Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseas...Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.展开更多
<b>Objective:</b> 120 patients with severe pneumonia who were kept in the comprehensive ICU of our hospital in 2018 were selected, and 16s rDNA sequencing was performed to analyze the composition of pathog...<b>Objective:</b> 120 patients with severe pneumonia who were kept in the comprehensive ICU of our hospital in 2018 were selected, and 16s rDNA sequencing was performed to analyze the composition of pathogenic bacteria in the sputum of severe pneumonia. <b>Methods:</b> The sputum samples of patients with severe bacterial pneumonia were collected, and the diversity of pathogens in the samples was analyzed by polymerase chain reaction (PCR) amplification and high-throughput sequencing (16s rDNA PCR-DGGE). <b>Results:</b> Sequence showed that sputum samples contained a relatively large number of species, and there were many species that were not detected by sequencing. The dominant bacteria were <i>Streptococcus, Sphingomonas, Corynebacterium, Denatobacteria, Aquobacteria, Acinetobacteria, Prevotella, Klebsiella, Pseudomonas</i>, etc. <b>Conclusion:</b> Bacteria caused by sputum of severe bacterial pneumonia are complex and diverse, which provides new methods and ideas for individualized treatment of patients with severe pneumonia.展开更多
The diagnosis of pathogenic bacteria in severe pneumonia is difficult and the prognosis is poor. Its outcome is closely related to bacterial pathogenicity and the timeliness and pertinence of antibiotic treatment. The...The diagnosis of pathogenic bacteria in severe pneumonia is difficult and the prognosis is poor. Its outcome is closely related to bacterial pathogenicity and the timeliness and pertinence of antibiotic treatment. Therefore, early diagnosis is of great significance to the prognosis of patients. Sputum examination and culture is the gold standard for the diagnosis of pathogens of severe pneumonia. However, due to the long time of bacterial culture, the early use of antibiotics, the change of bacteria species, mixed infection and other problems, the results of bacterial culture in sputum are often false negative. With the continuous application of new molecular biology techniques in clinical detection, the classification of bacteria and microorganisms has deepened from the identification of phenotypic characteristics to the classification of gene characteristics. Sequencing analysis with 16S rDNA sequencing technology has the characteristics of high sequencing flux, large amount of data obtained, short cycle, and can more comprehensively reflect the species composition of microbial community, real species distribution and abundance information. In this paper, 16S rDNA sequencing technology was used to analyze the bacterial population composition in the sputum of severe pneumonia, and to explore a new method of etiological diagnosis.展开更多
Objective:Osteosarcoma is a common primary highly malignant bone tumor.Kinesin family member 18B(K1F18B)has been identified as a potential oncogene involved in the development and metastasis of several cancer types.Wh...Objective:Osteosarcoma is a common primary highly malignant bone tumor.Kinesin family member 18B(K1F18B)has been identified as a potential oncogene involved in the development and metastasis of several cancer types.While KIF18B overexpression in osteosarcoma tissue is clearly detected,its specific function in the disease process remains to be established.Methods:K IF18B expression was assessed in osteosarcoma tissues and cells.We additionally evaluated the effects of KIF18B on proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.Results:Our results showed overexpression of KIF18B in osteosarcoma tissues and cells.Knockdown of K IF18B induced G1/S phase arrest and significantly inhibited proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.K IF18B regulated P-catenin expression at the transcriptional level by controlling nuclear aggregation of ATF2 and at the post-transcriptional level by interacting with the adenomatous polyposis coli(APC)tumor suppressor gene in osteosarcoma cells.Conclusions:KIF18B plays a carcinogenic role in osteosarcoma by regulating expression ofβ-catenin transcriptionally via decreasing nuclear aggregation of ATF2 or post-transcriptionally through interactions with APC.Our collective findings support the potential utility of KIF18B as a novel prognostic biomarker for osteosarcoma.展开更多
