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全球干细胞临床研究现状与展望 被引量:1
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作者 李佳潞 何斌 +1 位作者 汤红明 刘中民 《海南医学》 CAS 2024年第7期1044-1049,共6页
本文梳理了美国、欧洲、日本、韩国、中国不同的干细胞监管政策及干细胞临床研究现状,归纳了中国代表性地区的干细胞临床研究政策,提出推动地方立法工作、加快审批制度改革、建设区域临床研究中心、建立细胞质量合规保障机制、加强公众... 本文梳理了美国、欧洲、日本、韩国、中国不同的干细胞监管政策及干细胞临床研究现状,归纳了中国代表性地区的干细胞临床研究政策,提出推动地方立法工作、加快审批制度改革、建设区域临床研究中心、建立细胞质量合规保障机制、加强公众科普宣传等5点推进中国干细胞临床转化的建议,以期为中国实现干细胞临床研究向转化应用提供参考和借鉴。 展开更多
关键词 干细胞 临床研究 监管政策 现状 展望
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蓬莱19-3油田馆陶组粒度及储层特征分析
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作者 杨俊 唐洪明 +1 位作者 王昭 黄露 《石化技术》 CAS 2023年第4期38-40,共3页
粒度是沉积物的重要结构特征,通过粒度资料分析沉积物的搬运方式和水动力条件,能有效判断储层的沉积环境。在岩心观察、薄片鉴定、粒度分析、测井数据分析的基础上,利用多种方法对馆陶组疏松砂岩储层的粒度特征及沉积环境进行了分析与探... 粒度是沉积物的重要结构特征,通过粒度资料分析沉积物的搬运方式和水动力条件,能有效判断储层的沉积环境。在岩心观察、薄片鉴定、粒度分析、测井数据分析的基础上,利用多种方法对馆陶组疏松砂岩储层的粒度特征及沉积环境进行了分析与探索,并建立了浅水辫状河三角洲和粒度概率累计曲线演化模式,该研究成果可以为疏松砂岩储层特征分析提供一定的理论依据,从而指导研究区乃至渤海湾盆地疏松砂岩储层的保护和治理。 展开更多
关键词 沉积环境 C-M图 粒度特征 浅水辫状河三角洲 疏松砂岩储层
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Influence of Soil-Structure Interaction Models on the Dynamic Responses of An Offshore Wind Turbine Under Environmental Loads
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作者 tang hong-ming YUE Min-nan +3 位作者 YAN Yang-tian LI Zhi-hao LI Chun NIU Kai-lun 《China Ocean Engineering》 SCIE EI CSCD 2023年第2期218-231,共14页
Offshore wind turbines(OWTs) suffer wind, wave and earthquake loads. The investigation of OWTs' dynamic response under environmental loads is essential for structural safety assessment. The soil-structure interact... Offshore wind turbines(OWTs) suffer wind, wave and earthquake loads. The investigation of OWTs' dynamic response under environmental loads is essential for structural safety assessment. The soil-structure interaction(SSI)significantly affects the responses of OWT under environmental loads. However, there is few systematic research about the difference in the dynamic response of different SSI models under environmental loads. In order to solve the problem, the OWT is modeled by shell element, and several SSI models are built. The wind, wave and earthquake loads are taken into account. Moreover, the dynamic response, fatigue and buckling analysis are performed by ANSYS. The results indicate that SSI cannot be ignored in the dynamic response of the OWT under wind and wave loads. The SSI can decrease the displacement response of the OWT by 19% under wind and wave loads and reduce the fatigue damage of the pile. Multi-layer SSI can strongly influence the OWT's dynamic response under wind and wave loads or earthquake-only load. The vertical earthquake load increases the dynamic response in three directions.Besides, in order to simulate real environment, multi-layer SSI, soil damping and vertical SSI must be considered to evaluate the displacement response of the OWT under wind, wave and earthquake loads. The earthquake and gravity loads can cause more obvious response of the OWT than that of only wind and wave loads. The top and bottom of the tower are prone to occur buckling. 展开更多
关键词 OWT soil structure interaction EARTHQUAKE dynamic analysis structural damage
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上海市高行老年社区人群动脉硬化性心血管疾病患病率的现况调查与危险因素分析 被引量:18
