Effects of intensive psychological intervention on treatment compliance,psychological status,and quality of life of patients with epilepsy

BACKGROUND Epilepsy is a nervous system disease characterized by recurrent attacks,a long disease course,and an unfavorable prognosis.It is associated with an enduring therapeutic process,and finding a cure has been difficult.Patients with epilepsy are predisposed to adverse moods,such as resistance,anxiety,nervousness,and anxiety,which compromise treatment compliance and overall efficacy.AIM To explored the influence of intensive psychological intervention on treatment compliance,psychological status,and quality of life(QOL)of patients with epilepsy.METHODS The clinical data of 105 patients with epilepsy admitted between December 2019 and July 2023 were retrospectively analyzed,including those of 50 patients who underwent routine intervention(control group)and 55 who underwent intensive psychological intervention(research group).Treatment compliance,psychological status based on the Self-Rating Anxiety Scale(SAS)and Depression Scale Self-Rating Depression Scale(SDS)scores,hope level assessed using the Herth Hope Scale(HHS),psychological resilience evaluated using the Psychological Resilience Scale,and QOL determined using the QOL in Epilepsy-31 Inventory(QOLIE-31)were comparatively analyzed.RESULTS Treatment compliance in the research group was 85.5%,which is significantly better than the 68.0%of the control group.No notable intergroup differences in preinterventional SAS and SDS scores were identified(P>0.05);however,after the intervention,the SAS and SDS scores decreased significantly in the two groups,especially in the research group(P<0.05).The two groups also exhibited no significant differences in preinterventional HHS,Connor-Davidson Resilience Scale(CD-RISC),and QOLIE-31 scores(P>0.05).After 6 months of intervention,the research group showed evidently higher HHS,CD-RISC,tenacity,optimism,strength,and QOLIE-31 scores(P<0.05).CONCLUSION Intensive psychological intervention enhances treatment compliance,psychological status,and QOL of patients with epilepsy.

Study on conversion of microstates in breast cell ensemble at the gene level based on the eigen-microstate method

Breast cancer is a malignant disease that seriously threatens women's health.Studying the mechanism of cancer occurrence and development is an urgent problem to be solved.In this paper,the eigen-microstate method was used to study conversion of normal breast cells into breast cancer cells and the reason.The main conclusions are as follows:the microstates of normal breast cell and breast cancer cell are different.There is a state conversion when a normal breast cell transforms into a breast cancer cell.The main reason for this state conversion is the combined effect of tumor suppressor genes and oncogenes.By analyzing the function of key genes,it was found that these genes do play an important role in the development of breast cancer.The findings contribute to understanding the mechanism by which breast cancer occurs and progresses,and key genes can serve as potential biomarkers or target genes for breast cancer treatment.

飞秒激光辅助白内障手术联合三焦点人工晶状体植入术的疗效观察

目的:观察飞秒激光辅助白内障手术联合三焦点人工晶状体(IOL)植入术后的临床疗效。方法:回顾性自身前后对照研究。选择2016-09/2017-11就诊于山西省眼科医院植入三焦点IOL的白内障患者42例59眼,随访至术后6mo,分别观察术前、术后1wk,1、3、6mo单眼裸眼远、中、近距离视力(LogMAR)、离焦曲线、屈光稳定性、高阶像差、患者满意度和脱镜率。结果:所有患者在术后各随访时间点远、中、近距离均可获得优于0.1LogMAR的良好视力,术后各距离视力与术前相比显著提高(P<0.05)。术后6mo离焦曲线在0^-2.5D之间曲线过渡平缓,术眼达到优于0.8的视力水平。术后6mo,63%(37眼)的患眼SE位于±0.25D之间,88%(52眼)的患眼SE则位于±0.50D之间。术后各时期全眼的总高阶像差、彗差、球差、三叶草像差明显低于术前(P<0.05)。结论:飞秒激光辅助白内障手术联合三焦点IOL植入术可以为患者提供舒适自然的全程视力,实现真正的脱镜,患者术后满意度高。

Corneal biomechanical properties changes after coaxial 2,2-mm microincision and standard 3,0-mm phacoemulsification

AIM： To compare the changes in corneal biomechanics measured by ocular response analyzer （ORA） after 2.2-ram microincision cataract surgery and 3.0-mm standard coaxial phacoemulsification. METHODS： The prospective nonrandomized study comprised eyes with cataract that had 2.2-mm coaxial microincision or 3.0 -mm standard incision phacoemulsification. The corneal hysteresis （CH）, corneal resistance factor （CRF）, corneal-compensated intraocular pressure （IOPcc） and Goldmann-correlated intraocular pressure （IOPg） were measured by ORA preoperatively and at ld, 1-, 2-, 3- and 4-week postoperatively. Results were analyzed and compared between groups. RESULTS： In both groups, CH decreased in the immediate postoperative period （P〈0.05）, returned to the preoperative level at one week （P =0.249） in the 2.2-mm group, and at two weeks in the 3.0-mm group （P --0.264）; there was no significant change in CRF values. In 2.2-mm group, mean IOPcc and IOPg increased at ld postoperatively （both ,P〈0.05）, and returned to preoperative level at one week （,0 =0.491 and P =0.923, respectively）. In 3.0-mm group, mean IOPcc and IOPg increased at ld and lwk postoperatively （P =0.005 and ,P =0.029, respectively）, and returned to preoperative level at 2wk （P =0.347 and P =0.887, respectively）. CONCLUSION： Significant differences between preoperative and postoperative corneal biomechanical values were found for CH, IOPcc and IOPg. But the recovery time courses were different between the two groups. The 2.2-mm coaxial microincision cataract surgery group seemed recovery faster compared to the 3.0-mm standard coaxial phacoemulsification group.

Effect of aberrometry in diagnosis of isolated spherophakia

Dear Editor,We present two case reports about isolated spherophakia without systemic disorder and the essential role of ray tracing aberrometry in isolated spherophakia diagnosing.

Temperature Impacts on Transient Receptor Potential Channel Mediated Calcium Oscillations in Astrocytes

We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model and the result of thermosensitive TRP channels＇ open probabilities, some meaningful conclusions are obtained. It is shown that the occurrence of calcium oscillations depends on temperature and the molar heat capacity difference between the closed and open channels （ACp ）. The data indicate that calcium oscillations in astrocytes occurred in the ranges of 7℃-11 ℃ and 27℃-30℃ when/kgp is 16 kJ· mol- 1·K- 1, and ca/cium oscillations only occur in the range of 27℃-30℃ when Agp is 2kJ·mol-1·K-1. In this study, the frequency decreases rapidly at temperatures ranging from 7℃ to 11℃, and there is a contrary result in the range of 27℃-30℃.