A precise understanding of the aboveground biomass of desert steppe and its spatio-temporal variation is important to understand how arid ecosystems respond to climate change and to ensure that scarce grassland resour...A precise understanding of the aboveground biomass of desert steppe and its spatio-temporal variation is important to understand how arid ecosystems respond to climate change and to ensure that scarce grassland resources are used rationally. On the basis of 756 ground survey quadrats sampled in western Inner Mongolia steppe in 2005-2011 and remote sensing data from the Moderate Resolu- tion Imaging Spectroradiometer （MODIS）--the normalized difference vegetation index （NDVI） dataset for the period of 2001-2011--we developed a statistical model to estimate the aboveground biomass of the desert steppe and further explored the rela- tionships between aboveground biomass and climate factors. The conclusions are as follows： （1） the aboveground biomass of the steppe in the research area was 5.27 Tg （1 Tg=1012 g） on average over 11 years; between 2001 and 2011, the aboveground biomass of the western Inner Mongolia steppe exhibited fluctuations, with no significant trend over time; （2） the aboveground biomass of the steppe in the research area exhibits distinct spatial variation and generally decreases gradually from southeast to northwest; and （3） the important factor causing intemnnual variations in aboveground biomass is precipitation during the period from January to July, but we did not find a significant relationship between the aboveground biomass and the corresponding temperature changes. The precipitation in this period is also an important factor influencing the spatial distribution of aboveground biomass （R2=0.39, P〈0.001）, while the temperature might be a minor factor （R2=0.12, P〈0.01 ）. The uncertainties in our estimate are primarily due to uncertainty in converting the fresh grass yield estimates to dry weight, underestimates of the biomass of shrubs, and error in remote sensing dataset.展开更多
Due to increasing timber demands, large areas of secondary forests have been converted to larch plantations （LPs） in Northeast China because the secondary forests could not produce timber as much as LPs. However, th...Due to increasing timber demands, large areas of secondary forests have been converted to larch plantations （LPs） in Northeast China because the secondary forests could not produce timber as much as LPs. However, there are a series of ecological problems such as lower soil fertility, reduced water-holding capacity and acidification of surface runoff water occurring in LPs because of the single-species composition of LPs. Therefore, a guidance on how to transform LPs into larch-broadleaf mixed forests （LBMFs） at a large spatial scale is needed for local foresters. First, Landsat time series data set and SPOT-5 images were combined to map the spatial-temporal distribution of LPs in Northeast China. Then, the topographical characteristics of LPs in 2010s were determined. Furthermore, three sub-regions of LPs were divided closely linking to their ecosystem services and forest management aims. Finally, detailed information on how to transform the LPs into LBMFs was given according to the three sub-regions. The results showed that the area of LPs increased during 1980s and 2010s, and reached 2.61 million ha in 2010s. Of which, 0.72 million ha （27.6%） and 1.89 million ha （72.4%） LPs distributed in slopes less than 5° and greater than 5°, respectively. Of the LPs （72.4%） in slopes greater than 5°, 48.7 and 23.7% located in downslope （LPs locating at the down slope of adjacent secondary forests in the same aspect） and upslope （LPs locating at the up slope of adjacent secondary forests in the same aspect）, respectively; 0.10 million ha （3.8%） located in slopes greater than 25°. The LPs were divided into Sub-Regions-I, II, III according to slopes. For Sub-region-I （top role is to produce timber）, self-fertilizing shrub species can be intro- duced after clean cutting for young-aged LPs, and release thinning can be applied for middle-aged LPs, fast growth thinning for near-matured LPs, and clear cutting for matured LPs. For Sub-Region-II （the priority is to provide water conservation combined with timber production）, the LPs should be induced into LBMFs. The LPs located the downslope positions in Sub-Region-II can be transformed to LBMFs by natural regeneration of broadleaved tree species after thinning because of enough seed sources of broadleaved tree species from the secondary forests locating the upslope positions. The LPs located the upslope positions or the region where seed sources of broadleaved tree species are unavailable in Sub-Region-II must be induced to LBMFs by al＇tificial regeneration. For Sub-Re- gion-III （the preference is only for water conservation because the slope is greater than 25°）, the LPs should be particularly protected from intensive disturbances, and induced into LBMFs by natural regeneration.展开更多