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作者 郑亮 吴宏 +8 位作者 钱定广 丁许刚 徐增光 曾宪涛 兰琴 张玉珍 刘中民 汤红明 范慧敏 《中国循证心血管医学杂志》 2016年第6期680-682,690,共4页
目的 评估上海市老年社区居民动脉硬化性心血管疾病的患病率情况并探讨导致动脉粥样硬化性心血管疾病(ASCVD)高发的危险因素。方法 在上海市浦东高行社区采用整群随机抽样的方法选取研究对象,应用趋势卡方检验来评价不同年龄组间ASCV... 目的 评估上海市老年社区居民动脉硬化性心血管疾病的患病率情况并探讨导致动脉粥样硬化性心血管疾病(ASCVD)高发的危险因素。方法 在上海市浦东高行社区采用整群随机抽样的方法选取研究对象,应用趋势卡方检验来评价不同年龄组间ASCVD构成的变化趋势,并使用多元Logistic回归来探讨导致ASCVD高发的危险因素。结果 上海市老年社区居民动脉硬化性心血管疾病的患病率为21.51%;ASCVD组中年龄、体质指数(BMI)、收缩压等指标均高于对照组(P<0.05)而且ASCVD组中有睡眠障碍者构成比高于对照组(P<0.05)。趋势卡方检验提示随着年龄的升高ASCVD发病率有显著上升的趋势。多元回归分析结果显示,较高年龄、肥胖以及睡眠障碍是ASCVD高发的危险预测因子,其OR值与95%可信区间分别为1.03(1.01~1.06)、2.41(1.60~7.24)以及3.66(2.22~6.05)。结论 上海市老年社区居民动脉硬化性心血管疾病的患病率达到较高水平;老年、肥胖以及睡眠障碍等可能是导致ASCVD的危险预测因子。 展开更多
关键词 动脉硬化性心血管疾病 患病率 整群随机抽样
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苏里格气田东区盒8段-山1段-山2段储集层致密化差异性及影响因素研究 被引量:4
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作者 王猛 唐洪明 +5 位作者 卢浩 李林泽 王家敏 赵峰 郭红光 杨勇 《矿物岩石地球化学通报》 CSCD 北大核心 2017年第5期855-866,共12页
苏里格气田东区具有多层系含气特征,其中盒8段、山1段、山2段是该区主力产层,都呈现出低孔-特低孔,特低渗-超低渗这一典型致密储集层特征,由于差异性致密化,三层段的物性参数、孔隙结构等表现出较大的差异。综合应用岩石铸体薄片、扫描... 苏里格气田东区具有多层系含气特征,其中盒8段、山1段、山2段是该区主力产层,都呈现出低孔-特低孔,特低渗-超低渗这一典型致密储集层特征,由于差异性致密化,三层段的物性参数、孔隙结构等表现出较大的差异。综合应用岩石铸体薄片、扫描电镜、高压压汞、常规物性、X射线衍射、流体包裹体测温、成岩演化序列重建,以及多元回归分析等方法,对三层段的储集层特征、成岩作用、成岩演化序列及储集层致密化影响因素进行了定性、定量评价。结果表明,三层段储集层砂岩主要为富岩屑砂岩,经历的成岩演化序列具有一定相似性,孔隙演化与各段强度差异较大的成岩作用密切相关;储集层致密化时间盒8段为中成岩A期末,山1段为中成岩B期初,山2段为中成岩B期中期;定量分析了影响孔隙度和渗透率对各段物性的影响程度,并以此结果指导优选勘探区带。 展开更多
关键词 影响因素 致密化 成岩序列 苏里格气田东区 鄂尔多斯盆地
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破解“新农保”象征性缴费陷阱——基于“大饥荒”经历的经验证据 被引量:4
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作者 阳义南 唐鸿鸣 《科学决策》 CSSCI 2018年第7期45-62,共18页
基于CFPS2012年数据,将"大饥荒"经历作为认知因素中创伤性记忆的典型事件,检验其对"新农保"象征性缴费行为的解释力。研究发现"大饥荒"经历能显著提高参保人选择较高缴费档次的概率;这种影响还对不同年... 基于CFPS2012年数据,将"大饥荒"经历作为认知因素中创伤性记忆的典型事件,检验其对"新农保"象征性缴费行为的解释力。研究发现"大饥荒"经历能显著提高参保人选择较高缴费档次的概率;这种影响还对不同年龄段人群产生了程度不同的队列效应,对幼儿组观测值的效应显著为正,并且效应大于婴儿组与童年组。饥荒持续时间也能显著正向影响选择较高缴费档次的概率,但缴费档次的选择会随着饥荒严重程度的加剧而降低。"大饥荒"经历产生正向促进作用可归因于童年遭遇的饥荒经历能长期深刻影响农户的风险态度,进而影响其参保缴费档次的选择。鉴于此,改变农户的风险态度及政策认知应是"新农保"摆脱最低缴费痼疾的突破方向。 展开更多
关键词 大饥荒 新农保 缴费 创伤性记忆 风险态度
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引导式教学模式在地质类专业基础课教学中的探索与实践 被引量:2
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作者 周翊 唐洪明 +2 位作者 郗爱华 赵峰 屈海洲 《教育教学论坛》 2020年第31期239-240,共2页
在地质类专业基础课中进行引导式教学模式的探索与实践,是适应当代大学生自主学习能力培养的重要方式,也是新工科背景下培养创新型人才的有益尝试。讨论引导式教学模式在地质类专业基础课教学中的构建原则,并举例展现具体的教学设计,结... 在地质类专业基础课中进行引导式教学模式的探索与实践,是适应当代大学生自主学习能力培养的重要方式,也是新工科背景下培养创新型人才的有益尝试。讨论引导式教学模式在地质类专业基础课教学中的构建原则,并举例展现具体的教学设计,结合实际教学效果提出建议。 展开更多
关键词 新工科 引导式教学模式 地质类专业基础课
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稠油开采对疏松砂岩储层孔隙结构的影响 被引量:2
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作者 唐宁 唐洪明 《化工设计通讯》 CAS 2021年第2期21-22,共2页
稠油疏松砂岩油气藏分布范围广,储量大,产量高,胶结程度弱,油藏原油的黏度高,在采油过程中油水乳化、温压下降,以及外来流体等作用下,油井不同生产阶段不同程度地出砂,尤其在投产初期、修井、微压裂和增产作业后生产初期,微粒运移表现... 稠油疏松砂岩油气藏分布范围广,储量大,产量高,胶结程度弱,油藏原油的黏度高,在采油过程中油水乳化、温压下降,以及外来流体等作用下,油井不同生产阶段不同程度地出砂,尤其在投产初期、修井、微压裂和增产作业后生产初期,微粒运移表现更为严重。在稠油开采过程中黏土矿物极易分散、运移,使得储层的孔隙结构易发生变化,可能导致油井含水上升快等问题,开采难度会进一步增加。采用核磁共振技术进行在线高倍油驱室内实验,明确储层稠油开采前后孔隙结构变化,为油田稠油开采方案调整、剩余油定量描述、三次采油和提高最终采收率提供依据。 展开更多
关键词 稠油开采 疏松砂岩 孔隙结构 渗透率
