papers using RevMan 5.3 software.Results:12 studies with 1,395 patients were included.The results of the meta-analysis showed that compared to conventional nursing,midwife-led psychological intervention can improve the number of people who choose natural delivery[Z=7.53,95%CI(2.07,3.45),P<0.001],shorten the duration of the first stage of delivery[Z=45.10,95%CI(-4.43,-4.06),P<0.001),reduce postpartum hemorrhage after delivery for two hours[Z=21.68,95%CI(-63.92,-53.32),P<0.001];these differences were statistically significant.Conclusion:Psychological interventions led by midwives can improve the natural delivery rate of pregnant women,shorten the duration of the first stage of delivery,and decrease postpartum hemorrhage after delivery for two hours;thus,it can be popularized for clinical use.

Reporting and methodological quality of systematic reviews or meta-analyses in nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis

Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MAs of nasogastric and nasojejunal enteral nutrition for SAP published in the journal before July.1st 2018 were identified by searching the databases of OVID,Cochrane Library,Wiley,PubMed,CNKI,Wanfang Data and VIP.The methodological and reporting quality of included studies was respectively assessed by AMSTAR 2 scale and PRISMA statement.Results:A total of 6 articles included at last.(1)Several issues of methodological quality in 6 studies were reviewed,such as:no prior design,comprehensive searching strategy,assessment of publication bias,the reason for incorporating the type of research design,or the statement of conflict of interest.(2)The average PRISMA score is 18.83±1.97(17-22).Results on the quality of reporting evaluation showed that 5 SRs/MAs were rated as moderate and 1 as high.What’s more,we assessed the quality of indicators of the result by GRADE,but the grade was low.Conclusion:The quality of the involved studies published at home and abroad is uneven,so it is necessary to seek for further improvement of methodology and standardization of reporting to provide high-quality support for evidenced-based decision.

Effects of moxibustion on cancer-related fatigue: a meta-analysis

Objective: To systematically evaluate the efficacy of moxibustion in the treatment of cancer-related fatigue (CRF). Methods: Randomized controlled trials (RCTs) using moxibustion to treat cancer-related fatigue in Cochrane Library, PubMed, China Knowledge Network, Wanfang and VIP databases was searched. Two reviewers independently searched, reviewed the literature, extracted data, and evaluated the methodological quality. RevMan5.3 software was used for meta-analysis. Results: A total of 942 patients were included in 11 randomized controlled trials. The meta-analysis results showed that moxibustion can reduce fatigue score [MD =-2.04, 95% CI (-4.06,-0.33), P < 0.001], improve the score of quality of life QLQ-C30 [(MD = 8.44, 95% CI (1.85, 15.03), P < 0.001], also could boost the number of important immune-system cellular, such as CD3 [MD = 7.82, 95% CI (3.14, 12.49), P = 0.01], CD8 [MD =-3.15, 95% CI (-11.36, 5.06), P < 0.001], NK cells [MD=5.88, 95% CI (3.56, 8.20), P = 0.01];Conclusion: Moxibustion can improve the degree of cancer-related fatigue, improve the quality of life and enhance immune function.

Bibliometric analysis of researches of empowerment theory applied to nursing in China

Objective:To analysis the development trend and research focus of empowerment theory applied to Nursing in China.Methods:Literatures related to the objective were searched and collected from CNKI,WangFang,VIP and CBM,then Excel 2003 was used to setup the database and co-word matrix,SPSS 21.0 was utilized to make the visualized analysis by way of multivariate statistics analysis,cluster analysis and multidimensional scaling analysis.Results:Literatures with the number of 486 were selected out and 18 high frequency keywords were retrieved from 140 journals.Among the literatures,the first one was published in 2002,then a tremendous rising started since 2009,and reached the peak in 2017,mainly from the southern part of China,such as the province of Jiangsu,Guangdong,and Zhejiang.Regarding the content of the literatures,the research of intervention accounted for 61.32%,then the research of description came to the second at the ratio of 24.49%.What’s more,378(77.78%)were cited,154(31.69%)were funded.Conclusion:Nowadays,empowerment applied in the therapy of chronic disease is the focus and trend of the research of empowerment theory,and the psychological empowerment to nursing staff,as well as the constructed empowerment is going mature.In the future,more attention should be paid to the study and practice of empowerment theory,in order to vary the direction of research and enrich the theory.

Methodologic quality of systematic reviews and meta-analyses on the Mediterranean diet and cognitive function： a review