For delivering the nanoscaled extraordinary characteristics in macroscopical bulk,it is essential to integrate two-dimensional nanosheets into threedimensional(3D)porous monoliths,alternatively called as 3D architectu...For delivering the nanoscaled extraordinary characteristics in macroscopical bulk,it is essential to integrate two-dimensional nanosheets into threedimensional(3D)porous monoliths,alternatively called as 3D architectures,3D networks,or aerogels.The intersupported structure of porous monolithic 3D graphene(3DG)can prevent aggregation or restacking of graphene individuals,and the interconnected sp^(2) network of 3DG not only can provide the highway for the transport of electron/phonon but also can present continual cavities/channels for mass transfer.This review summarizes the synthesis methodology of 3DG porous monoliths and highlights the application for electric double-layer capacitors.Present challenges and future prospects about the manufacture and application of 3DG are also discussed.展开更多
Objective： To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor（DT） and analyze the prognostic factors.Methods：From November 2008 to April 2016,71 patients of inoperable DT were treated...Objective： To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor（DT） and analyze the prognostic factors.Methods：From November 2008 to April 2016,71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors,Peking University Cancer Hospital＆Institute,and enrolled in this retrospective study.The chemotherapy duration is one year.The efficacy of chemotherapy and the prognosis were observed.Results：Of the 71 patients,55% were female.Age of onset varied from 1 to 47 years,and the median age was 14years.Only 11（15.5%）cases suffered primary tumor.The distribution of the site of tumors was：31（43.7%）in the trunk,36（50.7%）in the limbs,and 4（5.6%）in the peritoneal and pelvic cavity.The size of tumor（the maximum diameter）differed from 2 to 37 cm with a mean of 9.3 cm.The median follow-up duration was 28（range,6–87）months.Common side effects included：nausea and vomiting,liver injury,bone marrow suppression and oral ulcers.When the chemotherapy finished,1（1.4%）case achieved complete response,24（33.8%）achieved partial response,37（52.1%）achieved stable disease and 9（12.7%）had progressive disease.The overall response rate was 87.3%.The progression-free survival（PFS）of the participants were from 6 to 87 months,and the 2-,3-and 5-year PFS was 79.9%,68.4% and 36.3%,respectively.No significant difference was identified in PFS in subgroups of gender,age of onset,age of chemotherapy,tumor site and tumor size.Conclusions：For recurrent,inoperable and progressive DT,enough course of chemotherapy with vinorelbine combined with low-dose methotrexate was an optional choice for local control.展开更多
A remote monitoring system for a secondary heating pipe network is designed on the basis of the KingSCADA software.Remote data communication is implemented through the IP mapping technology.Remote data are sorted thro...A remote monitoring system for a secondary heating pipe network is designed on the basis of the KingSCADA software.Remote data communication is implemented through the IP mapping technology.Remote data are sorted through IOServer,and the remote monitoring of the pipe network unit port return is implemented accordingly.Using data such as water temperature and pressure of the water supply and return pipes,valve opening can be remotely adjusted to optimize the performances of the network to meet user needs in real time.The research results show that this remote monitoring system displays a reasonable degree of stability and efficiency in remote communication.展开更多
Rare-earth sulfides are of research interest for lithium-ion batteries(LIBs)due to their abundant lithium intercalation sites and low redox voltage.However,their electrochemical performances are not satisfactory becau...Rare-earth sulfides are of research interest for lithium-ion batteries(LIBs)due to their abundant lithium intercalation sites and low redox voltage.However,their electrochemical performances are not satisfactory because of poor conductivity and volume change upon electrochemical cycling.Herein,nanoarchitectures ofγ-Ce_(2)S_(3)encapsulated in a hollow mesoporous carbon nanosphere(Ce_(2)S_(3)@HMCS)are fabricated using the self-template strategy combined with the in-sphere sulfuration method and tested