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Lower Es3 in Zhanhua Sag, Jiyang Depression: a case study for lithofacies classification in lacustrine mud shale 被引量:11
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作者 Yan Jian-Ping He Xu +4 位作者 Hu Qin-Hong Liang Qiang tang hong-ming Feng Chun-Zhen Geng Bin 《Applied Geophysics》 SCIE CSCD 2018年第2期151-164,361,共15页
Oil and gas exploration in lacustrine mud shale has focused on laminated calcareous lithofacies rich in type Ⅰ or type Ⅱ1 organic matter, taking into account the mineralogy and bedding structure, and type and abunda... Oil and gas exploration in lacustrine mud shale has focused on laminated calcareous lithofacies rich in type Ⅰ or type Ⅱ1 organic matter, taking into account the mineralogy and bedding structure, and type and abundance of organic matter. Using the lower third member of the Shahejie Formation, Zhanhua Sag, Jiyang Depression as the target lithology, we applied core description, thin section observations, electron microscopy imaging, nuclear magnetic resonance, and fullbore formation microimager (FMI) to study the mud shale lithofacies and features. First, the lithofacies were classified by considering the bedding structure, lithology, and organic matter and then a lithofacies classification scheme of lacustrine mud shale was proposed. Second, we used optimal filtering of logging data to distinguish the lithologies. Because the fractals of logging data are good indicators of the bedding structure, gamma-ray radiation was used to optimize the structural identification. Total organic carbon content (TOC) and pyrolyzed hydrocarbons (S2) were calculated from the logging data, and the hydrogen index (HI) was obtained to identify the organic matter type of the different strata (HI vs Tmax). Finally, a method for shale lithofacies identification based on logging data is proposed for exploring mud shale reservoirs and sweet spots from continuous wellbore profiles. 展开更多
关键词 mud shale lithofacies FILTERING fractals LOGGING
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Evolution of diagenetic fluid of ultra-deep Cretaceous Bashijiqike Formation in Kuqa depression 被引量:6
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作者 LI Ling tang hong-ming +7 位作者 WANG Xi LIAO Ji-jia QI Bai-long ZHAO Feng ZHANG Lie-hui FENG Wei tang Hao-xuan SHI Lan 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第10期2472-2495,共24页
Diagenetic fluid types of the Cretaceous Bashijiqike formation are restored based on the analysis of petrographic,electron microprobe composition,inclusions homogenization temperature,salinity and vapor composition an... Diagenetic fluid types of the Cretaceous Bashijiqike formation are restored based on the analysis of petrographic,electron microprobe composition,inclusions homogenization temperature,salinity and vapor composition and laser carbon and oxygen isotope of diagenetic mineral,and regional geological background.Diagenetic fluid evolution sequence is analyzed on this basis.The crystalline dolomite cement has a low concerntration of Sr,high concerntration of Mn and higher carbon isotope,showing that the crystalline dolomite is affected by meteoric fresh water,associated with the tectonic uplift of late Cretaceous.Similarδ13CPDB,negative transfer ofδ18OPDB and the