Background and aim： Several systematic reviews and meta-analyses published within the past years have examined the associations of Mediterranean-style diets （MedSDs） on cognitive. However, these reviews have not been evaluated for satisfying Contemporary methodologies quality standards. At the same time, due to the high demand for related care during the aging process in China, it is necessary to summarize the ex-isting system evaluation and evaluate the quality of it, so as to provide strong evidence for the development of relevant work and to standardize the research process and methods in this field. This study evaluated the quality of recent systematic reviews and meta-analyses on MedSD and cognitive outcomes by using an established methodology quality scale, and to provide some valuable references for future research and Chinese systematic review and meta-analysis developing. Methods： We used the AMSTAR Methodology Quality Assessment Scale to evaluate the quality of methodology of the existing meta-analyses and systematic review. Meta analysis and systematic review that meets our criteria must contain the following characteristics： 1） used systematic or meta-analytic procedures to review the lit-erature, and 2） had MedSD interventions independently. Results： Reviews satisfied with 5 to 9 of the AMSTAR MedSD items （mean 7.35, standard deviation： 1.27）, quality is above average with those published in higher-impact journals having a greater quality score. Conclusion： These data suggest that current meta-analyses/systematic reviews evaluating the effect of MedSD on cognitive do not fully meet contemporary methodology quality standards. The methodological quality of the literature needs to be im- proved. As a result, there are more research questions to answer to enhance our understanding of how MedSD affects cognitive. To clarify associations between MedSD and cognitive, future meta-analyses and systematic reviews should not only follow methodology quality standards but also include more statistical modeling results when data allow. And in order to make the conclusions more reliable, we expect higher quality RCTs in the future.

Research Progress in "Person-centered" Nursing

This paper reviews the research progress of “person-centered” nursing,and provides reference for the development of “person-centered” nursing in China.Currently,foreign scales have been developed to measure “person-centered” nursing,such as Individualized Care Scale,P-CA,Assess Health Care Providers’ Implementation of Patient-Cen,Person-centered Critical Care Nursing and Human-based Perioperative Care Scale.The “Person-centered” nursing model has been widely used in clinical nursing and nursing management.Studies have shown that “person-centered” nursing can improve patient satisfaction and promote the physical and mental health of patients.At the same time,the combination of “person-centered” nursing and teaching promotes the innovation of medical education medicine,and its combination with architecture promotes the progress of hospital construction.Future research should focus on the overall layout of hospitals and wards,use more holistic means of psychosomatic medicine to set up more comprehensive humanistic concepts such as accompanying family members area,improve the breadth and depth of humanistic nursing field,and promote the development of humanistic nursing in China.

Design and application of a new multifunctional uniform for hemodialysis patients

Objective:To design and apply a multifunctional uniform for hemodialysis patients.The new patients’uniform is designed as a medium-to-long dress.A PVC transparent pocket locates under the right collar with the size of 6 cm x 4 cm;an oblique opening starts from the collar to the downright by 46 cm x 2 cm,with 6 ties and concealed fasteners;a 45 cm opening at the edge of both side of the sleeves,with 4 ties and concealed buttons;There is a 5 cm x 1.5 cm urinary catheter opening at the crotch,with 2 cross-opening perforations and concealed buttons.The lower thighs of both sides of the patients’uniform,at which an elastic tie and a concealed button locate,are not sutured.Therefore,during hemodialysis,patients can fix the vascular access,prevent such adverse events as channel compression and detachment,improve the safety,comfort and privacy of dialysis patients,and reduce the incidence of complications such as infection compared with the traditional uniform.The design of the new multifunctional uniform for hemodialysis patients is reasonable,which ensures the safety of hemodialysis patients and is suitable for clinical application and promotion.

Soluble IL-2Rα correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis

Background Previous studies showed that soluble IL-2Rαis an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis.However,data regarding adult patients with brucellosis were unknown.The aim of study was to explore the potential role of serum sIL-2Rαevaluating treatment responses in adult patients with brucellosis,and T cell immune status was also examined.Methods During January 2016–April 2017,30 patients with acute brucellosis from the Third People’s Hospital of Linfen in Shanxi Province and Beijing Di Tan Hospital,and 28 healthy controls were included in this study.Peripheral blood samples were collected before and after six weeks of antibiotic treatment.Serum sIL-2Rαlevels were measured by enzyme-linked immunosorbent assay,and the percentage of Th1,Th2,Tc1,Tc2,and Tregs was detected by flow cytometry after intracellular staining for cytokines(interferon-γand interleukin-4)and Foxp3 in T lymphocytes from peripheral blood.The obtained data were analyzed with Wilcoxon ranked sum tests for paired values,Mann-Whitney U-tests for comparisons between patients and healthy controls,and Spearman rank tests for correlation analyses.Results Serum sIL-2Rαlevels were significantly higher in patients than in controls(P=0.001).A significant decline was observed in patients after the cessation of treatment(P<0.001)and return to normal(P>0.05).Th1,Tc1,Th2,and Tc2 cell frequencies were higher in patients than in healthy subjects(P<0.05),while the Th1/Th2 and Tc1/Tc2 ratios were significantly lower(P=0.0305 and 0.0005,respectively)and returned to normal levels after treatment.In patients with acute brucellosis,serum sIL-2Rαlevels were negatively correlated with the Th1/Th2 ratio(r=−0.478,P=0.028),Tc1/Tc2 ratio(r=−0.677,P=0.001),and Tc1 percentage(r=−0.516,P=0.017).Serum sIL-2Rαand Tc2 percentages were positively correlated(r=0.442,P=0.045).Conclusions Based on the correlations with Th1/Th2 and Tc1/Tc2 ratios,serum sIL-2Rαlevels may reflect the immune response status.sIL-2Rαmay be a marker for therapeutic efficacy in acute brucellosis.