as an LIB anode.The void space between the Ce_(2)S_(3)core and the outer layer of the carbon nanosphere has been properly designed and modulated to achieve excellent electrochemical performance in terms of electronic conductivity,reversibility,and rate capability.The reversible capacity of Ce_(2)S_(3)@HMCS is 2.6 times that of the pure Ce_(2)S_(3)anode,which can gradually increase and maintain a capacity of 282 mAh·g^(−1)at a current density of 1 A·g^(-1),and a high Coulombic efficiency(~100%)can be achieved even after 1000 cycles.This good performance is attributed to the unique yolk-shell nanostructure with a highly crystallized and stable Ce3S2 core and volume expansion buffer space upon lithiation/delithiation.Ex situ X-ray diffraction and nuclear magnetic resonance results indicate that the lithiation of Ce_(2)S_(3)@HMCS is an intercalation process.This study represents an important advancement in precise structural design with in-sphere sulfuration and sheds light on a potential direction for highperformance lithium storage.展开更多
In forest ecosystems,landslides are one of the most common natural disturbances,altering the physical,chemical and microbial characteristics of soil and thus further altering ecosystem properties and processes.Althoug...In forest ecosystems,landslides are one of the most common natural disturbances,altering the physical,chemical and microbial characteristics of soil and thus further altering ecosystem properties and processes.Although secondary forests comprise more than 50%of global forests,the influence of landslides on the soil properties in these forests is underappreciated.Therefore,this study investigates the influence of landslides on the chemical and microbial nature of the soil.Study of these modifications is critical,as it provides baseline evidence for subsequent forest revegetation.We selected four independent landslides and adjacent secondary forest stands as references in a temperate secondary forest in northeastern China.Soils were obtained from each stand at 0–10 cm and 10–20 cm depths to determine chemical and microbial properties.Soil total carbon(TC),total nitrogen(TN),nitrate(NO_(3)^(-)-N),available phosphorus(P),microbial biomass carbon(MBC),microbial biomass nitrogen(MBN),microbial biomass phosphorus(MBP)and phenol oxidase,exoglucanase,β-glucosidase,N-acetyl-β-glucosaminidase,L-asparaginase and acid phosphatase activities were 29.3–70.1%lower at the 0–10 cm soil depth in the landslide sites than at the secondary forest sites,whereas total phosphorus(TP)and ammonium(NH_(4)^(+)-N)were unaffected by the landslides.N-related enzymes,N-acetyl-β-glucosaminidase and L-asparaginase were reduced by more than 65%in the landslide sites,consistent with the decrease in nitrate concentration at the same 0–10 cm depth.At a depth of 10–20 cm,the variations in the soil properties were consistent with those at the 0–10 cm depth.The results demonstrated that soil chemical and microbial properties were significantly disrupted after the landslides,even though the landslides had occurred 6 years earlier.A long time is thus needed to restore the original C and nutrient levels.In temperate secondary forests,soil TC and TN contents were found to be more suitable for estimating the state of soil restoration than soil TP content.展开更多
The single crystals of Nd_(0.5)Pr_(0.5)FeO_(3)were successfully grown by optical floating zone method.Room temperature x-ray diffraction and Laue photograph declared the homogeneity and high quality of the crystal.The...The single crystals of Nd_(0.5)Pr_(0.5)FeO_(3)were successfully grown by optical floating zone method.Room temperature x-ray diffraction and Laue photograph declared the homogeneity and high quality of the crystal.The significant magnetic anisotropy and multiple magnetic transitions illustrate the complex magnetic structure.At high temperatures(T>66 K),it shows the typical characteristics ofΓ_(4)(G_(x),A_(y),F_(z))state.With the decrease of the temperature,it undergoes a first-order spin reorientation transition fromΓ_(4)(G_(x),A_(y),F_(z))toΓ_(2)(F_(x),C_(y),G_(z))state in the temperature window of 45-66 K under an applied magnetic field of 0.01 T.As the temperature drops to~17 K,a new magnetic interaction mechanism works,which results in a further enhancement of magnetization.The T-H phase diagram of Nd_(0.5)Pr_(0.5)FeO_(3)single crystal was finally constructed.展开更多
基金supported by the Lishui Science and Technology Plan Project(Grant Number:2022SJZC020)the Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission(Grant Number:2020KY1084)
文摘Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.
