Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm （CAS）. However, clinical features related to age on coronary artery spasm have been rare...Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm （CAS）. However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine （Ach） provocation test for induction of CAS. CAS was defined as 〉 70% luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; 〈 45 years （Group 1）, 45-54 years （Group 2）, 55-64 years （Group 3）, and 〉_ 65 years （Group 4）. Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging （47.36% vs. 58.3% vs. 62.6% vs. 61.5%; P 〈 0.001）. Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.展开更多
The research was conducted to develop a robot that can navigate a paddy in between rows or hills which were transplanted by the machine transplanter with equal distance. An initial prototype robotic battery-type weede...The research was conducted to develop a robot that can navigate a paddy in between rows or hills which were transplanted by the machine transplanter with equal distance. An initial prototype robotic battery-type weeder was manufactured and tested to navigate and control weeds in rice paddy fields, but a speed was so slow, and thus second engine-type prototype was developed. A working acreage for weed control has been attained at and up to 0.8 ha/day. Small and young weed seedlings were uprooted and destroyed by passive devices in between rows as well as hills. This robot was smoothly navigated in between rows on behalf of the guidance under camera and sensor systems and control weeds with mechanical by the use of implements such as passive rotary weeders and then weeds would be cut and buried into the soils. Also muddy water was generated during operation which was none penetrated by light for weed germination to occur. The authors concluded that the robotic was an effective alternative implement to control weeds in lowland rice paddy as long as this tool was systematically introduced into the rice fields at three time intervals, viz. 15-20 days, 25-30days, and 35-40 days after transplanting of rice seedlings.展开更多
Cardiovascular diseases cause huge socio-economic burden worldwide.Although a mammalian myocardium has its own limited healing capability,scaffold materials capable of releasing stem cell recruiting/engrafting factors...Cardiovascular diseases cause huge socio-economic burden worldwide.Although a mammalian myocardium has its own limited healing capability,scaffold materials capable of releasing stem cell recruiting/engrafting factors may facilitate the regeneration of the infarcted myocardium.The aim of this research was to develop cardiac patches capable of simultaneously eluting substance P(SP)and insulin-like growth factor-1C(IGF-1C)peptide.Polycaprolactone/collagen type 1-based patches with or without SP and IGF-1C peptide were fabricated by co-electrospinning,which exhibited nanofibrous morphology.SP and IGF-1C/SP patches recruited significantly higher numbers of bone marrow-mesenchymal stem cells than that of the negative control and patch-only groups in vitro.The developed patches were transplanted in an infarcted myocardium for up to 14 days.Mice underwent left anterior descending artery ligation and received one of the following treatments:(i)sham,(ii)saline,(iii)patch-only,(iv)IGF-1C patch,(v)SP patch and(vi)IGF-1C/SP patch.SP and IGF-1C/SP patch-treated groups exhibited better heart function and attenuated adverse cardiac remodeling than that of the saline,patch-only and individual peptide containing cardiac patches.SP patch and IGF-1C/SP patch-treated groups also showed higher numbers of CD31-positive vessels and isolectin B4-positive capillaries than that of other groups.IGF-1C/SP-treated group also showed thicker left ventricular wall in comparison to the saline and patch-only groups.Moreover,IGF-1C/SP patches recruited significantly higher numbers of CD29-positive cells and showed less numbers of Tunel-positive cells compared with the other groups.These data suggest that SP and IGF-1C peptides may act synergistically for in situ tissue repair.展开更多
文摘Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm （CAS）. However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine （Ach） provocation test for induction of CAS. CAS was defined as 〉 70% luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; 〈 45 years （Group 1）, 45-54 years （Group 2）, 55-64 years （Group 3）, and 〉_ 65 years （Group 4）. Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging （47.36% vs. 58.3% vs. 62.6% vs. 61.5%; P 〈 0.001）. Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.
文摘The research was conducted to develop a robot that can navigate a paddy in between rows or hills which were transplanted by the machine transplanter with equal distance. An initial prototype robotic battery-type weeder was manufactured and tested to navigate and control weeds in rice paddy fields, but a speed was so slow, and thus second engine-type prototype was developed. A working acreage for weed control has been attained at and up to 0.8 ha/day. Small and young weed seedlings were uprooted and destroyed by passive devices in between rows as well as hills. This robot was smoothly navigated in between rows on behalf of the guidance under camera and sensor systems and control weeds with mechanical by the use of implements such as passive rotary weeders and then weeds would be cut and buried into the soils. Also muddy water was generated during operation which was none penetrated by light for weed germination to occur. The authors concluded that the robotic was an effective alternative implement to control weeds in lowland rice paddy as long as this tool was systematically introduced into the rice fields at three time intervals, viz. 15-20 days, 25-30days, and 35-40 days after transplanting of rice seedlings.
基金supported by the KIST Institutional Program and by the KUKIST Graduate School of Converging Science and Technology Program.Project supported by the National Science Foundation for Young Scientists of China(Grant No.81701839)The Youth Foundation of Tianjin Medical University(Grant No.2015KYZQ14).
文摘Cardiovascular diseases cause huge socio-economic burden worldwide.Although a mammalian myocardium has its own limited healing capability,scaffold materials capable of releasing stem cell recruiting/engrafting factors may facilitate the regeneration of the infarcted myocardium.The aim of this research was to develop cardiac patches capable of simultaneously eluting substance P(SP)and insulin-like growth factor-1C(IGF-1C)peptide.Polycaprolactone/collagen type 1-based patches with or without SP and IGF-1C peptide were fabricated by co-electrospinning,which exhibited nanofibrous morphology.SP and IGF-1C/SP patches recruited significantly higher numbers of bone marrow-mesenchymal stem cells than that of the negative control and patch-only groups in vitro.The developed patches were transplanted in an infarcted myocardium for up to 14 days.Mice underwent left anterior descending artery ligation and received one of the following treatments:(i)sham,(ii)saline,(iii)patch-only,(iv)IGF-1C patch,(v)SP patch and(vi)IGF-1C/SP patch.SP and IGF-1C/SP patch-treated groups exhibited better heart function and attenuated adverse cardiac remodeling than that of the saline,patch-only and individual peptide containing cardiac patches.SP patch and IGF-1C/SP patch-treated groups also showed higher numbers of CD31-positive vessels and isolectin B4-positive capillaries than that of other groups.IGF-1C/SP-treated group also showed thicker left ventricular wall in comparison to the saline and patch-only groups.Moreover,IGF-1C/SP patches recruited significantly higher numbers of CD29-positive cells and showed less numbers of Tunel-positive cells compared with the other groups.These data suggest that SP and IGF-1C peptides may act synergistically for in situ tissue repair.