differentiation of the concerntration of Fe and Mn indicate that the diagenetic fluid of the vein dolomite cement is homologous with the diagenetic fluid of the crystalline dolomite cement,temperature and depth are the dominant factors of differential precipitation between these two carbonate cements.Anhydrite cements have high concerntration of Na,extremely low concerntration of Fe and Mn contents.Based on these data,anhydrite cements can be thought to be related to the alkaline fluid overlying gypsum-salt layer produced by dehydration.The barite vein has abnormally high concerntration of Sr,ultra-high homogenization temperature and high-density gas hydrocarbon inclusions,which is speculated to be the forward fluid by intrusion of late natural gas.Coexistence of methane inclusions with CO2 gas proves existence of acid water during the accumulation of natural gas in the late stages.Therefore,the alkaline environment and associated diagenesis between the meteoric fresh water in epidiagentic stage and carbonic acid in the late diagenesis have dominated the process of diagenesis and reservoir,the secondary porosity and fracture zone formed by gas accumulation is a favorable play for the exploration of ultra-deep reservoirs. 展开更多
关键词 ultra-deep reservoirs diagenetic minerals diagenetic fluids alkaline fluid meteoric fresh water
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Reservoir characteristics and hydrocarbon accumulation of Carboniferous volcanic weathered crust of Zhongguai high area in the western Junggar Basin, China 被引量:3
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作者 LI Hu tang hong-ming +4 位作者 QIN Qi-rong FAN Cun-hui HAN Song YANG Cang ZHONG Cheng 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第11期2785-2801,共17页
Based on the drilling,cores,logs,seismic,laboratory analysis and so on,reservoir characteristics and hydrocarbon accumulation of Carboniferous volcanic weathered crust in Zhongguai high area are studied.Volcanic rocks... Based on the drilling,cores,logs,seismic,laboratory analysis and so on,reservoir characteristics and hydrocarbon accumulation of Carboniferous volcanic weathered crust in Zhongguai high area are studied.Volcanic rocks were formed in an island arc environment.The lithology is mainly andesite and tuff;Reservoir spaces are mainly secondary pore,fracture and their combination forms,fractures have a better effect on reservoir seepage;There are four layer structures of volcanic weathered crust,weathered clay layer,strongly weathered zone,weakly weathered zone and unweathered zone and strongly weathered zone is the best,which is the main reservoir development zone;The development of reservoir is mainly affected by weathering-leaching,lithology and lithofacies,and fault(fracture);Effective reservoirs could reach to 480 m thickness(high quality reservoirs are within 240 m).Carboniferous volcanic reservoirs are distributed along three zones,which are near the fault zone,high structural part,favorable lithofacies development zone,and one plane,which is near the unconformity. 展开更多
关键词 reservoir characteristics volcanic weathered crust fracture hydrocarbon accumulation CARBONIFEROUS Zhongguai high area
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