文摘<b>Objective:</b> 120 patients with severe pneumonia who were kept in the comprehensive ICU of our hospital in 2018 were selected, and 16s rDNA sequencing was performed to analyze the composition of pathogenic bacteria in the sputum of severe pneumonia. <b>Methods:</b> The sputum samples of patients with severe bacterial pneumonia were collected, and the diversity of pathogens in the samples was analyzed by polymerase chain reaction (PCR) amplification and high-throughput sequencing (16s rDNA PCR-DGGE). <b>Results:</b> Sequence showed that sputum samples contained a relatively large number of species, and there were many species that were not detected by sequencing. The dominant bacteria were <i>Streptococcus, Sphingomonas, Corynebacterium, Denatobacteria, Aquobacteria, Acinetobacteria, Prevotella, Klebsiella, Pseudomonas</i>, etc. <b>Conclusion:</b> Bacteria caused by sputum of severe bacterial pneumonia are complex and diverse, which provides new methods and ideas for individualized treatment of patients with severe pneumonia.
文摘The diagnosis of pathogenic bacteria in severe pneumonia is difficult and the prognosis is poor. Its outcome is closely related to bacterial pathogenicity and the timeliness and pertinence of antibiotic treatment. Therefore, early diagnosis is of great significance to the prognosis of patients. Sputum examination and culture is the gold standard for the diagnosis of pathogens of severe pneumonia. However, due to the long time of bacterial culture, the early use of antibiotics, the change of bacteria species, mixed infection and other problems, the results of bacterial culture in sputum are often false negative. With the continuous application of new molecular biology techniques in clinical detection, the classification of bacteria and microorganisms has deepened from the identification of phenotypic characteristics to the classification of gene characteristics. Sequencing analysis with 16S rDNA sequencing technology has the characteristics of high sequencing flux, large amount of data obtained, short cycle, and can more comprehensively reflect the species composition of microbial community, real species distribution and abundance information. In this paper, 16S rDNA sequencing technology was used to analyze the bacterial population composition in the sputum of severe pneumonia, and to explore a new method of etiological diagnosis.
基金grants from the National Natural Science Foundation of China(Grant No.81802689)China International Medical Foundation(Grant No.Z-2014-06-15331)Conflict of interest。
文摘Objective:Osteosarcoma is a common primary highly malignant bone tumor.Kinesin family member 18B(K1F18B)has been identified as a potential oncogene involved in the development and metastasis of several cancer types.While KIF18B overexpression in osteosarcoma tissue is clearly detected,its specific function in the disease process remains to be established.Methods:K IF18B expression was assessed in osteosarcoma tissues and cells.We additionally evaluated the effects of KIF18B on proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.Results:Our results showed overexpression of KIF18B in osteosarcoma tissues and cells.Knockdown of K IF18B induced G1/S phase arrest and significantly inhibited proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.K IF18B regulated P-catenin expression at the transcriptional level by controlling nuclear aggregation of ATF2 and at the post-transcriptional level by interacting with the adenomatous polyposis coli(APC)tumor suppressor gene in osteosarcoma cells.Conclusions:KIF18B plays a carcinogenic role in osteosarcoma by regulating expression ofβ-catenin transcriptionally via decreasing nuclear aggregation of ATF2 or post-transcriptionally through interactions with APC.Our collective findings support the potential utility of KIF18B as a novel prognostic biomarker for osteosarcoma.
