In network-connected UAV(NCUAV) communication systems, user authentication is replaced by platform identity authentication and integrity check because many NC-UAVs are operated without human intervention. Direct anony...In network-connected UAV(NCUAV) communication systems, user authentication is replaced by platform identity authentication and integrity check because many NC-UAVs are operated without human intervention. Direct anonymous attestation(DAA) is an attractive cryptographic scheme that provides an elegant balance between platform authentication and anonymity. However, because of the low-level computing capability and limited transmission bandwidth in UAV, the existing DAA schemes are not suitable for NC-UAV communication systems. In this paper, we propose an enhanced DAA scheme with mutual authentication(MA-DAA scheme), which meets the security requirements of NC-UAV communication systems. The proposed MA-DAA scheme, which is based on asymmetric pairings, bundles the identities of trusted platform module(TPM) and Host to solve the malicious module changing attacks. Credential randomization, batch proof and verification, and mutual authentication are realized in the MA-DAA scheme. The computational workload in TPM and Host is reduced in order to meet the low computation and resource requirements in TPM and Host.The entire scheme and protocols are presented,and the security and efficiency of the proposed MA-DAA scheme are proved and analyzed.Our experiment results also confirm the high efficiency of the proposed scheme.展开更多
It is critical to acknowledge that the coexistence of genes related to carbapenem and polymyxin resistance can exacerbate challenges in antimicrobial therapy.In this study,we identified Klebsiella pneumoniae isolate L...It is critical to acknowledge that the coexistence of genes related to carbapenem and polymyxin resistance can exacerbate challenges in antimicrobial therapy.In this study,we identified Klebsiella pneumoniae isolate L2425 fromthe feces of an ICU patient in China.The isolate belongs to sequence type 11 and carries the antimicrobial resistance genes blaKPC-2,bla_(CTX-M-65) and mcr-8.Through S1-nuclease pulsed-field gel electrophoresis and Southern blotting analysis,we confirmed the presence of a~110 kb plasmid harboring the mcr-8 gene with a conserved structure(inhA-mcr-8-ompR-dgkA-IS903B).Furthermore,another~130 kb plasmid carrying bla_(KPC-2) was detected along with a composite transposon flanked by insertion sequence IS26.Conjugation experiments demonstrated that both pL2425-KPC-2 and pL2425-MCR-8 plasmids were transferable.Importantly,this is the first instance of clinical fecal samples from China containing a K.pneumoniae strain carrying both blaKPC-2 and mcr-8 genes.These findings underscore the significance of surveillance for carbapenemases and mobile colistin–resistance variants.展开更多
基金supported in part by the European Commission Marie Curie IRSES project "AdvIOT"the National Natural Science Foundation of China (NSFC) under grant No.61372103
文摘In network-connected UAV(NCUAV) communication systems, user authentication is replaced by platform identity authentication and integrity check because many NC-UAVs are operated without human intervention. Direct anonymous attestation(DAA) is an attractive cryptographic scheme that provides an elegant balance between platform authentication and anonymity. However, because of the low-level computing capability and limited transmission bandwidth in UAV, the existing DAA schemes are not suitable for NC-UAV communication systems. In this paper, we propose an enhanced DAA scheme with mutual authentication(MA-DAA scheme), which meets the security requirements of NC-UAV communication systems. The proposed MA-DAA scheme, which is based on asymmetric pairings, bundles the identities of trusted platform module(TPM) and Host to solve the malicious module changing attacks. Credential randomization, batch proof and verification, and mutual authentication are realized in the MA-DAA scheme. The computational workload in TPM and Host is reduced in order to meet the low computation and resource requirements in TPM and Host.The entire scheme and protocols are presented,and the security and efficiency of the proposed MA-DAA scheme are proved and analyzed.Our experiment results also confirm the high efficiency of the proposed scheme.
基金supported by the National Key Research and Development Programof China(2019YFC0840600,2019YFC0840609 and 2020YFE0204300)the National Natural Science Foundation of China(82072314)+3 种基金the Zhejiang Province Natural Science Foundation of China(LHDMZ22H190002 and LY19H160060)the Shandong Provincial Laboratory Project(SYS202202)the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022011B),the Fundamental Research Funds for the Central Universities(2022ZFJH003)the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-045).
文摘It is critical to acknowledge that the coexistence of genes related to carbapenem and polymyxin resistance can exacerbate challenges in antimicrobial therapy.In this study,we identified Klebsiella pneumoniae isolate L2425 fromthe feces of an ICU patient in China.The isolate belongs to sequence type 11 and carries the antimicrobial resistance genes blaKPC-2,bla_(CTX-M-65) and mcr-8.Through S1-nuclease pulsed-field gel electrophoresis and Southern blotting analysis,we confirmed the presence of a~110 kb plasmid harboring the mcr-8 gene with a conserved structure(inhA-mcr-8-ompR-dgkA-IS903B).Furthermore,another~130 kb plasmid carrying bla_(KPC-2) was detected along with a composite transposon flanked by insertion sequence IS26.Conjugation experiments demonstrated that both pL2425-KPC-2 and pL2425-MCR-8 plasmids were transferable.Importantly,this is the first instance of clinical fecal samples from China containing a K.pneumoniae strain carrying both blaKPC-2 and mcr-8 genes.These findings underscore the significance of surveillance for carbapenemases and mobile colistin–resistance variants.