AIM： To define the （co-）expression pattern of target receptor-tyrosine-kinases （RTK） in human gastric adenocarcinoma. METHODS： The （co-）expression pattern of VEGFR1-3, PDGFR（α/β and EGFR1 was analyzed by RT...AIM： To define the （co-）expression pattern of target receptor-tyrosine-kinases （RTK） in human gastric adenocarcinoma. METHODS： The （co-）expression pattern of VEGFR1-3, PDGFR（α/β and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition, IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS： The majority of samples revealed a VEGFR1 （98%）, VEGFR2 （80%）, VEGFR3 （67%）, PDGFRα （82%） and PDGFRβ （82%） expression, whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells, accompanied by an additional nuclear staining for VEGFR3, EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes, which also depicted a PDGFRα expression. CONCLUSION： Our results reveal a high rate ofreceptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy.展开更多
Monthly temperature and precipitation time-series for the Zhujiang River Basin are analyzed in order to identify changes in climate extremes. Daily temperature and precipitation data from 1961 to 2007 of 192 meteorolo...Monthly temperature and precipitation time-series for the Zhujiang River Basin are analyzed in order to identify changes in climate extremes. Daily temperature and precipitation data from 1961 to 2007 of 192 meteorological stations are used. Two temperature indicators （monthly mean and monthly maximum mean） and three precipitation indicators （monthly total, monthly maximum consecutive 5-day precipitation, and monthly dry days） are analyzed. Tendencies in all five indicators can be observed. Many stations show significant positive trends （above the 90% confidence level） for monthly mean temperatures and monthly maximum mean temperatures. For all months, a significant increase in temperature from 1961 to 2007 can be observed in the entire basin with the coastal area in particular. Positive trends of precipitation extremes can be observed from January to March. Negative trends are detected from September to November. The number of dry days in October increased significantly at 40% of all meteorological stations. Stations with changes of monthly precipitation extremes are scattered over the Zhujiang River Basin. An aggregation of heat waves and droughts can be detected which is accompanied by significant increases of temperature extremes and the negative tendencies in precipitation extremes. The detection of tendencies in climate station density. extremes essentially relies on a good data quality and high展开更多
1.Introduction The availability of reliable information describing our natural and anthropogenic environment—and its changes in particular—is crucial for understanding the complexity of structures and processes with...1.Introduction The availability of reliable information describing our natural and anthropogenic environment—and its changes in particular—is crucial for understanding the complexity of structures and processes within environmental systems.Modern remote sensing and monitoring methods provide an increasing amount of environmental data that can be used for a variety of management purposes[1,2].展开更多
Iron-cyanide (Fe-CN) complexes have been detected at Manufactured Gas Plant sites (MGP) worldwide. The risk of groundwater contamination depends mainly on the dissolution of ferric ferrocyanide. In order to design eff...Iron-cyanide (Fe-CN) complexes have been detected at Manufactured Gas Plant sites (MGP) worldwide. The risk of groundwater contamination depends mainly on the dissolution of ferric ferrocyanide. In order to design effective remediation strategies, it is relevant to understand the contaminant’s fate and transport in soil, and to quantify and mathematically model a release rate. The release of iron-cyanide complexes from four contaminated soils, originating from the former MGP in Cottbus, has been studied by using a column experiment. Results indicated that long-term cyanide (CN) release is governed by two phases: one readily dissolved and one strongly fixed. Different isotherm and kinetic equations were used to investigate the driving mechanisms for the ferric ferrocyanide release. Applying the isotherm equations assumed an approach by which two phases were separate in time, whereas the multiple first order equation considered simultaneous occurrence of both cyanide pools. Results indicated varying CN release rates according to the phase and soil. According to isotherm and kinetic models, the long-term iron cyanide release from the MGP soils is a complex phenomenon driven by various mechanisms parallely involving desorption, diffusion and transport processes. Phase I (rapid release) is presumably mainly constrained by the transport process of readily dissolved iron-cyanide complexes combined with desorption of CN bound to reactive heterogeneous surfaces that are in direct contact with the aqueous phase (outer-sphere complexation). Phase II (limited rate) is presumably driven by the diffusion controlled processes involving dissolution of precipitated ferric ferrocyanide from the mineral or inner-sphere complexation of ferricyanides. CN release rates in phase I and II were mainly influenced by the pH, organic matter (OM) and the total CN content. The cyanide release rates increased with increasing pH, decreased with low initial CN concentration and were retarded by the increase in OM content.展开更多
Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in ...Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.展开更多
Presenting a hard-to-predict typography-varying system predicated on Nazi-era cryptography, the Enigma cipher machine, this paper illustrates conditions under which unrepeatable phenomena can arise, even from straight...Presenting a hard-to-predict typography-varying system predicated on Nazi-era cryptography, the Enigma cipher machine, this paper illustrates conditions under which unrepeatable phenomena can arise, even from straight-forward mechanisms. Such conditions arise where systems are observed from outside of boundaries that arise through their observation, and where such systems refer to themselves in a circular fashion. It argues that the Enigma cipher machine is isomorphous with Heinz yon Foersters portrayals of non-triviality in his non-trivial machine （NTM）, but not with surprising human behaviour, and it demonstrates that the NTM does not account for spontaneity as it is observed in humans in general.展开更多
文摘AIM： To define the （co-）expression pattern of target receptor-tyrosine-kinases （RTK） in human gastric adenocarcinoma. METHODS： The （co-）expression pattern of VEGFR1-3, PDGFR（α/β and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition, IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS： The majority of samples revealed a VEGFR1 （98%）, VEGFR2 （80%）, VEGFR3 （67%）, PDGFRα （82%） and PDGFRβ （82%） expression, whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells, accompanied by an additional nuclear staining for VEGFR3, EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes, which also depicted a PDGFRα expression. CONCLUSION： Our results reveal a high rate ofreceptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy.