基金supported by the National High Technology Project "863" (Nos. 2006AA10Z242, 2008AA121805)National Natural Science Foundation of China (NSFC, 40701055)
文摘A precise understanding of the aboveground biomass of desert steppe and its spatio-temporal variation is important to understand how arid ecosystems respond to climate change and to ensure that scarce grassland resources are used rationally. On the basis of 756 ground survey quadrats sampled in western Inner Mongolia steppe in 2005-2011 and remote sensing data from the Moderate Resolu- tion Imaging Spectroradiometer （MODIS）--the normalized difference vegetation index （NDVI） dataset for the period of 2001-2011--we developed a statistical model to estimate the aboveground biomass of the desert steppe and further explored the rela- tionships between aboveground biomass and climate factors. The conclusions are as follows： （1） the aboveground biomass of the steppe in the research area was 5.27 Tg （1 Tg=1012 g） on average over 11 years; between 2001 and 2011, the aboveground biomass of the western Inner Mongolia steppe exhibited fluctuations, with no significant trend over time; （2） the aboveground biomass of the steppe in the research area exhibits distinct spatial variation and generally decreases gradually from southeast to northwest; and （3） the important factor causing intemnnual variations in aboveground biomass is precipitation during the period from January to July, but we did not find a significant relationship between the aboveground biomass and the corresponding temperature changes. The precipitation in this period is also an important factor influencing the spatial distribution of aboveground biomass （R2=0.39, P〈0.001）, while the temperature might be a minor factor （R2=0.12, P〈0.01 ）. The uncertainties in our estimate are primarily due to uncertainty in converting the fresh grass yield estimates to dry weight, underestimates of the biomass of shrubs, and error in remote sensing dataset.
基金supported by the National Basic Research Program of China(973 Program,No.2012CB416906)
文摘Due to increasing timber demands, large areas of secondary forests have been converted to larch plantations （LPs） in Northeast China because the secondary forests could not produce timber as much as LPs. However, there are a series of ecological problems such as lower soil fertility, reduced water-holding capacity and acidification of surface runoff water occurring in LPs because of the single-species composition of LPs. Therefore, a guidance on how to transform LPs into larch-broadleaf mixed forests （LBMFs） at a large spatial scale is needed for local foresters. First, Landsat time series data set and SPOT-5 images were combined to map the spatial-temporal distribution of LPs in Northeast China. Then, the topographical characteristics of LPs in 2010s were determined. Furthermore, three sub-regions of LPs were divided closely linking to their ecosystem services and forest management aims. Finally, detailed information on how to transform the LPs into LBMFs was given according to the three sub-regions. The results showed that the area of LPs increased during 1980s and 2010s, and reached 2.61 million ha in 2010s. Of which, 0.72 million ha （27.6%） and 1.89 million ha （72.4%） LPs distributed in slopes less than 5° and greater than 5°, respectively. Of the LPs （72.4%） in slopes greater than 5°, 48.7 and 23.7% located in downslope （LPs locating at the down slope of adjacent secondary forests in the same aspect） and upslope （LPs locating at the up slope of adjacent secondary forests in the same aspect）, respectively; 0.10 million ha （3.8%） located in slopes greater than 25°. The LPs were divided into Sub-Regions-I, II, III according to slopes. For Sub-region-I （top role is to produce timber）, self-fertilizing shrub species can be intro- duced after clean cutting for young-aged LPs, and release thinning can be applied for middle-aged LPs, fast growth thinning for near-matured LPs, and clear cutting for matured LPs. For Sub-Region-II （the priority is to provide water conservation combined with timber production）, the LPs should be induced into LBMFs. The LPs located the downslope positions in Sub-Region-II can be transformed to LBMFs by natural regeneration of broadleaved tree species after thinning because of enough seed sources of broadleaved tree species from the secondary forests locating the upslope positions. The LPs located the upslope positions or the region where seed sources of broadleaved tree species are unavailable in Sub-Region-II must be induced to LBMFs by al＇tificial regeneration. For Sub-Re- gion-III （the preference is only for water conservation because the slope is greater than 25°）, the LPs should be particularly protected from intensive disturbances, and induced into LBMFs by natural regeneration.
