Kinase inhibitors are a significant and continuously developing division of target therapeutics.The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases.The ...Kinase inhibitors are a significant and continuously developing division of target therapeutics.The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases.The Kinase inhibitors have been heralded as a game-changer in cancer treatment.For developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases,is currently undergoing extensive research.It may be beneficial to investigate whether cell-specific kinase inhibitor administration enhances therapeutic efficacy and decreases adverse effects.The goal of the current review is to gain insight into the role of kinase inhibitors in facilitating effective target drug delivery for the treatment of various anti-inflammatory,auto-immune,and anticancer disorders.The aim of this review is also to shed light on drug discovery approaches for kinase inhibitors,their mode of action,and delivery approaches.The variation in the binding of kinases bestows different target approaches in drug design,which can be employed for designing the targeted molecules.Several target sites have been studied,exceeding the design of drugs for various diseases like cancer,Alzheimer’s,rheumatoid arthritis,etc.Diverse delivery approaches have also been studied for the targeted application of kinase inhibitors.展开更多
Compared with common intelligent service,full-scene intelligent service has its uniqueness in high integration,synergy,and technological spillover.However,the traditional service or business model theories cannot prec...Compared with common intelligent service,full-scene intelligent service has its uniqueness in high integration,synergy,and technological spillover.However,the traditional service or business model theories cannot precisely elaborate its sociotechnical contextual nature and value creation logic.To fill this knowledge gap,we provide initial insights into the value co-creation logic in full-scene intelligent service by exploring the value co-creation elements using a data-driven text mining approach.We analyzed 171 business reports on the full-scene intelligent service by the topic modeling using the Latent Dirichlet Allocation(LDA).The findings reveal three main clusters:value proposition,participants,and connection platform.This study presents a theoretical framework for a further exploratory case study and quantitative research on full-scene intelligent service.This study also helps small and medium-sized enterprises to explore and exploit value co-creation opportunities.展开更多
Background:Renal calculi,commonly known as kidney stones,is a prevalent urological condition that affects a substantial portion of the population worldwide.The formation of kidney stones is a complex process influence...Background:Renal calculi,commonly known as kidney stones,is a prevalent urological condition that affects a substantial portion of the population worldwide.The formation of kidney stones is a complex process influenced by various factors,including diet,fluid intake,genetics,and metabolic abnormalities.The pathogenesis of renal calculi involves a complex interplay of multiple factors,including supersaturation of urine with stone-forming constituents,urinary supersaturation,crystallization,and aggregation.Objective:This review aims to provide an overview of the present understanding of renal calculi,their pathophysiology,diagnostic approaches,and available treatment modalities.Methods:This review discusses the different types of kidney stones,such as calcium oxalate,calcium phosphate,uric acid,and struvite stones,and explores their formation mechanisms and associated risk factors.The management of renal calculi relies on stone characteristics,patient symptoms,stone size,and location.Furthermore,counseling and education regarding lifestyle modifications and risk factor management are essential for long-term management.Conclusion:Accurate diagnosis and appropriate management based on stone characteristics and patient symptoms are essential for successful outcomes.Preventive strategies to reduce stone recurrence are vital for long-term management and patient well-being.However,further research is needed to refine diagnostic techniques,improve treatment options,and enhance the understanding of the underlying pathophysiology of renal calculi.展开更多
文摘Kinase inhibitors are a significant and continuously developing division of target therapeutics.The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases.The Kinase inhibitors have been heralded as a game-changer in cancer treatment.For developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases,is currently undergoing extensive research.It may be beneficial to investigate whether cell-specific kinase inhibitor administration enhances therapeutic efficacy and decreases adverse effects.The goal of the current review is to gain insight into the role of kinase inhibitors in facilitating effective target drug delivery for the treatment of various anti-inflammatory,auto-immune,and anticancer disorders.The aim of this review is also to shed light on drug discovery approaches for kinase inhibitors,their mode of action,and delivery approaches.The variation in the binding of kinases bestows different target approaches in drug design,which can be employed for designing the targeted molecules.Several target sites have been studied,exceeding the design of drugs for various diseases like cancer,Alzheimer’s,rheumatoid arthritis,etc.Diverse delivery approaches have also been studied for the targeted application of kinase inhibitors.
基金The authors thank seminar participants at the China Academic Conference on Computer Simulation and Information Technology for their helpful comments.
文摘Compared with common intelligent service,full-scene intelligent service has its uniqueness in high integration,synergy,and technological spillover.However,the traditional service or business model theories cannot precisely elaborate its sociotechnical contextual nature and value creation logic.To fill this knowledge gap,we provide initial insights into the value co-creation logic in full-scene intelligent service by exploring the value co-creation elements using a data-driven text mining approach.We analyzed 171 business reports on the full-scene intelligent service by the topic modeling using the Latent Dirichlet Allocation(LDA).The findings reveal three main clusters:value proposition,participants,and connection platform.This study presents a theoretical framework for a further exploratory case study and quantitative research on full-scene intelligent service.This study also helps small and medium-sized enterprises to explore and exploit value co-creation opportunities.
文摘Background:Renal calculi,commonly known as kidney stones,is a prevalent urological condition that affects a substantial portion of the population worldwide.The formation of kidney stones is a complex process influenced by various factors,including diet,fluid intake,genetics,and metabolic abnormalities.The pathogenesis of renal calculi involves a complex interplay of multiple factors,including supersaturation of urine with stone-forming constituents,urinary supersaturation,crystallization,and aggregation.Objective:This review aims to provide an overview of the present understanding of renal calculi,their pathophysiology,diagnostic approaches,and available treatment modalities.Methods:This review discusses the different types of kidney stones,such as calcium oxalate,calcium phosphate,uric acid,and struvite stones,and explores their formation mechanisms and associated risk factors.The management of renal calculi relies on stone characteristics,patient symptoms,stone size,and location.Furthermore,counseling and education regarding lifestyle modifications and risk factor management are essential for long-term management.Conclusion:Accurate diagnosis and appropriate management based on stone characteristics and patient symptoms are essential for successful outcomes.Preventive strategies to reduce stone recurrence are vital for long-term management and patient well-being.However,further research is needed to refine diagnostic techniques,improve treatment options,and enhance the understanding of the underlying pathophysiology of renal calculi.