基金the National Basic Research Program of China(973 Program)(No. 2010CB428401)the Special Fund of Climate Change of the China Meteorological Administration (CCSF-09-16)by the National Natural Science Foundation of China(40910177)
文摘Monthly temperature and precipitation time-series for the Zhujiang River Basin are analyzed in order to identify changes in climate extremes. Daily temperature and precipitation data from 1961 to 2007 of 192 meteorological stations are used. Two temperature indicators （monthly mean and monthly maximum mean） and three precipitation indicators （monthly total, monthly maximum consecutive 5-day precipitation, and monthly dry days） are analyzed. Tendencies in all five indicators can be observed. Many stations show significant positive trends （above the 90% confidence level） for monthly mean temperatures and monthly maximum mean temperatures. For all months, a significant increase in temperature from 1961 to 2007 can be observed in the entire basin with the coastal area in particular. Positive trends of precipitation extremes can be observed from January to March. Negative trends are detected from September to November. The number of dry days in October increased significantly at 40% of all meteorological stations. Stations with changes of monthly precipitation extremes are scattered over the Zhujiang River Basin. An aggregation of heat waves and droughts can be detected which is accompanied by significant increases of temperature extremes and the negative tendencies in precipitation extremes. The detection of tendencies in climate station density. extremes essentially relies on a good data quality and high
基金the German Federal Ministry of Education and Research(BMBF)for funding the Chaohu Lake project in the frame of the Chinese Major Water Program(02WCL1337A-E)the Sino-German Center for Science Promotion(CDZ)for the Poyang Lake project(GZ1167)+1 种基金the Helmholtz Association for supporting the establishment of Center for Environmental Information Science(HIRN 0002)the Chinese Academy of Sciences(CAS)for providing support to various activities through the CAS President’s International Fellowship Initiative(PIFI)
文摘1.Introduction The availability of reliable information describing our natural and anthropogenic environment—and its changes in particular—is crucial for understanding the complexity of structures and processes within environmental systems.Modern remote sensing and monitoring methods provide an increasing amount of environmental data that can be used for a variety of management purposes[1,2].
文摘Iron-cyanide (Fe-CN) complexes have been detected at Manufactured Gas Plant sites (MGP) worldwide. The risk of groundwater contamination depends mainly on the dissolution of ferric ferrocyanide. In order to design effective remediation strategies, it is relevant to understand the contaminant’s fate and transport in soil, and to quantify and mathematically model a release rate. The release of iron-cyanide complexes from four contaminated soils, originating from the former MGP in Cottbus, has been studied by using a column experiment. Results indicated that long-term cyanide (CN) release is governed by two phases: one readily dissolved and one strongly fixed. Different isotherm and kinetic equations were used to investigate the driving mechanisms for the ferric ferrocyanide release. Applying the isotherm equations assumed an approach by which two phases were separate in time, whereas the multiple first order equation considered simultaneous occurrence of both cyanide pools. Results indicated varying CN release rates according to the phase and soil. According to isotherm and kinetic models, the long-term iron cyanide release from the MGP soils is a complex phenomenon driven by various mechanisms parallely involving desorption, diffusion and transport processes. Phase I (rapid release) is presumably mainly constrained by the transport process of readily dissolved iron-cyanide complexes combined with desorption of CN bound to reactive heterogeneous surfaces that are in direct contact with the aqueous phase (outer-sphere complexation). Phase II (limited rate) is presumably driven by the diffusion controlled processes involving dissolution of precipitated ferric ferrocyanide from the mineral or inner-sphere complexation of ferricyanides. CN release rates in phase I and II were mainly influenced by the pH, organic matter (OM) and the total CN content. The cyanide release rates increased with increasing pH, decreased with low initial CN concentration and were retarded by the increase in OM content.
基金supported by the National Natural Science Foundation of China(Nos.42007421 and 42001013)the General Research Project Fund of Hong Kong Research Grants Council(Hong Kong,China)(No.11207520)+2 种基金the Key Program Special Fund(China)(No.KSF-E-43)the Research Development Fund(China)(No.RDF-19-02-13)of XJTLUthe Zhejiang Provincial Natural Science Foundation of China(No.Y23D050006).
文摘Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.
文摘Presenting a hard-to-predict typography-varying system predicated on Nazi-era cryptography, the Enigma cipher machine, this paper illustrates conditions under which unrepeatable phenomena can arise, even from straight-forward mechanisms. Such conditions arise where systems are observed from outside of boundaries that arise through their observation, and where such systems refer to themselves in a circular fashion. It argues that the Enigma cipher machine is isomorphous with Heinz yon Foersters portrayals of non-triviality in his non-trivial machine （NTM）, but not with surprising human behaviour, and it demonstrates that the NTM does not account for spontaneity as it is observed in humans in general.