基金The authors acknowledge the support from National Natural Science Foundation of China(51972168,51672124,21603096)Program for Innovative Talents and Entrepreneur in Jiangsu,State Key Laboratory of Catalytic Materials and Reaction Engineering(RIPP,SINOPEC),and Technical Center of Nano Fabrication and Characterization of Nanjing University.
文摘For delivering the nanoscaled extraordinary characteristics in macroscopical bulk,it is essential to integrate two-dimensional nanosheets into threedimensional(3D)porous monoliths,alternatively called as 3D architectures,3D networks,or aerogels.The intersupported structure of porous monolithic 3D graphene(3DG)can prevent aggregation or restacking of graphene individuals,and the interconnected sp^(2) network of 3DG not only can provide the highway for the transport of electron/phonon but also can present continual cavities/channels for mass transfer.This review summarizes the synthesis methodology of 3DG porous monoliths and highlights the application for electric double-layer capacitors.Present challenges and future prospects about the manufacture and application of 3DG are also discussed.
文摘Objective： To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor（DT） and analyze the prognostic factors.Methods：From November 2008 to April 2016,71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors,Peking University Cancer Hospital＆Institute,and enrolled in this retrospective study.The chemotherapy duration is one year.The efficacy of chemotherapy and the prognosis were observed.Results：Of the 71 patients,55% were female.Age of onset varied from 1 to 47 years,and the median age was 14years.Only 11（15.5%）cases suffered primary tumor.The distribution of the site of tumors was：31（43.7%）in the trunk,36（50.7%）in the limbs,and 4（5.6%）in the peritoneal and pelvic cavity.The size of tumor（the maximum diameter）differed from 2 to 37 cm with a mean of 9.3 cm.The median follow-up duration was 28（range,6–87）months.Common side effects included：nausea and vomiting,liver injury,bone marrow suppression and oral ulcers.When the chemotherapy finished,1（1.4%）case achieved complete response,24（33.8%）achieved partial response,37（52.1%）achieved stable disease and 9（12.7%）had progressive disease.The overall response rate was 87.3%.The progression-free survival（PFS）of the participants were from 6 to 87 months,and the 2-,3-and 5-year PFS was 79.9%,68.4% and 36.3%,respectively.No significant difference was identified in PFS in subgroups of gender,age of onset,age of chemotherapy,tumor site and tumor size.Conclusions：For recurrent,inoperable and progressive DT,enough course of chemotherapy with vinorelbine combined with low-dose methotrexate was an optional choice for local control.
基金This work was supported by the Hebei Province Innovation Capability Enhancement Project(19244503D)the Hebei Province Key R&D Program Project(20374504D)the Hebei Province Higher Education Science and Technology Research and Development Project(ZD2020332).
文摘A remote monitoring system for a secondary heating pipe network is designed on the basis of the KingSCADA software.Remote data communication is implemented through the IP mapping technology.Remote data are sorted through IOServer,and the remote monitoring of the pipe network unit port return is implemented accordingly.Using data such as water temperature and pressure of the water supply and return pipes,valve opening can be remotely adjusted to optimize the performances of the network to meet user needs in real time.The research results show that this remote monitoring system displays a reasonable degree of stability and efficiency in remote communication.
基金National Natural Science Foundation of China,Grant/Award Numbers:21974007,U1930401 and U1530402。
文摘Rare-earth sulfides are of research interest for lithium-ion batteries(LIBs)due to their abundant lithium intercalation sites and low redox voltage.However,their electrochemical performances are not satisfactory because of poor conductivity and volume change upon electrochemical cycling.Herein,nanoarchitectures ofγ-Ce_(2)S_(3)encapsulated in a hollow mesoporous carbon nanosphere(Ce_(2)S_(3)@HMCS)are fabricated using the self-template strategy combined with the in-sphere sulfuration method and tested as an LIB anode.The void space between the Ce_(2)S_(3)core and the outer layer of the carbon nanosphere has been properly designed and modulated to achieve excellent electrochemical performance in terms of electronic conductivity,reversibility,and rate capability.The reversible capacity of Ce_(2)S_(3)@HMCS is 2.6 times that of the pure Ce_(2)S_(3)anode,which can gradually increase and maintain a capacity of 282 mAh·g^(−1)at a current density of 1 A·g^(-1),and a high Coulombic efficiency(~100%)can be achieved even after 1000 cycles.This good performance is attributed to the unique yolk-shell nanostructure with a highly crystallized and stable Ce3S2 core and volume expansion buffer space upon lithiation/delithiation.Ex situ X-ray diffraction and nuclear magnetic resonance results indicate that the lithiation of Ce_(2)S_(3)@HMCS is an intercalation process.This study represents an important advancement in precise structural design with in-sphere sulfuration and sheds light on a potential direction for highperformance lithium storage.
基金supported by The National Natural Science Foundation of China(31922059)the Key Research Program of Frontier Sciences,CAS(QYZDJ SSW DQC027 and ZDBS LY DQC019)。
文摘In forest ecosystems,landslides are one of the most common natural disturbances,altering the physical,chemical and microbial characteristics of soil and thus further altering ecosystem properties and processes.Although secondary forests comprise more than 50%of global forests,the influence of landslides on the soil properties in these forests is underappreciated.Therefore,this study investigates the influence of landslides on the chemical and microbial nature of the soil.Study of these modifications is critical,as it provides baseline evidence for subsequent forest revegetation.We selected four independent landslides and adjacent secondary forest stands as references in a temperate secondary forest in northeastern China.Soils were obtained from each stand at 0–10 cm and 10–20 cm depths to determine chemical and microbial properties.Soil total carbon(TC),total nitrogen(TN),nitrate(NO_(3)^(-)-N),available phosphorus(P),microbial biomass carbon(MBC),microbial biomass nitrogen(MBN),microbial biomass phosphorus(MBP)and phenol oxidase,exoglucanase,β-glucosidase,N-acetyl-β-glucosaminidase,L-asparaginase and acid phosphatase activities were 29.3–70.1%lower at the 0–10 cm soil depth in the landslide sites than at the secondary forest sites,whereas total phosphorus(TP)and ammonium(NH_(4)^(+)-N)were unaffected by the landslides.N-related enzymes,N-acetyl-β-glucosaminidase and L-asparaginase were reduced by more than 65%in the landslide sites,consistent with the decrease in nitrate concentration at the same 0–10 cm depth.At a depth of 10–20 cm,the variations in the soil properties were consistent with those at the 0–10 cm depth.The results demonstrated that soil chemical and microbial properties were significantly disrupted after the landslides,even though the landslides had occurred 6 years earlier.A long time is thus needed to restore the original C and nutrient levels.In temperate secondary forests,soil TC and TN contents were found to be more suitable for estimating the state of soil restoration than soil TP content.
基金the National Natural Science Foundation of China(Grant Nos.12074242 and 51862032)the Ministry of Science and Higher Education of Russia(theme“Spin”No.AAAA-A-18-118020290104-2)the Government of the Russian Federation(Grant No.02.A03.21.0006)。
文摘The single crystals of Nd_(0.5)Pr_(0.5)FeO_(3)were successfully grown by optical floating zone method.Room temperature x-ray diffraction and Laue photograph declared the homogeneity and high quality of the crystal.The significant magnetic anisotropy and multiple magnetic transitions illustrate the complex magnetic structure.At high temperatures(T>66 K),it shows the typical characteristics ofΓ_(4)(G_(x),A_(y),F_(z))state.With the decrease of the temperature,it undergoes a first-order spin reorientation transition fromΓ_(4)(G_(x),A_(y),F_(z))toΓ_(2)(F_(x),C_(y),G_(z))state in the temperature window of 45-66 K under an applied magnetic field of 0.01 T.As the temperature drops to~17 K,a new magnetic interaction mechanism works,which results in a further enhancement of magnetization.The T-H phase diagram of Nd_(0.5)Pr_(0.5)FeO_(3)single crystal was finally constructed.
